长期目标是研究脂肪酸代谢和脂肪细胞分化的分子机制，阐明代谢紊乱包括肥胖、糖尿病等病症的致病机理，并开发新型而有效的生物医药手段实现疾病的早期诊断和治疗。
研究重点在： 脂肪酸代谢调控；脂肪细胞分化及转分化；代谢疾病的诊断和治疗。
目前正在实施的研究项目包括：
1. CPT I 的功能研究
2.脂肪细胞分化及转分化的化学生物学研究；
3. 疾病相关蛋白的结构功能研究。

博士生：3人
硕士生：3人

071010-生物化学与分子生物学

诱导干细胞定向分化研究
脂肪细胞转分化研究
代谢疾病分子机理的研究

   

-- 研究生

-- 博士

   

1980 – 1984 北京师范大学生物系学士
1985 – 1990 美国德州西南医学中心生物化学与分子生物学博士
1990 – 1992 美国德州西南医学中心生物化学系，博士后
1992 – 1994 美国肯塔基大学生物化学系，助理研究教授
1994 – 1998 美国肯塔基大学生物化学系，助理教授
1998 – 2004 美国佛罗里达大学药学院药物化学系，助理教授
2004 – 至今 中国科学院广州生物医药与健康研究院，研究员

专业综述(生物类）  2007—2008学年秋季学期

 

   

[1] 许永, 吴东海, 聂涛, 赵雪梅, 赵世亭, 惠晓艳. 非人哺乳动物模型及其构建方法和应用. CN: CN112126659A, 2020-12-25.
[2] 吴东海, 聂涛, 张羽薇, 赵世亭, 惠晓艳. 敲除载体、打靶载体、试剂盒、Prdm16检测用动物模型、检测方法及应用. CN: CN112111511A, 2020-12-22.
[3] 蒋白山, 聂涛, 赵文玲, 邹亚丽, 丁强, 丁胜, 吴东海. 用于诱导白色脂肪组织褐变的化合物和方法. CN: CN107635981B, 2020-08-04.
[4] 吴东海, 毛刘锋, 雷雯雯, 刘晓敏. 化合物Compound C的新应用. CN: CN109820856A, 2019-05-31.
[5] 吴东海, 毛刘锋, 丁克, 彭丽洁. 化合物DK45的新应用. CN: CN109820857A, 2019-05-31.
[6] 吴东海, 聂涛, 赵世亭, 张羽薇. Linifanib的新应用. CN: CN109464443A, 2019-03-15.
[7] 吴东海, 毛刘锋, 聂涛, 丁克. 阿西替尼的应用. 中国: CN105287552B, 2018.03.20.
[8] JIANG, Baishan, NIE, Tao, ZHAO, Wenling, ZOU, Yali, DING, Qiang, DING, Sheng, WU, Donghai. COMPOUNDS AND METHODS FOR INDUCING BROWNING OF WHITE ADIPOSE TISSUE. 欧盟: EP3259256(A1), 2017-12-27.
[9] 吴东海, 孙伟, 聂涛, 李快, 韩卫平. 重组人皮肤桥蛋白成熟肽段及其生产方法. 中国: CN107058369A, 2017-08-18.
[10] 吴东海, 聂涛, 徐爱民, 李鹏. 利用确定的细胞因子组合促进成纤维细胞转分化为脂肪细胞. 中国: CN104342401A, 2015-02-11.
[11] 吴东海, 聂涛, 毛刘锋, 惠晓艳, 聂宝明, 李鹏, 徐爱民. 哈尔明碱的新应用. 中国: CN104224780A, 2014-12-24.
[12] 吴东海, 孙伟, 赖允鑫, 李洪波, 唐小凤, 李鹏, 刘鹏涛. 重组人白介素15长肽段及其生产方法. 中国: CN104212808A, 2014-12-17.
[13] 吴东海, 聂涛, 毛刘峰, 李快, 唐小凤, 惠晓艳, 刘彭涛, 徐爱民. 敲入有解偶联蛋白1-荧光素酶基因的非人哺乳动物模型及其构建方法和应用. 中国: CN103947606A, 2014-07-30.
[14] 吴东海, 杨松, 刘月红, 李侍武, 徐爱民, 李鹏, 刘彭涛. 分泌表达外源蛋白的酵母转化子及其制备方法. 中国: CN103525712A, 2014-01-22.
[15] 胡文辉, 钟桂发, 吴东海. 哌嗪酰胺类化合物在制药中的应用. 中国: CN102512421B, 2013-11-06.
[16] 吴东海, 李洪波, 徐爱民, 金守光, 李娜, 李侍武. 重组人血管内皮细胞生长因子-165蛋白及其生产方法. 中国: CN103045633A, 2013-04-17.
[17] 吴东海, 李洪波, 胡兴, 徐爱民, 李鹏, 金守光, 李娜. Trx-hPTN融合蛋白及其生产方法. 中国: CN102965387A, 2013-03-13.
[18] 吴东海, 李洪波, 胡兴, 徐爱民, 李鹏, 金守光, 李娜. 重组人胰岛素样生长因子-2蛋白及其生产方法. 中国: CN102936602A, 2013-02-20.
[19] 吴东海. 一种用于基因治疗的细胞的构建方法及制得的细胞. 中国: CN102586324A, 2012-07-18.
[20] 吴东海, 李洪波, 金守光, 徐爱民, 李侍武. 一种人血小板源性生长因子A同源二聚体及其生成方法. 中国: CN102154305A, 2011.08.17.
[21] 吴东海, 李洪波, 李侍武, 金守光, 徐爱民. 高水平分泌表达人白细胞介素8的方法和酵母转化子. 中国: CN101575609B, 2011-11-09.
[22] 吴东海, 李洪波, 金守光, 徐爱民, 李侍武. 一种高效生产Trx-hCTRP2的方法. 中国: CN102206282A, 2011-10-05.
[23] 吴东海, 李洪波, 金守光, 徐爱民, 李侍武. 一种人重组白介素-3的表达纯化方法. 中国: CN102146413A, 2011-08-10.
[24] 丁克, 刘秀洁, 王东业, 惠晓艳, 徐爱民, 吴东海. 一种吡唑类化合物及其组合物和应用. 中国: CN101838239A, 2010.09.22.
[25] 丁克, 吴东海, 周毅, 常少华, 高学飞, 杨淑伟. 一种新型PAMAM的衍生物及其应用. 中国: CN101899154A, 2010-12-01.
[26] 吴东海, 朱强, 杨松, 刘兰英, 彭长兰. 青蒿素衍生物的新应用. 中国: CN101879158A, 2010-11-10.
[27] 吴东海, 李洪波, 汪玉, 金守光, 徐爱民, 李侍武. 一种高密度发酵生产人白细胞介素6的方法. 中国: CN101736009A, 2010-06-16.
[28] 吴东海, 罗 勇, 李侍武, 金守光, 许爱民. 人白细胞介素7在真核宿主中表达的方法. 中国: CN101302517, 2008-11-12.
[29] 吴东海, 高 野, 徐爱民. 腺苷酸激活的蛋白激酶抑制剂Compound C的新应用. 中国: CN101297806, 2008-11-05.
[30] 吴东海, 金晓辉, 魏孝义, 黄志伟. 2’,4’-二羟基-6’-甲氧基-3’,5’-二甲基查耳酮作为PPARγ激动剂的应用. 中国: CN101259118, 2008-09-10.

   

[1] Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu. Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist. J Med Chem[J]. 2021, [2] Liu, Xiaomin, Zhang, Yuwei, Chu, Yi, Zhao, Xuemei, Mao, Liufeng, Zhao, Shiting, Lin, Shaoqiang, Hui, Xiaoyan, Gu, Ping, Xu, Yong, Loomes, Kerry, Tang, Shibing, Nie, Tao, Wu, Donghai. The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 545: 189-194, http://dx.doi.org/10.1016/j.bbrc.2021.01.080.
[3] Huang, HuaLin, Li, Caiyue, Ma, Wenbo, Yin, Shikui, Zhao, Huifan, Deng, Sihao, Shu, Xiaodong, Wu, Donghai, Li, Ji, Huang, Rongqi, Cheng, Na, Huang, Jufang, Li, Zhiyuan. Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour. GENES BRAIN AND BEHAVIOR[J]. 2020, 19(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000502611800001.
[4] Zhang, Shaoping, Liu, Hong, Amarsingh, Greeshma Vazhoor, Cheung, Carlos C H, Wu, Donghai, Narayanan, Umayal, Zhang, Linda, Cooper, Garth J S. Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure. METALLOMICS[J]. 2020, 12(2): 259-272, https://www.webofscience.com/wos/woscc/full-record/WOS:000518036000008.
[5] Li, Zhenpeng, Cai, Zeqiong, Fu, Weixin, Liu, Ying, Tian, Chenglei, Wang, He, Fu, Tongtong, Wu, Zhenzhou, Wu, Donghai, Jin, Yongxin, Cheng, Zhihui, Terada, Naohiro, Liu, Lin, Wu, Weihui, Jin, Shouguang, Bai, Fang. High-efficiency protein delivery into transfection-recalcitrant cell types. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2020, 117(3): 816-831, https://www.webofscience.com/wos/woscc/full-record/WOS:000503876000001.
[6] Hu, Qingqing, Wang, Chao, Xiang, Qiuping, Wang, Rui, Zhang, Cheng, Zhang, Maofeng, Xue, Xiaoqian, Luo, Guolong, Liu, Xiaomin, Wu, Xishan, Zhang, Yan, Wu, Donghai, Xu, Yong. Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo d isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities. BIOORGANIC CHEMISTRY[J]. 2020, 94: http://dx.doi.org/10.1016/j.bioorg.2019.103424.
[7] Gao, Xuefei, NowakImialek, Monika, Chen, Xi, Chen, Dongsheng, Herrmann, Doris, Ruan, Degong, Chen, Andy Chun Hang, EckersleyMaslin, Melanie A, Ahmad, Shakil, Lee, Yin Lau, Kobayashi, Toshihiro, Ryan, David, Zhong, Jixing, Zhu, Jiacheng, Wu, Jian, Lan, Guocheng, Petkov, Stoyan, Yang, Jian, Antunes, Liliana, Campos, Lia S, Fu, Beiyuan, Wang, Shengpeng, Yong, Yu, Wang, Xiaomin, Xue, SongGuo, Ge, Liangpeng, Liu, Zuohua, Huang, Yong, Nie, Tao, Li, Peng, Wu, Donghai, Pei, Duanqing, Zhang, Yi, Lu, Liming, Yang, Fengtang, Kimber, Susan J, Reik, Wolf, Zou, Xiangang, Shang, Zhouchun, Lai, Liangxue, Surani, Azim, Tam, Patrick P L, Ahmed, Asif, Yeung, William Shu Biu, Teichmann, Sarah A, Niemann, Heiner, Liu, Pentao. Establishment of porcine and human expanded potential stem cells. NATURE CELL BIOLOGY[J]. 2019, 21(6): 687-+, http://dx.doi.org/10.1038/s41556-019-0333-2.
[8] Li, Hongbo, Bu, Xiufen, Li, Kuai, Wu, Donghai. Production of a novel Poria cocos immunomodulatory protein in Pichia pastoris: cloning, expression, purification and activities assays. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY[J]. 2019, 35(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000456685900001.
[9] Yi, Shiting, Chu, Yi, Zhang, Yuwei, Zhou, Yulai, Jiang, Zhiwu, Wang, Zhengqi, Mao, Liufeng, Li, Kuai, Sun, Wei, Li, Peng, Jia, Shiqi, Wang, Cunchuan, Xu, Aimin, Loomes, Kerry, Tang, Shibing, Wu, Donghai, Hui, Xiaoyan, Nie, Tao. Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation. LIFE SCIENCES[J]. 2019, 222: 117-124, http://dx.doi.org/10.1016/j.lfs.2019.01.047.
[10] Zhang, Yan, Wu, Xishan, Xue, Xiaoqian, Li, Chenchang, Wang, Junjian, Wang, Rui, Zhang, Cheng, Wang, Chao, Shi, Yudan, Zou, Lingjiao, Li, Qiu, Huang, Zenghong, Hao, Xiaojuan, Loomes, Kerry, Wu, Donghai, Chen, HongWu, Xu, Jinxin, Xu, Yong. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 62(9): 4716-4730, [11] Xiang, Qiuping, Wang, Chao, Zhang, Yan, Xue, Xiaoqian, Song, Ming, Zhang, Cheng, Li, Chenchang, Wu, Chun, Li, Kuai, Hui, Xiaoyan, Zhou, Yulai, Smaill, Jeff B, Patterson, Adam V, Wu, Donghai, Ding, Ke, Xu, Yong. Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 147: 238-252, https://www.webofscience.com/wos/woscc/full-record/WOS:000427217100019.
[12] Mao, Liufeng, Lei, Jiwen, Schoemaker, Marieke H, Ma, Bingxiu, Zhong, Yan, Lambers, Tim T, Van Tol, Eric A F, Zhou, Yulai, Nie, Tao, Wu, Donghai. Long-chain polyunsaturated fatty acids and extensively hydrolyzed casein-induced browning in a Ucp-1 reporter mouse model of obesity. FOOD & FUNCTION[J]. 2018, 9(4): 2362-2373, https://www.webofscience.com/wos/woscc/full-record/WOS:000436031600040.
[13] 李洪波, 罗海燕, 张树琴, 吴东海. 重组嗜热乳糖酶在毕赤酵母中的表达、纯化与活性分析. 食品与生物技术学报[J]. 2018, 37(8): 812-816, http://lib.cqvip.com/Qikan/Article/Detail?id=7000842862.
[14] Jin, Yongxin, Liu, Ying, Li, Zhenpeng, Santostefano, Katherine, Shi, Jing, Zhang, Xinwen, Wu, Donghai, Cheng, Zhihui, Wu, Weihui, Terada, Naohiro, Jin, Shouguang, Bai, Fang. Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery. PLOS ONE[J]. 2018, 13(3): https://doaj.org/article/03553cae399243e999b64a01552031bb.
[15] Nguyen, Amy D, Lee, Nicola J, Wee, Natalie K Y, Zhang, Lei, Enriquez, Ronaldo F, Khor, Ee Cheng, Nie, Tao, Wu, Donghai, Sainsbury, Amanda, Baldock, Paul A, Herzog, Herbert. Uncoupling protein-1 is protective of bone mass under mild cold stress conditions. BONE[J]. 2018, 106: 167-178, http://dx.doi.org/10.1016/j.bone.2015.05.037.
[16] Wang, Baile, Li, Ang, Li, Xiaomu, Ho, Philip Wl, Wu, Donghai, Wang, Xiaoqi, Liu, Zhuohao, Wu, Kelvin K L, Yau, Sonata S Y, Xu, Aimin, Cheng, Kenneth K Y. Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. EMBO REPORTS[J]. 2018, 19(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000429540900008.
[17] Sun, Wai Yan, Bai, Bo, Luo, Cuiting, Yang, Kangmin, Li, Dahui, Wu, Donghai, Feletou, Michel, Villeneuve, Nicole, Zhou, Yang, Yang, Junwei, Xu, Aimin, Vanhoutte, Paul M, Wang, Yu. Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury. JCI INSIGHT[J]. 2018, 3(17): https://www.webofscience.com/wos/woscc/full-record/WOS:000443880600005.
[18] Nie, Tao, Zhao, Shiting, Mao, Liufeng, Yang, Yiting, Sun, Wei, Lin, Xiaoliang, Liu, Shuo, Li, Kuai, Sun, Yirong, Li, Peng, Zhou, Zhiguang, Lin, Shaoqiang, Hui, Xiaoyan, Xu, Aimin, Ma, Chung Wah, Xu, Yong, Wang, Cunchuan, Dunbar, P Rod, Wu, Donghai. The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPAR gamma activity. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2018, 175(9): 1439-1450, https://www.webofscience.com/wos/woscc/full-record/WOS:000430116700004.
[19] Zhang, Maofeng, Zhang, Yan, Song, Ming, Xue, Xiaoqian, Wang, Junjian, Wang, Chao, Zhang, Cheng, Li, Chenchang, Xiang, Qiuping, Zou, Lingjiao, Wu, Xishan, Wu, Chun, Dong, Baijun, Xue, Wei, Zhou, Yulai, Chen, Hongwu, Wu, Donghai, Ding, Ke, Xu, Yong. Structure-Based Discovery and Optimization of Benzo&ITd&ITisoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(7): 3037-3058, https://www.webofscience.com/wos/woscc/full-record/WOS:000430256600027.
[20] Hui, Xiaoyan, Zhang, Mingliang, Gu, Ping, Li, Kuai, Gao, Yuan, Wu, Donghai, Wang, Yu, Xu, Aimin. Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. EMBO REPORTS[J]. 2017, 18(4): 645-657, [21] Nie, Baoming, Nie, Tao, Hui, Xiaoyan, Gu, Ping, Mao, Liufeng, Li, Kuai, Yuan, Ran, Zheng, Jiashun, Wang, Haixia, Li, Ke, Tang, Shibing, Zhang, Yu, Xu, Tao, Xu, Aimin, Wu, Donghai, Ding, Sheng. Brown Adipogenic Reprogramming Induced by a Small Molecule. CELL REPORTS[J]. 2017, 18(3): 624-635, http://dx.doi.org/10.1016/j.celrep.2016.12.062.
[22] Xinru Wei, Yunxin Lai, Baiheng Li, Le Qin, Youdi Xu, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Guohua Huang, Qiuhua Deng, Pentao Liu, Donghai Wu, Liangxue Lai, Yao Yao, Peng Li. CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(-/-) Mice Results in Severe Immunodeficiency. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/f445669279734610a20d18779a5652b2.
[23] Hoo, Ruby L C, Shu, Lingling, Cheng, Kenneth K Y, Wu, Xiaoping, Liao, Boya, Wu, Donghai, Zhou, Zhiguang, Xu, Aimin. Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy. SCIENTIFIC REPORTS[J]. 2017, 7: https://www.webofscience.com/wos/woscc/full-record/WOS:000392390900001.
[24] Aitken, Jacqueline F, Loomes, Kerry M, RibaGarcia, Isabel, Unwin, Richard D, Prijic, Gordana, Phillips, Ashley S, Phillips, Anthony R J, Wu, Donghai, Poppitt, Sally D, Ding, Ke, Barran, Perdita E, Dowsey, Andrew W, Cooper, Garth J S. Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 482(4): 625-631, http://dx.doi.org/10.1016/j.bbrc.2016.11.083.
[25] Ye, Wei, Jiang, Zhiwu, Lu, Xiaoyun, Ren, Xiaomei, Deng, Manman, Lin, Shouheng, Xiao, Yiren, Lin, Simiao, Wang, Suna, Li, Baiheng, Zheng, Yi, Lai, Peilong, Weng, Jianyu, Wu, Donghai, Ma, Yuguo, Chen, Xudong, Wen, Zhesheng, Chen, Yaoyu, Feng, Xiaoyan, Li, Yangqiu, Liu, Pentao, Du, Xin, Pei, Duanqing, Yao, Yao, Xu, Bing, Ding, Ke, Li, Peng. GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways. ONCOTARGET[J]. 2017, 8(50): 87002-87015, https://www.webofscience.com/wos/woscc/full-record/WOS:000413341400003.
[26] Lin, Shouheng, Huang, Guohua, Xiao, Yiren, Sun, Wei, Jiang, Yuchuan, Deng, Qiuhua, Peng, Muyun, Wei, Xinru, Ye, Wei, Li, Baiheng, Lin, Simiao, Wang, Suna, Wu, Qiting, Liang, Qiubin, Li, Yangqiu, Zhang, Xuchao, Wu, Yilong, Liu, Pentao, Pei, Duanqing, Yu, Fenglei, Wen, Zhesheng, Yao, Yao, Wu, Donghai, Li, Peng. CD215+Myeloid Cells Respond to Interleukin 15 Stimulation and Promote Tumor Progression. FRONTIERS IN IMMUNOLOGY[J]. 2017, 8: https://doaj.org/article/96f2c4549cc744b3808ed4bdd0b8a695.
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[82] Li, Hongbo, Gao, Xuefei, Zhou, Yi, Li, Na, Ge, Caozuo, Hui, Xiaoyan, Wang, Yu, Xu, Aimin, Jin, Shouguang, Wu, Donghai. High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli. PROTEIN EXPRESSION AND PURIFICATIONnull. 2011, 79(1): 1-6, http://dx.doi.org/10.1016/j.pep.2011.03.013.
[83] Park, Min, Youn, ByungSoo, Zheng, Xilong, Wu, Donghai, Xu, Aimin, Sweeney, Gary. Globular Adiponectin, Acting via AdipoR1/APPL1, Protects H9c2 Cells from Hypoxia/Reoxygenation-Induced Apoptosis. PLOS ONE[J]. 2011, 6(4): https://doaj.org/article/19e768224551467d939887f717fe43d4.
[84] Li, Hongbo, Wang, Yu, Xu, Aimin, Li, Shiwu, Jin, Shouguang, Wu, Donghai. Large-scale production, purification and bioactivity assay of recombinant human interleukin-6 in the methylotrophic yeast Pichia pastoris. FEMS YEAST RESEARCH[J]. 2011, 11(2): 160-167, https://www.webofscience.com/wos/woscc/full-record/WOS:000287317400002.
[85] Gao, Su, Zhu, Guangjing, Gao, Xuefei, Wu, Donghai, Carrasco, Patricia, Casals, Nuria, Hegardt, Fausto G, Moran, Timothy H, Lopaschuk, Gary D. Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(23): 9691-9696, https://www.webofscience.com/wos/woscc/full-record/WOS:000291341400073.
[86] Wang, Yi, Cheng, Kenneth K Y, Lam, Karen S L, Wu, Donghai, Wang, Yu, Huang, Yu, Vanhoutte, Paul M, Sweeney, Gary, Li, Yiming, Xu, Aimin. APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice. DIABETES[J]. 2011, 60(11): 3044-3054, https://www.webofscience.com/wos/woscc/full-record/WOS:000296954600044.
[87] Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. 中国科学基金：英文版. 2011, 30-30, http://lib.cqvip.com/Qikan/Article/Detail?id=39864553.
[88] Li, Hongbo, Li, Na, Gao, Xuefei, Kong, Xiangping, Li, Shiwu, Xu, Aimin, Jin, Shouguang, Wu, Donghai. High level expression of active recombinant human interleukin-3 in Pichia pastoris. PROTEIN EXPRESSION AND PURIFICATION[J]. 2011, 80(2): 185-193, http://dx.doi.org/10.1016/j.pep.2011.08.027.
[89] 吴东海. Adiponectin prevents hypoxia/reoxygenation-induced apoptosis in cardiomyocytes via AdipoR1/APPL1 signaling. 2011, [90] Lian, Wei, Wu, Donghai, Lim, Daniel V, Jin, Shouguang. Sensitive detection of multiplex toxins using antibody microarray. ANALYTICAL BIOCHEMISTRY[J]. 2010, 401(2): 271-279, http://dx.doi.org/10.1016/j.ab.2010.02.040.
[91] Wen, Luan, Yang, Yong, Wang, Yu, Xu, Aimin, Wu, Donghai, Chen, Yonglong. Appl1 is Essential for the Survival of Xertopus Pancreas, Duodenum, and Stomach Progenitor Cells. DEVELOPMENTAL DYNAMICS[J]. 2010, 239(8): 2198-2207, http://www.corc.org.cn/handle/1471x/2409137.
[92] 吴东海. Appl1 is Essential for the Survival of Xenopus Pancreas, Duodenum, and Stomach Progenitor Cells. 2010, [93] Ren, Xiaomei, Duan, Lei, He, Qiang, Zhang, Zhang, Zhou, Yi, Wu, Donghai, Pan, Jingxuan, Pei, Duanqing, Ding, Ke. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2010, 1(9): 454-459, https://www.webofscience.com/wos/woscc/full-record/WOS:000285237000001.
[94] Wen, Luan, Liu, Jiantao, Chen, Yonglong, Wu, Donghai. Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2010, 396(2): 419-424, https://www.webofscience.com/wos/woscc/full-record/WOS:000278658000041.
[95] Hui, Xiaoyan, Li, Huiying, Zhou, Zhiguang, Lam, Karen S L, Xiao, Yang, Wu, Donghai, Ding, Ke, Wang, Yu, Vanhoutte, Paul M, Xu, Aimin. Adipocyte Fatty Acid-binding Protein Modulates Inflammatory Responses in Macrophages through a Positive Feedback Loop Involving c-Jun NH2-terminal Kinases and Activator Protein-1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2010, 285(14): 10273-10280, http://dx.doi.org/10.1074/jbc.M109.097907.
[96] Zhou, Mingyan, Xu, Aimin, Lam, Karen S L, Tam, Paul K H, Che, ChiMing, Chan, Lawrence, Lee, InKyu, Wu, Donghai, Wang, Yu. Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. JOURNAL OF HEPATOLOGY[J]. 2010, 53(6): 1108-1116, http://dx.doi.org/10.1016/j.jhep.2010.05.034.
[97] Shi, Zhuliang, Liang, Ning, Xu, Wei, Li, Kuai, Sheng, Guoqing, Liu, Jinsong, Xu, Aimin, Li, XiaoJiang, Wu, Donghai. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the SH3 domain of human AHI1. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2009, 65: 361-363, https://www.webofscience.com/wos/woscc/full-record/WOS:000264770000011.
[98] Shi Zhuliang, Liang Ning, Xu Wei, Li Kuai, Sheng Guoqing, Liu Jinsong, Xu Aimin, Li XiaoJiang, Wu Donghai. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the SH3 domain of human AHI1. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2009, 65(Pt 4): 361-363, http://ir.gibh.ac.cn/handle/344009/221.
[99] Zhou, Yi, Wang, Dongye, Zhu, Qiang, Gao, Xuefei, Yang, Song, Xu, Aimin, Wu, Donghai. Inhibitory Effects of A-769662, a Novel Activator of AMP-Activated Protein Kinase, on 3T3-L1 Adipogenesis. BIOLOGICAL & PHARMACEUTICAL BULLETIN[J]. 2009, 32(6): 993-998, http://ir.gibh.ac.cn/handle/344009/209.
[100] 梁宁, 石珠亮, 王东业, 魏国威, 孔祥平, 陈昌友, 刘劲松, 徐爱民, 吴东海. 人类APPL2蛋白PTB结构域的表达纯化及其功能的研究. 中国生物工程杂志[J]. 2009, 29(8): 1-7, http://lib.cqvip.com/Qikan/Article/Detail?id=31424964.
[101] Li, Hongbo, Wang, Dongye, Xu, Aimin, Li, Shiwu, Jin, Shouguang, Wu, Donghai. High level expression and purification of active recombinant human interleukin-8 in Pichia pastoris. PROTEIN EXPRESSION AND PURIFICATION[J]. 2009, 68(1): 60-64, http://dx.doi.org/10.1016/j.pep.2009.06.010.
[102] Yau, Minghon, Wang, Yu, Lam, Karen S L, Zhang, Jialiang, Wu, Donghai, Xu, Aimin. A Highly Conserved Motif within the NH2-terminal Coiled-coil Domain of Angiopoietin-like Protein 4 Confers Its Inhibitory Effects on Lipoprotein Lipase by Disrupting the Enzyme Dimerization. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2009, 284(18): 11942-11952, http://dx.doi.org/10.1074/jbc.M809802200.
[103] Hui, Xiaoyan, Zhu, Weidong, Wang, Yu, Lam, Karen S L, Zhang, Jialiang, Wu, Donghai, Kraegen, Edward W, Li, Yixue, Xu, Aimin. Major Urinary Protein-1 Increases Energy Expenditure and Improves Glucose Intolerance through Enhancing Mitochondrial Function in Skeletal Muscle of Diabetic Mice. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2009, 284(21): 14050-14057, http://dx.doi.org/10.1074/jbc.M109.001107.
[104] 金晓辉, 魏孝义, 黄志伟, 吴东海. 水翁花提取物的PPARγ配体活性鉴定. 安徽农业科学. 2008, 36(21): 9106-9109, http://lib.cqvip.com/Qikan/Article/Detail?id=28015828.
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[106] Chen, Jinping, Sun, Min, Liang, Bing, Xu, Aimin, Zhang, Shuyi, Wu, Donghai. Cloning and expression of PDK4, FOX01A and DYRK1A from the hibernating greater horseshoe bat (Rhinolophus ferrumequinum). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY[J]. 2007, 146(2): 166-171, http://ir.foo.ac.cn/handle/2SETSVCV/691.
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已指导学生

金晓辉  硕士研究生  071010-生物化学与分子生物学  

高野  硕士研究生  071010-生物化学与分子生物学  

周毅  硕士研究生  071010-生物化学与分子生物学  

高学飞  博士研究生  071010-生物化学与分子生物学  

温栾  博士研究生  071010-生物化学与分子生物学  

现指导学生

林万华  博士研究生  071010-生物化学与分子生物学  

黄晓丽  硕士研究生  100701-药物化学  

聂涛  博士研究生  071010-生物化学与分子生物学  

李洪波  博士研究生  071010-生物化学与分子生物学  

杨松  博士研究生  071010-生物化学与分子生物学  

毛刘锋  博士研究生  071010-生物化学与分子生物学