基本信息
刘国生 男 博导 上海有机化学研究所
电子邮件:gliu@sioc.ac.cn
通信地址:上海市零陵路345号, 上海有机所 
邮政编码:200032

研究领域

Organic Chemistry, Organometallic Chemistry

• Transition metal-catalyzed fluorination of alkenes, alkynes, and arenes.
• Mechanistic study to address C-F bond formation in organometallic chemistry.
• Transition metal-catalyzed oxidative functionalization of alkenes and arenes by using O2 and H2O2 as oxidant.
• Synthesis of novel fluorinated heterocycle and .Arenes.

招生信息

招生专业: 化学
招生方向: 有机化学

教育背景

   
学历
-- 研究生
学位
-- 博士

工作经历

• 1991,9-1995,7 南京理工大学化工学院,获工学学士;
• 1996,9-1999,8 中科院大连化学物理研究所,获理学硕士;
• 1999,9-2002,8 中科院上海有机化学研究所,获理学博士;
• 2003,3-2005,7 美国Lehigh大学,博士后;
• 2005,8-2007,7 美国威斯康辛大学麦迪逊分校化学系,研究助理;
• 2007,7- 中科院上海有机所,“百人计划”入选者,研究员。

出版信息

 1. Claudio, Martinez; Yichen, Wu; Adam, B. Weinstein; Shannon, S Stahl;* Guosheng, Liu;* Kilian, Muniz,* “Palladium-Catalyzed Intermolecular Aminoacetoxylation of Alkenes and the Influence of PhI(OAc)2 on Aminopalladation Stereoselectivity.” J. Org. Chem. 2013, online.
2. Zhang, Zuxiao; Wang, Fei; Mu, Xin; Chen, Pinhong; Liu, Guosheng,* “Copper-Catlalyzed Regioselective Fluorination of Allylic Halides” Angew. Chem. Int. Ed. 2013, in press.
3. Peng, Haihui; Wang, Hao-Yang; Guo, Yin-Long; Liu, Guosheng,* “Palladium-Catalyzed Intermolecular Fluoroesterification of Styrenes: Exploration and Mechanistic Insight” Chem. Sci. 2013, in press.
4. Liu, Qilun; Chen, Pinhong; Liu, Guosheng,* “Palladium-Catalyzed C-C Triple Bond Cleavage: Efficient synthesis of 4H-benzo[d][1,3]oxazin-4-ones” ACS Catalysis, 2013, 3, 178-181 (Invited Paper).
5. Zhu, Haitao; Liu, Guosheng.* “Pd-Catalyzed Intermolecular Aminofluorination of Styrenes” Acta. Chim. Sinica. 2012, 70, 2404-2407.
6. Zhang, Hao; Chen, Pinhong; Liu, Guosheng.* “Palladium-catalyzed Arylakylation of Unactivated Alkenes: Pyridine Promote C-H Acitivation” Synlett, 2012, 23, 2749-2752 (Invited paper for C-H bond activation Cluster).
7. Liu, Guosheng* “Transition Metal-Catalyzed Fluorination of Unsaturated Carbon-Carbon Multibonds: A New Strategy for Fluorinated Heterocycles Synthesis.” Org. Biomol. Chem. 2012, 6243-6248 (Invited Review).
8. Xu, Tao; Liu, Guosheng* “A Concise and Selective Synthesis of 4-Fluoroisoquinolines and 4-Fluoropyrrolo[a]isoquinolines: Silver-Catalyzed Fluroination of Alkynes” Org. Lett, 2012, 14, 5416-5419.
9. Wu, Tao; Zhang, Hao; Liu, Guosheng* “Organocatalyzed Arylalkylation of Alkenes” Tetrahedron 2012, 52, 6450-6452. (Invited paper to the celebration of Prof. Zhangjie Shi for his Tetrahedron Award)
10. Xu, Tao; Liu, Guosheng* “Silver-Catalyzed Fluorination” SynLett, 2012, 23, 955-958. (Synpacts).
11. Mu, Xin; Wu, Tao; Wang Hao-yang; Guo, Yin-long; Liu, Guosheng* “Palladium-catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature” J. Am. Chem. Soc. 2012, 134, 878-881.
12. Yin, Guoyin; Wu, Tao; Liu, Guosheng* “Highly Selective Palladium-Catalyzed Chloroamination of Unactivated Alkenes by using Hydrogen Peroxide as Oxidant” Chem. Eur. J. 2012, 18, 451-455.
13. Wu, Tao; Mu, Xin; Liu, Guosheng* “Palladium-Catalyzed Oxidative Arylalkylation of Activated Alkenes via Dual C-H Bonds Cleavage of Arenes and Acetonitriles” Angew. Chem. Int. Ed. 2011, 50, 12578-12581.
14. Xu, Tao; Qiu, Shuifa; Liu, Guosheng* “Palladium-Catalyzed Intramolecular Aminofluorination of Styrene” Chin. J. Chem. 2011, 29, 2785-2790. (Invited Paper on the occasion of Prof . Weiyuan Huang’s 90th birthday).
15. Wu, Yichen; Liu, Guosheng* “Organocatalyzed Cycloaddition of CO2 and Aziridines” Tetrahedron Lett. 2011, 52, 6540-6542.
16. Xu, Tao; Mu, Xin; Peng, Haihui; Liu, Guosheng* “Silver-Catalyzed Intramolecular Aminofluorination of Activated Allenes” Angew. Chem. Int. Ed. 2011, 50, 8176-8179.
17. Mu, Xin; Chen, Shujun; Zheng, Xinliang; Liu, Guosheng* “Palladium-Catalyzed Trifluoromethylation of Indoles at Room Temperature” Chem. Eur. J. 2011, 17, 6039-6042.
18. Peng, Haihui; Liu, Guosheng* “Palladium-Catalyzed Tandem Fluorination and Cyclization of Enynes” Org. Lett. 2011, 13, 772-775. (Featured in Synfact, 2011, 12, 518)
19. Chen, Shujun; Wu, Tao; Zhen, Xinliang; Liu, Guosheng* “Highly selective Palladium-Catalyzed Oxidative Intramolecular Aminonitroxylation of Alkenes” Synlett, 2011, 891-894. (Invited Paper for the contribution of Prof. Xiyan Lu and Prof. Lixin Dai in Organic Chemistry).
20. Xu, Tao; Qiu, Shuifa; Liu, Guosheng* “Palladium-catalyzed intra- and intermolecular hydroamination of Styrenes”, J. Organometallic. Chem. 2011, 696, 46-49. (Invited Paper for the special issue on the H-B addition to C-C double bond).
21. Yin, Guoyin;Wu, Yichen;Liu,Guosheng* “Scope and Mechanism of Allylic C-H Amination of Terminal Alkenes by the Palladium/PhI(OPiv)2 Catalyst System: Insights into the Effect of Naphthoquinone”, J. Am. Chem. Soc. 2010, 132, 11978-11987. (This paper was listed as one of the journal’s Top 20 most downloaded papers in August of 2010)
22. Qiu, Shuifa; Xu, Tao; Zhou, Juan; Guo, Yanlong; Liu, Guosheng* “Palladium-Catalyzed Intermolecular Aminofluorination of Styrenes”, J. Am. Chem. Soc. 2010, 132, 2856-2857.
23. Wu, Yicheng; Liu, Guosheng* “Palladium-Catalyzed Allylic C-H Bond Functionalization of Olefins”, Top. Cur. Chem. 2010, 292, 195-209.
24. Wu, Tao; Yin, Guoyin; Liu, Guosheng* “Palladium-Catalyzed Intramolecular Aminofluorination of Unactivated Alkenes”, J. Am. Chem. Soc. 2009, 131, 16354-16355. (Featured in Synfact, 2010, 3, 276)
25. Wu, Liang; Qiu, Shuifa; Liu, Guosheng* “Brønsted Base-Modulated Regioselective Pd-Catalyzed Intramolecular Aerobic Oxidative Amination of Alkenes:Formation of Seven-Membered Amides and Evidence for Allylic C-H Activation.” Org. Lett. 2009, 11, 2707-2710.
26. Qiu, Shuifa; Wei, Yunyang; Liu, Guosheng* “Palladium-Catalyzed Intramolecular Hydro- amination of Allenes Coupled to Aerobic Alcohol Oxidation.” Chem. Eur. J. 2009, 15, 2751-2755.
27. Liu, Guosheng;* Yin, Guoyin; Wu, Liang; “Palladium-catalyzed intermolecular aerobic oxidative amination of terminal alkenes: efficient synthesis of linear allylamine derivatives.” Angew. Chem. Int. Ed. 2008, 47, 4733-4736.
28. Yin, Guoyin; Liu, Guosheng* “Palladium-catalyzed oxidative cyclization of enyne with hydrogen peroxide as the oxidant.” Angew. Chem. Int. Ed. 2008, 47, 5442-5445. (Hot paper, and Featured in Synfact, 2008, 10, 1066)

1. Liu, Guosheng;* Wu, Yichen, “Bathocupronie”, in e-EROS Encyclopedia of Reagents for Organic Synthesis (D. Crich, P. L. Fuchs, A. B. Charette, T Rovis, Ed.), Wiley-Interscience, 2011.

2. Mu, Xin; Liu, Guosheng,* “Chapter 11, Dioxygen-Coupled Palladium and Copper-Catalyzed Csp2-H Functionalization: Reactions and Mechanisms” in C-H and C-X Bond Functionalization: Transition Metal Mediation (X. Ribas, Ed.) RSC Publishing, 2013.

3. Chen, Pinhong; Liu, Guosheng;* Engle Keary M; Yu Jin-Quan,* “High-Valent Palladium in Catalysis”, in Houben-Weyl: Science of Synthesis knowledge Updates, volume 1: Compounds with Transition-Metal-Carbon p-Bond and Compounds of Group 10-8 (Ni, Pt, Co, Rh, Ir, Fe, Os), (B. M. Trost, P. J. Plietker, Ed.), Thieme: New York, 2013.

4. 刘国生 (Liu Guosheng),“绿色氧化”,10000 个科学难题-化学卷,267-269页,“10000 个科学难题”化学编委会主编,科学出版社,2009 年。

5. 刘国生 (Liu Guosheng),“金属催化的合成反应”,高速发展的中国化学1982-2012,科学出版社,2012年。

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指导学生

已指导学生

阴国印  博士研究生  070303-有机化学  

现指导学生

吴亮  博士研究生  070303-有机化学  

张祖骁  硕士研究生  070303-有机化学  

朱海涛  硕士研究生  070303-有机化学  

徐涛  博士研究生  070303-有机化学  

吴涛  博士研究生  070303-有机化学  

慕欣  博士研究生  070303-有机化学  

彭海辉  博士研究生  070303-有机化学