基本信息
黄英  女  博导  中国科学院微生物研究所
电子邮件: huangy@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

研究方向与内容

放线菌不仅产生丰富多样的生物活性物质,而且具有多种重要生态功能。它们广泛分布于各种生态环境,具有高度的遗传、功能和物种多样性。本研究组旨在应用和发展放线菌系统学与生态学研究的理论和方法,解析放线菌的生物多样性和功能,探索其物种和功能演化的途径和机制,促进原核生物物种模型的建立和放线菌资源的开发利用。

主要研究内容包括:

1)链霉菌物种形成与演化

(2)典型生境放线菌的多样性与生态功能

(3)放线菌天然产物发掘与功能演化

(4)空间环境因子对链霉菌的生物学效应


教育背景

1996-09--1999-07   北京大学医学部生化与分子生物学系   博士
1991-09--1994-07   四川大学生物工程系   硕士
1987-09--1991-07   华东理工大学生物工程系   学士
学历
-- 研究生
学位
-- 博士

代表性论著

研究论文:

1.     Liu M#, Wang K#, Wei J#, Liu N, Niu G, Tan H, Huang Y*. 2023. Comparative and functional analyses reveal conserved and variable regulatory systems that control lasalocid biosynthesis in different Streptomyces species. Microbiol Spectr, 11(2): e0385222

2.     Huang Jing#, Chen Ping#, Zhu Yaxin, Wang Jian, Song Lei, Han Xiqiu, Huang Ying*. 2023. Biogeography and potential ecological functions of prokaryotes in the hydrothermal and non-hydrothermal field sediments of the Indian Ocean Ridges. Front Mar Sci, 9:1072569. doi: 10.3389/fmars.2022.1072569

3.     Wang J, Li Y, Pinto-Tomás AA, Cheng K, Huang Y*. 2022. Habitat adaptation drives speciation of a Streptomyces species with distinct habitats and disparate geographic origins. mBio. 13(1): e02781-21. https://doi.org/10.1128/mBio.02781-21

4.     Li Y, Huang Y*. 2022. Distribution and evolutionary history of sialic acid catabolism in the phylum Actinobacteria. Microbiol Spectr. 10(1): e02380-21. https://doi.org/10.1128/Spectrum.02380-21

5.     Yan B, Liu N, Liu M, Du X, Shang F, Huang Y*. 2021. Soil actinobacteria tend to have neutral interactions with other co-occurring microorganisms, especially under oligotrophic conditions. Environ Microbiol, 23(8): 4126–4140. https://doi.org/10.1111/1462-2920.15483

6.     Zhang L, Chen Y, Xia Q, Kemner KM, Shen Y, O'Loughlin EJ, Pan Z, Wang Q, Huang Y, Dong H*, Boyanov MI*. 2021. Combined effects of Fe(III)-bearing clay minerals and organic ligands on U(VI) bioreduction and U(IV) speciation. Environ Sci Technol, 55(9):5929-5938. https://doi.org/10.1021/acs.est.0c08645

7.     Yan B, Guo X, Liu M, Huang Y*. 2020. Ktedonosporobacter rubrisoli gen. nov., sp. nov., a novel representative of the class Ktedonobacteria, isolated from red soil, and proposal of Ktedonosporobacteraceae fam. nov. Int J Syst Evol Microbiol, 70:1015-1025. https://doi.org/10.1099/ijsem.0.003864

8.     Zhang L, Zeng Q, Liu X, Chen P, Guo X, Ma LZ, Dong H*, Huang Y*. 2019. Iron reduction by diverse actinobacteria under oxic and pH-neutral conditions and the formation of secondary minerals. Chem Geol, 525: 390-399. https://doi.org/10.1016/j.chemgeo.2019.07.038

9.     Li Y, Pinto-Tomás AA, Rong X, Cheng K, Liu M, Huang Y*. 2019. Population genomics insights into adaptive evolution and ecological differentiation in streptomycetes. Appl Environ Microbiol, 85: e02555-18. https://doi.org/10.1128/AEM.02555-18

10.   Song F, Liu N, Liu M, Chen Y, Huang Y*. 2018. Identification and characterization of mycemycin biosynthetic gene clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp. FXJ1.235. Mar Drugs, 16: 98.

11.   Zhang L, Dong H*, Liu Y, Bian L, Wang X, Zhou Z, Huang Y*. 2018. Bioleaching of rare earth elements from bastnaesite-bearing rock by actinobacteria. Chem Geol, 483: 544-557. https://doi.org/10.1016/j.chemgeo.2018.03.023

12.   Zhang L, Xi L, Ruan J, Huang Y*. 2017. Kocuria oceani sp. nov, isolated from a deep-sea hydrothermal plume. Int J Syst Evol Microbiol, 67: 164-169.

13.   Chen P, Zhang L, Guo X, Dai X, Liu L, Xi L, Wang J, Song L, Wang Y, Zhu Y, Huang L, Huang Y*. 2016. Diversity, biogeography, and biodegradation potential of actinobacteria in the deep-sea sediments along the Southwest Indian Ridge. Front Microbiol, 7: 1340. https://doi.org/10.3389/fmicb.2016.01340

14.   Cheng K, Rong X*, Huang Y*. 2016. Widespread interspecies homologous recombination reveals reticulate evolution within the genus Streptomyces. Mol Phylogenet Evol, 102: 246-254. http://dx.doi.org/10.1016/j.ympev.2016.06.004

15.   Liu N#, Song L#, Liu M#, Shang F, Anderson Z, Fox DJ, Challis GL*, Huang Y*. 2016. Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chem Sci, 7(1): 482-488. https://doi.org/10.1039/c5sc03021h

16.   Liu M#, Liu N#, Shang F, Huang Y*. 2016. Activation and identification of NC-1, a cryptic cyclodepsipeptide from red soil-derived Streptomyces sp. FXJ1.172. Eur J Org Chem, 23: 3943-3948. https://doi.org/10.1002/ejoc.201600297.

17.   Liu N#, Song F#, Shang F, Huang Y*. 2015. Mycemycins A-E, new dibenzoxazepinones isolated from two different streptomycetes. Mar Drugs, 13(10): 6247-6258. https://doi.org/10.3390/md13106247

18.   Huang B, Liu N, Rong X, Ruan J, Huang Y*. 2015. Effects of simulated microgravity and spaceflight on morphological differentiation and secondary metabolism of Streptomyces coelicolor A3(2). Appl Microbiol Biotechnol, 99(10): 4409-4422. https://doi.org/10.1007/s00253-015-6386-7

19.   Guo X#, Liu N#, Li X, Ding Y, Shang F, Gao Y, Ruan J, Huang Y*. 2015. Red soils harbour diverse culturable actinomycetes that are promising sources of novel secondary metabolites. Appl Environ Microbiol, 81: 3086-3103. https://doi.org/10.1128/AEM.03859-14

20.   Cheng K#, Rong X#, Pinto-Tomás A, Fernández-Villalobos M, Murillo-Cruz C, Huang Y*. 2015. Population genetic analysis of Streptomyces albidoflavus reveals habitat barriers to homologous recombination in the diversification of streptomycetes. Appl Environ Microbiol, 81: 966-975. https://doi.org/10.1128/AEM.02925-14

21.   Rong X, Doroghazi JR, Cheng K, Zhang L. Buckley DH, Huang Y*. 2013. Classification of Streptomyces phylogroup pratensis (Doroghazi and Buckley, 2010) based on genetic and phenotypic evidence, and proposal of Streptomyces pratensis sp. nov. Syst Appl Microbiol, 36: 401-407.

22.   Liu N, Shang F, Xi L, Huang Y*. 2013. Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012. Mar Drugs, 11: 1524-1533.

23.   Rong X, Huang Y*. 2012. Taxonomic evaluation of the Streptomyces hygroscopicus clade using multilocus sequence analysis and DNA-DNA hybridization, validating the MLSA scheme for systematics of the whole genus. Syst Appl Microbiol, 35:7-18.

24.   Wang H#, Liu N#, Xi L, Rong X. Ruan J, Huang Y*. 2011. Genetic screening strategy for rapid access to polyether ionophore producers and products in actinomycetes. Appl Environ Microbiol, 77: 3433-3442.

25.   Rong X, Liu N, Ruan J, Huang Y*. 2010. Multilocus sequence analysis of Streptomyces griseus isolates delineating intraspecific diversity in terms of both taxonomy and biosynthetic potential. Antonie van Leeuwenhoek, 98: 237-248.

26.   Rong X, Huang Y*. 2010. Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA-DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species. Int J Syst Evol Microbiol, 60: 696-703.

27.   Gao P, Huang Y*. 2009. Detection, distribution, and organohalogen compound discovery implications of the reduced flavin adenine dinucleotide-dependent halogenase gene in major filamentous actinomycete taxonomic groups. Appl Environ Microbiol, 75: 4813-4820. 

28.   Rong X, Guo Y, Huang Y.* 2009. Proposal to reclassify the Streptomyces albidoflavus clade on the basis of multilocus sequence analysis and DNA-DNA hybridization, and taxonomic elucidation of Streptomyces griseus subsp. solvifaciens. Syst Appl Microbiol, 32: 314-322.

29.   Qiu D, Ruan J, Huang Y.* 2008. Selective isolation and rapid identification of members of the genus Micromonospora. Appl Environ Microbiol, 74: 5593-5597.

30. Guo Y, Zheng W, Rong X, Huang Y.* 2008. A multilocus phylogeny of Streptomyces griseus 16S rRNA gene clade: use of multilocus sequence analysis for streptomycete systematics. Int J Syst Evol Microbiol, 58: 149-159. 


 专著:

  1.  Huang Y. and Goodfellow M. 2012. Genus I. Pseudonocardia (Henssen 1957, 408AL) emend. Park, Park, Lee and Kim 2008, 2477VP. In Goodfellow M., Kämpfer P., Busse H.-J. et al. (Eds.) Bergey's Manual of Systematic Bacteriology, 2nd, ed., Vol. 5: The Actinobacteria, pp. 1305-1323. Springer, New York.

  2. 阮继生, 黄英. 放线菌快速鉴定与系统分类. 2011. 北京: 科学出版社.

专利与奖励

发明专利

1.     黄英, 刘宁, 郗丽君, 张利敏. 一株海洋链霉菌及其应用. 授权号: ZL201110140088.3, 授权日: 2012.12.19

2.     黄英, 刘宁, 郗丽君, 张利敏. 海洋链霉菌产生的化合物及其应用. 授权号: ZL201110174314.X, 授权日: 2013.03.20

3.     黄英, 张利敏, 郗丽, 宋磊. 一株深海放线菌及其应用. 授权号: ZL201410534724.4, 授权日: 2017.06.09

4.     黄英, 刘明皓, 刘宁. 用于生产拉沙里菌素的工程菌及其制备方法与应用. 授权号:ZL201710859521.6; 授权日:2020.05.01



指导学生

已指导学生

郭银平  硕士研究生  071005-微生物学  

刘宁  硕士研究生  071005-微生物学  

古强  硕士研究生  071005-微生物学  

邱旦恒  硕士研究生  071005-微生物学  

高鹏  硕士研究生  071005-微生物学  

王浩  硕士研究生  071005-微生物学  

郗丽君  博士研究生  071005-微生物学  

荣晓莹  博士研究生  071005-微生物学  

岳昌武  博士研究生  071005-微生物学  

黄兵  博士研究生  071005-微生物学  

郭晓璇  博士研究生  071005-微生物学  

刘明皓  博士研究生  071005-微生物学  

程坤  博士研究生  071005-微生物学  

陈萍  博士研究生  071005-微生物学  

张超波  博士研究生  071005-微生物学  

黄娇  硕士研究生  071005-微生物学  

宋方英  博士研究生  071005-微生物学  

李一凇  博士研究生  071005-微生物学  

闫兵法  博士研究生  071005-微生物学  

王开锐  硕士研究生  085238-生物工程  

黄娇  博士研究生  071005-微生物学  

王姣  博士研究生  071005-微生物学  

黄静  硕士研究生  071005-微生物学  

现指导学生

独学渊  博士研究生  071005-微生物学  

白冰冰  博士研究生  071005-微生物学  

孔啸鸣  硕士研究生  071005-微生物学  

王开锐  博士研究生  071005-微生物学  

李元媛  硕士研究生  071005-微生物学  

黄静  博士研究生  071005-微生物学  

周欣蕊  硕士研究生  086000-生物与医药