基本信息
王前飞  男  博导  中国科学院北京基因组研究所
电子邮件: wangqf@big.ac.cn
通信地址: 北京市朝阳区北辰西路一号院104号楼
邮政编码: 100101

研究领域

血液学和肿瘤基因组学


招生信息

血液学和肿瘤基因组学 

招生专业
071022-基因组学
071021-生物信息学
招生方向
白血病功能基因组和转录调控
基因转录调控研究的生物信息学方法

教育背景

2002-09--2006-12   美国加州大学伯克利分校   博士后
1997-09--2002-08   美国约翰霍普金斯大学   博士
1988-09--1993-07   山东医科大学   学士
学历
研究生

学位
博士

工作经历

   
工作简历
2009-07~现在, 中国科学院北京基因组研究所, 研究员
2007-01~2009-06,美国芝加哥大学, 研究助理教授
社会兼职
2016-05-01-2019-04-30, 中国医师协会临床精准医疗专业委员会委员,
2016-05-01-2019-04-30, 中国医师协会临床精准医疗专业委员会委员,
2015-01-01-今,科技导报编委,
2014-12-01-今,中国生理学会血液学专业委员会委员,
2014-10-01-今,儿童血液病与肿瘤分子分型北京市重点实验室学术委员会委员,
2011-01-01-今,中国医学科学院血液学国家重点实验室客座研究员,
2010-07-01-今,国家自然科学基金委员会第十三届和第十四届医学科学部血液系统专家评审组成员,
2010-01-01-今,Genomics, Proteomics&Bioinformatics编委,

教授课程

生命组学
基因组学前沿
基因组前沿
人类基因组学研究-进展与应用
基因组学

专利与奖励

   
奖励信息
(1) 天津市自然科学一等奖, 一等奖, 省级, 2015
专利成果
( 1 ) 一种检测SETD2基因突变的试剂盒, 发明, 2015, 第 2 作者, 专利号: 2013101078899

出版信息

   
发表论文
(1) Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice, stem cell reports, 2016, 通讯作者
(2) The priming induction regimen of HAG as a low dose chemotherapy strategy in AML clonal evolution, Sci China Life Sci, 2015, 通讯作者
(3) Cell Type-Specific Expression Profile and Signaling Requirements in Early Hematopoietic Reprogramming, Stem Cells and Development, 2015, 通讯作者
(4) Identification of Functional Cooperative Mutations of SETD2 in Human Acute Leukemia, Nature Genetics, 2014, 通讯作者
(5)  PU.1 is Essential for MLL Leukemia Partially via Crosstalk with the MEIS/HOX Pathway, Leukemia, 2014, 通讯作者
(6) Regulation of MEIS1 by distal enhancer elements in acute leukemia, Leukemia, 2014, 通讯作者
(7) Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells, Stem Cell Reports, 2014, 通讯作者
(8) Evidences for mutations in the histone modifying gene SETD2 as critical drivers in leukemia development, Sci China Life Sci, 2014, 通讯作者
(9) iASeq: integrative analysis of allele-specificity of protein-DNA interactions in multiple ChIP-seq datasets, BMC Genomics, 2012, 第 3 作者
(10) MLL Fusion Proteins Preferentially Regulate a Subset of Wild Type MLL Target Genes in the Leukemic Genome , Blood, 2011, 第 1 作者
(11) Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning, Chemico-Biological Interactions, 2010, 通讯作者
(12) Modulation of antigen-induced anaphylaxis in mice by a traditional Chinese medicine formula, guo min kang, Am J Chin Med, 2009, 第 2 作者
(13) The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells, Oncology Reports, 2009, 第 3 作者
(14) Detection of Weakly Conserved Ancestral Mammalian Regulatory Sequences by Primate Comparisons, Genome Biology, 2007, 第 1 作者
(15) Primate-Specific Evolution of an LDLR Enhancer, Genome Biology, 2006, 第 1 作者
(16) Haplotypes in the APOA1-C3-A4-A5 Gene Cluster affect Plasma Lipids in both Humans and Baboons, Human Molecular Genetics, 2004, 第 1 作者
(17) C/EBPalphap30, a myeloid leukemia oncoprotein, limits G-CSF receptor expression but not terminal granulopoiesis via site- selective inhibition of C/EBP DNA-binding, Oncogene, 2004, 第 2 作者
(18) Regulation of granulocyte and monocyte differentiation by CCAAT/enhancer binding protein alpha, Blood Cells Mol Dis, 2003, 通讯作者
(19) Cell cycle inhibition mediated by the outer surface of the C/EBPalpha basic region is required but not sufficient for granulopoiesis, Oncogene, 2003, 第 1 作者
(20) Reciprocal effects of C/EBPα and PKCδ on JunB expression and monocytic differentiation depend upon the C/EBPα basic region, Blood, 2003, 第 3 作者
(21) C/EBPs are required for granulopoiesis independent of their induction of the granulocyte-colony stimulating factor receptor, Blood, 2002, 第 1 作者
(22) c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells, Molecular and Cellular Biology, 2000, 第 1 作者
(23) Induction of pulmonary allergic responses by antigen-specific Th2 cells, Journal of Immunology, 1998, 第 3 作者
发表著作
   

科研活动

   
科研项目
( 1 ) 血液谱系建立的转录调控研究, 主持, 部委级, 2011-01--2015-12
( 2 ) 中医健康状态体质辨识法研究, 参与, 国家级, 2011-01--2015-08
( 3 ) 药物干预下选择肿瘤细胞增殖的基因组变异与进化规律, 主持, 国家级, 2014-01--2016-12
( 4 ) 肿瘤异质性的基因组和表观遗传机制, 主持, 国家级, 2014-01--2018-08
( 5 ) 急性白血病的基因组学和表观遗传机制研究, 主持, 国家级, 2015-01--2019-12
( 6 ) 恶性肿瘤的基因组演化和精准医学研究, 主持, 部委级, 2015-09--2018-12
( 7 ) 血干细胞的体外扩增以及巨核谱系的发育分化, 主持, 部委级, 2016-01--2018-12
( 8 ) 儿童白血病化疗耐药基因突变和新靶标SETD2的功能研究, 主持, 部委级, 2016-01--2017-12
参与会议
(1)The Genome and Transcriptome of MLL Leukemia: Biological Insights Beyond the Fusion Pathway   第十届国际髓系干细胞和白血病分子研讨会   Jun Wu, Xiaofan Zhu, Fuhong He, Huimin Zeng, Bo Li, Shaoping Ling, Aili Chen, Gang Huang, Tao Cheng , Qian-fei Wang   2014-05-04
(2)PU.1 Is Essential For MLL Leukemia Via Activation Of The Meis/HOX Pathway and A Monocytic Cytokine Mediated Anti-Apoptotic Inflammatory Program   Jing Zhou, Jun Wu, Bo Li   2013-12-05
(3)Whole-Genome Sequencing of a Monozygotic Twin Pair Reveals Functional Cooperative Mutations of SETD2 in Acute Leukemia   Xiaofan Zhu, Fuhong He, Huimin Zeng, Shaoping Ling, Xiaomei Yan, Yaqin Wang, Aili Chen,,Wei Wei, Yue Zhang, Hui Cheng, Jun Wu, Xia Li, Lingtong Hao, Lihua Cao, Lili Dong, Wei Zou, Xuejing Yang, Xin Lu   2012-12-08
(4)Essential Role for PU.1 in MEIS1 Activation and MLL Fusion Leukemia   Zhou J, Li B, Wu J, He FH, Li Q, Yan XM, Zhang Y, Zhang LX, Zhao XH, Yan J, Nobrega M, Tenen DG , Huang G and Wang QF   2011-12-10
(5)MLL-PTD Causes Hypomorph Condition of CBF Complex (RUNX1/CBFβ) and Predisposes the Abnormal Hematopoietic Stem and Progenitor Cells (HSPCs) to Clonal Expansion   Zhang Y, Yan XM, Sashida G, Zhao XH, Rao Y, Goyama S, Whitman SP, Zorko N, Bernot KM, Witte D, Wang QF, Tenen DG, Xiao ZJ, Marcucci G, Mulloy JC, Caligiuri MA and Huang G   2011-12-10
(6)Genome Wide Location Analysis Reveals Deregulated microRNA Genes in MLL Rearragned Leukemic Genome   Mi SL, He FH, Wu J, Zhou J, Wu G, Thirman MJ, Ji HK, Wang QF   2010-12-04
(7)MLL Translocation: Epigenetic Landscapes in the Development of Acute Leukemia   王前飞   2010-04-15
(8)MLL Fusion Proteins Directly Regulate a Small Set of Wild Type MLL Target Genes   Wang QF, Wu G, Mi SL, He FH, Dong JF, Mattison RJ, Kaberlein J , Wang QB, Prabhakar S, Ji HK and Thirman MJ   2009-12-05
(9)Autoregulation of MEIS1 through a Distal Enhancer in Acute Leukemia   Wang QF, Dong JF, Mattison R, Prabhakar S, Arimura FE, Kaberlein J, Wang CZ, Wang QB, Nobrega M and Thirman M.   2008-12-06
(10)Targeted Inhibition of FLT3 Overcomes the Block to Myeloid Differentiation in 32Dcl3 Caused by Expression of FLT3/ITD Mutants   Zheng R, Wang QF, Friedman A, Small D   2001-12-07
(11)C/EBPs Are Required for Granulopoiesis Independent of Their Induction of G1 Arrest, PU.1, and the Granulocyte-Colony Stimulating Factor Receptor   Wang QF, Friedman AD.   2001-12-07

合作情况

   
项目协作单位
   

指导学生

已指导学生

刘丹  02  19187  

张立霞  02  52764  

邹正勇  02  19187  

李博  01  52764  

陆新  02  63236  

郑思  02  19187  

李霞  01  52764  

陈艾莉  01  52764  

何建林  02  63236  

郝伶童  02  67917  

现指导学生

杨雪静  01  67687  

徐泽辉  02  67917  

卜佳晨  01  67687  

詹滴  01  67917  

孙舒  02  67917  

杨静宜  01  67917  

金晨  01  67687  

张亚   02  67917  

陈蕾   01  67917