General
Huifeng Jiang, Ph.D.

Investigator, TIB, Tianjin, China

Tel: 022-24828732 

E-mail: jiang_hf(AT)tib.cas.cn


Education

1999/9-2003/7  Wuhan Polytechnic University, Wuhan, China,B.Eng. in Biological and Chemical Engineering

2003/9-2008/6  Kunming Institution of Zoology, Chinese Academy of Sciences (CAS), Kuming, China,Ph.D. in Zoology, Supervisor: Prof. Wen Wang


Experience

   
Work Experience

2003/9-2004/7    Visiting Student: Beijing Institute of Genomics, CAS, Beijing

2005/5-2005/6    Visiting Student: Institute of Biochemistry and Cell Biology, CAS Shanghai

2006/12-2008/1  Visiting Student: Division of Nutritional Sciences, Cornell University, Ithaca

2008/9-2012/8    Post-doc research associate with Dr. Zhenglong Gu, Division of Nutritional Sciences, Cornell University, Ithaca


Publications

   
Papers

1.Ying Liu, Zhihui Yan, Xiaoyun Lu, Dongguang Xiao & Huifeng Jiang (2016) Improving the catalytic activity of isopentenyl phosphate kinase through protein coevolution analysis.Scientific Reports. 6:24117, doi: 10.1038/srep24117

2. Dan Li, Zhihui Yan, Lina Lu, Huifeng Jiang & Wen Wang (2014) Pleiotropy of the de novo-originated gene MDF1. Scientific Reports.4:doi:10.1038/srep07280.

3. Huifeng Jiang, Lin Xu, Zhe Wang, Jack Keene& Zhenglong Gu (2014) Coordinating Expression of RNA Binding Proteins with Their mRNA Targets. Scientific Reports.4:doi:10.1038/srep07175.

4. Liu X*, Jiang H*, Gu Z, Roberts J. (2013) High Resolution View of Bacteriophage Lambda Gene Expression by Ribosome Profiling. Proc Natl Acad Sci USA 110(29): 11928-11933.

5.  Jiang H*, Guo X, Xu L, Gu Z (2012) Rewiring of post-transcriptional RNA regulons: Puf4p in fungi as an example. Mol Biol Evol 29(9): 2169-2176.

6.  Xu L, Jiang H, Chen H, Gu Z. (2011). Genetic architecture of growth traits revealed by global epistatic interactions. Genome Biol Evol 3: 909-914.

7.  Jiang H, Xu L, Gu Z. (2011). Growth of novel epistatic interactions by gene duplication. Genome Biol Evol 3: 295-301.

8.  Jiang H*, Guan W*, Gu Z (2010) Tinkering evolution of post-transcriptional RNA regulons: puf3p in fungi as an example. PLoS Genet  6: e1001030.

9.  Sun J*, Jiang H*, Flores R, Wen J (2010) Gene duplication in the genome of parasitic Giardia lamblia. BMC Evol Biol 10: 49.

10. Li D*, Dong Y*, Jiang Y*, Jiang H*, Cai J, et al. (2010)  A de novo originated gene depresses budding yeast mating pathway and is  repressed by the protein encoded by its antisense strand. Cell Res 20: 408-420.

11. Guan W, Jiang H, Guo X, Mancera E, Xu L, et al. (2010)  Antagonistic changes in sensitivity to antifungal drugs by mutations of  an important ABC transporter gene in a fungal pathogen. PLoS One 5: e11309.

12. Li X, Zhao L, Jiang H, Wang W (2009) Short homologous sequences are strongly associated with the generation of chimeric RNAs in eukaryotes. J Mol Evol 68: 56-65.

13. Jiang H*,  Zhang Y*, Sun J, Wang W, Gu Z (2008) Differential selection on gene  translation efficiency between the filamentous fungus Ashbya gossypii  and yeasts. BMC Evol Biol 8: 343.

14. Jiang H, Guan W, Pinney D, Wang W, Gu Z (2008) Relaxation of yeast mitochondrial functions after whole-genome duplication. Genome Res 18: 1466-1471.

15. Cai J, Zhao R, Jiang H, Wang W (2008) De novo origination of a new protein-coding gene in Saccharomyces cerevisiae. Genetics 179: 487-496.

16. Jiang H, Liu D, Gu Z, Wang W (2007) Rapid evolution in a pair of recent duplicate segments of rice. J Exp Zool B Mol Dev Evol 308: 50-57.

17. Zhao S, Jiang H, Wang W, Mao B (2007) Cloning and developmental expression of the Xenopus Nkx6 genes. Dev Genes Evol 217: 477-483.

18. Yu H, Jiang H, Zhou Q, Yang J, Cun Y, et al. (2006) Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup. Hum Mol Genet 15: 1870-1875.

19. Wang W, Zheng H, Yang S, Yu H, Li J, Jiang H, et al. (2005) Origin and evolution of new exons in rodents. Genome Res 15: 1258-1264.


Patents

( 1 ) 一种将多个外源基因同时克隆到微生物基因组的方法, 发明, 2014, 第 1 发明人, 专利申请号: 201410621447.0
( 2 ) 一种灯盏花糖基转移酶、制备方法及其应用, 发明, 2014, 第 1发明人, 专利申请号: 201410620716.1
( 3 ) 一种具有催化DMA合成DMAPP功能的酶及其应用, 发明, 2015, 第 1 发明人, 专利申请号: 201510178127.7
( 4 ) 具有催化甲醛合成1,3-二羟基丙酮功能的酶及其制备方法, 发明, 2015, 第 1 发明人, 专利申请号: 201510446357.7

(5)黄酮-6-羟化酶及其在灯盏乙素合成中的应用,发明,2016,第 1 发明人, 专利申请号:201610824470.9


Conferences

2005  Conference Presentation: Rapid Evolution in a Pair of Recent  Duplication Segments of Rice. Annual meeting of Molecular Biology and  Evolution;

2009  Conference Poster: Relaxation of yeast mitochondrial functions after  whole-genome duplication. Annual meeting of Molecular Biology and  Evolution;

2010  Conference Poster: Tinkering evolution of post-transcriptional RNA  regulons: puf3p in fungi as an example. Yeast Genetics & Molecular  Biology meeting;

2016 Conference Presentation: Synthesis of plant natural products by synthetic biology in yeast. Regional Workshop on“Economic Prosperity through Research and Development in Natural Products";


Students

现指导学生

王千  02  19183  

徐占梅  02  63228  

刘晓楠  01  19183  

杨一群  02  63228  

郭丹  02  63228