分子药理学和治疗学领域，主要聚焦于

1)        肿瘤早期筛查及靶向治疗；

2)        光动力抗病原微生物；

3)        心脑血管疾病的相关靶标发现；

4)        代谢性疾病等重大疾病的药物研发。

The field of molecular pharmacology and therapeutics, with a primary focus on

1) Early tumor screening and targeted therapy;

2) Photodynamic killing of pathogenic microorganisms;

3) Discovery of related targets in cardiovascular and cerebrovascular diseases;

4) Research and development of drugs for major diseases such as metabolic diseases.

Practical course in Molecular Cell Biology
药理学

   

（1） 省引才“****”创新类, 省级, 2018
（2） 中科院海西院“****”, 研究所（学校）, 2018
（3） 巾帼建功先进个人, 研究所（学校）, 2017
（4） Danida Fellowship, 国家级, 2012

[1] 陈卓, 戴涛, 胡萍, 潘小宏, 陈锦灿, 张蕾. 一种用于光动力治疗的细菌载体及其制备方法与应用. CN: CN113398275B, 2023-07-25.

[2] 张蕾, 陈卓. 用于双向增强 BAY-1082439 与 LEE011 联合逆转 ABCB1 介导的肿瘤耐药性的多功能纳米载药体系. 202310323258.4, 2023-03-29.

[3] 陈卓, 张蕾, 林瑞坤, 叶碧蔚. 由金纳米粒桥联用于增强 BAY-1082439 逆转 ABCB1 介导的肿瘤耐药性的纳米载药体系 及其应用. 202310322183.8, 2023-03-29.

[4] 陈卓, 刘雯珍, 宋晓荣, 陈学元, 张宇翔. 一种复合材料、其制备方法和在治疗泛耐药性鲍曼不动杆菌引起的深部组织感染中的应用. CN: CN113491770A, 2021-10-12.

[5] 周山勇, 马恩, 黄丽冰, 杨鸿艺, 叶斯哲, 张云, 陈卓, 陈学元. 一种宽波段时间分辨荧光免疫分析装置及分析方法. CN: CN113075175A, 2021-07-06.

[6] 陈卓, 郭晗晗, 宋晓荣, 陈学元, 周山勇. 一种基于稀土纳米材料荧光放大的循环肿瘤细胞检测试剂盒及其应用. CN: CN112034160A, 2020-12-04.

[7] Xueyuan Chen, Zhou, Shanyong, Wei Zheng, En Ma, Mingdong Huang, Zhuo Chen, Datao Tu. Dissolution Enhancing Time-Resolved Fluorescence Immunoassay For Rare Earth Nano Material. Japan Patent No. 6563475, 2019-02-08.

[8] 陈学元, ZHOU, Shanyong, ZHENG, Wei, MA, En, HUANG, Mingdong, CHEN, Zhuo, 涂大涛. DISSOLUTION ENHANCING TIME-RESOLVED FLUORESCENCE IMMUNOASSAY FOR RARE EARTH NANO MATERIAL. 欧盟: EP3124971(A4), 2017-10-25.

[9] 黄明东, 陈锦灿, 陈卓, 胡萍. 一种可用于光动力抗菌的纤维素材料及其制备方法. CN: CN106637992A, 2017-05-10.

[10] 黄明东, 陈卓, 郑科, 李睿, 袁彩. 一种白蛋白与蒽环霉素类抗癌药的分子复合物及其制备方法. CN: CN106177972A, 2016-12-07.

[11] 黄明东, 李世杰, 袁彩, 陈卓, 陈锦灿, 雪光浦, 郑科. 去除血清白蛋白及其融合蛋白中杂质的方法. CN: CN106046149A, 2016-10-26.

[12] 黄明东, 李睿, 陈卓, 胡萍, 陈锦灿, 周山勇, 袁彩, 陈松. 用于光学成像和光动力治疗的肿瘤靶向融合蛋白药物载体. CN: CN104800855A, 2015-07-29.

[13] 陈学元, 周山勇, 郑伟, 马恩, 黄明东, 陈卓, 涂大涛. 一种稀土纳米材料溶解增强时间分辨荧光免疫分析方法. 中国: CN103969432A, 2014.08.06.

[14] 黄明东, 陈卓, 徐芃, 陈锦灿, 周山勇, 胡萍, 陈学元. 靶向表达尿激酶受体的肿瘤的光敏剂及其制备方法和用途. CN: CN104069492A, 2014-10-01.

[15] 陈学元, 周山勇, 郑伟, 马恩, 黄明东, 陈卓, 涂大涛. 一种氟化钇锂纳米复合材料及其制备方法和在光动力学治疗中的应用. 中国: CN103980904A, 2014-08-13.

[16] 黄明东, 周山勇, 胡萍, 陈锦灿, 陈卓. 五聚赖氨酸酞菁锌在制备杀菌药物中的应用. CN: CN102755647A, 2012-10-31.

[17] 黄明东, 周山勇, 陈卓, 陈锦灿, 胡萍. 肿瘤靶向光敏免疫偶联物的制备方法及其应用. CN: CN102585003A, 2012-07-18.

[18] 黄明东, 徐芃, 陈卓, 陈锦灿, 周山勇, 胡萍, 陈学元. 一种具有肿瘤靶向性的光敏剂及其制备方法. CN: CN102321159A, 2012-01-18.

   

[1] Chen, Jincan, Zhou, Yang, Song, Meiru, Chen, Yijian, Wang, Dong, Huang, Yunmei, Hu, Ping, He, Chen, Dai, Tao, Zhang, Lei, Huang, Mingdong, Chen, Zhuo, Xu, Peng. A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2023, 646: 959-969, http://dx.doi.org/10.1016/j.jcis.2023.05.131.
[2] Fan Liu, Wusen Zhou, Xingjun Li, Zhuo Li, Shan Lu, Xiaoying Shang, Chong Tan, Ping Hu, Zhuo Chen, Xueyuan Chen. AIEgen-sensitized lanthanide nanocrystals as luminescent probes for intracellular Fe3+ monitoring. Talanta[J]. 2023, 262: 124729-, [3] Ruikun Lin, Lei Zhang, Biwei Ye, Yanan Wang, YiDong Li, Hsu Jason, Wenzhen Liu, Ping Hu, Jincan Chen, ZheSheng Chen, Zhuo Chen. A multi-functional nano-system combining PI3K-110 alpha/Beta inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency. CANCER LETTERS[J]. 2023, 563: http://dx.doi.org/10.1016/j.canlet.2023.216181.
[4] Li, Zhuo, Lu, Shan, Li, Xingjun, Chen, Zhuo, Chen, Xueyuan. Lanthanide Upconversion Nanoplatforms for Advanced Bacteria-Targeted Detection and Therapy. ADVANCED OPTICAL MATERIALSnull. 2023, 11(11): https://www.doi.org/10.1002/adom.202202386.
[5] Zhang, Lei, Ye, Biwei, Chen, Zhuo, Chen, ZheSheng. Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers. ACTA PHARMACEUTICA SINICA Bnull. 2023, 13(3): 982-997, http://dx.doi.org/10.1016/j.apsb.2022.10.002.
[6] 刘若湄, 冯艳辉, 李卓, 卢珊, 关天用, 李幸俊, 刘䶮, 陈卓, 陈学元. A novel near-infrared responsive lanthanide upconversion nanoplatform for drug delivery based on photocleavage of cypate. Acta Chim. Sinica[J]. 2022, 80(4): 423-427, http://sioc-journal.cn/Jwk_hxxb/CN/10.6023/A22010001.
[7] Wang, Le, Pan, Xiaohong, Tang, Shuzhi, Wang, Yaqi, Shi, Haixing, Wang, Huanhuan, Liu, Wenzhen, Chen, Zhuo. An intelligent photosensitizer that selectively kills Gram-positive pathogenic cocci while preventing harm to beneficial bacilli. DYES AND PIGMENTS[J]. 2022, 201: http://dx.doi.org/10.1016/j.dyepig.2022.110197.
[8] Wang, Yaqi, Pan, Xiaohong, Dai, Tao, Wang, Le, Shi, Haixing, Wang, Huanhuan, Chen, Zhuo. An AIE photosensitizer with unquenched fluorescence based on nitrobenzoic acid for tumor-targeting and image-guided photodynamic therapy. BIOMATERIALS SCIENCE[J]. 2022, 10(17): 4866-4875, http://dx.doi.org/10.1039/d2bm00704e.
[9] 刘若湄, 冯艳辉, 李卓, 卢珊, 关天用, 李幸俊, 刘, 陈卓, 陈学元. 基于cypate光裂解的新型近红外光响应稀土上转换纳米载药系统. 化学学报. 2022, 80(4): 423-427, https://d.wanfangdata.com.cn/periodical/hxxb202204001.
[10] Zhang, Lei, Ye, Biwei, Lin, Yunfeng, Li, YiDong, Wang, JingQuan, Chen, Zhuo, Ping, FengFeng, Chen, ZheSheng. Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells. FRONTIERS IN PHARMACOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fphar.2022.867128.
[11] Shi, Haixing, Pan, Xiaohong, Wang, Yaqi, Wang, Huanhuan, Liu, Wenzhen, Wang, Le, Chen, Zhuo. Restricting Bond Rotations by Ring Fusion: A Novel Molecular Design Strategy to Improve Photodynamic Antibacterial Efficacy of AIE Photosensitizers. ACS APPLIED MATERIALS & INTERFACES[J]. 2022, 14(15): 17055-17064, http://dx.doi.org/10.1021/acsami.1c24329.
[12] Hu, Ping, Xu, Gan, Yang, DeChao, Liu, JianYong, Chen, Zhuo, Huang, Mingdong. An advanced multifunctional prodrug combining photodynamic therapy with chemotherapy for highly efficient and precise tumor ablation. DYES AND PIGMENTS[J]. 2022, 205: http://dx.doi.org/10.1016/j.dyepig.2022.110500.
[13] Li, Zhuo, Lu, Shan, Liu, Wenzhen, Dai, Tao, Ke, Jianxi, Li, Xingjun, Li, Renfu, Zhang, Yuxiang, Chen, Zhuo, Chen, Xueyuan. Synergistic Lysozyme-Photodynamic Therapy Against Resistant Bacteria based on an Intelligent Upconversion Nanoplatform. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(35): 19201-19206, http://dx.doi.org/10.1002/anie.202103943.
[14] He, Chen, Zhang, Lei, Liu, Wenzhen, Huang, Yunmei, Hu, Ping, Dai, Tao, Xu, Jianhua, Chen, Zhuo. Albumin-based nanoparticles combined with photodynamic therapy enhance the antitumor activity of curcumin derivative C086. DYES AND PIGMENTS[J]. 2021, 189: http://dx.doi.org/10.1016/j.dyepig.2021.109258.
[15] 戴涛, 叶发荣, 胡萍, 潘小宏, 陈锦灿, 黄云梅, 王欢欢, 张蕾, 黄明东, 刘见永, 苏建强, 陈学元, 陈卓. 一种基于大肠杆菌驱动药物递送系统增强光动力治疗的肿瘤靶向策略. 中国科学:材料科学(英文版)[J]. 2021, 64(1): 232-240, http://lib.cqvip.com/Qikan/Article/Detail?id=7103798294.
[16] Wang, Huanhuan, Pan, Xiaohong, Wang, Yaqi, Liu, Wenzhen, Dai, Tao, Yuan, Binbin, Chen, Xueyuan, Chen, Zhuo. A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy. SCIENCE CHINA-MATERIALS[J]. 2021, 64(10): 2601-2612, http://dx.doi.org/10.1007/s40843-021-1652-2.
[17] Zhang, Lei, Li, Zhen, Ye, Xianren, Chen, Zhuo, Chen, ZheSheng. Mechanisms of thrombosis and research progress on targeted antithrombotic drugs. DRUG DISCOVERY TODAY[J]. 2021, 26(10): 2282-2302, http://dx.doi.org/10.1016/j.drudis.2021.04.023.
[18] 王欢欢, 潘小宏, 王亚琪, 刘雯珍, 戴涛, 袁彬彬, 陈学元, 陈卓. 基于硝基苯甲酸结构的新型AIE光敏剂的光动力抗菌作用. 中国科学:材料科学(英文版)[J]. 2021, 64(10): 2601-2612, http://lib.cqvip.com/Qikan/Article/Detail?id=7105633838.
[19] 王乐, 张志强, 陈建松, 陈卓. 循环肿瘤细胞上皮-间质转化对肿瘤发生发展的影响及其临床应用潜力. 福建医科大学学报[J]. 2021, 55(02期): 157-161, [20] Dai, Tao, Ye, Farong, Hu, Ping, Pan, Xiaohong, Chen, Jincan, Huang, Yunmei, Wang, Huanhuan, Zhang, Lei, Huang, Mingdong, Liu, Jianyong, Su, Jianqiang, Chen, Xueyuan, Chen, Zhuo. A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system. SCIENCE CHINA-MATERIALS[J]. 2021, 64(1): 232-240, https://www.webofscience.com/wos/woscc/full-record/WOS:000547355300002.
[21] Lin, Yunfeng, Chen, Zhuo, Hu, Chaohua, Chen, ZheSheng, Zhang, Lei. Recent progress in antitumor functions of the intracellular antibodies. DRUG DISCOVERY TODAY[J]. 2020, 25(6): 1109-1120, http://dx.doi.org/10.1016/j.drudis.2020.02.009.
[22] Li, Linlin, Chen, Dan, Zheng, Ke, Jiang, Libin, Dai, Tao, Yang, Ling, Jiang, Longguang, Chen, Zhuo, Yuan, Cai, Huang, Mingdong. Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(4): 4221-4230, http://dx.doi.org/10.1021/acsami.9b18396.
[23] Liu, Wenzhen, Zhang, Yuxiang, You, Wenwu, Su, Jianqiang, Yu, Shaohua, Dai, Tao, Huang, Yunmei, Chen, Xueyuan, Song, Xiaorong, Chen, Zhuo. Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistant Acinetobacter baumannii based on lanthanide nanoparticles. NANOSCALE[J]. 2020, 12(26): 13948-13957, https://www.webofscience.com/wos/woscc/full-record/WOS:000547632900045.
[24] Ke, Jianxi, Lu, Shan, Li, Zhuo, Shang, Xiaoying, Li, Xingjun, Li, Renfu, Tu, Datao, Chen, Zhuo, Chen, Xueyuan. Multiplexed intracellular detection based on dual-excitation/dual-emission upconversion nanoprobes. NANO RESEARCH[J]. 2020, 13(7): 1955-1961, http://lib.cqvip.com/Qikan/Article/Detail?id=7102716205.
[25] Hu, Ping, Shang, Le, Chen, Jincan, Chen, Xuzheng, Chen, Chun, Hong, Wanjin, Huang, Mingdong, Xu, Peng, Chen, Zhuo. A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2020, 8(3): 504-514, http://dx.doi.org/10.1039/c9tb02081k.
[26] Wang, Dong, Yang, Yongshuai, Wang, Yu, Proulle, Valerie, Andreasen, Peter A, Hong, Wanjin, Chen, Zhuo, Huang, Mingdong, Xu, Peng. Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis. BIOMEDICINE & PHARMACOTHERAPY[J]. 2020, 130: http://dx.doi.org/10.1016/j.biopha.2020.110528.
[27] Wang, Dong, Liu, Wenzhen, Wang, Le, Wang, Yu, Liao, Christopher Kai, Chen, Jincan, Hu, Ping, Hong, Wanjin, Huang, Mingdong, Chen, Zhuo, Xu, Peng. Suppression of cancer proliferation and metastasis by a versatile nanomedicine integrating photodynamic therapy, photothermal therapy, and enzyme inhibition. ACTA BIOMATERIALIA[J]. 2020, 113: 541-553, http://dx.doi.org/10.1016/j.actbio.2020.06.021.
[28] Liu, Jihao, Chen, Zhuo, Huang, Mingdong, Tang, Shuzhi, Wang, Qianchao, Hu, Ping, Gupta, Pranav, Ashby, Charles R, Chen, ZheSheng, Zhang, Lei. Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells. EXPERIMENTAL CELL RESEARCH[J]. 2020, 391(1): http://dx.doi.org/10.1016/j.yexcr.2020.111987.
[29] Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang, ZheSheng Chen. The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer. MOLECULAR CANCER[J]. 2020, 19(1): 1-18, http://dx.doi.org/10.1186/s12943-019-1112-1.
[30] Zhang Lei, Chen Zhuo. Research Progress of Structure Based Antitumor Drug Design. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY[J]. 2020, 39(12): 2085-2090, http://lib.cqvip.com/Qikan/Article/Detail?id=7103737695.
[31] Sun, Jing, Zhang, Yuxiang, Su, Jianqiang, Dai, Tao, Chen, Jincan, Zhang, Lei, Wang, Huanhuan, Liu, Wenzhen, Huang, Mingdong, Chen, Zhuo. Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression. DYES AND PIGMENTS[J]. 2020, 179: http://dx.doi.org/10.1016/j.dyepig.2020.108392.
[32] Lian, Wei, Tu, Datao, Hu, Ping, Song, Xiaorong, Gong, Zhongliang, Chen, Tao, Song, Jibin, Chen, Zhuo, Chen, Xueyuan. Broadband excitable NIR-II luminescent nano-bioprobes based on CuInSe2 quantum dots for the detection of circulating tumor cells. NANO TODAY[J]. 2020, 35: http://dx.doi.org/10.1016/j.nantod.2020.100943.
[33] Tang, Shuzhi, Liu, Wenzhen, Pan, Xiaohong, Liu, Libin, Yang, Yongshuai, Wang, Dong, Xu, Peng, Huang, Mingdong, Chen, Zhuo. Specific inhibition of plasminogen activator inhibitor 1 reduces blood glucose level by lowering TNF-a. LIFE SCIENCES[J]. 2020, 246: http://dx.doi.org/10.1016/j.lfs.2020.117404.
[34] Zhang, Lei, Li, Yidong, Wang, Qianchao, Chen, Zhuo, Li, Xiaoyun, Wu, Zhuoxun, Hu, Chaohua, Liao, Dan, Zhang, Wei, Chen, ZheSheng. The PI3K subunits, P110 alpha and P110 beta are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer. MOLECULAR CANCER[J]. 2020, 19(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000513723900001.
[35] Li, Xiuxiu, Chen, Zhuo, Zhang, Guomin, Lu, Hongwei, Qin, Peng, Qi, Ming, Yu, Ying, Jiao, Bingke, Zhao, Xianfeng, Gao, Qiang, Wang, Hao, Wu, Yunyu, Ma, Juntao, Zhang, Liyan, Wang, Yongli, Deng, Lingwei, Yao, Shanguo, Cheng, Zhukuang, Yu, Diqiu, Zhu, Lihuang, Xue, Yongbiao, Chu, Chengcai, Li, Aihong, Li, Shigui, Liang, Chengzhi. Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 63(11): 1688-1702, http://lib.cqvip.com/Qikan/Article/Detail?id=7104062130.
[36] Shen, Chen, Du, Huilong, Chen, Zhuo, Lu, Hongwei, Zhu, Fugui, Chen, Hong, Meng, Xiangzhao, Liu, Qianwen, Liu, Peng, Zheng, Lihua, Li, Xiuxiu, Dong, Jiangli, Liang, Chengzhi, Wang, Tao. The Chromosome-Level Genome Sequence of the Autotetraploid Alfalfa and Resequencing of Core Germplasms Provide Genomic Resources for Alfalfa Research. MOLECULAR PLANT[J]. 2020, 13(9): 1250-1261, http://lib.cqvip.com/Qikan/Article/Detail?id=7103401570.
[37] Zhuo Chen. Suppression of cancer proliferation and metastasis by a versatile nanomedicine integrating multiple therapeutic mechanisms. Acta Biomaterialia. 2020, [38] Peng, Hua, Wang, Kai, Chen, Zhuo, Cao, Yinghao, Gao, Qiang, Li, Yan, Li, Xiuxiu, Lu, Hongwei, Du, Huilong, Lu, Min, Yang, Xin, Liang, Chengzhi. MBKbase for rice: an integrated omics knowledgebase for molecular breeding in rice. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(D1): D1085-D1092, https://www.webofscience.com/wos/woscc/full-record/WOS:000525956700139.
[39] Yan, Shufeng, Guo, Hanhan, Su, Jianqiang, Chen, Jincan, Song, Xiaorong, Huang, Mingdong, Zhang, Juncheng, Chen, Zhuo. Effects of hydroxyl radicals produced by a zinc phthalocyanine photosensitizer on tumor DNA. DYES AND PIGMENTS[J]. 2020, 173: http://dx.doi.org/10.1016/j.dyepig.2019.107894.
[40] 委娇娇, 郑伟, 商晓颖, 李仁富, 黄萍, 刘, 宫仲亮, 周山勇, 陈卓, 陈学元. 基于Mn2+激活氟化钙纳米荧光探针的时间分辨荧光生物分析（英文）. 中国科学:材料科学(英文版)[J]. 2019, 62: 130-137, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SCMA201901014&DbName=CJFDLAST2019&DbCode=CJFQ&yx=&pr=&URLID=&bsm=QKK0203;.
[41] Peng, Shuangzhou, Xue, Guangpu, Chen, Shanli, Chen, Zhuo, Yuan, Cai, Li, Jinyu, Huang, Mingdong. tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity. THROMBOSIS AND HAEMOSTASIS[J]. 2019, 119(1): 77-86, https://www.webofscience.com/wos/woscc/full-record/WOS:000454595900010.
[42] Wang, Dong, Yang, Yongshuai, Jiang, Longguang, Wang, Yu, Li, Jinyu, Andreasen, Peter A, Chen, Zhuo, Huang, Mingdong, Xu, Peng. Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 62(4): 2172-2183, http://dx.doi.org/10.1021/acs.jmedchem.8b01908.
[43] Wang, Yu, Wang, Sen, Nie, Xinyi, Yang, Kunlong, Xu, Peng, Wang, Xiuna, Liu, Mengxin, Yang, Yongshuai, Chen, Zhuo, Wang, Shihua. Molecular and structural basis of nucleoside diphosphate kinase-mediated regulation of spore and sclerotia development in the fungus Aspergillus flavus. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(33): 12415-12431, http://dx.doi.org/10.1074/jbc.RA119.007505.
[44] 杨永帅, 贾玉华, 蔡良知, 徐芃, 戴涛, 陈锦灿, 胡萍, 黄明东, 陈卓. 酞菁光敏剂抗小鼠宫颈癌的光动力学实验. 福州大学学报:自然科学版[J]. 2019, 47(6): 859-864, http://lib.cqvip.com/Qikan/Article/Detail?id=7100523546.
[45] Yan, Shufeng, Huang, Qingqing, Song, Xiaorong, Chen, Zhuo, Huang, Mingdong, Zhang, Juncheng. A series of photosensitizers with incremental positive electric charges for photodynamic antitumor therapy. RSC ADVANCES[J]. 2019, 9(42): 24560-24567, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069672/.
[46] Yu Wang, Sen Wang, Xinyi Nie, Kunlong Yang, Peng Xu, Xiuna Wang, Mengxin Liu, Yongshuai Yang, Zhuo Chen, Shihua Wang. Molecular and structural basis of nucleoside diphosphate kinase–mediated regulation of spore and sclerotia development in the fungus Aspergillus flavus. JOURNAL OF BIOLOGICAL CHEMISTRY. 2019, 294(33): 12415-12431, http://dx.doi.org/10.1074/jbc.RA119.007505.
[47] Chen, Jingyi, Yang, Ling, Chen, Jincan, Liu, Wenzhen, Zhang, Di, Xu, Peng, Dai, Tao, Shang, Le, Yang, Yongshuai, Tang, Shuzhi, Zhang, Yuxiang, Lin, Huajian, Chen, Zhuo, Huang, Mingdong. Composite of silver nanoparticles and photosensitizer leads to mutual enhancement of antimicrobial efficacy and promotes wound healing. CHEMICAL ENGINEERING JOURNAL[J]. 2019, 374: 1373-1381, http://dx.doi.org/10.1016/j.cej.2019.05.184.
[48] Guo, Hanhan, Song, Xiaorong, Lei, Wen, He, Cheng, You, Wenwu, Lin, Qingzhong, Zhou, Shanyong, Chen, Xueyuan, Chen, Zhuo. Direct Detection of Circulating Tumor Cells in Whole Blood Using Time-Resolved Luminescent Lanthanide Nanoprobes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(35): 12195-12199, https://www.doi.org/10.1002/anie.201907605.
[49] Jianxi Ke, Shan Lu, Xiaoying Shang, Yan Liu, Hanhan Guo, Wenwu You, Xingjun Li, Jin Xu, Renfu Li, Zhuo Chen, Xueyuan Chen. A Strategy of NIR Dual‐Excitation Upconversion for Ratiometric Intracellular Detection. ADVANCED SCIENCE[J]. 2019, 6(22): n/a-n/a, https://doaj.org/article/5a21835e8fc44375bd0e6daa31466548.
[50] Gao, Yu, Li, Renfu, Zheng, Wei, Shang, Xiaoying, Wei, Jiaojiao, Zhang, Meiran, Xu, Jin, You, Wenwu, Chen, Zhuo, Chen, Xueyuan. Broadband NIR photostimulated luminescence nanoprobes based on CaS:Eu2+, Sm3+ nanocrystals. CHEMICAL SCIENCE[J]. 2019, 10(21): 5452-5460, https://www.webofscience.com/wos/woscc/full-record/WOS:000474412700025.
[51] Wei, Jiaojiao, Zheng, Wei, Shang, Xiaoying, Li, Renfu, Huang, Ping, Liu, Yan, Gong, Zhongliang, Zhou, Shanyong, Chen, Zhuo, Chen, Xueyuan. Mn2+-activated calcium fluoride nanoprobes for time-resolved photoluminescence biosensing. SCIENCE CHINA-MATERIALS[J]. 2019, 62(1): 130-137, https://www.webofscience.com/wos/woscc/full-record/WOS:000455325400014.
[52] Zhuo Chen. Direct detection of circulating tumor cells in whole blood based on time-resolved luminescent lanthanide nanoprobes. ANGEWCHEMINTED. 2019, [53] Li, Shijie, Yuan, Cai, Chen, Jincan, Chen, Dan, Chen, Zhuo, Chen, Wenlie, Yan, Shufeng, Hu, Ping, Xue, Jinping, Li, Rui, Zheng, Ke, Huang, Mingdong. Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release. THERANOSTICS[J]. 2019, 9(3): 884-899, [54] Yan, Shufeng, Huang, Qingqing, Chen, Jincan, Song, Xiaorong, Chen, Zhuo, Huang, Mingdong, Xu, Peng, Zhang, Juncheng. Tumor-targeting photodynamic therapy based on folate-modified polydopamine nanoparticles. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2019, 14: 6799-6812, https://doaj.org/article/d0617edeaa514afa9fef27986daf98ee.
[55] 刘吉昊, 唐述志, 胡立宏, 黄明东, 陈卓. 靶向纤溶酶原激活物抑制剂1的肿瘤治疗研究进展. 生物化学与生物物理进展[J]. 2019, 663-, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2019&filename=SHSW201907003&v=MTg5OTRxVHJXTTFGckNVUjdxZmIrWnBGQ3JrVjd6Tk5pWFllYkc0SDlqTXFJOUZaNFI4ZVgxTHV4WVM3RGgxVDM=.
[56] Liu JiHao, Tang ShuZhi, Hu LiHong, Huang MingDong, Chen Zhuo. Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2019, 46(7): 663-672, [57] Song, Xiaorong, Li, Shihua, Guo, Hanhan, You, Wenwu, Shang, Xiaoying, Li, Renfu, Tu, Datao, Zheng, Wei, Chen, Zhuo, Yang, Huanghao, Chen, Xueyuan. Graphene-Oxide-Modified Lanthanide Nanoprobes for Tumor-Targeted Visible/NIR-II Luminescence Imaging. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(52): 18981-18986, http://dx.doi.org/10.1002/anie.201909416.
[58] Yan, Shufeng, Chen, Jincan, Cai, Liangzhi, Xu, Peng, Zhang, Yaxin, Li, Shijie, Hu, Ping, Chen, Xueyuan, Huang, Mingdong, Chen, Zhuo. Phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(38): 6080-6088, http://dx.doi.org/10.1039/c8tb01884g.
[59] Li, Shijie, Li, Linlin, Chen, Zhuo, Xue, Guangpu, Jiang, Longguang, Zheng, Ke, Chen, Jincan, Li, Rui, Yuan, Cai, Huang, Mingdong. A novel purification procedure for recombinant human serum albumin expressed in Pichia pastoris. PROTEIN EXPRESSION AND PURIFICATION[J]. 2018, 149: 37-42, http://dx.doi.org/10.1016/j.pep.2018.04.012.
[60] Zhang, Yuxiang, Huang, Ping, Wang, Dong, Chen, Jincan, Liu, Wenzhen, Hu, Ping, Huang, Mingdong, Chen, Xueyuan, Chen, Zhuo. Near-infrared-triggered antibacterial and antifungal photodynamic therapy based on lanthanide-doped upconversion nanoparticles. NANOSCALE[J]. 2018, 10(33): 15485-15495, http://dx.doi.org/10.1039/c8nr01967c.
[61] 黄明东, 刘大锋, 袁彩, 陈静怡, 陈卓. 两亲性光敏剂五聚赖氨酸酞菁锌的抗菌机理. 福建农林大学学报：自然科学版[J]. 2018, 47(5): 626-632, http://lib.cqvip.com/Qikan/Article/Detail?id=7000845470.
[62] Zhuo Chen. House-hold light source for potent photodynamic antimicrobial effect and wound healing in infective animal model. Biomedical Optics Express. 2018, [63] Zhuo Chen. A Smart Photosensitizer: Tumor-triggered Oncotherapy by Self-Assembly Photodynamic Nanodots. ACS Applied Materials & Interfaces. 2018, [64] Ullah, Azeem, Zhang, Yuxiang, Iqbal, Zafar, Zhang, Yaxin, Wang, Dong, Chen, Jincan, Hu, Ping, Chen, Zhuo, Huang, Mingdong. Household light source for potent photodynamic antimicrobial effect and wound healing in an infective animal model. BIOMEDICAL OPTICS EXPRESS[J]. 2018, 9(3): 1006-1019, http://dx.doi.org/10.1364/BOE.9.001006.
[65] Yan, Shufeng, Song, Xiaorong, Liu, Yan, Dai, Tao, Huang, Mingdong, Chen, Xueyuan, Chen, Zhuo. An efficient synergistic cancer therapy by integrating cell cycle inhibitor and photosensitizer into polydopamine nanoparticles. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(17): 2620-2629, http://dx.doi.org/10.1039/c8tb00076j.
[66] Liu, Dafeng, Li, Linsen, Chen, Jincan, Chen, Zhuo, Jiang, Longguang, Yuan, Cai, Huang, Mingdong. Dissociation of zinc phthalocyanine aggregation on bacterial surface is key for photodynamic antimicrobial effect. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2018, 22(9-10): 925-934, http://dx.doi.org/10.1142/S1088424618500888.
[67] 邓静泽, 黄明东, 陈卓, 张明鑫, 陈锦灿, 李林森. 水溶性寡聚赖氨酸锌酞菁的合成及其光动力学活性. 沈阳药科大学学报[J]. 2018, 35(11): 936-942, http://lib.cqvip.com/Qikan/Article/Detail?id=676840226.
[68] Jia, Yuhua, Li, Jinyu, Chen, Jincan, Hu, Ping, Jiang, Longguang, Chen, Xueyuan, Huang, Mingdong, Chen, Zhuo, Xu, Peng. Smart Photosensitizer: Tumor-Triggered Oncotherapy by Self-Assembly Photodynamic Nanodots. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(18): 15369-15380, http://dx.doi.org/10.1021/acsami.7b19058.
[69] Zhuo Chen. A long-acting PAI-1 inhibitor reduce thrombus formation. Thrombosis and Haemostasis. 2017, [70] Chen, Jincan, Wang, Weijie, Hu, Ping, Wang, Dong, Lin, Fan, Xue, Jingping, Chen, Zhuo, Iqbal, Zafar, Huang, Mingdong. Dual antimicrobial actions on modified fabric leads to inactivation of drug-resistant bacteria. DYES AND PIGMENTS[J]. 2017, 140: 236-243, http://dx.doi.org/10.1016/j.dyepig.2017.01.032.
[71] Zhang, Yaxin, Zheng, Ke, Chen, Zhuo, Chen, Jincan, Hu, Ping, Cai, Linrong, Iqbal, Zafar, Huang, Mingdong. Rapid killing of bacteria by a new type of photosensitizer. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2017, 101(11): 4691-4700, http://dx.doi.org/10.1007/s00253-017-8133-8.
[72] Zhang, Zaizhong, He, Yang, Tu, Xiaohuang, Huang, Sheng, Chen, Zhuo, Wang, Lie, Song, Jingxiang. Mapping of DNA Hypermethylation and Hypomethylation induced by Folate Deficiency in Sporadic Colorectal Cancer and Clinical Implication Analysis of Hypermethylation Pattern in CBS Promoter. CLINICAL LABORATORY[J]. 2017, 63(4): 733-748, https://www.webofscience.com/wos/woscc/full-record/WOS:000398985100011.
[73] 李世杰, 袁彩, 郑科, 陈锦灿, 雪光浦, 陈卓, 黄明东. 一种新颖的除去重组人血清白蛋白杂质的方法. 福建师范大学学报(自然科学版)[J]. 2017, 65-72, [74] Zhuo Chen. Dual antimicrobial mechanisms of a material leads to an inactivation of drug-resistant bacteria. Dyes and Pigments. 2017, [75] Wang, Dong, Zhang, Yuxiang, Yan, Shufeng, Chen, Zihan, Deng, Yicai, Xu, Peng, Chen, Jincan, Liu, Wenzhen, Hu, Ping, Huang, Mingdong, Chen, Zhuo. An effective zinc phthalocyanine derivative against multidrug-resistant bacterial infection. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2017, 21(3): 205-210, http://dx.doi.org/10.1142/S1088424617500298.
[76] Peng, Shuangzhou, Xue, Guangpu, Gong, Lihu, Fang, Chao, Chen, Jingfei, Yuan, Cai, Chen, Zhuo, Yao, Lishan, Furie, Bruce, Huang, Mingdong. A long-acting PAI-1 inhibitor reduces thrombus formation. THROMBOSIS AND HAEMOSTASIS[J]. 2017, 117(7): 1338-1347, https://www.webofscience.com/wos/woscc/full-record/WOS:000404671700014.
[77] Zhuo Chen. Effects of a combination therapy with a compound Chinese medicine and an enteral nutrition powder in the treatment of mice with chronic obstructive pulmonary diseases. China Medical Herald. 2017, [78] Zhuo Chen. A novel method of removing impurities from recombinant human serum albumin. Journal of Fujian Normal University. 2017, [79] Xu, Peng, Jia, Yuhua, Yang, Yongshuai, Chen, Jincan, Hu, Ping, Chen, Zhuo, Huang, Mingdong. Photodynamic Oncotherapy Mediated by Gonadotropin-Releasing Hormone Receptors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 60(20): 8667-8672, https://www.webofscience.com/wos/woscc/full-record/WOS:000414114300029.
[80] Wang, Huiqi, Tu, Datao, Xu, Jin, Shang, Xiaoying, Hu, Ping, Li, Renfu, Zheng, Wei, Chen, Zhuo, Chen, Xueyuan. Lanthanide-doped LaOBr nanocrystals: controlled synthesis, optical spectroscopy and bioimaging. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2017, 5(25): 4827-4834, https://www.webofscience.com/wos/woscc/full-record/WOS:000404613200002.
[81] 邓宜材, 黄明朝, 陈丽, 叶永佺, 游锦惠, 苏标堃, 陈卓, 董芳. 血管紧张素转换酶Ⅱ在肺栓塞大鼠肺动脉中的表达及其对肺动脉血管的影响. 中国医药导报[J]. 2017, 14(32): 4-7, http://lib.cqvip.com/Qikan/Article/Detail?id=673812262.
[82] Zhuo Chen. Secretion and effects of angiotensin-converting enzyme 2 on pulmonary vascular remodeling in pulmonary embolism rats. China Medical Herald. 2017, [83] 陈卓, 顾飞腾, 朱建林, 陈月媛, 张再重, 涂小煌. 术前外周血中性粒细胞和淋巴细胞比值与结直肠癌术后病理的相关性分析. 临床医药文献杂志（电子版）[J]. 2017, 4(82): 16193-16195, http://lib.cqvip.com/Qikan/Article/Detail?id=7000661759.
[84] Zhou, Zhihao, Zheng, Wei, Kong, Jintao, Liu, Yan, Huang, Ping, Zhou, Shanyong, Chen, Zhuo, Shi, Jianlin, Chen, Xueyuan. Rechargeable and LED-activated ZnGa2O4 : Cr3+ near-infrared persistent luminescence nanoprobes for background-free biodetection. NANOSCALE[J]. 2017, 9(20): 6846-6853, http://ir.sic.ac.cn/handle/331005/25404.
[85] 邓宜材, 刘雯珍, 陈子晗, 张雅馨, 鄢树枫, 郑志凌, 董芳, 陈卓. 健脾益气复方中药联合肠内营养粉剂对慢性阻塞性肺疾病小鼠的治疗作用. 中国医药导报[J]. 2017, 14(14): 20-24, http://lib.cqvip.com/Qikan/Article/Detail?id=672251541.
[86] Rui Li, Ke Zheng, Cai Yuan, Zhuo Chen, Mingdong Huang. Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials. NANOTHERANOSTICS. 2017, 1(4): 346-357, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646738/.
[87] Zhuo Chen. Application of polymerase chain reaction technology in food microbe examination. Journal of Fujian Medical University. 2016, [88] Bag, Partha Pratim, Wang, Dong, Chen, Zhuo, Cao, Rong. Outstanding drug loading capacity by water stable microporous MOF: a potential drug carrier. CHEMICAL COMMUNICATIONS[J]. 2016, 52(18): 3669-3672, [89] Liu, Yongsheng, Zhou, Shanyong, Zhuo, Zhu, Li, Renfu, Chen, Zhuo, Hong, Maochun, Chen, Xueyuan. In vitro upconverting/downshifting luminescent detection of tumor markers based on Eu3+-activated core-shell-shell lanthanide nanoprobes. CHEMICAL SCIENCE[J]. 2016, 7(8): 5013-5019, https://www.webofscience.com/wos/woscc/full-record/WOS:000380893900028.
[90] Zhuo Chen. Outstanding drug loading capacity by water stable microporous 2D MOF: A potential drug carrier. Chemical Communications. 2016, [91] 王栋, 王旭, 陈卓. 聚合酶链式反应技术在食品微生物检测中的应用进展. 福建医科大学学报[J]. 2016, 50(3): 213-216, http://lib.cqvip.com/Qikan/Article/Detail?id=669737590.
[92] 陈锦灿, 陈卓, 林华建, 黄明东. 酞菁光敏剂抗菌效果的实验研究. 福建医药杂志[J]. 2016, 38(5): 53-56, http://lib.cqvip.com/Qikan/Article/Detail?id=670336248.
[93] Xu, Jin, Zhou, Shanyong, Tu, Datao, Zheng, Wei, Huang, Ping, Li, Renfu, Chen, Zhuo, Huang, Mingdong, Chen, Xueyuan. Sub-5 nm lanthanide-doped lutetium oxyfluoride nanoprobes for ultrasensitive detection of prostate specific antigen. CHEMICAL SCIENCE[J]. 2016, 7(4): 2572-2578, [94] Zhuo Chen. Experimental study on antibacterial effect of phthalocyanine photosensitizer. Fujian Medical Journal. 2016, [95] Chen, Zhuo, Zhang, Yaxin, Wang, Dong, Li, Linsen, Zhou, Shanyong, Huang, Joy H, Chen, Jincan, Hu, Ping, Huang, Mingdong. Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection. JOURNAL OF BIOMEDICAL OPTICS[J]. 2016, 21(1): http://www.corc.org.cn/handle/1471x/2374551.
[96] Zhou, Xiaolei, Zheng, Ke, Li, Rui, Chen, Zhuo, Yuan, Cai, Hu, Ping, Chen, Jincan, Xue, Jinping, Huang, Mingdong. A drug carrier targeting murine uPAR for photodynamic therapy and tumor imaging. ACTA BIOMATERIALIA[J]. 2015, 23: 116-126, http://dx.doi.org/10.1016/j.actbio.2015.05.017.
[97] Lu, Shan, Tu, Datao, Hu, Ping, Xu, Jin, Li, Renfu, Wang, Meng, Chen, Zhuo, Huang, Mingdong, Chen, Xueyuan. Multifunctional Nano-Bioprobes Based on Rattle-Structured Upconverting Luminescent Nanoparticles. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(27): 7915-7919, http://dx.doi.org/10.1002/anie.201501468.
[98] Zheng, Wei, Tu, Datao, Huang, Ping, Zhou, Shanyong, Chen, Zhuo, Chen, Xueyuan. Time-resolved luminescent biosensing based on inorganic lanthanide-doped nanoprobes. CHEMICAL COMMUNICATIONS[J]. 2015, 51(20): 4129-4143, http://dx.doi.org/10.1039/c4cc10432c.
[99] 黄萍, 涂大涛, 郑伟, 周山勇, 陈卓, 陈学元. 基于无机稀土纳米探针的无背景荧光生物检测（英文）. SCIENCE CHINA MATERIALS[J]. 2015, 156-177, http://lib.cqvip.com/Qikan/Article/Detail?id=83677765504849534850484856.
[100] Zheng Wei, Tu Datao, Huang Ping, Zhou Shanyong, Chen Zhuo, Chen Xueyuan. Time-resolved luminescent biosensing based on inorganic lanthanide-doped nanoprobes.. CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND). 2015, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD77801EE96D18F45ED3189304ED7F1C38&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[101] Zhuo Chen. A novel drug carrier targeting uPAR for tumor imaging and treatment. Photonics & Lasers in Medicine. 2015, [102] Zheng K, Li R, Zhou X, Hu P, Zhang Y, Huang Y, Chen Z, Huang M. Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2015, 10: 5327-5342, https://doaj.org/article/75e3265bc0634b0b86bb54cdd2bbdd9a.
[103] Huang, Ping, Tu, Datao, Zheng, Wei, Zhou, Shanyong, Chen, Zhuo, Chen, Xueyuan. Inorganic lanthanide nanoprobes for background-free luminescent bioassays. SCIENCE CHINA-MATERIALS[J]. 2015, 58(2): 156-177, http://dx.doi.org/10.1007/s40843-015-0019-4.
[104] Iqbal, Zafar, Chen, Jincan, Chen, Zhuo, Huang, Mingdong. Phthalocyanine-Biomolecule Conjugated Photosensitizers for Targeted Photodynamic Therapy and Imaging. CURRENT DRUG METABOLISM[J]. 2015, 16(9): 816-832, http://dx.doi.org/10.2174/1389200217666151120165404.
[105] Lu Shan, Tu Datao, Hu Ping, Xu Jin, Li Renfu, Wang Meng, Chen Zhuo, Huang Mingdong, Chen Xueyuan. Multifunctional Nano-Bioprobes Based on Rattle-Structured Upconverting Luminescent Nanoparticles.. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH). 2015, [106] Chen, Zhuo, Zheng, Wei, Huang, Ping, Tu, Datao, Zhou, Shanyong, Huang, Mingdong, Chen, Xueyuan. Lanthanide-doped luminescent nano-bioprobes for the detection of tumor markers. NANOSCALEnull. 2015, 7(10): 4274-4290, http://dx.doi.org/10.1039/c4nr05697c.
[107] Zhou, Shanyong, Zheng, Wei, Chen, Zhuo, Tu, Datao, Liu, Yongsheng, Ma, En, Li, Renfu, Zhu, Haomiao, Huang, Mingdong, Chen, Xueyuan. Dissolution-Enhanced Luminescent Bioassay Based on Inorganic Lanthanide Nanoparticles. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2014, 53(46): 12498-12502, https://www.webofscience.com/wos/woscc/full-record/WOS:000344649900024.
[108] Chen Song, Wang Yu, Zhao BaoYu, Chen Zhuo, Huang MingDong. Maltose-binding Protein Improving the Crystallizability of C2 Domain of Human Coagulation Factor. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY[J]. 2014, 33(2): 216-222, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000332057900008.
[109] Li, Rui, Zheng, Ke, Hu, Ping, Chen, Zhuo, Zhou, Shanyong, Chen, Jincan, Yuan, Cai, Chen, Song, Zheng, Wei, Ma, En, Zhang, Fengling, Xue, Jinping, Chen, Xueyuan, Huang, Mingdong. A Novel Tumor Targeting Drug Carrier for Optical Imaging and Therapy. THERANOSTICS[J]. 2014, 4(6): 642-659, http://dx.doi.org/10.7150/thno.8527.
[110] Huang, Ping, Zheng, Wei, Zhou, Shanyong, Tu, Datao, Chen, Zhuo, Zhu, Haomiao, Li, Renfu, Ma, En, Huang, Mingdong, Chen, Xueyuan. Lanthanide-Doped LiLuF4 Upconversion Nanoprobes for the Detection of Disease Biomarkers. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2014, 53(5): 1252-1257, https://www.webofscience.com/wos/woscc/full-record/WOS:000336504500006.
[111] Chen, Zhuo, Zhang, Yaxin, Li, Linsen, Zhou, Shanyong, Chen, Jincan, Hu, Ping, Huang, Mingdong, Luo, Q, Wang, LV, Tuchin, VV. Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivative for bacterial skin infection. TWELFTH INTERNATIONAL CONFERENCE ON PHOTONICS AND IMAGING IN BIOLOGY AND MEDICINE (PIBM 2014)null. 2014, 9230: [112] Wang, Meng, Chen, Zhuo, Zheng, Wei, Zhu, Haomiao, Lu, Shan, Ma, En, Tu, Datao, Zhou, Shanyong, Huang, Mingdong, Chen, Xueyuan. Lanthanide-doped upconversion nanoparticles electrostatically coupled with photosensitizers for near-infrared-triggered photodynamic therapy. NANOSCALE[J]. 2014, 6(14): 8274-8282, https://www.webofscience.com/wos/woscc/full-record/WOS:000338638900073.
[113] Chen, Zhuo, Zhou, Shanyong, Chen, Jincan, Li, Linsen, Hu, Ping, Chen, Song, Huang, Mingdong. An effective zinc phthalocyanine derivative for photodynamic antimicrobial chemotherapy. JOURNAL OF LUMINESCENCE[J]. 2014, 152: 103-107, http://dx.doi.org/10.1016/j.jlumin.2013.10.067.
[114] Chen, Zhuo, Xu, Peng, Chen, Jincan, Chen, Hongwei, Hu, Ping, Chen, Xueyuan, Lin, Lin, Huang, Yunmei, Zheng, Ke, Zhou, Shanyong, Li, Rui, Chen, Song, Liu, Jianyong, Xue, Jinping, Huang, Mingdong. Zinc phthalocyanine conjugated with the amino-terminal fragment of urokinase for tumor-targeting photodynamic therapy. ACTA BIOMATERIALIA[J]. 2014, 10(10): 4257-4268, http://dx.doi.org/10.1016/j.actbio.2014.06.026.
[115] 张雅馨, 黄明东, 陈卓. 叶酸介导的纳米材料在肿瘤检测与治疗中的应用. 福建医科大学学报[J]. 2014, 48(3): 209-212, http://lib.cqvip.com/Qikan/Article/Detail?id=662235931.
[116] Zheng, Wei, Zhou, Shanyong, Chen, Zhuo, Hu, Ping, Liu, Yongsheng, Tu, Datao, Zhu, Haomiao, Li, Renfu, Huang, Mingdong, Chen, Xueyuan. Sub-10nm Lanthanide-Doped CaF2 Nanoprobes for Time-Resolved Luminescent Biodetection. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(26): 6671-6676, https://www.webofscience.com/wos/woscc/full-record/WOS:000320733600019.
[117] Ai, Yu, Tu, Datao, Zheng, Wei, Liu, Yongsheng, Kong, Jintao, Hu, Ping, Chen, Zhuo, Huang, Mingdong, Chen, Xueyuan. Lanthanide-doped NaScF4 nanoprobes: crystal structure, optical spectroscopy and biodetection. NANOSCALE[J]. 2013, 5(14): 6430-6438, http://dx.doi.org/10.1039/c3nr01529g.
[118] Zheng Wei, Zhou Shanyong, Chen Zhuo, Hu Ping, Liu Yongsheng, Tu Datao, Zhu Haomiao, Li Renfu, Huang Mingdong, Chen Xueyuan. Sub-10 nm lanthanide-doped CaF2 nanoprobes for time-resolved luminescent biodetection.. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH). 2013, [119] Ju, Qiang, Tu, Datao, Liu, Yongsheng, Li, Renfu, Zhu, Haomiao, Chen, Jincan, Chen, Zhuo, Huang, Mingdong, Chen, Xueyuan. Amine-Functionalized Lanthanide-Doped KGdF4 Nanocrystals as Potential Optical/Magnetic Multimodal BioProbes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(2): 1323-1330, https://www.webofscience.com/wos/woscc/full-record/WOS:000301084300094.
[120] Kenneth A Botkjaer, Elena I Deryugina, Daniel M Dupont, Henrik Grdsvoll, Erin M Bekes, Cathrine K Thuesen, Zhou Chen, Michael Ploug, James P Quigley, Peter A Andreasen. TARGETING TUMOUR CELL INVASION AND DISSEMINATION IN VIVO BY AN APTAMER THAT INHIBITS UROKINASE-TYPE PLASMINOGEN ACTIVATOR THROUGH A NOVEL MULTI-FUNCTIONAL MECHANISM. MOLECULAR CANCER RESEARCH : MCR. 2012, 10(12): 1532-1543, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528818/.
[121] Xu, Peng, Chen, Jincan, Chen, Zhuo, Zhou, Shanyong, Hu, Ping, Chen, Xueyuan, Huang, Mingdong. Receptor-Targeting Phthalocyanine Photosensitizer for Improving Antitumor Photocytotoxicity. PLOS ONE[J]. 2012, 7(5): http://dx.doi.org/10.1371/journal.pone.0037051.
[122] Li, Linsen, Luo, Zhipu, Chen, Zhuo, Chen, Jincan, Zhou, Shanyong, Xu, Pen, Hu, Ping, Wang, Jundong, Chen, Naisheng, Huang, Jinling, Huang, Mingdong. Enhanced Photodynamic Efficacy of Zinc Phthalocyanine by Conjugating to Heptalysine. BIOCONJUGATE CHEMISTRY[J]. 2012, 23(11): 2168-2172, https://www.webofscience.com/wos/woscc/full-record/WOS:000311325000003.
[123] Liu, Yongsheng, Zhou, Shanyong, Tu, Datao, Chen, Zhuo, Huang, Mingdong, Zhu, Haomiao, Ma, En, Chen, Xueyuan. Amine-Functionalized Lanthanide-Doped Zirconia Nanoparticles: Optical Spectroscopy, Time-Resolved Fluorescence Resonance Energy Transfer Biodetection, and Targeted Imaging. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(36): 15083-15090, http://dx.doi.org/10.1021/ja306066a.
[124] Jiang, Longguang, Svane, Anna S P, Sorensen, Hans Peter, Jensen, Jan K, Hosseini, Masood, Chen, Zhuo, Weydert, Caroline, Nielsen, Jakob T, Christensen, Anni, Yuan, Cai, Jensen, Knud J, Nielsen, Niels Chr, Malmendal, Anders, Huang, Mingdong, Andreasen, Peter A. The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor. JOURNAL OF MOLECULAR BIOLOGY[J]. 2011, 412(2): 235-250, http://dx.doi.org/10.1016/j.jmb.2011.07.028.
[125] Zhuo Chen. Substituted zinc phthalocyanine as an antimicrobial photosensitizer for periodontal disease treatment. Journal of Porphyrins and Phthalocyanines. 2011, [126] Botkjaer, Kenneth A, Fogh, Sarah, Bekes, Erin C, Chen, Zhuo, Blouse, Grant E, Jensen, Janni M, Mortensen, Kim K, Huang, Mingdong, Deryugina, Elena, Quigley, James P, Declerck, Paul J, Andreasen, Peter A. Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies. BIOCHEMICAL JOURNAL[J]. 2011, 438: 39-51, http://dx.doi.org/10.1042/BJ20110129.
[127] Ngo, Jacky Chi Ki, Jiang, Longguang, Lin, Zhonghui, Yuan, Cai, Chen, Zhuo, Zhang, Xu, Yu, Haiyang, Wang, Jundong, Lin, Lin, Huang, Mingdong. Structural Basis for Therapeutic Intervention of uPA/uPAR System. CURRENT DRUG TARGETS[J]. 2011, 12(12): 1729-1743, http://ir.fjirsm.ac.cn/handle/335002/949.
[128] Chen, Jincan, Chen, Zhuo, Zheng, Yuqian, Zhou, Shanyong, Wang, Jundong, Chen, Naisheng, Huang, Jinling, Yan, Fuhua, Huang, Mingdong. Substituted zinc phthalocyanine as an antimicrobial photosensitizer for periodontitis treatment. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2011, 15(4): 293-299, http://dx.doi.org/10.1142/S1088424611003276.
[129] Zhuo Chen. Zinc Pentalysine β-carbonyl-phthalocyanine: An Effective Tumor-targeting Photosensitizer for Photodynamic Therapy. ChemMedChem. 2010, [130] Chen, Zhuo, Zhou, Shanyong, Chen, Jincan, Deng, Yicai, Luo, Zhipu, Chen, Hongwei, Hamblin, Michael R, Huang, Mingdong. Pentalysine beta-Carbonylphthalocyanine Zinc: An Effective Tumor-Targeting Photosensitizer for Photodynamic Therapy. CHEMMEDCHEM[J]. 2010, 5(6): 890-898, http://dx.doi.org/10.1002/cmdc.201000042.
[131] Zhu, Lili, Yuan, Cai, Chen, Zhuo, Wang, Wanyu, Huang, Mingdong. Expression, purification and characterization of recombinant Jerdonitin, a P-II class snake venom metalloproteinase comprising metalloproteinase and disintegrin domains. TOXICON[J]. 2010, 55(2-3): 375-380, http://dx.doi.org/10.1016/j.toxicon.2009.08.016.
[132] Chen, Zhuo, Lin, Lin, Huai, Qing, Huang, Mingdong. Challenges for Drug Discovery - A Case Study of Urokinase Receptor Inhibition. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING[J]. 2009, 12(10): 961-967, http://ir.fjirsm.ac.cn/handle/335002/2613.
[133] Carrasco, Gonzalo A, Van de Kar, Louis D, Jia, Cuihong, Xu, Hao, Chen, Zhuo, Chadda, Ritu, Garcia, Francisca, Muma, Nancy A, Battaglia, George. Single exposure to a serotonin 1A receptor agonist, (+) 8-hydroxy-2-(di-n-propylamino)-tetralin, produces a prolonged heterologous desensitization of serotonin 2A receptors in neuroendocrine neurons in vivo. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS[J]. 2007, 320(3): 1078-1086, http://dx.doi.org/10.1124/jpet.106.116004.
[134] 刘光英, 陈金富, 李常春, 陈卓. 杀灭齿龈内阿米巴的药物实验研究. 中国人兽共患病杂志[J]. 2002, 18(5): 108-109,63, http://lib.cqvip.com/Qikan/Article/Detail?id=6831694.
[135] 陈卓. 中药复方治疗实验性糖尿病研究进展. 福建医科大学学报[J]. 2001, http://lib.cqvip.com/Qikan/Article/Detail?id=1000502198.
[136] 黄自强, 陈卓. 金钱莲水提物的降血糖作用. 中药药理与临床[J]. 2000, 16(6): 23-, http://lib.cqvip.com/Qikan/Article/Detail?id=6093819.
[137] 陈卓, 黄自强. 金线莲及其提取物降血糖实验研究. 福建医科大学学报[J]. 2000, 34(4): 350-353, http://lib.cqvip.com/Qikan/Article/Detail?id=4831028.
[138] Lei Zhang, Biwei Ye, Zhuo Chen, ZheSheng Chen. Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers. ACTA PHARMACEUTICA SINICA B. http://dx.doi.org/10.1016/j.apsb.2022.10.002.
[139] Shuzhi Tang, Wenzhen Liu, Xiaohong Pan, Libin Liu, Yongshuai Yang, Dong Wang, Peng Xu, Mingdong Huang, Zhuo Chen. Specific inhibition of plasminogen activator inhibitor 1 reduces blood glucose level by lowering TNF-α. LIFE SCIENCES. http://dx.doi.org/10.1016/j.lfs.2020.117404.

（1） Tumor specific imaging and photodynamic therapy targeting on urokinase receptor, CRC Press, Taylor & Francis Group, 2017-12, 第 3 作者

   

（ 1 ） 酞菁锌偶合物抗菌作用研究, 主持, 国家级, 2012-01--2015-12
（ 2 ） 核受体/间质蛋白酶在闽台高发恶性肿瘤发病和防治中的作用与机制研究, 主持, 国家级, 2015-01--2018-12
（ 3 ） 稀土荧光慢性病诊断（子课题：肿瘤标志物体外诊断试剂盒研制), 主持, 部委级, 2013-01--2017-12
（ 4 ） 上转换纳米靶向光敏剂及其在肿瘤诊疗一体化中的应用, 主持, 国家级, 2016-01--2019-12
（ 5 ） 系列酞菁光敏剂抗肿瘤活性研究, 主持, 国家级, 2010-01--2012-12
（ 6 ） 化学新药“光汰净”的抗菌活性实验研究, 主持, 省级, 2013-01--2015-12
（ 7 ） 基于纳米稀土荧光标记材料的FRET生物检测, 主持, 国家级, 2009-06--2012-05
（ 8 ） 基于结构的抗肿瘤药物设计及其药学研究, 主持, 省级, 2009-03--2011-12
（ 9 ） 稀土上转换纳米材料介导的光动力学抗深部组织耐药菌感染研究, 主持, 国家级, 2020-01--2023-12
（ 10 ） 福建省引进高层次创业创新人才-陈卓, 主持, 省级, 2018-08--2021-07
（ 11 ） 基于高效光敏剂的耐药菌及耐药基因的环境污染控制, 主持, 市地级, 2018-12--2020-11
（ 12 ） 稀土清洁高效分离和均衡高质利用——肿瘤检测与诊断试剂盒, 主持, 市地级, 2017-01--2020-12
（ 13 ） 茉莉花提取物在安神助眠功效方面的研究, 参与, 院级, 2020-11--2022-12
（ 14 ） PAI-1抑制剂在调节糖脂代谢中的作用及其机制, 主持, 省级, 2020-09--2023-08
（ 15 ） 循环肿瘤细胞的异质性在转移性乳腺癌中的作用, 主持, 研究所（学校）, 2020-01--2021-12