基本信息
陈佺  男  博导  中国科学院动物研究所
电子邮件: chenq@ioz.ac.cn
通信地址: 朝阳区北辰西路1号院5号D-419
邮政编码: 100101

研究领域

线粒体在细胞凋亡中的作用
线粒体自噬的分子机制的研究
循环肿瘤干细胞

招生信息

   
招生专业
071009-细胞生物学
招生方向
分子细胞生物学
肿瘤干细胞
线粒体生物学

教育背景

1990-09--1993-09   中国科学院动物研究所   博士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
1999-12--今 中国科学院动物研究所 研究员
1997-09--2000-06 Cleveland Clinic Foundation 博士后
1994-10--1997-08 Manchester University 博士后
1993-10--1994-08 中国科学院动物研究所 助研
社会兼职
2011-08--今 中国细胞生物学会,常务理事
2009-07--今 中国生物物理学会,常务理事

教授课程

分子细胞生物学进展、 高级细胞生物学

专利与奖励

   
奖励信息
(1) 第七届全国优秀科技工作者, 国家级, 2016
(2) 第四届谈家桢生命科学创新奖, , 其他, 2011
(3) 长江学者, , 部委级, 2008
(4) 优秀教师奖, , 院级, 2006
(5) 优秀教师奖, , 院级, 2005
(6) 国家杰出青年基金, , 部委级, 2003
专利成果
(1) 人截断型重组可溶性TRAIL-170蛋白及其在制备肿瘤药物中的应用,实用新型,2002,第1作者,专利号:02116263.8
(2) 棉酚及其衍生物在制备治疗骨髓瘤药物中的应用,实用新型,2003,第3作者,专利号:Zl 03142555
(3) 一种用于检测SARS抗体的免疫微球及其制备方法和用途,实用新型,2004,第2作者,专利号:200410070147.4
(4) 用于检测SARS抗原的免疫微球及其制备方法和用途,实用新型,2004,第3作者,专利号:200410070146.X
(5) 抗细胞型朊蛋白单克隆抗体在制备抗肿瘤药物中的应用,发明,2014,第1作者,专利号:201110284158.2
(6) 抗细胞型朊蛋白单克隆抗体及其在诊断检测试剂盒中的应用,发明,2014,第1作者,专利号:201110283471.4
(7) 一种人结直肠癌肿瘤细胞系及其制备方法和应用,发明,2014,第1作者,专利号:201210033124.0
(8) 针对人PrPc的单克隆抗体及其应用,发明,2014,第1作者,专利号:201410206719.0

出版信息

   
发表论文
(1) Parkin promotes proteasomal degradation of p62:Implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease, Parkin promotes proteasomal degradation of p62:Implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease, 2016, 通讯作者
(2) Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy, Autophagy, 2016, 通讯作者
(3) 3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of alpha-synuclein in PC12 cells, Bioorganic and Medicinal Chemistry Letters, 2015, 通讯作者
(4) Hypoxia Activation of Mitophagy and Its Role in Disease Pathogenesis, Antioxidants and Redox Signaling, 2015, 通讯作者
(5) A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells, Journal of Biological Chemistry, 2015, 通讯作者
(6) Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses., Biochimica et Biophysica Acta-Molecular Cell Research, 2015, 通讯作者
(7) Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy, Autophagy, 2015, 通讯作者
(8) Hypoxia regulates Hippo signaling through the SIAH2 ubiquitin E3 ligase., Nature Cell Biology, 2014, 通讯作者
(9) Monitoring mitophagy in Mammalian Cells, Methods in Enzymology, 2014, 通讯作者
(10) A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy, Molecular Cell, 2014, 通讯作者
(11) The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy, Autophagy, 2014, 通讯作者
(12) Receptor-mediated mitophagy in yeast and in mammalian systems, Cell Research, 2014, 通讯作者
(13) Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells, Cell Death Dis., 2013, 通讯作者
(14)  CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer, Cancer Research, 2013, 通讯作者
(15)  Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs.,  Acta Pharmacologica Sinica, 2013, 通讯作者
(16) Molecular signaling toward mitophagy and its physiological significance, Experimental Cell Research, 2013, 通讯作者
(17) Phosphorylation Events in Selective Mitophagy: Possible Biochemical Markers, Curr Pathobiol Rep, 2013, 通讯作者
(18) A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30, Cell Research, 2013, 通讯作者
(19)  Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer., Clinical Cancer Research , 2013, 通讯作者
(20) A natural compound elevates expression of Bim that interacts with Bcl-2 converting the anti-apoptotic protein to a pro-apoptotic Bax-like molecule, Journal of Biological Chemistry, 2012, 通讯作者
(21) Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells Through Upregulation of Bim, Clinical Cancer Research, 2012, 通讯作者
(22) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells, Nature Cell Biology, 2012, 通讯作者
(23) Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release, Cell Research, 2012, 通讯作者
(24) Superoxide flashes: early mitochondrial signals for oxidative stress induced apoptosis, Journal of Biological Chemistry, 2011, 通讯作者
(25) Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson’s disease,  Journal of Biological Chemistry, 2011, 通讯作者
(26) The BH3-mimetic gossypol induces both beclin 1-dependent and beclin 1-independent cytoprotective autophagy in cancer cells, Journal of Biological Chemistry, 2010, 通讯作者
(27) Morphine induces Beclin 1- and ATG5 dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus, Autophagy, 2010, 通讯作者
(28) G protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion, Nature Communications, 2010, 通讯作者
(29) Targeted Expression of Uncoupling Protein 2 to Mouse Liver Increases the Susceptibility to LPS/GalN-Induced Acute Liver Injury, Hepatology, 2009, 通讯作者
(30) Selenite induces redox dependent Bax activation and apoptosis in colorectal cancer cells, Free Radical Biology and Medicine, 2009, 通讯作者
(31) Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells, Biochem Biophys Res Commun, 2009, 通讯作者
(32) CD44 is of functional importance for colorectal cancer stem cell, Clinic Cancer research, 2008, 通讯作者
(33) Cysteine 62 of Bax is critical for its conformational activation and its pro-apoptotic activity in response to H2O2 -induced apoptosis, Journal of Biological Chemistry, 2008, 通讯作者
(34) Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG(2)) to arsenic trioxide-induced cell death, Cell Research, 2008, 通讯作者
(35) Nitric Oxide Signaling in Stretch-induced Apoptosis of Neonatal Rat Cardiomyocytes, FASEB Journal, 2006, 通讯作者
(36) Bak/Bax activation and mPTP opening independent cytochrome c release and apoptosis induced by gossypol which triggers Bcl-2 conformational change,  FASEB Journal , 2006, 通讯作者
(37) Involvement of death receptor signaling in mechanical stretch-induced cardiomyocyte apoptosis, Life Sciences, 2005, 通讯作者
(38) Arsenic trioxide induces apoptosis through activation of Bax in hematopoietic cells , Oncogene, 2005, 通讯作者
(39) Disruption of Smad5 gene induces mitochondria-dependent apoptosis in cardiomyocytes, Experimental Cell Research, 2005, 通讯作者
(40) The mitochondrial Voltage-Dependent Anion Channel (VDAC) plays an essential rolein Arsenic Trioxide-Induced cytochrome c release and apoptosis in multiple myeloma cells, Oncogene, 2004, 通讯作者
(41) Role of Ca2+signaling in initiation of stretch-induced apoptosis in neonatal heart cells, BBRC, 2003, 第 3 作者
(42) One step On column affinity purification and functional analysis of recombinant human VDAC1, BBRC, 2003, 通讯作者
(43) Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins, BBRC, 2003, 通讯作者
(44) The late increase of intracellular free radical species during apoptosis is associated with cytochrome c release, Caspase activation and mitochondrial dysfunction, Cell Death and Differentiation, 2003, 第 1 作者
(45) A study on permeability transition pore opening and cytochrome c release from mitochondria induced by Caspase -3 in vitro, FEBS Letters, 2002, 通讯作者
(46) Cyclin E cleavage is associated with the ionizing radiation induced apoptosis and cell cycle deregulation, Molecular and Cellular Biology, 2002, 第 3 作者
(47) Bid BH3 peptide, but its mutant form G94E, induces permeability transition pore opening and cytochrome c release in vitro, Chinese Science Bulletin, 2002, 通讯作者
(48) TRAIL/Apo2L Induction and Modulation of Bcl-2-related Proteins Regulates Interferon –induced Apoptosis in Multiple Myeloma, Blood, 2001, 通讯作者
(49) Distinct stages of cytochrome C release:evidence of the feedback of the amplification of cytochrome C release from mitochondria by Caspases linking to the dysfunction of mitochondria, Cell Death and Differentiation, 2000, 第 1 作者
(50) Ionizing radiation-induced, Bax -mediated cell death is dependent on activation of Cysteine and Serine proteases, Cell Growth and Differentiation, 1999, 第 2 作者
(51) he activation of Na+/H+ exchange on rat preadipocyte plasma membrane and its role in cell proliferation and differentiation, Science in China, 1999, 第 1 作者
(52) Blood cells with reduced mitochondria membrane potential and cytosolic cytochrome can survive and maintain clonogenicity given appropriate signals to suppress apoptosis, Blood, 1998, 第 1 作者
(53) Ionizing radiation induces mitochondria gene expression and stimulates mitochondria activities in a glioblastoma cell line, Radiation Research, 1998, 第 2 作者
(54)  V-Abelson protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with up-regulation of Bcl-x/L, Oncogene, 1997, 第 1 作者
(55) The role of acid/base homeostasis in the suppression of apoptosis in IL-3 dependent haemopoietic cells by Abelson protein tyrosine kinase, J. Cell. Sci., 1997, 第 1 作者
发表著作
(1) 《分子细胞生物学》,Molecular Cell Biology,清华大学出版社,2006-09,第3作者

科研活动

   
科研项目
(1) 基于小分子探针的细胞命运决定的分子机制研究,参与,国家级,2013-01--2015-12
(2) 肿瘤干细胞与肿瘤转移的分子机制和靶向药物(PrPc),参与,院级级,2012-01--2014-12
(3) 线粒体自噬的分子调控及其在肿瘤发生中的作用,主持,国家级,2012-01--2016-12
(4) 线粒体自由基代谢调控与线粒体质量控制,参与,国家级,2011-01--2015-12
参与会议
(1) Hypoxia activation of mitophagy,2014-05,Chen Quan
(2) Molecular regulation of receptor mediated mitophagy in mammalian system,2013-11,Chen Quan
(3) A regulatory signaling loop controls receptor mediated mitophagy,2013-10,Chen Quan
(4) Cellular prion protein co-expresses in CD44 positive cancer stem cells and contributes to metastatic capacity in colorectal cancer,2013-10,Du Lei
(5) Reversible phosphorylation of FUNDC1 regulate mitophagy,2013-10,Chen Quan
(6) Molecular signaling of receptor-mediated mitophagy,2013-10,Chen Quan
(7) 线粒体质量控制与衰老,双清论坛,衰老转化医学研究的关键科学问题,2013-10,Chen Quan
(8) 肿瘤干细胞与癌症的早期诊断和治疗,北京生命科学论坛,干细胞生物学研讨会,2013-06,Du Lei
(9) Molecular regulation of Fundc1 mediated mitochondrial autophagy,2013-05,Liu Lei
(10) Cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cance,2013-05,Rao Guanhua
(11) 结肠癌干细胞生物标志物的鉴定与临床意义,第十三届北京生命科学领域学术年会基因组医学与人类健康,2013-04,Chen Quan
(12) 肿瘤干细胞表面分子与靶向单克隆抗体,北京生命科学论坛, 第二届干细胞转化医学研讨会,2013-03,Du Lei
(13) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells,2013-02,Chen Quan
(14) Molecular regulation of Fundc1 mediated mitochondrial autophagy,2012-12,Liu Lei
(15) Parkin regulates proteosomal degradation of its substrates. Implication of dysregulated parkin activity in the pathogenesis of Parkinson’s disease,第三次国际暨第十二次全国膜生物学学术研讨会,2012-11,Song Pingping
(16) Molecular Signaling of Mitochondria Autophagy,2012海峡两岸线粒体医学研究暨国际研讨会,2012-10,Liu Lei
(17) Role of outer-membrane and Src signaling in hypoxia-induced mitophagy in mammalian cells,2012-03,Liu Lei
(18) Functional conversion of Bcl-2 into a Bax-like molecule through interaction with Bim,2011-10,Zhao Lixia
(19) Colorectal cancer stem cell and its role in cancer initiation and metastasis,2011-10,Du Lei
(20) Redox signals towards apoptosis,2011-08,Ma Qi
(21) Myostatin Regulates Glucose Metabolism and Induces Apoptosis in Cancer Cell,2011-07,Chen Quan
(22) Molecular regulation of mitochondrial dynamics and its implication in Parkinson’s disease,2011-04,Wang Hongxia
(23) Molecular regulation of mitochondrial dymanics and its implication in neurodegenerative diseases,2010-12,陈佺
(24) Molecular regulation of mitochondrial dynamics,2008-07,陈佺
(25) Redox signals to activate apoptotic machinery,第XIV届国际自由基大会,2008-01,陈佺
(26) Bax dependent and independent cell death,2007-10,陈佺

合作情况

   
项目协作单位
南开大学生命科学学院
北京大学生命科学学院
北京大学北京肿瘤防治研究所
南京大学模式动物研究所
中国科学院生物物理研究所
中国科学院遗传与发育生物学研究所
中国科学院微生物研究所

指导学生

已指导学生

田长海   博士研究生  071009-细胞生物学  

雷晓波   博士研究生  071009-细胞生物学  

蒋春笋  博士研究生  071009-细胞生物学  

商营利  博士研究生  071009-细胞生物学  

刘垒  博士研究生  071009-细胞生物学  

吕建华  博士研究生  071009-细胞生物学  

赵相轩  博士研究生  071009-细胞生物学  

杜蕾  博士研究生  071009-细胞生物学  

赵丽霞  博士研究生  071009-细胞生物学  

张西玲  硕士研究生  071009-细胞生物学  

刘泳  博士研究生  071009-细胞生物学  

张娟  博士研究生  071009-细胞生物学  

梁晓亮  博士研究生  071009-细胞生物学  

倪碧云  硕士研究生  071009-细胞生物学  

王斌  博士研究生  071009-细胞生物学  

高平  博士研究生  071009-细胞生物学  

乐雯  博士研究生  071009-细胞生物学  

李佳音  博士研究生  071009-细胞生物学  

郑巧霞  硕士研究生  071009-细胞生物学  

马淇  博士研究生  071009-细胞生物学  

黄理  硕士研究生  430139-生物工程  

现指导学生

李保伟  博士研究生  071009-细胞生物学  

魏慧芳  硕士研究生  071009-细胞生物学  

杨岩磊  硕士研究生  071009-细胞生物学  

吴浩  博士研究生  071009-细胞生物学  

朱重卓  博士研究生  071009-细胞生物学  

陈明  博士研究生  071009-细胞生物学  

李文辉  硕士研究生  071009-细胞生物学  

陈子恒  博士研究生  071009-细胞生物学  

王悦颖  硕士研究生  071009-细胞生物学  

任杰  硕士研究生  071010-生物化学与分子生物学