基本信息
电子邮件:xuexy@dicp.ac.cn
联系电话:0411-84379529
手机号码:13998582669
通信地址:辽宁省大连市中山路457号
邮政编码:116023

研究领域

1. 复杂样品分离制备:利用新型分离材料与现代分离平台,对中药、环境、生物等复杂样品进行高效分离与制备;
2. 复杂样品色谱及联用分析:开展GC、HPLC及GC/MS,HPLC/MS用于复杂样品分析的方法研究,包括条件优化、工业放大、指纹谱与质谱规律研究。
3. 化学生物信息管理与分析:采用大型关系数据库技术,构建复杂样品的化学与生物信息数据库,同时应用化学计量学方法,研究结构与活性间的定量关系,开展组-效、谱-效关系研究。

招生信息

   
招生专业
070302-分析化学
081701-化学工程
100704-药物分析学
招生方向
复杂样品分离分析及化学生物信息学

教育背景

1988.09-1992.07 大连理工大学化工学院煤化工专业 本科生
1992.09-1995.07 大连理工大学研究生院有机化工专业 硕士研究生
1998.09-2004.09 中国科学院大连化学物理研究所分析化学专业 博士研究生
学历
研究生
学位
工学硕士;理学博士
出国学习工作
2000.02-2001.02 德国GSF环境与健康研究中心生态化学研究所 助研,合作研究

工作经历

1995.07-1997.07 中国科学院大连化学物理研究所 研实员
1997.07-2005.08 中国科学院大连化学物理研究所 助研
2005.08-今 中国科学院大连化学物理研究所 副研
工作简历
主要从事多模式多维色/质谱联用技术、色谱理论基础、复杂样品的分离与表征。围绕色谱的基本理论、技术、方法发展、软件开发和应用,开展了系统工作。所发展的复杂样品分析软件系统,通过线性梯度/程序升温条件预实验,可快速准确获取复杂未知样品的液相/气相色谱保留参数和峰形规律,具有重叠峰解析、辅助定性、仿真优化、活指纹谱构建等功能,成功应用于复杂样品的气、液相色谱分离分析。目前承担国家自然科学基金面上项目“针对生物活性肽分离的高正交性多二维液相色谱方法研究”(20975100)。作为子课题负责人,参加并完成两项重大新药创制专项子课题“基准物的制备”(2009ZX09308-001-2)”和“中药质量控制及标准制作技术平台”(2009ZX09313-003-2);作为项目骨干,参加并完成了中科院知识创新工程重要方向项目“基于现代理论和技术的复方中药系统研究”(KGCX2-SW-213),国家自然科学基金重点项目“中药药效组分的指纹图谱分析的方法研究”(20235020),科技部国际合作项目“中药抗抑郁活性成分的高通量制备与筛选”(20071816);作为项目负责人,完成大连市科技计划重点项目“基于定量组分的板蓝根新药开发”(2007E11SF057)。已发表SCI论文65篇,授权专利8项。
社会兼职

党支部书记

专利与奖励

   
专利成果
1. 发明专利: 梁鑫淼, 孙衍国, 丰加涛, 薛兴亚, 徐青; 一种葛根有效组分的制备方法; 申请号: 200710011630.9; 申请日: 2007.06.08, 授权日: 2010.12.22, 证书号: 718795.
2. 发明专利: 梁鑫淼, 王联芝, 刘仁华, 徐青, 薛兴亚, 章飞芳; 一种模拟自然光催化降解雌激素类污染物的方法; 申请号: 200610134016.7; 申请日: 2006.10.25, 授权日: 2010.08.25, 证书号: 665652.
3. 发明专利: 梁鑫淼, 丰加涛, 徐青, 薛兴亚; 一种表告依春的分离制备方法; 申请号: 200710011038.9; 申请日: 2007.04.20, 授权日: 2010.08.25, 证书号: 665787.
4. 发明专利: 梁鑫淼, 王金成, 徐青, 薛兴亚, 章飞芳; 一种对染料木素、大豆黄素具有选择性的分子印迹聚合物; 申请号: 200610135106.8; 申请日: 2006.12.27, 授权日: 2010.07.21, 证书号: 650748.
5. 发明专利: 梁鑫淼, 王联芝, 刘仁华, 徐青, 薛兴亚, 章飞芳; 一种太阳光照射下海水催化降解氯酚类污染物的方法; 申请号: 200710011047.8; 申请日: 2007.04.20, 授权日: 2010.05.19, 证书号: 620507.
6. 发明专利: 梁鑫淼, 王金成, 徐青, 薛兴亚, 章飞芳, 张岩; 一种对葛根粗提物中染料木素选择性的富集分离方法; 申请号: 200610135093.4; 申请日: 2006.12.27, 授权日: 2010.05.12, 证书号: 619367.
7. 发明专利: 梁鑫淼, 彭艳蓉, 刘仁华, 徐青, 薛兴亚, 章飞芳; 一种催化湿式氧化降解染料污染物的方法; 申请号: 200610134018.6; 申请日: 2006.10.25, 授权日: 2009.12.16.
8. 授权发明专利: 梁鑫淼, 王联芝, 刘仁华, 徐青, 薛兴亚, 章飞芳; 一种催化湿式氧化降解雌激素污染物的方法; 申请号: 200610134022.2; 申请日: 2006.10.25, 授权日: 20091021, 证书号: 561712.

出版信息

   
发表论文
1. Jing Zeng, Xiuli Zhang, Zhimou Guo, Jiatao Feng, Xingya Xue, Xinmiao Liang, A new method for chemical identification based on orthogonal parallel liquid chromatography separation and accurate molecular weight confirmation, Journal of Chromatography A, 2011, 1218(13): 1749-1755.
2. Xiaoming Cai, Chaoran Wang, Junyan Xu, Xingya Xue, Xiuli Zhang, Xinmiao Liang, Application of matrix solid-phase dispersion methodology to the extraction of endogenous peptides from porcine hypothalamus samples for MS and LC–MS analysis, Journal of Chromatography B, 2011, 879(9-10): 657-661.
3. Jun Dong, Long Yu, Xiuli Zhang, Xingya Xue, Zhimou Guo, Xinmiao Liang, Analytical and Bioanalytical Chemistry, DOI: 10.1007/s00216-010-4462-5.
4. Jingyu Yan, Xiuling Li, Long Yu, Yu Jin, Xiuli Zhang, Xingya Xue, Yanxiong Ke* and Xinmiao Liang*, Selective enrichment of glycopeptides/phosphopeptides using porous titania microspheres, Chemical Communications, 2010, 46(30): 5488-5490.
5. Jing Zhang, Yuansheng Xiao*, Jiatao Feng, Sophia L. Wu, Xingya Xue, Xiuli Zhang*, Xinmiao Liang, Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants, Journal of Pharmaceutical and Biomedical Analysis, 2010, 52(4): 446-451.
6. Gaowa Jin, Yuntao Dai, Jiatao Feng, Xuemei Qin, Xingya Xue, Feifang Zhang*, Xinmiao Liang, 2-D RP/RPLC method to separate components in Fructus schisandrae chinensis, Journal of Separation Science, 2010, 33: 564-569.
7. Yanfang Liu, Yuansheng Xiao, Xingya Xue, Xiuli Zhang*, Xinmiao Liang*, Systematic screening and characterization of novel bufadienolides from toad skin using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry, Rapid Communications in Mass Spectrometry, 2010, 24(5): 667-678.
8. Yaqin Wang, Zhimou Guo, Yu Jin, Xiuli Zhang, Li Wang, Xingya Xue, Xinmiao Liang*, Identification of prenyl flavonoid glycosides and phenolic acids in Epimedium koreanum Nakai by Q-TOF-MS combined with selective enrichment on “click oligo (ethylene glycol):” column, Journal of Pharmaceutical and Biomedical Analysis, 2010, 51(3): 606-616.
9. Jun Dong, Xiaoming Cai, Lili Zhao, Xingya Xue, Lijuan Zou*, Xiuli Zhang*, Xinmiao Liang Lysophosphatidylcholine profiling of plasma: discrimination of isomers and discovery of lung cancer biomarkers, Metabolomics, 2010, 6(4): 478-488.
10. Huihui Wan, Jingyu Yan, Long Yu, Xiuli Zhang, Xingya Xue, Xiuling Li*, Xinmiao Liang*, Zirconia layer coated mesoporous silica microspheres used for highly speci?c phosphopeptide enrichment, Talanta, 2010, 82 (5): 1701–1707.
11. Yanfang Liu, Jiatao Feng, Yuansheng Xiao, Zhimou Guo, Jing Zhang, Xingya Xue, Jin Ding, Xiuli Zhang*, Xinmiao Liang*, Puri?cation of active bufadienolides from toad skin by preparative reversed-phase liquid chromatography coupled with hydrophilic interaction chromatography, Journal of Separation Science, 2010, 33(10): 1487-1494.
12. Wei Li, Shisheng Wang, Jiatao Feng, Yuansheng Xiao, Xingya Xue, Hui Zhang, Yaqin Wang, Xinmiao Liang, Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa, Magnetic Resonance in Chemistry, 2009, 47(10): 902-908.
13. Huihui Wan, Lin Liu, Cunman Li, Xingya Xue, Xinmiao Liang, Facile synthesis of mesoporous SBA-15 silica spheres and its application for high-performance liquid chromatography, Journal of Colloid and Interface Science, 2009, 337(2): 420-426.
14. Hongxia Zhao, Feifang Zhang, Baocheng Qu, Xingya Xue, Xinmiao Liang, Wet air co-oxidation of decabromodiphenyl ether (BDE209) and tetrahydrofuran, Journal of Hazardous Materials, 2009, 169(1-3): 1146-1149.
15. Xiaoming Cai, Lijuan Zou, Jun Dong, Lili Zhao, Yuanyuan Wang, Qing Xu, Xingya Xue, Xiuli Zhang, Xinmiao Liang, Analysis of highly polar metabolites in human plasma by ultra-performance hydrophilic interaction liquid chromatography coupled with quadrupole-time of flight mass spectrometry, Analytica Chimica Acta, 2009, 650(1): 10-15.
16. Gaowa Jin, Xingya Xue, Feifang Zhang, Yu Jin, Xinmiao Liang, Computer-aided target optimization for traditional Chinese medicine by ultra-performance liquid chromatography, Talanta, 2009, 78(1): 278-283.
17. Yanyan Zhao, Zhimou Guo, Yongping Zhang, Xingya Xue, Qing Xu, Xiuling Li, Xinmiao Liang, Yukui Zhang, Retention properties of novel β-CD bonded stationary phases in reversed-phase HPLC mode, Talanta, 2009, 78(3): 916-921.
18. Jing Zhang, Yu Jin, Jun Dong, Yuansheng Xiao, Jiatao Feng, Xingya Xue, Xiuli Zhang, Xinmiao Liang, Systematic screening and characterization of tertiary and quaternary alkaloids from corydalis yanhusuo W. T. Wang using ultra-performance liquid chromatography–quadrupole-time-of-flight mass spectrometry, Talanta, 2009, 78(2): 513-522.
19. Yanming Liu, Zhimou Guo, Jiatao Feng, Xingya Xue, Feifang Zhang, Qing Xu, Xinmiao Liang, Development of orthogonal two-dimensional hydrophilic interaction chromatography systems with the introduction of novel stationary phases, Journal of Separation Science, 2009, 32(17): 2871-2876.
20. Jing Zhang, Yu Jin, Yanfang Liu, Yuansheng Xiao, Jiatao Feng, Xingya Xue, Xiuli Zhang, Xinmiao Liang, Two-dimensional RPLC-RPLC system with different pH in two dimensions for separation of alkaloids from Corydalis yanhusuo W. T. Wang, Journal of Separation Science, 2009, 32(12): 2084-2089.
21. Jing Zhang, Yu Jin, Yanfang Liu, Yuansheng Xiao, Jiatao Feng, Xingya Xue, Xiuli Zhang, Xinmiao Liang, Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2-D HPLC, Journal of Separation Science, 2009, 32(9): 1401-1406.
22. Hui Zhang, Zhimou Guo, Wei Li, Jiatao Feng, Yuansheng Xiao, Feifang Zhang, Xingya Xue, Xinmiao Liang, Purification of flavonoids and triterpene saponins from the licorice extract using preparative HPLC under RP and HILIC mode, Journal of Separation Science, 2009, 32(4): 526-535.
23. Da-Yong Zhou, Xiu-Li Zhang, Qing Xu, Xing-Ya Xue, Fei-Fang Zhang and Xin-Miao Liang, UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii, Journal of Pharmaceutical and Biomedical Analysis, 2009, 50(1): 2-8.
24. Wei Li; Jia-Tao Feng; Yuan-Sheng Xiao; Ya-Qin Wang; Xing-Ya Xue; Xin-Miao Liang, Three novel terpenoids from the rhizomes of Curcuma longa, Journal of Asian Natural Products Research, 2009, 11(6): 569-575.
25. Yanping Wang, Feifang Zhang, Xingya Xue, Yuansheng Xiao, Jiatao Feng and Xinmiao Liang, Use of an Orthogonal System, RP-LC–HILIC, for Evaluation of Purity, Chromatographia, 2009, 69(11-12): 1379-1384.
26. Yanguo Sun, Xi Zhang, Xingya Xue, Yan Zhang, Hongbin Xiao, Xinmiao Liang, Rapid Identification of Polyphenol C-Glycosides from Swertia franchetiana by HPLC-ESI-MS-MS, Journal of Chromatographic Science, 2009, 47(3): 190-196.
27. Da-Yong Zhou, Qing Xu, Xing-Ya Xue, Fei-Fang Zhang and Xin-Miao Liang, Characterization of polymethoxylated flavones in Fructus aurantii by off-line two-dimensional liquid chromatography/electrospray ionization-ion trap mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2009, 49(2): 207-213.
28. Da-Yong Zhou, De-Liang Chen, Xian-Dong Yang, Qing Xu, Xing-Ya Xue, Fei-Fang Zhang, Xin-Miao Liang, Determination of Tangeretin in Rat Plasma by LC-Electrospray-Ion Trap MS, Chromatographia, 2009, 69(1-2): 27-31.
29. Da-Yong Zhou, De-Liang Chen, Xian-Dong Yang, Qing Xu, Xing-Ya Xue, Fei-Fang Zhang, Xin-Miao Liang, Determination of Tangeretin in Rat Plasma by LC-Electrospray-Ion Trap MS, Chromatographia, 2009, 69(1): 27-31.
30. Jing Zhang, Yu Jin, Jun Dong, Yuansheng Xiao, Jiatao Feng, Xingya Xue, Xiuli Zhang, Xinmiao Liang, Systematic screening and characterization of tertiary and quaternary alkaloids from corydalis yanhusuo W. T. Wang using ultra-performance liquid chromatography–quadrupole-time-of-flight mass spectrometry, Talanta, 2009, 78(2): 513-522.
31. Yanming Liu, Xingya Xue, Zhimou Guo, Qing Xu, Feifang Zhang, Xinmiao Liang, Novel two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography, an excellent orthogonal system for practical analysis, Journal of Chromatography A, 2008, 1208(1-2): 133-140.
32. Yanming Liu, Zhimou Guo, Yu Jin, Xingya Xue, Qing Xu, Feifang Zhang, Xinmiao Liang, “Click oligo(ethylene glycol)”: An excellent orthogonal stationary phase to C18 for two-dimensional reversed-phase/reversed-phase liquid chromatography, Journal of Chromatography A, 2008, 1206(2): 153-159.
33. Gaowa Jin, Xingya Xue, Feifang Zhang, Xiuli Zhang, Qing Xu, Yu Jin and Xinmiao Liang, Prediction of retention times and peak shape parameters of unknown compounds in traditional Chinese medicine under gradient conditions by ultra performance liquid chromatography, Analytica Chimica Acta, 2008, 628(1): 95-103.
34. Yan-Guo Sun, Shi-Sheng Wang, Jia-Tao Feng, Xing-Ya Xue and Xin-Miao Liang, Two new isoflavone glycosides from pueraria lobata, Journal of Asian Natural Products Research, 2008, 10(8): 719-723.
35. Yu Jin, Xiu-li Zhang, Hui Shi, Yuan-shengXiao, Yan-xiong Ke, Xing-ya Xue, Fei-fang Zhang and Xin-miao Liang, Characterization of C-glycosyl quinochalcones in Carthamus tinctorius L. by ultra performance liquid chromatography coupled with quadrupole-time-of-flightmassspectrometry, Rapid Communications in Mass Spectrometry, 2008, 22(8): 1275–1287.
36. Cunman Li, Xingya Xue, Dayong Zhou, Feifang Zhang, Qing Xu, Lingling Ren, Xinmiao Liang, Analysis of iridoid glucosides in Hedyotis diffusa by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2008, 48(1): 205–211.
37. Cunman Li, Xiuli Zhang, Xingya Xue, Feifang Zhang, Qing Xu and Xinmiao Liang. Structural characterization of iridoid glucosides by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2008; 22(12): 1941–1954.
38. Da-Yong Zhou, Rong Xing, Qing Xu, Xing-Ya Xue, Fei-Fang Zhang, Xin-Miao Liang, Polymethoxylated flavones metabolites in rat plasma after the consumption of Fructus aurantii extract: Analysis by liquid chromatography/electrospray ion trap mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2008, 46(3): 543-529.
39. Gaowa Jin, Zhimou Guo, Feifang Zhang, Xingya Xue, Yu Jin, Xinmiao Liang, Study on the retention equation in hydrophilic interaction liquid chromatography, Talanta, 2008, 76: 522-527.
40. Yanping Wang, Xingya Xue, Yuansheng Xiao, Feifang Zhang, Qing Xu, Xinmiao Liang, Purification and Preparation of Compounds from an Extract of Scutellaria barbata D. Don using Purification Factory, Journal of Separation Science, 2008, 31(10): 1669-1676.
41. Yanming Liu, Qing Xu, Xingya Xue, Feifang Zhang, Xinmiao Liang, Two-dimensional LC–MS analysis of components in Swertia franchetiana Smith, Journal of Separation Science, 2008, 31(6-7): 935-944.
42. Zhimou Guo, Yanfang Liu, Junyan Xu, Qing Xu, Xingya Xue, Feifang Zhang, Yanxiong Ke, Xinmiao Liang, Aiwen Lei, Novel reversed phase-high performance liquid chromatography stationary phase with oligo (ethylene glycol) “click” to silica, Journal of Chromatography A, 2008, 1191(1-2): 78-82.
43. Yanrong Peng, Dongmei Fu, Renhua Liu, Feifang Zhang, Xingya Xue, Qing Xu, Xinmiao Liang. NaNO2/FeCl3 dioxygen recyclable activator: An efficient approach to active oxygen species for degradation of a broad range of organic dye pollutants in water, Applied Catalysis B: Environmental, 2008, 79(2): 163-170
44. Yu Jin, Xing-ya Xue, Fei-fang Zhang, Jing Zhang, Hui Shi, Yuan-sheng Xiao, Yan-xiong Ke, Xin-miao Liang, Rapid prediction and optimization of concentration condition for preparative fractions by solid-phase extraction, Journal of Separation Science, 2008, 31(4): 615-621.
45. Yu Jin, Xingya Xue, Yanfang Liu, Yuansheng Xiao, Jing Zhang, Hui Shi, Feifang Zhang, Xinmiao Liang, A novel method of prediction and optimization for preparative high-performance liquid chromatography separation, Journal of Chromatography A, 2008, 1183(1-2), 76-86.
46. Yu Jin, Yuan-sheng Xiao, Fei-fang Zhang, Xing-ya Xue, Qing Xu, Xin-miao Liang, Systematic screening and characterization of flavonoid glycosidesin Carthamustin ctorius L. by liquid chromatography/UV diode-array detection/electrospray ionization tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2008, 46(3): 418-430.
47. Lingling Ren, Xingya Xue, Feifang Zhang, Yongcan Wang, Yanfang Liu, Cunman Li and Xinmiao Liang, Studies of iridoid glycosides using liquid chromatography/electrospray ionization tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 2007; 21: 3039-3050.
48. Yanrong Peng, Dongmei Fu, Renhua Liu, Feifang Zhang, Xingya Xue, Qing Xu, Xinmiao Liang. NaNO2/FeCl3 dioxygen recyclable activator: an efficient approach to active oxygen species for degradation of a broad range of organic dye pollutants in water, Applied Catalysis B: Environmental, 2007, 79: 163-170.
49. Dongmei Fu, Renhua Liu, Qing Xu, Xingya Xue, Feifang Zhang and Xinmiao Liang, Kinetic Study on Wet Air Co-Oxidation of Phenol at Presence of Nitrobenzene, Fresenius Environmental Bulletin, 2007, 16(1): 71-75.
50. Lianzhi Wang, Feifang Zhang, Renhua Liu, Tony Y. Zhang, Xingya Xue, Qing Xu, and Xinmiao Liang, FeCl3/NaNO2: An Efficient Photocatalyst for the Degradation of Aquatic Steroid Estrogens under Natural Light Irradiation, Environmental Science and Technology, 2007, 41, 3747-3751.
51. Zhimou Guo, Aiwen Lei, Yongping Zhang, Qing Xu, Xingya Xue, Feifang Zhang, Xinmiao Liang, “Click saccharides”: novel separation materials for hydrophilic interaction liquid chromatography, Chem. Commun., 2007, 2491-2493.
52. Lingling Ren, Xingya Xue, Feifang Zhang, Qing Xu, Xinmiao Liang, High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs, J. of Separation Science, 2007, 30(6): 833-842.
53. Da-yong Zhou, Qing Xu, Xing-ya Xue, Fei-fang Zhang, Yu Jin, Xin-miao Liang, Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS, J. Sep. Sci., 2007, 30(6): 858-867.
54. Da-Yong Zhou, De-Liang Chen, Qing Xu, Xing-Ya Xue, Fei-Fang Zhang, Xin-Miao Liang, Characterization of Polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2007, 43: 1692-1699.
55. Yanguo Sun, Xi Zhang, L Wang, Xingya Xue, Hongbin Xiao, Xinmiao Liang.Structure Analysis on Complexes of Xanthone Glycosides and Metal Ions Using Electrospray Ionization Tandem Mass Spectrometry, Polish Journal of Chemistry, 2007 81(10): 1687-1700.
56. Xi Zhang, Hongbin Xiao, Xingya Xue, Yanguo Sun, Xinmiao Liang. Simultaneous characterization of isoflavonoids and astragalosides in two Astragalus species by high-performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry, Journal of Separation Science, 2007, 30 (13): 2059-2069.
57. Da-yong Zhou, Qing Xu, Xing-ya Xue, Fei-fang Zhang and Xin-miao Liang, Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2006, 42(4): 441-448.
58. Hongxia Zhao, Xingya Xue, Qing Xu, Feifang Zhang and Xinmiao Liang, Gas chromatographic peak identification for polybrominated diphenyl ethers under different temperature programs, J. of Chromatography A, 2006, 1107(1-2): 248-256.
59. Hongxia Zhao, Qing Zhang, Xingya Xue, Xinmiao Liang, A Ketrrup, Predicting gas chromatograhpic retention times of 209 polybrominated diphenyls (PBBs) for different temperature programs, Analytical and Bioanalytical Chemistry, 2005, 382: 1304-1310.
60. Hongxia Zhao, Qing Zhang, Jiping Chen, Xingya Xue and Xinmiao Liang. Prediction of octanol-air partition coefficients of semivolatile organic compounds based on molecular connectivity index. Chemosphere, 2005, 59(10): 1421-1426.
61. Jingwen Chen, Tom Harner, K.-W.Schramm, Qie Quan, Xingya Xue, Antonius Kettrup Quantitative relationships between molecular structures,environmental temperatures and octanol-air partition coefficients of polychlorinated biphenyls, Computational Biology and Chemistry, 2003, 27: 405-421.
62. Jingwen Chen, Xingya Xue, Karl-Werner Schramm, Xie Quan, Fenglin Yang, Antonius Kettrup Quantitative structure-property relationships for octanol-air partition coefficients of polychlorinated naphthalenes,chlorobenzenes and p,p'-DDT, Computational Biology and Chemistry, 2003, 27: 165-171.
63. Xingya Xue, Qing Zhang, Xinmiao Liang, K. Oxynos, A. Kettrup, Peizhang Lu, Computer-assisted automatic peak recognition and result evaluation for analysis of chlorinated hydrocarbons in environmental samples, Journal of Chromatography A, 2002, 957: 37-44.
64. Jingwen Chen, Tom Harner, K.-W.Schramm, Xie Quan, Xingya Xue, Wenzhong Wu, Antonius Kettrup, Quantitative relationships between molecular structures,environmental temperatures and octanol-air partition coefficients of PCDD/Fs, The Science of the Total Environment, 2002, 300: 155-166.
65. Jingwen Chen, Xingya Xue, Karl-Werner Schramm, Xie Quan, Fenglin Yang, Antonius Kettrup, Quantitative structure–property relationships for octanol-air partition coefficients of polychlorinated biphenyls, Chemosphere, 2002, 48: 535-544.
66. 李存满, 梁鑫淼, 薛兴亚*, 张秀莉, 章飞芳, 白花蛇舌草超高效液相色谱特征图谱研究Ⅰ——非强极性组分特征谱研究, 药物分析杂志, 2010, 30(2): 253-258.
67. 李存满, 薛兴亚*, 章飞芳, 张秀莉, 梁鑫淼, 白花蛇舌草超高效液相色谱特征图谱研究Ⅱ——强极性组分特征图谱研究, 药物分析杂志, 2010, 30(2): 259-262.
68. 张慧, 王世盛, 李伟, 王亚琴, 薛兴亚, 梁鑫淼*, 乌拉尔甘草中的一个新三萜皂苷成分, 世界科学技术—中医药现代化, 2009, 11(2): 253-256.
69. 代云桃, 金高娃, 秦雪梅, 薛兴亚, 章飞芳, 梁鑫淼, 五味子提取物高效液相色谱分析方法的优化, 色谱, 2009, 27(4): 442-446.
70. 王艳萍, 薛兴亚, 张秀莉, 金郁, 章飞芳, 梁鑫淼, HPLC/ESI-MS法鉴定半枝莲乙酸乙酯组分中黄酮苷元类化合物, 质谱学报, 2009, 30(3): 129-138.
71. 王艳萍, 丰加涛, 金郁, 刘艳芳, 肖远胜, 章飞芳, 薛兴亚, 张秀莉, 梁鑫淼, 中药物质基础研究的思路与方法, 中国天然药物, 2009, 7(1): 13-18.
72. 张峰, 郭志谋, 章飞芳, 薛兴亚, 梁鑫淼, 串联固相萃取法选择性富集白花蛇舌草中的环烯醚萜苷类成分, 色谱, 2009, 27(4): 436-441.
73. 金郁, 薛兴亚, 肖远胜, 章飞芳, 石慧, 梁鑫淼, 中药复杂样品高效液相色谱和超高效液相色谱分析条件转换方法, 世界科学技术-中医药现代化, 2008, 10(1): 80-84.
74. 王联芝, 章飞芳, 薛兴亚, 徐青, 梁鑫淼, 土壤中阴离子表面活性剂对17β-雌二醇吸附脱附的影响, 精细化工, 2008, 25(7): 691-695.
75. 李存满, 徐青, 薛兴亚, 章飞芳, 梁鑫淼. 白花蛇舌草中环烯醚萜苷类化合物的稳定性研究, 世界科学技术一中医药现代化, 2007, 9(4): 51-55.
76. 石慧, 金郁, 肖远胜, 薛兴亚, 梁鑫淼. 大孔树脂联用分离大黄水提组分. 世界科学技术—中医药现代化. 2007, 9(5): 60-67.
77. 聂波, 刘勇, 徐青, 薛兴亚, 梁鑫淼,肖培根, 地笋中挥发油化学成分的气相色谱-质谱分析, 精细化工, 2007, 24(7): 653-656.
78. 周大勇, 徐青, 薛兴亚, 章飞芳, 梁鑫淼, 高效液相色谱-电喷雾质谱法测定枳壳中黄酮苷类化合物[J]. 分析化学, 2006, 34(特): S31-S35.
79. 刘艳明, 徐青, 薛兴亚, 章飞芳, 梁鑫淼, 中药皂角刺的化学组成及液相色谱研究[J]. 精细化工, 2006, 23(10)967-976.
80. 金高娃, 章飞芳, 薛兴亚, 肖远胜, 徐青, 梁鑫淼, 超高效液相色谱在复杂体系中药分离分析中的应用[J]. 世界科学技术-中医药现代化, 2006, 8(3): 106-111.
81. 金郁, 章飞芳, 肖远胜, 薛兴亚, 徐青, 梁鑫淼, 中药标准组分的高效液相色谱/质谱联用(HPLC/MS)表征[J]. 世界科学技术-中医药现代化, 2006, 8(3): 99-105.
82. 丰加涛, 徐青, 薛兴亚, 章飞芳, 肖远胜, 梁鑫淼, 中药标准组分制备与组分库的构建[J]. 世界科学技术-中医药现代化, 2006, 8(3): 95-98, 111.
83. 薛兴亚, 徐青, 章飞芳, 梁鑫淼, 中药信息数据系统构建[J]. 世界科学技术-中医药现代化, 2006, 8(3): 91-94.
84. 章飞芳, 张峰, 薛兴亚, 徐青, 金郁, 梁鑫淼, 中药组分的系统化学表征[J]. 世界科学技术-中医药现代化, 2006, 8(3): 85-90.
85. 肖远胜, 徐青, 金郁, 薛兴亚, 章飞芳, 梁鑫淼, 中药标准组分系统分离制备研究[J]. 世界科学技术-中医药现代化, 2006, 8(3): 79-84.
86. 徐青, 王金成, 郭志谋, 章飞芳, 薛兴亚, 梁鑫淼, 中药组分选择性分离材料研究[J]. 世界科学技术-中医药现代化, 2006, 8(3): 74-78.
87. 任洁, 薛兴亚, 章飞芳, 徐青, 梁鑫淼, 气相色谱-质谱联用分析青风藤挥发油中化学成分[J]. 世界科学技术-中医药现代化, 2006, 8(3): 21-26, 121.
88. 梁鑫淼, 徐青, 薛兴亚, 章飞芳, 肖远胜, . 组分中药系统研究[J]. 世界科学技术-中医药现代化, 2006, 8(3): 1-7.
89. 金高娃, 章飞芳, 薛兴亚, 徐青, 梁鑫淼, 气相色谱-质谱法分析山楂中的脂肪酸[J]. 精细化工, 2006, 23(8): 760-761, 770.
90. 赵洪霞, 马立新, 徐青, 薛兴亚, 章飞芳, 梁鑫淼, 气相色谱法测定多溴联苯的蒸气压[J]. 色谱, 2006, 24(4): 385-388.
91. 张岩, 薛兴亚, 徐青, 章飞芳, 梁鑫淼, 葛根提取物高效液相色谱分析方法的优化[J]. 色谱, 2006, 24(4): 354-358.
92. 王金成, 徐青, 薛兴亚, 章飞芳, 梁鑫淼, 苯基脲类除草剂分子印迹聚合物的合成和识别性能研究[J]. 高等学校化学学报, 2006, 27(7): 1227-1231.
93. 金高娃, 章飞芳, 薛兴亚, 徐青, 梁鑫淼, 反相高效液相色谱法测定山楂中的有机酸[J]. 分析化学, 2006, 34(7): 987-990.
94. 杨志军, 张青, 薛兴亚, 陈吉平, 梁鑫淼, 复杂环境样品中未知组分峰的跟踪识别方法[J]. 环境化学, 2006, 25(2): 225-227.
95. 张岩, 徐青, 薛兴亚, 章飞芳, 梁鑫淼, 葛根组分库的构建[J]. 世界科学技术-中医药现代化, 2005, 7(6): 62-66.
96. 薛兴亚, 于万滢, 陈吉平, 黄威东, 梁鑫淼, 气相色谱保留参数用于刺五加果挥发油中萜烯及萜烯氧化物的分类, 色谱, 2005, 23(4): 422-425.
97. 任玲玲, 薛兴亚, 徐青, 梁鑫淼, 黄连解毒汤高效液相色谱分析方法的建立, 世界科学技术-中医药现代化, 2005, 7(5): 41-44.
98. 张子忠, 梁鑫淼, 卢佩章, 张青, 薛兴亚, 当归特征组分的识别与定量对比, 色谱, 2001, 19(2): 157-160.
99. 李海燕, 梁鑫淼, 肖红斌, 薛兴亚, 钟虹敏, 曲线拟合定量法在高效液相色谱手性分离中的应用, 色谱, 2000, 18(4): 283-286.
100. 李海燕, 梁鑫淼, 薛兴亚, 钟虹敏, 用离子对色谱分离氨基酸衍生物的对映体, 色谱, 1999, 27(5): 523-527.
101. 徐青, 梁鑫淼, 张青, 薛兴亚, 周永正, 反相高效液相色谱与紫外光谱对硝基苯类化合物的联合定性, 分析测试学报, 1998, 17(5): 36-39.
发表著作
1. 梁鑫淼,张秀莉,郭志谋,丰加涛,薛兴亚,金郁,柯燕雄,叶金星,章飞芳,本草物质组,科学前沿与未来,北京:科学出版社,ISBN 978-7-03-023972-3, 2009: 92-100.
2. 梁鑫淼, 徐青, 薛兴亚, 中药复杂成分分离、分析的技术与方法学探索(第三章第八节), 中药现代研究的思路与方法, 北京:化学工业出版社,ISBN 7-5025-8922-8, 2006: 257-267.

科研活动

   
科研项目
1. 科技重大专项“重大新药创制”课题“中药标准物质研制和开发的技术平台建设”子课题2“基准物的制备”(2009ZX09308-001-2),2008.10-2010.10,子课题负责人。
2. 科技重大专项“重大新药创制”课题“络病理论指导药物开发集成创新技术平台建设” 子课题2“中药质量控制及标准制作技术平台”(2009ZX09313-003-2),2008.10-2010.10,子课题负责人。
3. 国家自然科学基金面上项目“针对生物活性肽分离的高正交性多二维液相色谱方法研究”(20975100),2010.1-2012.12,项目负责人。
4. 大连市重大科技专项“基于定量组分的板蓝根新药开发”(2007E11SF057), 2007-2009,项目负责人。
5. 科技部国际合作项目“中药抗抑郁活性成分的高通量制备与筛选”(2007DFC30550),2007.09-2010.08,项目骨干。
6. 国家自然科学基金重点项目“中药药效组分的指纹图谱分析的方法研究”(20235020),2003.1-2006.12,项目参加者。
7. 中国科学院知识创新工程重要方向项目“基于现代理论和技术的复方中药系统研究” (KGCX2-SW-213),2004.4-2007.4,项目骨干。
参与会议
1. Xinmiao Liang, Xiuli Zhang, Xingya Xue, Jiatao Feng, Chromatographic Methodology and Technology for Developing TCM, Program of the 2nd Annual Symposium on Chemical and Pharmaceutical Structure Analysis, Shanghai, 2011, 9.
2. Xinmiao Liang, Yanfang Liu, Xingya Xue, Xiuli Zhang, Methodology for Separation and Analysis of Complex Samples, ABSTRACTS & PROGRAM of Analytica China Conference, 2010, 61.
3. Xinmiao Liang, Xiuli Zhang, Xingya Xue, Jiatao Feng, Yuansheng Xiao, Herbalome, Handbook for Shanghai International Conference on Traditional Chinese Medicine and Natural Medicines, Shanghai, 2009, 41.
4. Xinmiao Liang, Xiuli Zhang, Xingya Xue, Jiatao Feng, Yuansheng Xiao, Xiuling Li, Chromatographic Methodology and Technology for Developing Multi-Component Chinese Medicine, The 1st Sino-US Symposium on Separation Sciences, Dalian, 2009, 28.
5. Xinmiao Liang, Xingya Xue, Xiuli Zhang, Jiatao Feng, Methodology and Technology for Developing Multi-Component Chinese Medicine——Standardization and Resourcing, Forum Life Science 2009 special report, Munich, 2009, 9.
6. Jing Zeng, Zhimou Guo, Xiuli Zhang, Yuansheng Xiao, Chaoran Wang, Xinya,Xue, Xinmiao, Liang, Identification and Characterization of the low-abundant constituents of Radix isatidis by off-line 2D-LC coupled with Q-TOF MS, 24th International Symposium on Microscale Bioseparations, Dalian, 2009, 272.
7. Xinmiao Liang, Xiuli Zhang, Xingya Xue, Jiatao Feng, Chromatographic Methodology and Technology for Developing Multi-Component Chinese Medicine, Proceedings of The 13th Beijing Conference and Exhibition on Instrumental Analysis, Beijing, 2009.
8. Dong Jun, Zhang Xiuli,Cai Xiaoming, Zou lijuan, Xue Xingya, Liang Xinmiao, Lysophosphatidylcholines profiling of plasma: isomers discrimination and biomarkers discovery in lung cancer, 24th International Symposium on Microscale Bioseparations, Dalian, 2009, 273.
9. Xinmiao Liang, Xingya Xue, Xiuli Zhang, Jiatao Feng, Methodology and Technology for Developing Multi-Component Chinese Medicine——Standardization and Resourcing, New horizons in chinese medicines and health foods - The 4th International Functional Foods Symposium, Hongkong, 2009, 13.
10. 张秀莉,Dieter Martens, 薛兴亚, 丰加涛, 梁鑫淼, SPE-HPLC联用测定水中15中取代脲类农药,第十七届全国色谱学术报告会及仪器展览会会议论文集, 长沙, 2009, 616.
11. 章飞芳, 金高娃, 薛兴亚, 梁鑫淼, 五味子提取物二维正交分离,第十七届全国色谱学术报告会及仪器展览会会议论文集, 长沙, 2009, 730.
12. 赵艳艳, 郭志谋, 薛兴亚, 梁鑫淼, 张玉奎, 新型环糊精固定相的制备及其在反相模式下的表征,第十七届全国色谱学术报告会及仪器展览会会议论文集, 长沙, 2009, 914.
13. Gaowa Jin, Xingya Xue, Xinmiao Liang, Study on the retention equation in hydrophilic interaction liquid chromatography, Final Program and Abstracts of The 33rd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Kyoto, 2008, 261.
14. Xinmiao Liang, Yanming Liu, Zhimou Guo, Xingya Xue, Qing Xu, Excellent orthogonal two-dimensional liquid chromatography systems based on novel stationary phases, Proceedings of 2nd Sino-German workshop on separation and analysis of complex samples, Shanghai, 2008, 27-28.
15. Xinmiao Liang, Yanfang Liu, Xiuli Zhang, Xingya Xue, Qing Xu, High-throughput method for preparation and characterization of screening multi-components of TCMs, Abstracts & Program of 4th Shanghai International Symposium on Analytical Chemistry, Shanghai, 2008, 7.
16. Dong Jun, Cai Xiaoming, Zhang Xiuli, Zhao Lili, Wang Yuanyuan, Xue Xingya, Liang Xinmiao, An alternative method for blood plasma preparation prior to metabonomics study, Abstracts of 13th International Biotechnology Symposium & Exhibition, Dalian, 2008, S54.
17. Yanfang Liu, Xiuli Zhang, Xingya Xue, Xinmiao Liang, Improved concentration technique for purified preparative fractions via solid phase extraction using oasis HLB as sorbent, Abstracts of 13th International Biotechnology Symposium & Exhibition, Dalian, 2008, S83.
18. Yanming Liu, Xingya Xue, Qing Xu, Feifang Zhang, Xinmiao Liang, Development and comparison of three different methods for the analysis of traditional Chinese medicine, Abstracts of 13th International Biotechnology Symposium & Exhibition, Dalian, 2008, S89-S90.
19. Jing Zhang, Yanfang Liu, Feifang Zhang, Xingya Xue, Qing Xu, Xinmiao Liang, Investigation of alkaloids concentration using solid phase extraction, Abstracts of 13th International Biotechnology Symposium & Exhibition, Dalian, 2008, S104-S105
20. Yanyan Zhao, Yongping Zhang, Zhimou Guo, Xingya Xue, Xinmiao Liang, A new chemically bonded β-Cd silica based stationary phases for the separation of anthraquinones from Rheum palmatum L., Abstracts of 13th International Biotechnology Symposium & Exhibition, Dalian, 2008, S755.
21. 王艳萍, 丰加涛, 金郁, 刘艳芳, 肖远胜, 章飞芳, 薛兴亚, 张秀莉, 梁鑫淼, 中药物质基础研究的思路与方法, 第二届“中国天然药物研究与发展论坛”, 南京, 2008.
22. 丰加涛, 金郁, 薛兴亚, 张秀莉, 梁鑫淼, 基于药效物质基础的中药质量控制技术, 中国科学技术协会青年科学家论坛第178次会议论文集, 昆明, 2008, 124-130.
23. 郭志谋, 薛兴亚, 肖远胜, 丰加涛, 张秀莉, 梁鑫淼, 寡糖分离分析与制备, 中国科学技术协会青年科学家论坛第178次会议论文集, 昆明, 2008, 133-135.
24. 梁鑫淼, 张秀莉, 郭志谋, 丰加涛, 薛兴亚, 金郁, 柯燕雄, 叶金星, 章飞芳, “本草物质组”, 中国科学技术协会青年科学家论坛第178次会议论文集, 昆明, 2008, 1-11.
25. 张秀莉, 薛兴亚, 丰加涛, 肖远胜, 梁鑫淼, 高内涵本草物质资源库, 中国科学技术协会青年科学家论坛第178次会议论文集, 昆明, 2008, 117-118.
26. 梁鑫淼, 张秀莉, 刘艳芳, 薛兴亚, 分离分析在本草物质组中的应用, 全国生物医药色谱学术交流会, 武夷山, 2008.
27. Xinmiao Liang, Xingya Xue, Feifang Zhang, Qing Xu; Methodology and Technology for Developing Multi-Component Chinese Medicine——Standardization and Resourcing; Handbook for Sino-European Conference on Traditional Chinese Medicine (TCM) International Cooperation and Perspective in Science and Technology; Rome, 2007: 144-148 .
28. Xinmiao Liang, Xingya Xue, Feifang Zhang, Qing Xu, Methodology and Technology for Developing Multi-Component Chinese Medicine—Standardization and Resourcing; Handbook for Sino-European Conference on Traditional Chinese Medicine (TCM) - International Cooperation and Perspective in Science and Technology; Rome, 2007: 144-148.
29. Liang X M, Lei A W, Guo Z M, Xu Q, Xue X Y, Zhang F F; Novel separation materials for HPLC and applications in the separation of Traditional Chinese Medicine; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy; Dalian, 2007: 205.
30. Lingling Ren, Xingya Xue, Feifang Zhang, Qing Xu, Xinmiao Liang; Analysis of strong polar compounds in extract of Gardenia jasminoisdes fruit using hydrophilic interaction liquid chromatography with evaporative light-scattering detection; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 14-15.
31. Yanping Wang, Xingya Xue, Feifang Zhang, Qing Xu, Xinmiao Liang; Study of Flavonoid Aglycones by High Performance Liquid Chromatography; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 21-22.
32. Yan Zhang, Xiaozhe Zhang, Feifang Zhang, Xingya Xue, Qing Xu, Xinmiao Liang; Strategically searching for estrogenic compounds from Radix puerariae; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 26-27.
33. 付冬梅,彭艳蓉,刘仁华,章飞芳,薛兴亚,徐青,梁鑫淼; 三氯苯酚废水降解中的含量测定; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 5-6.
34. 金高娃,薛兴亚,章飞芳,,徐青,梁鑫淼; 气相色谱法预测脂肪酸甲酯在任意程序升温条件下的保留时间; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 7-8.
35. 金郁,石慧,肖远胜,薛兴亚,章飞芳,梁鑫淼; 复杂样品分离的液相色谱条件优化方法; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 8-9.
36. 石慧,金郁,肖远胜,薛兴亚,梁鑫淼; LC/MS方法对大黄水提组分游离蒽醌类化合物的快速鉴定; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 15-17.
37. 孙衍国,王亚琴,薛兴亚,徐青,粱鑫淼; 抱茎獐芽菜中山酮C-苷和黄酮C-苷的HPLC-ESI-MS分析; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 17-19.
38. 王亚琴,孙衍国,李伟,薛兴亚,梁鑫淼; 朝鲜淫羊藿总黄酮酸水解条件的研究; Proceedings of Dalian International Symposia and Exhibition on Chromatograhpy (Supplement); Dalian, 2007: 19-20.
39. Xinmiao Liang, Zhimou Guo, Qing Xu, Xingya Xue, Feifang Zhang; Novel Separation Material for RP-HPLC and HILIC: Design, Preparation and Application; Proceedings of the workshop of Sino-German cooperation research group for separation and analysis of complex samples; Munich, 2007: 34-35.
40. Xinmiao Liang, Xingya Xue, Feifang Zhang, Qing Xu; Systematic Separation and Analysis of Traditional Chinese Medicine; Proceedings of the 4th International Symposium of Worldwide Chinese Scholars on Analytical Chemistry; Dalian, 2006: 48.
41. Xinmiao Liang, Xingya Xue, Feifang Zhang, Qing Xu; Systematic Research on Multi-Component Chinese Medicine; Abstract Book & Program of the 3rd Shanghai International Symposium on Analytical Chemistry; Shanghai, 2006: 64.
42. 梁鑫淼,徐青,薛兴亚,章飞芳,肖远胜,张岩; 组分中药的系统研究; 中国科学技术协会青年科学家论坛第122次会议论文集; 广州,2006.
43. Xinmiao Liang, Xingya Xue; Rapid Method Development for Chromatographic Analysis of Natural Medicine; Proceedings of International Fifth Natural Medicine Conference; ShenYang, 2004.
44. Xingya Xue, Xinmiao Liang; Optimization for Chromatographic Analysis of Unknown Complex Samples; Proceedings of 7th Sino-German Symposium on Chromatography; Chongqing, 2004: 93-98.
45. 薛兴亚; 自动拟合方法与“活”色谱指纹技术; 现代分析科学与中药质量控制技术研讨会论文摘要集; 青岛,2004:2.
46. Xingya Xue, Jiping Chen, Xinmiao Liang, Qing Zhang, Dieter Martens, Antonius Kettrup, Optimization for analysis of CHCs with temperature programmed gas chromatography, Proceedings of International Tenth Beijing Conference and Exhibitton on Instrumental Analysis (ISBN 7-301-06514-0/O.0577) - Environmental Analysis; Beijing, 2003: H107-108.
47. Xinmiao Liang, Xingya Xue, Longxing Wang, Qing Xu, Qing Zhang, Jiping Chen, Advances in chromatographic methodology for the analysis of unknown complex samples, Proceedings of International Tenth Beijing Conference and Exhibition on Instrumental Analysis (ISBN 7-301-06514-0/O.0577) –Chromatography; Beijing, 2003: D149-151.

指导学生

现指导学生

龙珍  硕士研究生  070302-分析化学