• Dissecting the role of α-catenin in cancer metabolism.

• Identifying the function of YB1, MDK (Midkine) and FBXLs in cancer.  

• Metabolic signaling in cancer development and progression.

• Biochemical reactions in metabolite-protein interaction.

02/2009 Division of Applied Biological Science, Gyeongsang National University, Jinju, South Korea, Ph.D., Molecular Biology

02/2003 Division of Applied Biological Science, Gyeongsang National University, Jinju, South Korea, M.S., Molecular Biology

9/2009 –1/2014,Postdoctoral, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

3/2009 –8/2009, Research Scientist, Division of Applied Biological Science, Gyeongsang National University, Jinju, South Korea

06/2015 - Present   Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

04/2014 - 06/2015   Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

1.      Zhang XX, Qi H, Lu MH, Yang SQ, Li P, Piao HL^#, Han KL^#. Semi-Quantitatively Designing Two-Photon High-Sensitive Fluorescent Probes for Glutathione S-Transferases with Negligible Background Noise. Research. 2020 Mar 18;2020:7043124. (^#Corresponding Author)

2.      Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao HL^#, Liu H^#. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics. 2020; 10(9):4150-4167. (^#Corresponding Author)

3.      Chen D, Zhao X, Sui1 Z, Niu H, Chen L, Hu C, Xuan Q, Hou X, Zhang R, Zhou L, Li Y, Yuan H, Zhang Y, Wu J, Zhang L^#, Wu R^#, Piao HL^#, Xu G^#, Jia W^#. A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases. Theranostics. 2020 Jan; 10(5): 2029-2046. (^#Corresponding Author)

4.      Chen D, Ning Z, Chen H, Lu C, Liu X, Xia T, Qi H, Wang W, Ling T, Guo X, Tekcham DS, Liu X, Liu J, Wang A, Yan Q, Liu JW^#, Tan G^#, Piao HL^#. An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases. Oncogene. 2020 Jan;39 (3):587-602. (^#Corresponding Author)

5.      Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC^#. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019 Sep 3;3 0(3):508-524.

6.      Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H, Piao HL^#. A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network. iScience. 2019 Jun 28;16:177-191.

7.      Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC^#. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Res. 2019 Jun;29 (6):460-473.

8.      Yan M, Qi H, Xia T, Zhao X, Wang W, Wang Z, Lu C, Ning Z, Chen H, Li T, Tekcham DS, Liu X, Liu J, Chen D, Liu X, Xu G^#, Piao HL^#. Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα. Metabolism. 2019 Feb;91:18-29. (#Corresponding Author)

9.      Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L^#. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018 Dec; 50(12):1705-1715..

10.  Wang J, Qi H, Zhang X, Si W, Xu F, Hou T, Zhou H, Wang A, Li G, Liu Y, Fang Y, Piao HL^#, Liang X^#. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling. Biomed Pharmacother. 2018 Sep 21;108:724-733. (^#Corresponding Author)

11.  Lu C, Ning Z, Wang A, Chen D, Liu X, Xia T, Tekcham DS, Wang W, Li T, Liu X, Liu J, Qi H, Luo H, Du J, Ma C, Yan Q, Liu J, Xu G, Piao HL^#, Tan G^#. USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma. Cancer Lett. 2018 Nov 1;436:139-148  (^#Corresponding Author)

12.  Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG^#, Lin SC^#. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 2017 Aug 3; 548 (7665):112-116.

13.  Wang W, Tekcham DS, Yan M, Wang Z, Qi H, Liu X, Piao HL^#. Biochemical reactions in metabolite-protein interaction. Chinese Chemical Letters, 13 October 2017.

14.  Piao HL, Yuan Y, Wang M, Sun Y, Liang H, Ma L. α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling. Nat Cell Biol. 2014 Mar;16 (3):245-54.

15.  Lin A^#, Piao HL^#, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway. Cancer Res. 2014 Mar 15;74 (6):1682-93. (^#Contributed equally to this work)

Molecular Biology, Chemical Biology, Singnaling transduction, Metabolomics