1. Chemical biology study: To discover new drug targets and new biological mechanisms, our lab mainly focuses on several signaling pathway related with viral infection, hepatoma and breast cancer, including interferon-mediated JAK/STAT pathway, aromatase-mediated estrogen biosynthesis, microRNA signaling pathway and ubiquitin-26S proteasome pathway by using natural products or synthetic compounds as probes. We also conduct structure-activity relationship study to optimize the bioactive compounds and isolate their cellular targets.

2. Develop new labeling methods to quantitatively observe the dynamic distribution of cell membrane receptors and new tools to disrupt protein-protein interactions.

3. Elucidate the chemical constituents of Traditional Chinese Medicines and their biological mechanism for anti-inflammation and antiosteoporosis.

1996.09-2000.07   Henan Normal University, B.S., Biology

2000.09-2005.09  Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Ph.D, Developmental Biology

2005.10-2008.02  University of California San Francisco, CA, USA, Postdoctoral Fellow

2008.03-present  Chengdu Institute of Biology, Chinese Academy of Sciences, Associate Professor (2008), Professor (2013)

（1）Junli Zhou, Fei Wang, Wenshi Ma, Yansheng Zhang, Bin Han, Yongbiao Xue. Structural and transcriptional analysis of S-locus F-box genes in Antirrhinum.  Sexual Plant Reproduction 2003, 16:165-177.

（2）Hong Qiao#, Fei Wang#, Lan Zhao#, Junli Zhou, Zhao Lai, Yansheng Zhang, Timothy P. Robbins, and Yongbiao Xue. The F-box protein AhSLF-S2 controls the pollen function of S-RNase-based self-incompatibility. Plant Cell, 2004, 16: 2307-2322.  (# equal contribution) 

（3）杨笛笑，李麒麟，张国林，王飞*。齐墩果醇-龙胆三糖苷雌激素样作用及其对肝癌HepG2细胞增殖的影响。 《天然产物研究与开发》2010，22: 697-700.

（4）王玉梅，陈前锋，杨莉娟，王飞*。 女贞子对大鼠成骨细胞增殖与分化的影响。《天然产物研究与开发》2011，23: 232-235。

（5） Lijuan Yang, Qianfeng Chen, Fei Wang*, Guolin Zhang*. Antiosteoporotic compounds from seeds of Cuscuta chinensis. Journal of Ethnopharmacology 2011, 135:553-560.

（6）  Wenchen Pu, Fei Wang, Chun Wang. Bioactivities and synthetic methods of 2-arylbenzo[b]furans. Chinese Journal of Organic Chemistry 2011, 31:155-165.

（7） Xing Wang, Guangyin Lv, Lijuan Yang, Fei Wang, Chun Wang. Synthesis and selective estrogen receptor binding affinity of 7-hydroxylisoflavones. Chinese Journal of Organic Chemistry 2011, 31:1245-1251.

（8） Zhengfu Tai, Guolin Zhang, Fei Wang*. Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening. Biological & Pharmaceutical Bulletin 2012, 35: 65-71.

（9） Danfeng Lu, Lijuan Yang, Qilin Li, Xiaoping Gao, Fei Wang*, Guolin Zhang*. Egonol gentiobioside and egonol gentiotrioside from Styrax perkinsiae promote the biosynthesis of estrogen by aromatase. European Journal of Pharmacology 2012, 691: 275-282.

（10）Dan-feng Lu, Li-juan Yang, Fei Wang*, Guolin Zhang*. Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). Journal of Agricultural and Food Chemistry 2012, 60: 8411-8418.

（11） Lei Hua, Ya Li, Fei Wang, Dan-feng Lu, Kun Gao. Biologically active steroids from the aerial parts of Vernomia anthelmintica Wild. Fitoterapia 2012, 83:1036-1041.

（12） Qianfeng Chen, Lijuan Yang, Guolin Zhang*, Fei Wang*. Bioactivity-guided isolation of antiosteoporotic compounds from Ligustrum lucidum. Phytotherapy Research 2013, 27: 973-979. 

（13） Lijuan Yang, Danfeng Lu, Jiajia Guo, Xianli Meng, Guolin Zhang*, Fei Wang*. Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19). Journal of Ethnopharmacology 2013, 145: 715-721. 

（14） Han-wei Liu, Xiu-zhu Yu, Daniele Padula, Gennaro Pescitelli, Zhi-wei Lin, Fei Wang, Kai Ding, Ming Lei, Jin-ming Gao. Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity. European Journal of Medicinal Chemistry 2013, 59: 265-273.

（15） Pu-zhao Zhang, Fei Wang, Li-juan Yang, Guo-lin Zhang. Pregnane alkaloids from Sarcococca hookeriana var. digyna. Fitoterapia, 2013, 89:143-148.

（16）Yuan Lin, Fei Wang, Li-juan Yang, Ze Chun, Jin-ku Bao, Guolin Zhang*. Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum. Phytochemistry 2013, 95: 242-251.

（17）郭加加，黄君梅，王飞*。 冰乙酸水解法提高女贞子提取物中红景天苷含量。 《应用与环境生物学报》 2013, 19: 723-726. 

（18）鲁丹枫，Azimova Bahtigul Jovliqizi, 张国林，王飞*。 采用磁微粒酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型。《天然产物研究与开发》 2013，25: 27-30. 

（19） Jin-Bao Xu, Yuan Lin, Shi-Hui Dong, Fei Wang, Jian-Min Yue*. Trichinenlides A-T, Mexcicanolide-Type Limonoids from Trichilia sinensis. Journal of Natural Products 2013, 76: 1872-1880.

（20） Zhengfu Tai, Yuan Lin, Yujiao He, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*, Fei Wang*. Luteolin Sensitizes the Antiproliferative Effect of Interferon α/β by Activation of Janus Kinase/Signal Transducer and Activator of Transcription Pathway Signaling through Protein Kinase A-Mediated Inhibition of Protein Tyrosine Phosphatase SHP-2 in Cancer Cells. Cellular Signalling 2014, 26: 619-628.

（21） Boyang Hu, Hai Zhang, Xianli Meng, Fei Wang*, Ping Wang*. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. Journal of Ethnopharmacology 2014, 153: 846-853.

（22）Chunyan Yang, Fu Li, Baowen Du, Fei Wang*, Mingkui Wang*. Isolation and characterization of new phenolic compounds with estrogen biosynthesis-inhibiting and antioxidation activities from Broussonetia papyrifera leaves. PLoS ONE. 2014. 9: e94198.

（23）Jiajia Guo, Yun Yuan, Danfeng Lu, Baowen Du, Liang Xiong, Jiangong Shi, Wanli Liu, Lijuan Yang, Xiaohong Yuan, Guolin Zhang*, Fei Wang*. Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19). Toxicology and Applied Pharmacology 2014, 279:23-32. 

(24) Liling Xu, Gen Li, Jing Wang, Yilin Fan, Zhengpeng Wan, Shaosen Zhang, Samina Shaheen, Jing Li, Li Wang, Cai Yue, Yan Zhao, Fei Wang, Joseph Brzostowski, Ying-Hua Chen, Wenjie Zheng, Wanli Liu. Through an ITIM-independent mechanism the FcγRIIB blocks B cell activation by disrupting the colocalized microclustering of the B cell receptor and CD19. Journal of Immunology 2014, 192:5179-5191.

（25）袁韵，林之蔚，郭加加，王飞，袁小红。细胞膜结合的雌激素受体的特异性标记。《应用与环境生物学报》2014，20:227-232.

(26) Wenchen Pu, Yuan Lin, Jianshuo Zhang, Fei Wang, Chun Wang, Guolin Zhang. 3-Arylcoumarins: Synthesis and potent anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters 2014, 24: 5432-5434.

(27) Nilubon Sornkaew, Yuan Lin, Fei Wang, Guolin Zhang, Ratchanaporn Chokchaisiri, Ailian Zhang, Kanjana Wongkrajang, Parichart Suebsakwong, Pawinee Piyachaturawat, Apichart Suksamrarn. Diarylheptanoids of Curcuma comosa with Inhibitory Effects on Nitric Oxide Production in Macrophage RAW 264.7 Cells. Natural Product Communications 2015, 10:89-93.

(28) Yingyue Zeng, Junyang Yi, Zhengpeng Wan, Kai Liu, Ping Song, Alicia Chau, Fei Wang,  Zai Chang, Weidang Han, Wenjie Zheng, Ying-Hua Chen, Chunyang Xiong, Wanli Liu. Substrate stiffness regulates B-cell activation, proliferation, class switch, and T-cell-independent antibody responses in vivo. European Journal of Immunology 2015, 45: 1621-1634.

(29) Ce Liu, XingWang Zhao,  LiLing Xu, JunYang Yi, Samina Shaheen, Weidong Han, Fei Wang, Wenjie Zheng, Chenqi Xu, Wanli Liu. A negative-feedback function of PKC in the formation and accumulation of signaling-active B cell receptor microclusters within B cell immunological synapse. Journal of Leukocyte Biology 2015, 97:887-900.

(30) Zhengpeng Wan, Xiangjun Chen, Haodong Chen, Qinghua Ji, Yingjia Chen, Jing Wang, Yiyun Cao, Fei Wang, Jizhong Lou, Zhuo Tang, Wanli Liu. The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold. eLife 2015, 4:e06925.

（31）邓腾，杨莉娟，罗国勇，李晟，杜宝文，王飞*。蛋白酪氨酸磷酸酶SHP2抑制剂体外筛选模型的建立及应用。《应用与环境生物学报》2015，21:602-606.

（32）Wei-Hua Wang, Yin Nian, Yu-Jiao He, Luo-Sheng Wan, Ni-Man Bao, Guo-Lei Zhu, Fei Wang*, Ming-hua Qiu*. New cycloartane triterpenes from the aerial parts of Cimicifuga heracleifolia. Tetrahedron 2015, 71:8018-8025.

（33）Yujiao He, Junmei Huang, Ping Wang, Sheng Li, Lijuan Yang, Apichart Suksamrarn, Wanli Liu, Guolin Zhang* and Fei Wang*.  Emodin potentiates the antiproliferative effect of Interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget 2016, 7: 4664-4679.

（34）Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guo-lin Zhang,Yinggang Luo. Iridoid Glucosides and Diterpenoids from Caryopteris glutinosa. Journal of Natural Products 2016. 79: 886–893.

（35）Lian-qi Chen, Xiao-fei Shen, Bo-yang Hu, Yuan Lin, Ighodaro Igbe, Cheng-gang Zhang, Guo-lin Zhang, Xiao-hong Yuan*, Fei Wang*. Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages. Bioorganic & Medicinal Chemistry Letters 2016, 26:2521-2525.

（36）Jiasi Wu, Hai Zhang, Boyang Hu, Lijuan Yang, Ping Wang, Fei Wang*, Xianli Meng*. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. European Journal of Pharmacology 2016. 780: 106-114.

(37) Zhong-Hua Gao, Yi-Ming Shi, Zhe Qiang, Xia Wang, Shan-Zhai Shang, Yan Yang, Bao-Wen Du, Hui-Pan Peng, Xu Ji, Honglin Li*, Fei Wang*, Wei-Lie Xiao*. Plasiatine, an Unprecedented Indole–Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2. Scientific Reports 2016, 6:24945.

(38) Sheng Li, Li-juan Yang, Ping Wang, Yu-jiao He, Jun-mei Huang, Han-wei Liu, Xiao-fei Shen, Fei Wang*. Dietary apigenin potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation. Food & Nutrition Research 2016, 60:31288.

[39] Wenchen Pu , Yun Yuan , Danfeng Lu, Xin Wang , Hanwei Liu, Chun Wang, Fei Wang, Guolin Zhang*. 2-Phenylbenzo[b]furans: Synthesis and promoting activity on estrogen biosynthesis. Bioorganic & Medicinal Chemistry Letters 2016, 26: 5497–5500.

[40] Samina Shaheen, Zhengpeng Wan, Zongyu Li, Alicia Chau, Xinxin Li, Shaosen Zhang, Yang Liu, Junyang Yi, Yingyue Zeng, Jing Wang, Xiangjun Chen, Liling Xu, Wei Chen, Fei Wang, Yun Lu, Wenjie Zheng, Yan Shi, Xiaolin Sun, Zhanguo Li, Chunyang Xiong, Wanli Liu. Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase. eLife 2017, 6:e23060.

[41] Fu Li, Bao-Wen Du, Dan-Feng Lu, Wen-Xuan Wu, Kanjana Wongkrajang, Lun Wang, Wen-Chen Pu, Chang-Lu Liu, Han-Wei Liu, Ming-Kui Wang*, Fei Wang*. Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects. Scientific Reports 2017, 7:7760.

[42] Orawan Wonganan, Yu-jiao He, Xiao-fei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guo-lin Zhang*, Fei Wang*. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicology and Applied Pharmacology 2017.

[43] Ighodaro Igbe, Xiao-fei Shen, Wei Jiao, Zhe Qiang, Teng Deng, Sheng Li, Wan-li Liu, Han-wei Liu, Guo-lin Zhang, Fei Wang*. Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. Oncotarget 2017 in press.

[44] Xiaojuan Han, Honghan Chen,Jiao Zhou, Haoran Tai, Hui Gong,Xiaobo Wang, Ning Huang, Jianqiong Qin, Tingting Fang, Fei Wang, Hengyi Xiao*. The inhibitory effect of Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. Journal of Cellular Physiology 2017. DOI: 10.1002/jcp.26169.

已指导学生

郭加加  硕士研究生  077901-药物化学  

邓腾  硕士研究生  078001-药物化学  

李晟  硕士研究生  085238-生物工程  

彭辉盼  硕士研究生  105500-药学  

盛钰雯  硕士研究生  085238-生物工程  

史楠  硕士研究生  077804-病理学与病理生理学  

现指导学生

史小可  硕士研究生  100104-病理学与病理生理学  

周宗元  博士研究生  100706-药理学  

李润择  硕士研究生  077804-病理学与病理生理学  

曹东怡  博士研究生  100701-药物化学  

靳钰洁  硕士研究生  078006-药理学  

盛钰雯  博士研究生  100706-药理学