My research interests root in fundamental understanding of how fungal genomes and genes work. My recent research activity has been centered around the most deadly mushrooms called Amanita. My group focuses on obtaining genomes of important Amanita species and deducing the molecular mechanisms of how these mushrooms biosynthesize the cyclic peptide toxins. We use genetics, biochemistry, molecular biology, phylogeny, and bioinformatics to address important questions pertaining to toxin biosynthesis, poisoning, artificial cyclic peptide libraries, and evolution of the mushrooms.
Research Areas
Fungal genomics, gene function, and secondary metabolic pathway.
Education
Ph.D. Microbiology, 2006 (Excellent thesis of the year) | Yunnan University
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M.Sc. Microbiology, 2003 (Direct Ph.D. Candidate award)
| Yunnan University
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B.Sc. Polymer Science & Engineering, 1998 (Excellent design honour) | Sichuan University
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Experience
Work Experience
Postdoctoral Research 210 Plant Biology |
East Lansing, Michigan 48824 USA |
Publications
（1） Genes and evolutionary fates of the amanitin biosynthesis pathway in poisonous mushrooms, Proc. Natl. Acad. Sci. U. S. A., 2022
（2） Novel Cyclic Peptides from Lethal Amanita Mushrooms through a Genome-Guided Approach, JOURNAL OF FUNGI, 2021
（3） Differential Expression of Amanitin Biosynthetic Genes and Novel Cyclic Peptides in Amanita molliuscula, JOURNAL OF FUNGI, 2021
（4） Morphology, Multilocus Phylogeny, and Toxin Analysis Reveal Amanita albolimbata, the First Lethal Amanita Species From Benin, West Africa, FRONTIERS IN MICROBIOLOGY, 2020, 第 4 作者
（5） 鹅膏环肽毒素生源合成的研究进展, Research advances in biosynthesis of Amanita cyclic peptide toxins, 菌物学报, 2020
（6） 毒蘑菇的组学研究, Advances of omics research on poisonous mushrooms, 菌物学报, 2019
（7） Genome of lethal Lepiota venenata and insights into the evolution of toxin-biosynthetic genes, BMC GENOMICS, 2019
（8） The MSDIN family in amanitin-producing mushrooms and evolution of the prolyl oligopeptidase genes, IMA FUNGUS, 2018
（9） Production of 15N-labeled α-amanitin in Galerina marginata, Toxicon, 2015
（10） Production of N-15-labeled alpha-amanitin in Galerina marginata, TOXICON, 2015
（11） Extensive sampling of basidiomycete genomes demonstrates inadequacy of the white-rot/brown-rot paradigm for wood decay fungi, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014
（12） Peptide Macrocyclization Catalyzed by a Prolyl Oligopeptidase Involved in α-Amanitin Biosynthesis, Chemistry & Biology, 2014
（13） Ribosomal biosynthesis of alpha-amanitin in Galerina marginata, FUNGAL GENETICS AND BIOLOGY, 2012
（14） Cyclic peptides from poisonous mushrooms, Method Enzymol, 2012
（15） Colocalization of Amanitin and a Candidate Toxin-Processing Prolyl Oligopeptidase in Amanita Basidiocarps ▿, EUKARYOTIC CELL, 2010
（16） Coprinus comatus damages nematode cuticles mechanically with spiny balls and produces potent toxins to immobilize nematodes, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007
（17） Compounds inhibitory to nematophagous fungi produced by Bacillus sp strain H6 isolated from fungistatic soil, EUROPEAN JOURNAL OF PLANT PATHOLOGY, 2007
（18） Gene family encoding the major toxins of lethal Amanita mushrooms, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007
（19） Acanthocytes of Stropharia rugosoannulata Function as a Nematode-Attacking Device, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006
（20） A new species of Harposporium parasitic on nematodes, CANADIAN JOURNAL OF BOTANY-REVUE CANADIENNE DE BOTANIQUE, 2005
（21） Coprinus comatus: A basidiomycete fungus forms novel spiny structures and infects nematode, MYCOLOGIA, 2004
（22） Processing of the Phalloidin Proprotein by Prolyl Oligopeptidase from the Mushroom Conocybe albipes *, The Journal of Biological Chemistry, 2009
Patents
Please see the webpage in Chinese.
Research Interests
Fungal genomes and gene function.
Conferences
Please see the webpage in Chinese.
Collaboration
MoU signed with Plant Research Laboratory at Michigan State University