围绕生物安全防控和国民大健康的重大战略需求，发展快速、灵敏、准确的高通量生物标志物新技术、新方法，探索生物样本中标志物的变化规律与疾病之间的关联，研发生物侦检、疾病检测与健康监测的技术产品。重点突破基于合成生物材料的核心检测原料、基于微纳制造的新型传感元件、基于集成微系统/柔性电子学的新型检测装置、生物标志物检测新原理和人工催化纳米机器等。预期在以下方面获得突破性创新成果：

1）合成生物传感元件

利用合成生物学与纳米生物学等新兴生物技术，结合生物标志物的特点，创制新型生物探针，提高生物探针的特异性、敏感性、结合力和信号放大能力。发展基于生物自组装体的新型催化纳米机器。

2）新型生物传感器

结合新原理传感器件与柔性电子学，发展分子水平可控的分子连接-界面修饰技术，研制柔性可穿戴与气溶胶传感等新型生物传感器。

3）基于集成微系统的传染病现场检测（POCT）装备

结合微纳加工技术，发展能够高度集成从样本处理到结果分析全过程的集成微系统，发展高性能现场诊断装备。

   

071010-生物化学与分子生物学
0703J1-纳米科学与技术
071011-生物物理学

生物传感
纳米生物学
生物催化

2006-09--2011-07   中国科学院武汉病毒研究所   生物化学与分子生物学 理学博士
2001-09--2005-07   河南大学   生物科学 理学学士

博士研究生

生物化学与分子生物学 理学博士

2020-08~今，中国科学院武汉病毒研究所 分子识别与纳米生物传感学科组, 研究员

2017-08~2020-08，中国科学院武汉病毒研究所 分子识别与纳米生物传感学科组, 青年研究员

2014-05~2017-08，中国科学院武汉病毒研究所 分子识别与纳米生物传感学科组, 副研究员

2011-07~2014-05，中国科学院武汉病毒研究所 病毒纳米生物学学科组, 助理研究员

2018-04-01-2021-10-31,中国微生物学会—微生物生物安全专业委员会, 青年学组委员
2017-10-01-今,中国生物工程学会—生物传感、生物芯片与纳米生物技术专业委员会, 学术秘书
2017-10-01-今,中国生物工程学会—生命科学仪器专业委员会, 委员

   

（1） “国科大杯”创新创业大赛初创组, 三等奖, 部委级, 2019
（2） 国科大杯”创新创业大赛创意组, 二等奖, 部委级, 2019
（3） 中科院首届“率先杯”未来技术创新大赛, 部委级, 2018
（4） 中国科学院青年创新促进会优秀会员, 部委级, 2018
（5） 湖北省优秀自然科学学术论文奖, 特等奖, 省级, 2016
（6） 湖北省自然科学一等奖, 一等奖, 省级, 2015
（7） 中国科学院青年创新促进会, 院级, 2014
（8） 中国科学院优秀博士学位论文, , 院级, 2012
（9） 中国科学院院长奖, , 院级, 2011
（10） 湖北省自然科学优秀学术论文奖, 特等奖, 省级, 2010
（11） The Elsevier Biosensors & Bioelectronics Awards., , 其他, 2010

[1] 门冬, 张先恩, 周昆, 曹姗姗, 周娟. 蛋白或肽与核酸共价连接的方法. CN: CN112851765A, 2021-05-28.

[2] 门冬, 张先恩, 周昆, 曹姗姗, 周娟. 连接核酸与蛋白或肽的方法. CN: CN112851771A, 2021-05-28.

[3] 门冬, 张先恩, 周昆, 曹姗姗, 周娟. 一种或多种目标蛋白或肽纯化方法. CN: CN112851784A, 2021-05-28.

[4] 门冬, 张先恩, 陈晨, 周娟, 曹姗姗. 多功能自组装纳米颗粒的可控生物合成方法. CN: CN112553232A, 2021-03-26.

[5] 王强, 周娟, 门冬, 段金香. 一种手性分子的识别方法. CN: CN108663336B, 2021-01-22.

[6] 高丁, 张先恩, 门冬, 冯夏奕, 周娟. 一种细胞标记方法及在稀少细胞MRI成像中的应用. CN: CN111671921A, 2020-09-18.

[7] 高丁, 章强, 韩坤, 钱庆, 程文播, 门冬. 一种用于生物防护的集成装置. CN: CN211375358U, 2020-08-28.

[8] 高丁, 章强, 韩坤, 钱庆, 程文播, 门冬. 一种用于生物防护的集成装置及控制电路. CN: CN111025972A, 2020-04-17.

[9] 门冬, 张先恩, 陈晨, 周娟. 一种基于FRET的融合蛋白、荧光纳米颗粒及其应用. CN: CN111018997A, 2020-04-17.

[10] 章强, 高丁, 韩坤, 刘骜, 钱庆, 程文播, 门冬. 用于荧光成像的变焦检测系统. CN: CN110652284A, 2020-01-07.

[11] 门冬, 张先恩, 周昆, 曹姗姗, 周娟. 共价连接核酸和肽或蛋白的方法及应用. CN: CN110452303A, 2019-11-15.

[12] 门冬, 张先恩, 张玉威, 周娟. 一种新型纳米反应容器的合成及应用. CN: CN110438095A, 2019-11-12.

[13] 张先恩, 李一苇, 门冬, 周娟, 张治平, 梁晓声. 一种基于电化学原位石墨烯合成的碳基电极修饰方法. CN: CN109856204A, 2019-06-07.

[14] 门冬, 张先恩, 魏翠华. 酶复合物及自组装催化纳米线. 中国: CN108004226A, 2018.05.08.

[15] 门冬, 张先恩, 陈晨, 周娟. 一种快速免疫检测装置及其应用. 中国: CN108535241A, 2018-09-14.

[16] 门冬, 张先恩, 周娟, 张治平, 李唯. 一种基于蛋白纳米线的3D探针‑磁性微珠复合物及其应用. 中国: CN105717287B, 2017-11-14.

[17] 门冬, 张先恩, 郭永超, 张治平, 周娟. 一种采样管. 中国: CN206127294U, 2017-04-26.

[18] 门冬, 张先恩, 周娟, 张治平. 多功能荧光蛋白纳米线及其介导的免疫分析方法. 中国: CN105652015A, 2016-06-08.

[19] 门冬, 张治平, 张先恩, 张婷婷, 侯利伟. 一种酶纳米复合物及其可控自组装方法和在免疫分析中的应用. 中国: CN104655833A, 2015-05-27.

[20] 危宏平, 冷 艳, 张先恩, 张治平, 门 冬, 尤祥宇. 一种纳米分子生物传感器及制备方法和用途. 中国: CN101624568, 2010-01-13.

   

[1] Juan ZHOU, Dong MEN, XianEn ZHANG. Progress in wearable sweat sensors and their applications. Chinese Journal of Analytical Chemistry. 2022, 50(2): 87-96, [2] wei cuihua, Juan Zhou, Tiangang Liu, Wanqi Zhao, xian-en zhang, 门冬. Self-Assembled Enzymatic Nanowires with a "Dry and Wet" Interface Improve the Catalytic Performance of Januvia Transaminase in Organic Solvents. Acs Catalysis[J]. 2021, 12(1): 372-382, [3] Li, RunHao, Feng, XiaYi, Zhou, Juan, Yi, Fan, Zhou, ZhongQiang, Men, Dong, Sun, Yue. Rhomboidal Pt(II) Metallacycle-Based Hybrid Viral Nanoparticles for Cell Imaging. INORGANIC CHEMISTRY[J]. 2021, 60(1): 431-437, https://www.webofscience.com/wos/woscc/full-record/WOS:000606803600049.
[4] Ali, Ashaq, Rashid, Zubia, Zhou, Jieqiong, Yousaf, Muhammad Zubair, Galani, Saddia, Ashraf, Asma, AlGhanim, Khalid A, AlSuliman, Emin, Ahmed, Zubair, Farooq, Muhammad, Virik, Promy, Kaimkhani, Z A, AlMulhm, Norah, Mahboob, Shahid, Dong, Men, Huang, Qiuxiang. Evaluating antibody response pattern in asymptomatic virus infected pregnant females: Human well-being study. JOURNAL OF KING SAUD UNIVERSITY SCIENCE[J]. 2021, 33(1): 101255-101255, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709611/.
[5] Zhou, Xiaoli, Zhou, YaNa, Ali, Ashaq, Liang, Cuiqin, Ye, Zhiqin, Chen, Xiaomin, Zhang, Qing, Deng, Lihua, Sun, Xinyi, Zhang, Qian, Luo, Jihong, Li, Wei, Zhou, Kun, Cao, Shanshan, Zhang, Xiaowei, Li, XiaoDong, Zhang, XianEn, Cui, Zongqiang, Men, Dong. Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fimmu.2021.701295.
[6] Zheng, Yang, Zhang, Qing, Ali, Ashaq, Li, Ke, Shao, Nan, Zhou, Xiaoli, Ye, Zhiqin, Chen, Xiaomin, Cao, Shanshan, Cui, Jing, Zhou, Juan, Wang, Dianbing, Hou, Baidong, Li, Min, Cui, Mengmeng, Deng, Lihua, Sun, Xinyi, Zhang, Qian, Yang, Qinfang, li, Yong, Wang, Hui, Lei, Yake, Yu, Bo, Cheng, Yegang, Tong, Xiaolin, Men, Dong, Zhang, XianEn. Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months. VIROLOGICA SINICA[J]. 2021, 36(5): 869-878, http://dx.doi.org/10.1007/s12250-021-00360-4.
[7] Zhang, Yuwei, Zhou, Juan, Zhang, Yuchen, Liu, Tiangang, Lu, Xiaoyun, Men, Dong, Zhang, XianEn. Auxiliary Module Promotes the Synthesis of Carboxysomes in E. coli to Achieve High-Efficiency CO2 Assimilation. ACS SYNTHETIC BIOLOGY[J]. 2021, 10(4): 707-715, http://dx.doi.org/10.1021/acssynbio.0c00436.
[8] Chen, Xiaohua, Zhou, Juan, Chen, Chen, Hou, Baidong, Ali, Ashaq, Li, Feng, Hua, Zhaolin, Wu, Yingtao, Yang, Qin, Chen, Min, Zhang, Rong, Huang, Qianchuan, Ding, Jinya, Zhang, XianEn, Men, Dong. Consecutive Monitoring of Interleukin-6 Is Needed for COVID-19 Patients. VIROLOGICA SINICAnull. 2021, 36(5): 1093-1096, http://dx.doi.org/10.1007/s12250-021-00425-4.
[9] Ali, Ashaq, Noman, Muhammad, Guo, Yong, Liu, Xu, Zhang, Rong, Zhou, Juan, Zheng, Yang, Zhang, XianEn, Qi, Yong, Chen, Xiaohua, Men, Dong. Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality. SCIENTIFIC REPORTS[J]. 2021, 11(1): http://dx.doi.org/10.1038/s41598-021-85426-9.
[10] Cui, Lan, Feng, Xiayi, Liu, Wentao, Liu, Hao, Qin, Qian, Wu, Shuangxia, He, Suqin, Pang, Xinchang, Men, Dong, Zhu, Chengshen. Cell Type-Dependent Specificity and Anti-Inflammatory Effects of Charge-Reversible MSNs-COS-CMC for Targeted Drug Delivery in Cervical Carcinoma. MOLECULAR PHARMACEUTICS[J]. 2020, 17(6): 1910-1921, https://www.webofscience.com/wos/woscc/full-record/WOS:000538337600012.
[11] Chen, Qingmei, Men, Dong, Sun, Tianyu, Zhang, Yan, Yuan, Qianqian, Hu, Taidou, Hu, Zhangsheng, Wu, Jun, Deng, Yiqun, Zhang, XianEn, Wen, Jikai. Supreme Catalytic Properties of Enzyme Nanoparticles Based on Ferritin Self-Assembly. ACS APPLIED BIO MATERIALS[J]. 2020, 3(10): 7158-7167, [12] Li, Yiwei, Zhou, Juan, Song, Jin, Liang, Xiaosheng, Zhang, Zhiping, Men, Dong, Wang, Dianbing, Zhang, XianEn. Chemical nature of electrochemical activation of carbon electrodes (vol 144, 111534, 2019). BIOSENSORS & BIOELECTRONICSnull. 2020, 149: https://www.webofscience.com/wos/woscc/full-record/WOS:000504514100013.
[13] Liu, Lixing, Yang, Hongyu, Men, Dong, Wang, Meng, Gao, Xiaolei, Zhang, Ting, Chen, Deyong, Xue, Chunlai, Wang, Yixiang, Wang, Junbo, Chen, Jian. Development of microfluidic platform capable of high-throughput absolute quantification of single-cell multiple intracellular proteins from tumor cell lines and patient tumor samples. BIOSENSORS & BIOELECTRONICS[J]. 2020, 155: http://dx.doi.org/10.1016/j.bios.2020.112097.
[14] Chen, Xiaohua, Zhao, Binghong, Qu, Yueming, Chen, Yurou, Xiong, Jie, Feng, Yong, Men, Dong, Huang, Qianchuan, Liu, Ying, Yang, Bo, Ding, Jinya, Li, Feng. Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019. CLINICAL INFECTIOUS DISEASES[J]. 2020, 71(8): 1937-1942, http://dx.doi.org/10.1093/cid/ciaa449.
[15] Khan, Suliman, Ali, Ashaq, Shi, Hongwei, Siddique, Rabeea, Shabana, Nabi, Ghulam, Hu, Junjie, Wang, Tiejun, Dong, Men, Zaman, Wajid, Han, Guang. COVID-19: Clinical aspects and therapeutics responses. SAUDI PHARMACEUTICAL JOURNAL[J]. 2020, 28(8): 1004-1008, https://doaj.org/article/28b0433da9f1444bb385ba5dc294da9f.
[16] Li, Feng, Wang, Dianbing, Zhou, Juan, Men, Dong, Zhan, XianEn. Design and biosynthesis of functional protein nanostructures. SCIENCE CHINA-LIFE SCIENCESnull. 2020, 63(8): 1142-1158, http://lib.cqvip.com/Qikan/Article/Detail?id=7102433151.
[17] Wang, Ming, Fu, Aisi, Hu, Ben, Tong, Yongqing, Liu, Ran, Liu, Zhen, Gu, Jiashuang, Xiang, Bin, Liu, Jianghao, Jiang, Wen, Shen, Gaigai, Zhao, Wanxu, Men, Dong, Deng, Zixin, Yu, Lilei, Wei, Wu, Li, Yan, Liu, Tiangang. Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS-CoV-2 and Other Respiratory Viruses. SMALL[J]. 2020, 16(32): http://dx.doi.org/10.1002/smll.202002169.
[18] Xiaohua Chen, Binghong Zhao, Yueming Qu, Yurou Chen, Jie Xiong, Yong Feng, Dong Men, Qianchuan Huang, Ying Liu, Bo Yang, Jinya Ding, Feng Li. Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 2020, [19] Jiang, Hewei, Li, Yang, Zhang, Hainan, Wang, Wei, Yang, Xiao, Qi, Huan, Li, Hua, Men, Dong, Zhou, Jie, Tao, Shengce. SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses. NATURE COMMUNICATIONS[J]. 2020, 11(1): 1-11, http://dx.doi.org/10.1038/s41467-020-17488-8.
[20] Yiwei Li, Juan Zhou, Jin Song, Xiaosheng Liang, Zhiping Zhang, Dong Men, Dianbing Wang, XianEn Zhang. Chemical nature of electrochemical activation of carbon electrodes. Biosensors and Bioelectronics. 2019, 144: http://dx.doi.org/10.1016/j.bios.2019.111534.
[21] Wang, Tingting, Li, Guang, Wang, Dianbing, Li, Feng, Men, Dong, Hu, Tao, Xi, Yan, Zhang, XianEn. Quantitative profiling of integrin alpha v beta 3 on single cells with quantum dot labeling to reveal the phenotypic heterogeneity of glioblastoma. NANOSCALE[J]. 2019, 11(39): 18224-18231, https://www.webofscience.com/wos/woscc/full-record/WOS:000512634500030.
[22] Li, Yiwei, Zhou, Juan, Song, Jin, Liang, Xiaosheng, Zhang, Zhiping, Men, Dong, Wang, Dianbing, Zhang, XianEn. Chemical nature of electrochemical activation of carbon electrodes. BIOSENSORS & BIOELECTRONICS[J]. 2019, 144: http://dx.doi.org/10.1016/j.bios.2019.111534.
[23] Men, Dong, Zhou, Juan, Li, Wei, Wei, CuiHua, Chen, YuanYuan, Zhou, Kun, Zheng, Ying, Xu, Ke, Zhang, ZhiPing, Zhang, XianEn. Self-Assembly of Antigen Proteins into Nanowires Greatly Enhances the Binding Affinity for High-Efficiency Target Capture. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(48): 41019-41025, http://www.corc.org.cn/handle/1471x/2373208.
[24] Li, Xiufeng, Fan, Beiyuan, Liu, Lixing, Chen, Deyong, Cao, Shanshan, Men, Dong, Wang, Junbo, Chen, Jian. A Microfluidic Fluorescent Flow Cytometry Capable of Quantifying Cell Sizes and Numbers of Specific Cytosolic Proteins. SCIENTIFIC REPORTS[J]. 2018, 8(1): http://202.127.146.157/handle/2RYDP1HH/5715.
[25] Fan, Beiyuan, Li, Xiufeng, Liu, Lixing, Chen, Deyong, Cao, Shanshan, Men, Dong, Wang, Junbo, Chen, Jian. Absolute Copy Numbers of -Actin Proteins Collected from 10,000 Single Cells. MICROMACHINES[J]. 2018, 9(5): http://www.corc.org.cn/handle/1471x/2373259.
[26] Zhou, Juan, Duan, Jinxiang, Zhang, XianEn, Wang, Qiang, Men, Dong. A chiral responsive carbon dots-gold nanoparticle complex mediated by hydrogen peroxide independent of surface modification with chiral ligands. NANOSCALE[J]. 2018, 10(39): 18606-18612, http://www.corc.org.cn/handle/1471x/2373231.
[27] Li, Xiufeng, Fan, Beiyuan, Cao, Shanshan, Chen, Deyong, Zhao, Xiaoting, Men, Dong, Yue, Wentao, Wang, Junbo, Chen, Jian. A microfluidic flow cytometer enabling absolute quantification of single-cell intracellular proteins. LAB ON A CHIP[J]. 2017, 17(18): 3129-3137, http://www.corc.org.cn/handle/1471x/2373380.
[28] d.men@wh.iov.cn. A Microfluidic Flow Cytometry Enabling Absolute Quantification of Single-Cell Intracellular Proteins. Lab Chip. 2017, [29] 李峰, 门冬, 王殿冰, 张先恩. 生物大分子自组装合成多维纳米生物结构与器件. 生物工程学报[J]. 2017, 33(3): 404-421, [30] Men, Dong, Zhou, Juan, Li, Wei, Leng, Yan, Chen, Xinwen, Tao, Shengce, Zhang, XianEn. Fluorescent Protein Nanowire-Mediated Protein Microarrays for Multiplexed and Highly Sensitive Pathogen Detection. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(27): 17472-17477, https://www.webofscience.com/wos/woscc/full-record/WOS:000379794100055.
[31] Wen, Na, Zhao, Zhan, Fan, Beiyuan, Chen, Deyong, Men, Dong, Wang, Junbo, Chen, Jian. Development of Droplet Microfluidics Enabling High-Throughput Single-Cell Analysis. MOLECULES[J]. 2016, 21(7): https://doaj.org/article/e37289f823b74ad787156e20b9c1102d.
[32] 冷艳, 门冬. 蛋白质元器件的合成与组装. 科技创新导报. 2016, 13(17): 173-174, http://lib.cqvip.com/Qikan/Article/Detail?id=670128231.
[33] Gao, Ding, Lin, XiuPing, Zhang, ZhiPing, Li, Wei, Men, Dong, Zhang, XianEn, Cui, ZongQiang. Intracellular cargo delivery by virus capsid protein-based vehicles: From nano to micro. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE[J]. 2016, 12(2): 365-376, http://dx.doi.org/10.1016/j.nano.2015.12.028.
[34] Men, Dong, Zhang, TingTing, Hou, LiWei, Zhou, Juan, Zhang, ZhiPing, Shi, YuanYuan, Zhang, JinLi, Cui, ZongQiang, Deng, JiaoYu, Wang, DianBing, Zhang, XianEn. Self-Assembly of Ferritin Nanoparticles into an Enzyme Nanocomposite with Tunable Size for Ultrasensitive Immunoassay. ACS NANO[J]. 2015, 9(11): 10852-10860, https://www.webofscience.com/wos/woscc/full-record/WOS:000365464800032.
[35] Yin, Juan, Zhu, Duanhao, Zhang, Zhiping, Wang, Wei, Fan, Jinyu, Men, Dong, Deng, Jiaoyu, Wei, Hongping, Zhang, XianEn, Cui, Zongqiang. Imaging of mRNA-Protein Interactions in Live Cells Using Novel mCherry Trimolecular Fluorescence Complementation Systems. PLOS ONE[J]. 2013, 8(11): https://doaj.org/article/61dbff468a424f4ba1e104c19a6e75c9.
[36] Gao, Ding, Zhang, ZhiPing, Li, Feng, Men, Dong, Deng, JiaoYu, Wei, HongPing, Zhang, XianEn, Cui, ZongQiang. Quantum dot-induced viral capsid assembling in dissociation buffer. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2013, 8: 2119-2128, http://www.irgrid.ac.cn/handle/1471x/1044501.
[37] 门冬. 基于朊蛋白自组装的多功能纳米线及超灵敏生物传感. 2011, [38] 门冬, 张先恩, 张治平. 自组装病毒样纳米结构与超灵敏生物传感. 东南大学学报：医学版. 2011, 30(1): 92-99, http://lib.cqvip.com/Qikan/Article/Detail?id=36794255.
[39] Dong Men, Zhi-Ping Zhang, Yong-Chao Guo, Duan-Hao Zhu, Li-Jun Bi, Jiao-Yu Deng, Zong-Qiang Cui, Hong-Ping Wei, Xian-En Zhang. An auto-biotinylated bifunctional protein nanowire for ultra-sensitive molecular biosensing. Biosensors and Bioelectronics. 2010, 26(4): 1137-1141, http://dx.doi.org/10.1016/j.bios.2010.07.103.
[40] Men, Dong, Zhang, ZhiPing, Guo, YongChao, Zhu, DuanHao, Bi, LiJun, Deng, JiaoYu, Cui, ZongQiang, Wei, HongPing, Zhang, XianEn. An auto-biotinylated bifunctional protein nanowire for ultra-sensitive molecular biosensing. BIOSENSORS & BIOELECTRONICS[J]. 2010, 26(4): 1137-1141, http://dx.doi.org/10.1016/j.bios.2010.07.103.
[41] Leng, Yan, Wei, HongPing, Zhang, Zhi Ping, Zhou, YaFeng, Deng, JiaoYu, Cui, ZongQiang, Men, Dong, You, XiangYu, Yu, ZiNiu, Luo, Ming, Zhang, XianEn. Integration of a Fluorescent Molecular Biosensor into Self-Assembled Protein Nanowires: A Large Sensitivity Enhancement. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2010, 49(40): 7243-7246, http://www.corc.org.cn/handle/1471x/2375760.
[42] Zhang Xianen. Construction of bifunctional phage display for biological analysis and immunoassay.. Anal Biochem.. 2010, [43] Luo, Ming, Guo, YongChao, Deng, JiaoYu, Wei, HongPing, Zhang, ZhiPing, Leng, Yan, Men, Dong, Song, LiRong, Zhang, XianEn, Zhou, YaFeng. Characterization of a Monomeric Heat-Labile Classical Alkaline Phosphatase from Anabaena sp PCC7120. BIOCHEMISTRY-MOSCOW[J]. 2010, 75(5): 655-664, http://ir.ihb.ac.cn/handle/342005/13785.
[44] Guo, Yongchao, Liang, Xiaosheng, Zhou, Yafeng, Zhang, Zhiping, Wei, Hongping, Men, Dong, Luo, Ming, Zhang, XianEn. Construction of bifunctional phage display for biological analysis and immunoassay. ANALYTICAL BIOCHEMISTRYnull. 2010, 396(1): 155-157, http://www.corc.org.cn/handle/1471x/2375754.
[45] Men, Dong, Guo, YongChao, Zhang, ZhiPing, Wei, Hongping, Zhou, YaFeng, Cui, ZongQiang, Liang, XiaoSheng, Li, Ke, Leng, Yan, You, XiangYu, Zhang, XianEn. Seeding-Induced Self-assembling Protein Nanowires Dramatically Increase the Sensitivity of Immunoassays. NANO LETTERS[J]. 2009, 9(6): 2246-2250, http://www.corc.org.cn/handle/1471x/2375538.
[46] Suliman Khan, Ashaq Ali, Hongwei Shi, Rabeea Siddique, Shabana, Ghulam Nabi, Junjie Hu, Tiejun Wang, Men Dong, Wajid Zaman, Guang Han. COVID-19: Clinical aspects and therapeutics responses. Saudi Pharmaceutical Journal. http://dx.doi.org/10.1016/j.jsps.2020.06.022.

（1） Nanowire Biosensors, Springer Link, 2013-12, 第 2 作者

   

（ 1 ） 模块化设计多功能蛋白纳米线及超灵敏生物传感应用, 主持, 国家级, 2013-01--2015-12
（ 2 ） 高效纳米催化器件的可控制备, 主持, 部委级, 2014-01--2015-12
（ 3 ） 中科院青促会, 主持, 部委级, 2014-01--2018-12
（ 4 ） 创新重点专项, 主持, 部委级, 2015-07--2016-06
（ 5 ） 创新重点专项, 主持, 部委级, 2015-07--2017-06
（ 6 ） 青促会, 主持, 部委级, 2015-01--2018-12
（ 7 ） 基于可控多层级自组装酶纳米复合物的超灵敏心肌肌钙蛋白分析, 主持, 省级, 2015-01--2016-12
（ 8 ） 快速检测技术和产品研发, 主持, 部委级, 2016-01--2018-12
（ 9 ） 单细胞特定蛋白高通量定量检测分析仪, 主持, 部委级, 2017-01--2018-12
（ 10 ） 高灵敏现场分析技术, 主持, 部委级, 2017-01--2017-12
（ 11 ） 现场免疫分析技术, 主持, 国家级, 2016-07--2018-12
（ 12 ） 3D探针检测技术, 主持, 国家级, 2018-10--2019-10
（ 13 ） 三特异性Janus纳米颗粒的胞内可控制备与多效应肿瘤免疫治疗, 主持, 国家级, 2018-01--2021-12
（ 14 ） 中国科学院青年创新促进会优秀会员, 主持, 部委级, 2019-01--2021-12
（ 15 ） ****现场分析系统, 主持, 国家级, 2018-01--2021-01
（ 16 ） ****快速筛选技术, 主持, 国家级, 2017-07--2020-07
（ 17 ） 单细胞蛋白定量分析及肿瘤研究中的应用创新交叉团队, 参与, 部委级, 2017-01--2020-12
（ 18 ） 生物工业过程监控合成生物传感系统创建于工业应用, 参与, 国家级, 2020-01--2023-12
（ 19 ） 传感器构建, 主持, 部委级, 2019-01--2021-12
（ 20 ） 新型冠状病毒现场快速检测产品研发, 主持, 国家级, 2020-02--2020-04
（ 21 ） 新冠病毒复阳、持阳机制与对策, 主持, 国家级, 2020-07--2020-12

（1）Specific antigen assay to assist diagnosis of SARS-CoV-2   2020-10-16
（2）Specific antigen assay for SARS-CoV-2   2020-06-22
（3）Micro-/Nano-biosensing based point of care test system   2019-01-28
（4）Self-assembled protein nanostructure for highly sensitive immunoassay   2017-08-18
（5）Self-assembled protein nanostructure for highly sensitive immunoassay   2017-07-23
（6）Self-assembled protein nanostructure for highly sensitive biosensing    2016-07-28
（7）Self-assembly of ferritin nanoparticles into an enzyme nanocomposite with tunable size for ultrasensitive immunoassay   Dong Men, Ting-Ting Zhang, Juan Zhou and Xian-En Zhang   2016-05-26
（8）Controllable slef-assembly of nanoparticles into an enzyme nano-composite with tunable size for ultra-sensitive immunoassay   门冬   2015-11-15
（9）Multifunctional Self-assembling Protein Nanowires Dramatically Increase the Sensitivity of Immunoassays.    Dong Men, Zhiping Zhang，Zongqiang Cui, Xian-en Zhang*   2011-09-27
（10）Seeding-Induced Self-assembling Protein Nanowires Dramatically Increase the Sensitivity of Immunoassays.   世界生物传感器大会   D Men*, XE Zhang, ZP Zhang, YC Guo   2010-05-28

已指导学生

曹姗姗  硕士研究生  071010-生物化学与分子生物学  

李一苇  博士研究生  071010-生物化学与分子生物学  

陈晨  博士研究生  071010-生物化学与分子生物学  

冯夏奕  硕士研究生  085238-生物工程  

史苘  硕士研究生  085238-生物工程  

马钰莹  硕士研究生  071010-生物化学与分子生物学  

胡劲超  硕士研究生  071010-生物化学与分子生物学  

现指导学生

叶天玺  硕士研究生  085238-生物工程  

张子薇  硕士研究生  071010-生物化学与分子生物学  

郑瑛  博士研究生  071010-生物化学与分子生物学  

冯夏奕  博士研究生  071010-生物化学与分子生物学