基本信息
韩丹翔  女  博导  中国科学院水生生物研究所
电子邮件: danxianghan@ihb.ac.cn
通信地址: 武汉市东湖南路7号
邮政编码: 430072

研究领域

微藻油脂代谢,藻类高附加值产品的开发和应用,藻类在水产养殖中的应用

招生信息

   
招生专业
071004-水生生物学
090801-水产养殖
招生方向
藻类生物学与生物技术;微藻油脂生物合成、调控及储存机制
微藻类胡萝卜素等高附加值产品的生物合成
藻类系统生物学

教育背景

2001-09--2006-06   Institute of Hydrobiology, CAS   Ph.D.
1997-09--2001-06   Wuhan University   B.S.
学位
博士

工作经历

   
工作简历
2014-09~现在, 中国科学院水生生物研究所, 研究员
2010-01~2014-09,Arizona State University, Assistant Research Professor
2006-07~2009-12,Arizona State University, Postdoctoral Research Associate
社会兼职
2020-01-01-今,《Algal Research》杂志副主编, 副主编

专利与奖励

   
专利成果
( 1 ) PCT on Novel Pseudochlorococcum Species and Uses Therefore, 发明, 2010, 第 3 作者, 专利号: 2173854
( 2 ) 雨生血球藻突变株及其应用, 发明, 2015, 第 1 作者, 专利号: 201510983423.40
( 3 ) 一种用农杆菌介导对雨生红球藻进行基因转化的方法及其应用, 发明, 2015, 第 1 作者, 专利号: 201510994162.6
( 4 ) 莱茵衣藻溶血性磷脂酸酰基转移酶及其基因和用途, 发明, 2015, 第 3 作者, 专利号: 201511001292.1
( 5 ) 超临界CO2提取螺旋藻中脂类物质的方法, 发明, 2016, 第 2 作者, 专利号: 201610739457.3
( 6 ) 一种微藻培养方法, 发明, 2016, 第 2 作者, 专利号: 201610791128.3
( 7 ) 一种微藻异养培养方法(氨水调控pH和替代部分铵盐补氮), 发明, 2016, 第 2 作者, 专利号: 201611137997
( 8 ) 雨生红球藻破壁及虾青素提取方法, 发明, 2017, 第 3 作者, 专利号: 201710270196X
( 9 ) 一种微藻快速生长突变体筛选方法及应用, 发明, 2017, 第 1 作者, 专利号: 201710355791.3
( 10 ) 索罗金小球藻合成淀粉缺陷型突变株及其应用, 发明, 2017, 第 1 作者, 专利号: 201710286674.6
( 11 ) 尖状栅藻合成淀粉缺陷型突变株及其应用, 发明, 2017, 第 1 作者, 专利号: 201710400736.1
( 12 ) 一种小球藻chlorella zofingiensis异养高密度培养方法, 发明, 2019, 第 5 作者, 专利号: 20191013602.3
( 13 ) 一种微藻细胞壁突变体的筛选方法, 发明, 2019, 第 1 作者, 专利号: 201910131605.7
( 14 ) 螺旋藻γ-亚麻酸的新用途, 发明, 2019, 第 5 作者, 专利号: 201910215558.4
( 15 ) 一种高产蛋白质小球藻的培养方法, 发明, 2019, 第 1 作者, 专利号: 201910389527.0
( 16 ) 索罗金小球藻在改善鱼类健康状况的功能性饲料中的应用, 发明, 2019, 第 3 作者, 专利号: 201910427021.4
( 17 ) 一种螺旋藻生物活性物质分级分离方法, 发明, 2020, 第 2 作者, 专利号: 202010682601.0
( 18 ) 一种能特异性识别别藻蓝蛋白的人工结合蛋白及获取方法, 发明, 2020, 第 3 作者, 专利号: 202010683209.8
( 19 ) 一种通过金藻发酵高效生产水溶性β-1,3-葡聚糖的方法, 发明, 2020, 第 5 作者, 专利号: 202010902426.1
( 20 ) 半乳糖脂-半乳糖脂半乳糖基转移酶及其基因和应用, 发明, 2021, 第 1 作者, 专利号: 202110197943.8

出版信息

   
发表论文
(1) Functional divergence of diacylglycerol acyltransferases in the unicellular green alga Haematococcus pluvialis, Journal of Experimental botany, 2020, 通讯作者
(2) Identification and Biotechnical Potential of a Gcn5-Related N-Acetyltransferase Gene in Enhancing Microalgal Biomass and Starch Production, Frontiers in Plant Science, 2020, 通讯作者
(3) High-throughput fluorescence-activated cell sorting for cell wall-deficient microalgal mutants screening, Algal Research, 2020, 通讯作者
(4) PGRL1 overexpression in Phaeodactylum tricornutum inhibits growth and reduces apparent PSII activity, Plant Journal, 2020, 第 4 作者
(5) Microalgal plastidial lysophosphatidic acid acyltransferase interacts with upstream glycerol-3-phosphate acyltransferase and defines its substrate selectivity via the two transmembrane domains, Algal Research, 2020, 通讯作者
(6) Unraveling enhanced membrane lipid biosynthesis in Chlamydomonas reinhardtii starchless mutant sta6 by using an electrospray ionization mass spectrometry-based lipidomics method, Journal of Oceanology and Limnology, 2019, 通讯作者
(7) Metabolic plasticity of the starchless mutant of Chlorella sorokiniana and mechanisms underlying its enhanced lipid production revealed by comparative metabolomics analysis, Algal Research, 2019, 通讯作者
(8) Solid Matrix-supported Supercritical CO2 Enhances Extraction of γ-linolenic Acid from the Cyanobacterium Arthrospira (Spirulina) platensis and Bioactivity Evaluation in Zebrafish, Marine Drugs, 2019, 通讯作者
(9) Ultrahigh-cell-density heterotrophic cultivation of the unicellular green microalga Scenedesmus acuminatus and application of the cells to photoautotrophic culture enhance biomass and lipid production, Biotechnology and Bioengineering, 2019, 通讯作者
(10) Two filamentous microalgae as feed ingredients improved flesh quality and enhanced antioxidant capacity and immunity of the gibel carp (Carassius auratus gibelio), Aquaculture Nutrition, 2019, 第 6 作者
(11) Biosynthesis of Triacylglycerol Molecules with Tailored PUFA Profile in Industrial Microalgae, Molecular Plant, 2018, 第 8 作者
(12) Metabolic remodeling of membrane glycerolipids in the microalga Nannochloropsis oceanica under nitrogen deprivation, Frontiers in Marine Science, 2017, 通讯作者
(13) Raman-activated droplet sorting (RADS) for label-free high-throughput screening of microalgal single-cells, Analytical Chemistry, 2017, 第 8 作者
(14) Characterization of type 2 diacylglycerol acyltransferase in Chlamydomonas reinhardtii reveals their distinct substrate specificities and function in triacylglycerol biosynthesis, Plant Journal, 2016, 第 2 作者
(15) A new paradigm for producing astaxanthin from the unicellular green alga Haematococcus pluvialis., Biotechnology & Bioengineering, 2016, 通讯作者
(16) Molecular mecahnisms for photosynthetic carbon partitioning into storage neutral lipids in Nannochloropsis oceanica under nitrogen-depletion conditions, Algal Research, 2015, 通讯作者
(17) Cellular capacities for high-light acclimation and changing lipid profiles across life cycle stages of the green alga Haematococcus pluvialis, Plos One, 2014, 通讯作者
(18) Choreography of transcriptomes and lipidomes in Nannochloropsis reveals the mechanisms of oleaginousness in microalgae, Plant Cell, 2014, 第 1 作者
(19) Comparative analyses of lipidomes and transcriptomes reveal a concerted action of multiple defensive systems against photooxidative stress in Haematococcus pluvialis, Journal of Experimental Botany, 2014, 通讯作者
(20) Astaxanthin in microalgae: Biosynthesis pathways, regulation and biotechnological applications, Algae, 2013, 第 1 作者
(21) Phospholipid:diacylglycerol acyltransferase is a multifunctional enzyme involved in membrane lipid turnover and degradation while synthesizing triacylglycerol in the unicellular green microalga Chlamydomonas reinhardtii,  Plant Cell , 2012, 第 1 作者
(22) Effect of initial biomass density on growth and astaxanthin production of Haematococcus pluvialis in an outdoor photobioreactor, Journal of Applied Phycology, 2012, 第 2 作者
(23) Susceptibility and protective mechanisms of motile and non-motile cells of Haematococcus pluvialis (Chlorophyceae) to photooxidative stress, Journal of Phycology , 2012, 第 1 作者
(24) Carotenoid distribution in living cells of Haematococcus pluvialis (Chlorophyceae), Plos ONE, 2011, 第 3 作者
(25) Photosynthetic carbon partitioning and lipid production in the oleaginous microalga Pseudochlorococcum sp. (Chlorophyceae) under nitrogen-limited conditions, Bioresource Technology, 2011, 第 2 作者
(26) Inhibition of starch synthesis results in overproduction of lipids in starchless mutants of Chlamydomonas reinhardtii., Biotechnology and Bioengineering, 2010, 第 2 作者
(27) Chlamydomonas starchless mutant defective in ADP-glucose pyrophosphorylase hyper-accumulates triacylglycerol, Metabolic Engineering, 2009, 第 2 作者
(28) An evaluation of four phylogenetic markers in Nostoc: Implications for cyanobacterial phylogenetic studies at the intrageneric level, Current Microbiology , 2009, 第 1 作者
(29) Mutations stabilize small subunit ribosomal RNA in desiccation-tolerant cyanobacteria Nostoc, Current Microbiology, 2007, 第 1 作者
(30) Progress in Nostoc research and its application, High Technology Letters, 2004, 第 1 作者
发表著作
(1) HANDBOOK OF MICROALGAL CULTURE, Industrial production of microalgal cell-mass and secondary products - Major industrial species: Nostoc , WILEY Blackwell, 2004-01, 第 1 作者
(2) HANDBOOK OF MICROALGAL CULTURE , Chapter 3 Basic culturing and analytical measurement techniques , WILEY Blackwell, 2013-01, 第 4 作者
(3) HANDBOOK OF MICROALGAL CULTURE , Chapter 28 Molecular and cellular mechanisms for lipid synthesis and accumulation in microalgae: biotechnological implication, WILEY Blackwell, 2013-01, 第 2 作者
(4) HANDBOOK OF MICROALGAL CULTURE, Chapter 20 Biology and commercial aspects of Haematococcus pluvialis, WILEY Blackwell, 2013-01, 第 1 作者
(5) HANDBOOK OF MICROALGAL CULTURE , Chapter 23 Biology and biotechnology of edible Nostoc , WILEY Blackwell, 2013-01, 第 1 作者

科研活动

   
科研项目
( 1 ) 能源微藻遗传改良, 主持, 院级, 2015-06--2017-04
( 2 ) 微藻高附加值产品开发, 主持, 院级, 2015-06--2017-04
( 3 ) ****专项, 主持, 市地级, 2014-09--2016-12
( 4 ) 微藻合成次生类胡萝卜素的调控机制, 主持, 国家级, 2016-01--2019-12
( 5 ) ****择优, 主持, 部委级, 2016-01--2018-12
( 6 ) 探讨不同LED光源对微藻生长及生物合成油脂及高附加值产品的影响, 主持, 部委级, 2015-05--2017-08
( 7 ) 小球藻蛋白合成调节, 主持, 部委级, 2017-01--2019-12
( 8 ) 饵料微藻高密度培养, 主持, 院级, 2019-01--2019-12
( 9 ) 用于水产饲料的藻种资源评价病虫害防治与收获工艺开发, 主持, 院级, 2018-01--2018-12
( 10 ) 微藻生物岩藻黄素的藻种资源评价、病虫害防治和收获工艺技术, 主持, 院级, 2018-01--2018-12
( 11 ) 药用单细胞真核微藻活性成分研究与规模化培养示范, 主持, 国家级, 2019-07--2024-06
( 12 ) 三角褐指藻EPA全景代谢与调控网络解析及新型细胞工厂开发, 参与, 研究所(学校), 2019-09--2021-08
参与会议
(1)Functional divergence of diacylglycerol acyltransferases in the unicellular green alga Haematococcus pluvialis   第8界亚太植物脂质研讨会   2019-11-19
(2)Biorefinery of high-value products from the cyanobacterium Arthrospira (Spirulina) platensis   第一届中德蓝细菌双边会议   2019-09-25
(3)• Novel function of galactolipids as temporary carbon reservior in microalgae   2019 年中国首届衣藻分子细胞学术研讨会   2019-05-17
(4)微藻生物技术与蓝色粮仓的筑建:机遇与挑战   青岛海洋科学与技术国家实验室   2017-12-28
(5)Leveraging a lipidomics platform to dissect lipid metabolism in microalgae   中国海洋湖沼学会藻类学分会第十九次学术讨论会   2017-11-30
(6)Triacylglycerol Biosynthesis and Compartmentation in Microalgae   2017-10-19
(7)A new technological platform enabling sustainable production of astaxanthin   2017-10-07
(8)• A new technological platform enabling sustainable production of astaxanthin   2017-10-07
(9)From host-pathogen warfare to crop protection development in industrial cultures of Haematococcus pluvialis   2016-10-22
(10)From host-pathogen warfare to crop protection development in industrial cultures of Haematococcus pluvialis   第四届亚太藻类创新峰会   2016-09-18
(11)illing the gaps remaining in understanding triacylglycerol biosynthesis in the unicellulcar green alga Chlamydomonas reinhardtii.    Danxiang Han, Kang-sup Yoon, Guanqun Chen, Zhongze Li, Qiang Hu   2015-06-18
(12)Glycerolipid metabolism and trafficking in the unicellular green alga Chlamydomonas reinharditii   Han, D., Li, Y., Yoon KS, Sommerfeld M, Hu Q.   2013-04-07
(13)Triacylglyceorl Biosynthesis Pathways in the Unicellular Green Alga Chlamydomonas reinharditii: Insights from Lipidomics Analysis   Han, D., Li, Y, Yoon, KS, Sommerfeld, M., Hu, Q.    2012-09-24
(14)Biogenesis of Lipid Bodies in Microalgae: New Insights from the Study of Chlamydomonas reinhardtii.    Han, D., Zhu, S., Wang, SB, Sommerfeld, M and Hu, Q   2012-07-24

指导学生

已指导学生

曹黎  硕士研究生  071004-水生生物学  

李中泽  博士研究生  071007-遗传学  

郭晓烨  硕士研究生  071004-水生生物学  

顾小松  博士研究生  071004-水生生物学  

祝棉棉  硕士研究生  071004-水生生物学  

现指导学生

严海龙  博士研究生  071004-水生生物学  

肖玲  硕士研究生  071004-水生生物学  

邹松  博士研究生  071004-水生生物学  

冯晓云  硕士研究生  086000-生物与医药  

徐全  博士研究生  071004-水生生物学  

陈桥红  博士研究生  071004-水生生物学