基本信息
黄英  女  博导  中国科学院微生物研究所
电子邮件: huangy@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

研究方向与内容

放线菌是一类产生丰富天然活性物质的重要微生物资源,广泛分布于多种生态环境,具有高度的物种、遗传和功能多样性。本研究组旨在发展和应用放线菌系统学与资源评估的理论和方法,解析放线菌的生物多样性和功能,探索其物种和功能演化的途径和机制,促进放线菌的资源开发和生态学研究。主要研究内容包括:
1放线菌分子系统学与物种演化
2)典型生境放线菌的群落结构与生态功能
3)放线菌的天然产物发掘与功能演化
4)空间环境因子对链霉菌的生物学效应

教育背景

1996-09--1999-07   北京大学医学部生化与分子生物学系   博士
1991-09--1994-07   四川大学生物工程系   硕士
1987-09--1991-07   华东理工大学生物工程系   学士
学历
-- 研究生
学位
-- 博士

代表性论著

研究论文:

  1. Song F, Liu N, Liu M, Chen Y, Huang Y*. Identification and characterization of mycemycin biosynthetic gene clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp. FXJ1.235. Mar Drugs, 2018, 16: 98.

  2. Zhang L, Dong H*, Liu Y, Bian L, Wang X, Zhou Z, Huang Y*. Bioleaching of rare earth elements from bastnaesite-bearing rock by actinobacteria. Chem Geol, 2018, 483: 544-557.

  3. Zhang L, Xi L, Ruan J, Huang Y*. Kocuria oceani sp. nov., isolated from a deep-sea hydrothermal plume. Int J Syst Evol Microbiol, 2017, 67: 164-169.

  4. Chen P, Zhang L, Guo X, Dai X, Liu L, Xi L, Wang J, Song L, Wang Y, Zhu Y, Huang L, Huang Y*. Diversity, biogeography, and biodegradation potential of actinobacteria in the deep-sea sediments along the Southwest Indian Ridge. Front Microbiol, 2016, 7: 1340.

  5. Cheng K, Rong X*, Huang Y*. Widespread interspecies homologous recombination reveals reticulate evolution within the genus Streptomyces. Mol Phylogenet Evol, 2016, 102: 246-254.

  6. Liu M#, Liu N#, Shang F, Huang Y*. Activation and identification of NC-1, a cryptic cyclodepsipeptide from red soil-derived Streptomyces sp. FXJ1.172. Eur J Org Chem, 2016, 23: 3943-3948.

  7. Liu N#, Song L#, Liu M#, Shang F, Anderson Z, Fox DJ, Challis GL*, Huang Y*. 2016. Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chem Sci, 7(1): 482-488. doi:10.1039/c5sc03021h

  8. Liu N., Song F., Shang F. and Huang Y.* 2015. Mycemycins A-E, new dibenzoxazepinones isolated from two different streptomycetes. Mar Drugs, 13(10): 6247-6258. doi:10.3390/md13106247

  9. Huang B., Liu N., Rong X., Ruan J., Huang Y.* 2015. Effects of simulated microgravity and spaceflight on morphological differentiation and secondary metabolism of Streptomyces coelicolor A3(2). Appl Microbiol Biotechnol, 2015, 99(10): 4409-4422. doi:10.1007/s00253-015-6386-7

  10. Guo X., Liu N., Li X., Ding Y., Shang F., Gao Y., Ruan J. and Huang Y.* 2015. Red soils harbour diverse culturable actinomycetes that are promising sources of novel secondary metabolites. Appl Environ Microbiol, 81: 3086-3103. doi:10.1128/AEM.03859-14.

  11. Cheng K., Rong X., Pinto-Tomás A., Fernández-Villalobos M., Murillo-Cruz C. and   Huang Y.*2015. Population genetic analysis of Streptomyces albidoflavus reveals habitat barriers to homologous recombination in the diversification of streptomycetes. Appl Environ Microbiol, 81: 966-975.

  12. Rong X. and Huang Y.* 2014.  Multi-locus sequence analysis: taking prokaryotic systematics to the next level. In Michael Goodfellow, Iain Sutcliffe and Jongsik Chun. Method Microbiol, 41: 221-251.

  13. Rong X., Doroghazi J.R., Cheng K., Zhang L., Buckley D.H., Huang Y*. 2013. Classification of Streptomyces phylogroup pratensis (Doroghazi and Buckley, 2010) based on genetic and phenotypic evidence, and proposal of Streptomyces pratensis sp. nov. Syst Appl Microbiol, 36: 401-407.

  14. Liu N. Shang F. Xi L. and Huang Y*. 2013. Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012. Mar Drugs, 11: 1524-1533.

  15. Rong X. and Huang Y.* 2012. Taxonomic evaluation of the Streptomyces hygroscopicus clade using multilocus sequence analysis and DNA-DNA hybridization, validating the MLSA scheme for systematics of the whole genus. Syst Appl Microbiol, 35:7-18.

  16. Xi L., Ruan J. and Huang Y.* 2012. Diversity and biosynthetic potential of culturable actinomycetes associated with marine sponges in the China seas. Int J Mol Sci, 13: 5917-5932.

  17. Zhang L., Xi L., Ruan J. and Huang Y.* 2012. Microbacterium marinum sp. nov., isolated from deep-sea water. Syst Appl Microbiol, 35: 81-85.

  18. Xi L., Zhang L., Ruan J. and Huang Y.* 2012. Verrucosispora qiuiae sp. nov., isolated from mangrove swamp, and emended description of the genus Verrucosispora. Int J Syst Evol Microbiol, 62: 1564-1569.

  19. Wang H., Liu N., Xi L., Rong X., Ruan J. and Huang Y.* 2011. Genetic screening strategy for rapid access to polyether ionophore producers and products in actinomycetes. Appl Environ Microbiol, 77: 3433-3442.

  20. Rong X., Liu N., Ruan J. and Huang Y.* 2010. Multilocus sequence analysis of Streptomyces griseus isolates delineating intraspecific diversity in terms of both taxonomy and biosynthetic potential. Antonie van Leeuwenhoek, 98: 237-248.

  21. Rong X. and Huang Y.* 2010. Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA-DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species. Int J Syst Evol Microbiol, 60: 696-703.

  22. Gao P. and Huang Y.* 2009. Detection, distribution, and organohalogen compound discovery implications of the reduced flavin adenine dinucleotide-dependent halogenase gene in major filamentous actinomycete taxonomic groups. Appl Environ Microbiol, 75: 4813-4820.

  23. Rong X., Guo Y. and Huang Y.* 2009. Proposal to reclassify the Streptomyces albidoflavus clade on the basis of multilocus sequence analysis and DNA-DNA hybridization, and taxonomic elucidation of Streptomyces griseus subsp. solvifaciens. Syst Appl Microbiol, 32: 314-322.

  24. Qiu D., Ruan J. and Huang Y.* 2008. Selective isolation and rapid identification of members of the genus Micromonospora. Appl Environ Microbiol, 74: 5593-5597.

  25. Guo Y. Zheng W., Rong X. and Huang Y.* 2008. A multilocus phylogeny of Streptomyces griseus 16S rRNA gene clade: use of multilocus sequence analysis for streptomycete systematics. Int J Syst Evol Microbiol, 58: 149-159. 

 专著:

  1.  Huang Y. and Goodfellow M. 2012. Genus I. Pseudonocardia (Henssen 1957, 408AL) emend. Park, Park, Lee and Kim 2008, 2477VP. In Goodfellow M., Kämpfer P., Busse H.-J. et al. (Eds.) Bergey's Manual of Systematic Bacteriology, 2nd, ed., Vol. 5: The Actinobacteria, pp. 1305-1323. Springer, New York.

  2. 阮继生, 黄英. 放线菌快速鉴定与系统分类. 2011. 北京: 科学出版社.

专利与奖励

发明专利

  1. 黄英, 刘宁, 郗丽君, 张利敏. 一株海洋链霉菌及其应用. 申请号: CN201110140088.3, 申请日: 2011.05.27;授权号: ZL201110140088.3, 授权日: 2012.12.19
  2. 黄英, 刘宁, 郗丽君, 张利敏. 海洋链霉菌产生的化合物及其应用. 申请号: CN201110174314.X, 申请日: 2011.06.24; 授权号: ZL201110174314.X, 授权日: 2013.03.20 
  3. 黄英, 张利敏, 郗丽君, 宋磊. 一株深海放线菌及其应用. 申请号: CN201410534724.4, 申请日: 2014.10.11; 授权号: ZL201410534724.4, 授权日: 2017.06.09


指导学生

已指导学生

郭银平  硕士研究生  071005-微生物学  

刘宁  硕士研究生  071005-微生物学  

古强  硕士研究生  071005-微生物学  

邱旦恒  硕士研究生  071005-微生物学  

高鹏  硕士研究生  071005-微生物学  

王浩  硕士研究生  071005-微生物学  

郗丽君  博士研究生  071005-微生物学  

荣晓莹  博士研究生  071005-微生物学  

岳昌武  博士研究生  071005-微生物学  

黄兵  博士研究生  071005-微生物学  

郭晓璇  博士研究生  071005-微生物学  

刘明皓  博士研究生  071005-微生物学  

程坤  博士研究生  071005-微生物学  

陈萍  博士研究生  071005-微生物学  

黄娇  硕士研究生  071005-微生物学  

宋方英  博士研究生  071005-微生物学  

现指导学生

张超波  博士研究生  071005-微生物学  

李一凇  博士研究生  071005-微生物学  

闫兵法  博士研究生  071005-微生物学  

王开锐  硕士研究生  085238-生物工程  

黄娇  博士研究生  071005-微生物学  

王姣  博士研究生  071005-微生物学  

黄静  硕士研究生  071005-微生物学  

独学渊  博士研究生  071005-微生物学