基本信息

2005年毕业于东北林业大学,获生物技术专业学士学位;2011年毕业于北京大学,获细胞生物学专业博士学位;2011年至2016年先后在美国约翰霍普金斯大学 (The Johns Hopkins University) 和纪念斯隆凯特琳癌症研究所 (Memorial Solan Kerttering Cancer Center) 接受博士后训练,从事肿瘤生物学研究;2015年获选纪念斯隆凯特琳癌症研究所NYSTEM Fellow2016年入选中组部“青年千人”人才计划;20168月全职回中科院上海生物化学与细胞生物学研究所工作,任研究员,研究组长,博士生导师。


部门/实验室:生物化学与细胞生物学研究所

研究领域

成体干细胞、类器官与组织重建、前列腺癌、胰腺癌、细胞可塑性与肿瘤的抗药性、肿瘤类器官模型库。


招生信息

2018年计划招收1名硕博连读研究生,欢迎有志于从事成体干细胞和肿瘤研究的学生报考本实验室。

招生专业
071009-细胞生物学
招生方向
类器官模型与肿瘤的靶向治疗
肿瘤细胞抗药性机理

教育背景

2006-09--2011-07   北京大学   理学博士
2001-09--2005-07   东北林业大学   理学学士

指导学生

现指导学生

郭旺昕  02  19183  

李飞   02  19181  

论文

1.    Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Andrew J. Aguirre AJ, Viswanathan SR, Tamayo P, Yang WS, Rees MG, Chen SX, Boskovic ZV, Javaid S, Huang C, Wu XY, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Daniel A. Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR & Schreiber SL#. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 July.

2.   Wang SQ, Gao D, Chen Y#. The potential of organoids in urological cancer research. Nature Reviews Urology. 2017 May 23. doi:10.1038/nrurol.2017.65

3.  Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA#, Barbieri CE#. SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer Cell. 2017 Mar 13;31(3):436-451.

4.    Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science. 2017 Jan 6;355(6320):84-88.

5.    Yang ZH, Peng YC, Gopalan A, Gao D, Chen Y, Joyner AL. Stromal Hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. Disease Models & Mechanisms. 2016 : doi: 10.1242/dmm.027417

6.   Dardenne E*, Beltran H*, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA, Francesca Demichelis F and Rickman DS#. N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer. Cancer Cell. 2016 Oct; 30:563-577.

7.     Gao D#, Zhan Y, Di W, Moore AR, Sher JJ, Guan YX, Wang SQ, Zhang ZD, Murphy DA, Sawyers CL, Chi P and Chen Y#. A Tmprss2-CreERT2 knock-in mouse model for cancer genetic studies on prostate and colon. PLoS One 11(8): e0161084.

8.   Drost J*, Karthaus WR*, Gao D, Driehuis E, Sawyers CL, Chen Y and Clevers H#. Organoid culture systems for prostate epithelial tissue and prostate cancer tissue. Nature Protocols. 2016 Jan; Doi:10.1038/347–358.

9.   Wiesner T, Lee W, Obenauf A, Ran L, Murali R, Zhang Q, Wong E, Hu W, Sasinya S,  Shah R, Scott S, Sboner A, Button J, Landa I, Gao D, Cao Z, Shukla S, , Merghoub T, Schwartz G, Wang L, Ladanyi M, Fagin J, Hollmann T, Busam K, BergerM , Chen Y# and Chi P#. Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 2015 Oct; Doi:10.103811.

10.   Ran LL, Sirota I, Cao Z, Murphy D, Chen YD, Shukla S, Xie YY, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y# and Chi P#. Combined inhibition of MAP kinase and KIT signaling pathways destabilizes the ETV1 protein and synergistically suppress GIST tumorigenesis. Cancer Discovery. 2015 Jan; DOI: 10.1158/2159-829011.

11.   Gao D and Chen Y#. Organoid Development in Cancer Genome Discovery. Current Opinion in Genetics and Development. 2015 Mar 18; 30:42-48. (Invited Cover Review).

12.   Gao D*, Vela I*, Sboner A*, Iaquinta PJ*, Karthaus WL, Gopalan A, Wanjala JN, Dowling C, Undvall EA, Wongvipat J, Kossai M, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran Ll, Solomon SB, MacDonald TY, Beltran H, Mosquera J,  Eastham JA, Touijer KA, Scardino PT, Laudone VP, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Chi P, Clevers H, Carver B, Rubin MA, Scher HI, Sawyers CL#, Chen Y#. Generation of in vitro organoids cultures derived from patients with advanced prostate cancer. Cell, 2014 Sep; 159: 176-187. 

13.   Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, Wongvipat J, Gao D, Befthel H, Sachs N, Vries RG.J, Cuppen E, Chen Y, Sawyers CL and Clevers H#. Identification of luminal stem cells in the human prostate using a novel epithelial culture system. Cell, 2014 Sep; 159: 163-175. 

14.   Zeng Y#, Gao D, Kim JJ, Shiraishi T, Terada N, Kakehi Y, Kong CZ, Getzenberg RH, Kulkarni P#. Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production. American Journal of Clinical and Experimental Urology, 2013 Dec; 1(1):39-52.11.

15.   Chen Y, Chi P, Rockowitz S, Iaquinta P.J, Shamu T, Shukla S, Gao D, Sirota I, Carver B.S, Wongvipat J, Scher H.I, Zheng D, Sawyers CL#.  ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nature Medicine, 2013 Aug; 19(8):1023-9. 11.

16.   Zeng Y#, Wodzenski D, Gao D, Shiraishi T, Terada N, Li Y, Griend D.J.V, Luo J, Kong C, Getzenberg R.H, Kulkarni P#. Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing. Cancer Research. 2013 Jul; 73(13): 4123-4133. 11.

17.    Yang YK, Qu H, Gao D, Zhai ZH, and Chen DY#. ARF-like protein 16(ARL16) inhibits RIG-I by binding with CTD in GTP dependent manner. J. Biol. Chem. 2011, 286: 10568-10580.11

18.   Gao D, Yang YK, Wang RP, Zhou X, Diao FC, Li MD, Zhai ZH, Jiang ZF, and Chen DY#.  REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. PLoS One. 2009; 4(6):e5760. 11.

19.   Gao D*, Wang RP*, Li B, Yang Y, Zhai ZH, and Chen DY#. WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. Cell Mol Life Sci. 2009; 6615:2573-84.

20.   Zhang M, Wang RP, Diao FC, Lu F, Gao D, Chen D, Zhai ZH, and Shu HB#. A CXXC ring finger protein is required for DNA damage-induced p53 activation. Science in China Series C: Life Science. 2009; 52(6):528-538.

21.    Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, and Shu HB#. Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. Cell Research. 2008 Nov; 18(11):1096-104.