100706-药理学

神经精神药理学
离子通道药理学
细胞器离子通道

2009-09--2014-07   中国科学院上海药物研究所   博士学位
2005-09--2009-06   湖北大学   学士学位

   

2021-01~现在, 中国科学院上海药物研究所, 研究员
2015-10~2020-09,美国密西根大学, 博士后
2014-07~2015-06,中国科学院深圳先进技术研究院, 博士后

   

（1） Gordon Research Seminar Travel Award, 其他, 2019
（2） 中国科学院“朱李月华”优秀毕业生, 院级, 2014
（3） 博士研究生国家奖学金, 国家级, 2013
（4） 上海市浦东新区第七届优秀科技论文一等奖, 一等奖, 专项, 2013
（5） 中国科学院大学“三好学生”, 院级, 2013

（ 1 ） 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用。, 发明, 2014, 第 5 作者, 专利号: 201210377079.0

   

[1] 李平. Functional characterization and in vitro pharmacological rescue of KCNQ2 pore mutations associated with epileptic encephalopathy. 中国药理学报[J]. 2023, [2] 李平. Characterization of the role of TMEM175 in an in vitro lysosomal H+ fluxes model. FEBS J[J]. 2023, [3] Li, Ping, Hu, Meiqin, Wang, Ce, Feng, Xinghua, Zhao, ZhuangZhuang, Yang, Ying, Sahoo, Nirakar, Gu, Mingxue, Yang, Yexin, Xiao, Shiyu, Sah, Rajan, Cover, Timothy L, Chou, Janet, Geha, Raif, Benavides, Fernando, Hume, Richard I, Xu, Haoxing. LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(46): 29155-29165, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682592/.
[4] Zhang, Xiaoli, Chen, Wei, Li, Ping, Calvo, Raul, Southall, Noel, Hu, Xin, BryantGenevier, Melanie, Feng, Xinghua, Geng, Qi, Gao, Chenlang, Yang, Meimei, Tang, Kaiyuan, Ferrer, Marc, Marugan, Juan Jose, Xu, Haoxing. Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels. ELIFE[J]. 2019, 8: https://doaj.org/article/fcccf21ebaa14918a7f692c9773d3322.
[5] Li, Ping, Gu, Mingxue, Xu, Haoxing. Lysosomal Ion Channels as Decoders of Cellular Signals. TRENDS IN BIOCHEMICAL SCIENCESnull. 2019, 44(2): 110-124, http://dx.doi.org/10.1016/j.tibs.2018.10.006.
[6] Bai, Fang, Pi, Xiaoping, Li, Ping, Zhou, Pingzheng, Yang, Huaiyu, Wang, Xicheng, Li, Min, Gao, Zhaobing, Jiang, Hualiang. A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel. FRONTIERS IN PHARMACOLOGY[J]. 2018, 9: https://doaj.org/article/c7346be566b94751a8dafbb424f95ffd.
[7] Wang, Wuyang, Zhang, Xiaoli, Gao, Qiong, Lawas, Maria, Yu, Lu, Cheng, Xiping, Gu, Mingxue, Sahoo, Nirakar, Li, Xinran, Li, Ping, Ireland, Stephen, Meredith, Andrea, Xu, Haoxing. A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores. JOURNAL OF CELL BIOLOGY[J]. 2017, 216(6): 1715-1730, https://www.webofscience.com/wos/woscc/full-record/WOS:000402702500022.
[8] Li Ping. Biomodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage dependent inactivation.. PFLUGERSARCH. 2014, [9] Wan, Xia, Lu, Yungang, Chen, Xueqin, Xiong, Jian, Zhou, Yuanda, Li, Ping, Xia, Bingqing, Li, Min, Zhu, Michael X, Gao, Zhaobing. Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY[J]. 2014, 466(7): 1273-1287, https://www.webofscience.com/wos/woscc/full-record/WOS:000338224700004.
[10] Li, Ping, Chen, Xueqin, Zhang, Qiansen, Zheng, Yueming, Jiang, Hualiang, Yang, Huaiyu, Gao, Zhaobing. The Human Ether-A-Go-Go-Related Gene Activator NS1643 Enhances Epilepsy-Associated KCNQ Channels. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS[J]. 2014, 351(3): 596-604, https://www.webofscience.com/wos/woscc/full-record/WOS:000345219800013.
[11] Li, Ping, Chen, Zhuxi, Yang, Huaiyu, Gao, Zhaobing, Jiang, Hualiang, Li, Min. An Activator Binding Site in the Gating Charge Pathway of KCNQ2 Channel. BIOPHYSICAL JOURNALnull. 2014, 106(2): 143A-143A, https://www.webofscience.com/wos/woscc/full-record/WOS:000337000400709.
[12] Li, Ping, Zhu, Jin, Kong, Qingya, Jiang, Baifeng, Wan, Xia, Yue, Jinfeng, Li, Min, Jiang, Hualiang, Li, Jian, Gao, Zhaobing. The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel. TOXICOLOGY LETTERS[J]. 2013, 219(3): 211-217, http://dx.doi.org/10.1016/j.toxlet.2013.03.020.
[13] Yao, Xingang, Chen, Fanglei, Li, Ping, Quan, Lingling, Chen, Jing, Yu, Liang, Ding, Hong, Li, Chenjing, Chen, Lili, Gao, Zhaobing, Wan, Ping, Hu, Lihong, Jiang, Hualiang, Shen, Xu. Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2013, 150(1): 285-297, https://www.webofscience.com/wos/woscc/full-record/WOS:000326998400032.
[14] Li, Ping, Chen, Zhuxi, Xu, Haiyan, Sun, Haifeng, Li, Hao, Liu, Hong, Yang, Huaiyu, Gao, Zhaobing, Jiang, Hualiang, Li, Min. The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. CELL RESEARCH[J]. 2013, 23(9): 1106-1118, https://www.webofscience.com/wos/woscc/full-record/WOS:000323930200009.
[15] Liu, HongBing, Zhang, Hua, Li, Ping, Wu, Yan, Gao, ZhaoBing, Yue, JianMin. Kv1.2 potassium channel inhibitors from Chukrasia tabularis. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2012, 10(7): 1448-1458, https://www.webofscience.com/wos/woscc/full-record/WOS:000299476800018.
[16] Ping LI, Hai-feng SUN, Ping-zheng ZHOU, Chao-ying MA, Guo-yuan HU, Hua-liang JIANG, Min LI, Hong LIU, Zhao-bing GAO. Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels. 中国药理学报：英文版[J]. 2012, 33(6): 728-736, http://lib.cqvip.com/Qikan/Article/Detail?id=42328315.
[17] Li Ping. The inhibitory effects of DC031050,a class III antiarrhythmic agent with high selectivity for hERG channels, on three neuronal potassium channels.. Acta Pharmacologica Sinica. 2012, [18] Liu, HongBing, Zhang, Hue, Li, Ping, Gao, ZhaoBing, Yue, JianMin. Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia tabularis. ORGANIC LETTERS[J]. 2012, 14(17): 4438-4441, https://www.webofscience.com/wos/woscc/full-record/WOS:000308390000036.
[19] Yang, Huaiyu, Gao, Zhaobing, Li, Ping, Yu, Kunqian, Yu, Ye, Xu, TianLe, Li, Min, Jiang, Hualiang. A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2 Potassium Channel. BIOPHYSICAL JOURNAL[J]. 2012, 102(8): 1815-1825, https://www.webofscience.com/wos/woscc/full-record/WOS:000303003300015.
[20] Li, Ping, Sun, Haifeng, Zhou, Pingzheng, Ma, Chaoying, Hu, Guoyuan, Jiang, Hualiang, Li, Min, Liu, Hong, Gao, Zhaobing. Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels. ACTA PHARMACOLOGICA SINICA[J]. 2012, 33(6): 728-736, http://lib.cqvip.com/Qikan/Article/Detail?id=42328315.
[21] 李平. 电压门控钾离子通道电压感受区成药性研究. 

   

（ 1 ） 细胞器新型离子通道的鉴定及其小分子调节剂的发现, 主持, 市地级, 2021-01--2026-01

（1）Lysosomes Are Osmo-Sensitive Organelles that Regulate the Volume of the Cytosol   2019-08-03