基本信息

朴海龙 博士

研究员

中国科学院大连化学物理研究所

生物技术部 生物分子功能研究组

大连市中山路457 116023

Tel: +86-411-82463004 

E-mail: HPiao@dicp.ac.cn 

研究领域

细胞分子生物学、化学生物学、生物信息学及组学等多学科交叉为研究基础,在疾病发生发展过程中,探索生物大小分子的功能解析和分子机制,以及开展基于化学蛋白质组学和非天然氨基酸的生物大小分子相互结合靶点研究。


Ø症相关生物分子的功能解析和分子机制研 
ØABPPUAA化学生物学方法的生物分子功能研 
Ø基于生物信息学的生物分子功能研

招生信息

对癌症代谢、化学生物学相关基础科学研究感兴趣的同学,

欢迎加入我们团队一起探索科学的奥秘!

招生方向
细胞分子生物学,肿瘤生物学,癌症代谢,化学生物学

工作经历

06/2015-present   Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
02/2014-05/2015   Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences


专利与奖励

   

出版信息

   
发表论文
(1) Semi-Quantitatively Designing Two-Photon High-Sensitive Fluorescent Probes for Glutathione S-Transferases with Negligible Background Noise, Research, 2020, 通讯作者
(2) F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects, Theranostics, 2020, 通讯作者
(3) A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases, Theranostics, 2020, 通讯作者
(4) An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases, Oncogene, 2020, 通讯作者
(5) Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK., Cell Metabolism, 2019, 其他(合作组作者)
(6) A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network, iScience, 2019, 通讯作者
(7) Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress, Cell Research, 2019, 其他(合作组作者)
(8) Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα, Metabolism, 2019, 通讯作者
(9) Biochemical reactions in metabolite-protein interaction, Chinese Chemical Letters, 2018, 通讯作者
(10) Long noncoding RNA MALAT1 suppresses breast cancer metastasis, Nature Genetics, 2018, 第 2 作者
(11) Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling, Biomed Pharmacother., 2018, 通讯作者
(12) USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma, Cancer letters, 2018, 通讯作者
(13) Identification of metabolic pathways related to SPOP mutations in prostate cancer, Oncotarget, 2017, 通讯作者
(14) Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK, Nature, 2017, 第 3 作者
(15) Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer., Scientific Rep, 2016, 第 3 作者
(16) α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling, Nat Cell Biol, 2014, 第 1 作者
(17) FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway, Cancer Research, 2014, 第 1 作者