2003/09-2009/07: Ph.D. in Biochemistry and Molecular Biology

Institute of Biochemistry and Cell Biology (IBCB), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS).

1999/09-2003/07: B.S. in Biology

College of Life Sciences, Nankai University.

2015/10-present: Principal Investigator

Institute of Biochemistry and Cell Biology (IBCB), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS).

2009/11-2015/09: Postdoctoral Fellow

Howard Hughes Medical Institute; Program of Cellular & Molecular Medicine at Boston Children's Hospital; Harvard Medical School.  

Book Chapter and Review:

Meng FL, Alt FW, Tian M, “The Mechanism of Class Switch Recombination” in Molecular Biology of B Cells, 2nd Edition, Honjo T, Alt FW, Reth M, Radbruch A; Elsevier, 2014

  Research Journal Articles:

1. Meng FL*, Du Z*, Federation A*, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig M, Bradner JE^#, Liu XS^#, Alt FW^# (2014) Convergent Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability Cell. 159, 1538-1548. * Co-first author ^# Co-senior author

2. Basu U*, Meng FL*, Keim C*, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. (2011) The RNA Exosome Targets Activation Induced Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates. Cell 144(3):353-63. * Co-first author

3. Ba Z*, Meng FL*, Gostissa M*, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, and Alt FW. (2015) A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 Cancer Immunology Research 2015 Jun; 3(6):641-9.  * Co-first author

4. Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW. (2015) Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature 525, 134-139.

5. Hu Ji, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW. (2015) Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes Cell 163(4):947-959

6. Yeap LS*, Hwang JK*, Du Z, Meyers RM, Meng FL, Jakubauskaite A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH and Alt FW. (2015) Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell 163(5):1124-1137

7. Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, Sun J, Wu CJ, Gostissa M, Alt FW and Chiarle R. (2017). Phosphatidylinositol 3-kinase delta blockade increases genomic instability in B cells. Nature 542, 489-493

8. Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW and Wu H. (2017) AID Recognizes Structured DNA for Class Switch Recombination. Molecular Cell 67,361-373 e364

Graduate Research: Telomere and Cellular Aging

1. Fu XH, Duan YM, Liu YT, Cai C, Meng FL, Zhou JQ. (2014) Telomere Recombination Preferentially Occurs at Short Telomeres in Telomerase-Null Type II Survivors. PLoS One. 2014 Mar 3;9(3):e90644.

2. Hu Y, Tang HB, Liu NN, Tong XJ, Dang W, Duan YM, Fu XH, Zhang Y, Peng J, Meng FL, Zhou JQ. (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators. PLoS Genet. 9(1):e1003208

3. Meng FL, Chen XF, Hu Y, Tang HB, Dang W and Zhou JQ (2010) Sua5p is required for telomere recombination in Saccharomyces cerevisiae. Cell Research 20(4),495-8

    4.    Zhou BO, Wang SS, Xu LX, Meng FL, Xuan YJ, Duan YM, Wang JY, Hu H, Dong X, Ding J, Zhou JQ (2010) SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol Cell Biol. 30(10):2391-400.

5. Meng FL, Hu Y, Shen N, Tong XJ, Wang J, Ding J and Zhou JQ (2009) Sua5p a Single-stranded Telomeric DNA Binding Protein Facilitates Telomere Replication, EMBO Journal 28, 1466-1478.

6. Chen, XF, Meng, FL, and Zhou, JQ (2009). Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. PLoS Genet 5, e1000535

7. Fu XH*, Meng FL*, Hu Y, Zhou JQ (2008) Candida albicans, a distinctive fungal model for cellular aging study. Aging Cell 7: 746-757  * Co-first author

    8.    Yang CP, Chen YB, Meng FL, Zhou JQ (2006) Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo. Nucleic Acids Res 34: 407-416. 

Invited Presentations:

2011: The RNA Exosome Targets Activation Induced Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates, New England RNA Data (NERD) Club, Harvard, Boston

1. STCSM-16ZR1441600 (PI: Meng)                   

2016/07/01-2019/06/30

Antibody ex vivo class switch with CRISPR-Cas9 tools

Role: PI (RMB 200,000)

2. National 1000 Young Talents Program of China (PI: Meng)               

2016/01/01-2018/12/31

Antibody Diversification and B cell Lymphoma

Role: PI (RMB 3,000,000)

3. National Science Fund for Excellent Young Scholars (8162200437) (PI: Meng)  2017/01/01-2019/12/31

Antibody Diversification and Related Diseases

Role: PI (Direct Cost: RMB 1,300,000)

4. NSFC Grant (31670929) (PI: Meng)                              

2017/01/01-2020/12/31

Unique Role of 53BP1 during Antibody Diversification in B Lymphocytes

Role: PI (Direct Cost: RMB 700,000)

5. Strategic Priority Research Program of the Chinese Academy of Sciences-XDB19000000

2016/07/01-2020/06/30

3.2.1 T and B Cell Receptor Diversification

Role: Investigator (Direct Cost: RMB 425,000 per year)

6. MOST- National Key R&D Program of China (2017YFA0506700) (PI: Meng)    

2017/07/01-2021/12/31

Maintenance of Genomic Integrity during Immune Diversification

Role: PI (RMB 4,820,000 in total; 2,210,000 for the Meng lab)

Xiaojing Liu,             Postdoctoral Fellow,    2016-now

 Dingpeng Yang,             Graduate Student,               2015-now

Xia Xie,                      Graduate Student,               2015-now

Pengfei Dai,              Graduate Student,               2016-now

Liu Liu,                Graduate Student,               2016-now

Yafang Shang,         Graduate Student,               2017-now

Min Huang,               Graduate Student,               2017-now

2016:          National Science Fund for Excellent Young Scholars

2016:          National 1000 Young Talents Program of China

2015:          Harvard Chinese Life Science Research Award

2014-15:     Lymphoma Research Foundation Postdoctoral Fellowship

2011-13:     Cancer Research Institute Research Fellowship

2009:           The President Award of Chinese Academy of Sciences

2008:              Travel Grant of International Union of Biochemistry and   Molecular Biology (IUBMB) Fellowship

2002:           Chinese Academy of Sciences Scholarship

2001:          Diagnostic Products Corporation (DPC) Scholarship

2000-02:     Scholarships for Academic Excellence, Nankai University