General

Dr. Yan has done plenty of research, focusing on ultrasound molecular imaging and ultrasound-assisted drug delivery. He developed a novel flow-focusing microfluidic device to produce monodisperse microbubbles with precisely controlled diameters in real-time. Based on this system, a series of highly sensitive ultrasound imaging probes were fabricated. The remarkable ultrasound molecular imaging effects were acquired in the early detection of vascular inflammation, tumor angiogenesis when these targeted probes were applied. By taking advantage of the function of microbubbles as carriers which can control drug release under ultrasound irradiation, the proposer designed and fabricated the drug-loaded liposome-microbubble complexes. The drug efficacy against tumor growth was enhanced when combined with ultrasound irradiation. A faster drug transport was clarified and its corresponding mechanisms were revealed. All of these researches provided a new idea or tool to promote the integrative clinical application of diagnosis and treatment. In recent years, the proposer has published 47 peer-reviewed international journal papers, including Theranostics, J Controlled Release, et al. He has applied for 8 chinese invention patents（4 patents were licensed).

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Research Areas

1. Ultrasound molecular imaging

2. Ultrasound-assisted drug delivery

3. Ultrasound neuromodulation

Education

2004/09 - 2007/07, Sichuan University, Cell biology, Ph.D

2001/09 - 2004/07, Southwestern University, Biochemistry and molecular biology, Master

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Experience

   
Work Experience

2017/01 – present, Professor at Shenzhen Institute of Advanced Technology, Chinese Academy of Science

2011/09 –2016/12, Associate professor at Shenzhen Institute of Advanced Technology, Chinese Academy of Science

2010/09 - 2011/08, Assistant professor at Shenzhen Institute of Advanced Technology, Chinese Academy of Science

2008/09 - 2010/08, Postdoc at Tsinghua University

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Publications

   
Papers

Selected publications

  1. Zhang L, Sun Z, Ren P, You M, Zhang J, Fang L, Wang J, Chen Y, Yan F*, Zheng H*, Xie M*. Localized delivery of shRNA against PHD2 protects the heart from acute myocardial infarction through ultrasound-targeted cationic microbubble destruction. Theranostics, 2017;7(1):51-66.
  2. Deng Z, Xiao Y, Pan M, Li F, Duan W, Meng L, Liu X, Yan F*, Zheng H*. Hyperthermia-triggered drug delivery from iRGD-modified temperaturesensitive liposomes enhances the anti-tumor efficacy using high intensity focused ultrasound. Journal of Control Release. 2016, 243:333-341.
  3. Yan F, Duan W, Li Y, Wu H, Zhou Y, Pan M, Liu H, Liu Xin, Zheng H. NIR-laser-controlled drug release from DOX/IR-780-loaded temperature-sensitive-liposomes for chemo-photothermal synergistic tumor therapy. Theranostics, 2016; 6(13):2337-2351.
  4. Yan F, Wu H, Liu H, Deng Z, Liu H, Duan W, Liu X, Zheng H. Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles. Journal of Control Release. 2016;224:217-28.
  5. Ma M#; Yan F#; Yao M; Wei Z; Zhou D; Yao H; Zheng H; Chen H; Shi J. Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules towards MRI-guided high intensity focused ultrasound therapy. ACS Applied Materials & Interfaces, 2016; 8(44):29986-29996.
  6. Li Y, Zhou Q, Deng Z, Pan M, Liu X, Wu J, Yan F*, Zheng H*. IR-780 Dye as a Sonosensitizer for Sonodynamic Therapy of Breast Tumor. Scientific Reports. 2016;6:25968.
  7. Liu XY#, Yan F#, Niu LL, Chen QN, Zheng HR, Li JY. Strong correlation between early stage atherosclerosis and electromechanical coupling of aorta. Nanoscale. 2016;8(13):6975-80.
  8. Zhu X, Guo J, He C, Geng H, Yu G, Li J, Zheng H, Ji X*, Yan F*. Ultrasound triggered image-guided drug delivery to inhibit vascular reconstruction via paclitaxel-loaded microbubbles. Scientific Reports. 2016;6:21683.
  9. Liu H, Chen Y, Yan F*, Han X, Wu J, Liu X, Zheng H*. Ultrasound molecular imaging of vascular endothelial growth factor receptor 2 expression for endometrial receptivity evaluation. Theranostics 2015;5(2):206-17.
  10. Deng Z, Yan F*, Jin Q, Li F, Wu J, Liu X, Zheng H*. Reversal of multidrug resistance phenotype in human breast cancer cells using doxorubicin-liposome-microbubble complexes assisted by ultrasound. J Control Release. 2014,174:109-116.

Research Interests

1. Ultrasound molecular imaging

2. Ultrasound-assisted drug delivery

3. Ultrasound neuromodulation

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