100701-药物化学
0703Z1-化学生物学

疾病靶向诊治的探针与药物分子开发

2015-09--2020-06   华东理工大学   工学博士
2011-09--2015-06   山东理工大学   工学学士

   

2020-07~2022-06,华东理工大学, 博士后

2022-04-01-今,《Frontier in Chemistry》, 评审编辑

   

（ 1 ） 二噻吩乙烯类化合物及其制备方法和用途, 发明专利, 2019, 第 3 作者, 专利号: CN110105413A

   

[1] Han, HaiHao, Wang, HanMin, Jangili, Paramesh, Li, Mingle, Wu, Luling, Zang, Yi, Sedgwick, Adam C, Li, Jia, He, XiaoPeng, James, Tony D, Kim, Jong Seung. The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy. CHEMICAL SOCIETY REVIEWSnull. 2023, 52(3): 879-920, [2] Xu, FangZhou, Zhu, Ling, Han, HaiHao, Zou, JianWei, Zang, Yi, Li, Jia, James, Tony D, He, XiaoPeng, Wang, ChengYun. Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy. CHEMICAL SCIENCE[J]. 2022, 13(32): 9373-9380, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000835919800001.
[3] HaiNa Xie, YuYuan Chen, GuoBiao Zhu, HaiHao Han, XiLe Hu, ZhiQiang Pan, Zang, Yi, DongHao Xie, XiaoPeng He, Li, Jia, James, Tony D. Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial. CHEMICAL COMMUNICATIONS[J]. 2022, 58(32): 5029-5032, http://dx.doi.org/10.1039/d1cc06809a.
[4] Dou, WeiTao, Han, HaiHao, Sedgwick, Adam C, Zhu, GuoBiao, Zang, Yi, Yang, XinRong, Yoon, Juyoung, James, Tony D, Li, Jia, He, XiaoPeng. Fluorescent probes for the detection of disease-associated biomarkers. SCIENCE BULLETINnull. 2022, 67(8): 853-878, https://www.sciengine.com/doi/10.1016/j.scib.2022.01.014.
[5] Wu, Luling, Liu, Jihong, Tian, Xue, Groleau, Robin R, Feng, Beidou, Yang, Yonggang, Sedgwick, Adam C, Han, HaiHao, Wang, Yang, Wang, HanMin, Huang, Fang, Bull, Steven D, Zhang, Hua, Huang, Chusen, Zang, Yi, Li, Jia, He, XiaoPeng, Li, Ping, Tang, Bo, James, Tony D, Sessler, Jonathan L. Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5 '-triphosphate in Cellular Applications. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(1): 174-183, http://dx.doi.org/10.1021/jacs.1c07954.
[6] Sun, YiHang, Han, HaiHao, Huang, JiaMin, Li, Jia, Zang, Yi, Wang, ChengYun. A long-wavelength fluorescent probe with a large Stokes shift for lysosome-targeted imaging of Cys and GSH. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY[J]. 2021, 261: http://dx.doi.org/10.1016/j.saa.2021.120055.
[7] Tian, He, Jr, Sedgwick, Adam C, Han, HaiHao, Sen, Sajal, Chen, GuoRong, Zang, Yi, Sessler, Jonathan L, James, Tony D, Li, Jia, He, XiaoPeng. Fluorescent probes for the imaging of lipid droplets in live cells. COORDINATION CHEMISTRY REVIEWSnull. 2021, 427: http://dx.doi.org/10.1016/j.ccr.2020.213577.
[8] Steinbrueck, Axel, Sedgwick, Adam C, Han, HaiHao, Zhao, Michael Y, Sen, Sajal, Huang, DanYing, Zang, Yi, Li, Jia, He, XiaoPeng, Sessler, Jonathan L. In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics. CHEMICAL COMMUNICATIONS[J]. 2021, 57(46): 5678-5681, http://dx.doi.org/10.1039/d0cc08156f.
[9] Dong, Lei, Zhang, MinYu, Han, HaiHao, Zang, Yi, Chen, GuoRong, Li, Jia, He, XiaoPeng, Vidal, Sebastien. A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters. CHEMICAL SCIENCE[J]. 2021, 13(1): 247-256, http://dx.doi.org/10.1039/d1sc05057e.
[10] Sedgwick, Adam C, Yan, KaiCheng, Mangel, Daniel N, Shang, Ying, Steinbrueck, Axel, Han, HaiHao, Brewster, James T, II, Hu, XiLe, Snelson, Dylan W, Lynch, Vincent M, Tian, He, He, XiaoPeng, Sessler, Jonathan L. Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(3): 1278-1283, http://dx.doi.org/10.1021/jacs.0c11641.
[11] Zhao, Dan, Han, HaiHao, Zhu, Ling, Xu, FangZhou, Ma, XingYu, Li, Jia, James, Tony D, Zang, Yi, He, XiaoPeng, Wang, Chengyun. Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells. ACS APPLIED BIO MATERIALS[J]. 2021, 4(9): 7016-7024, [12] Han, HaiHao, Tian, He, Jr, Zang, Yi, Sedgwick, Adam C, Li, Jia, Sessler, Jonathan L, He, XiaoPeng, James, Tony D. Small-molecule fluorescence-based probes for interrogating major organ diseases. CHEMICAL SOCIETY REVIEWSnull. 2021, 50(17): 9391-9429, http://dx.doi.org/10.1039/d0cs01183e.
[13] Han, HaiHao, Sedgwick, Adam C, Shang, Ying, Li, Na, Liu, Tingting, Li, BoHan, Yu, Kunqian, Zang, Yi, Brewster, James T, II, Odyniec, Maria L, Weber, Maria, Bull, Steven D, Li, Jia, Sessler, Jonathan L, James, Tony D, He, XiaoPeng, Tian, He. Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes. CHEMICAL SCIENCE[J]. 2020, 11(4): 1107-1113, http://dx.doi.org/10.1039/c9sc03961a.
[14] Weber, Maria, Han, HaiHao, Li, BoHan, Odyniec, Maria L, Jarman, Charlotte E F, Zang, Yi, Bull, Steven D, Mackenzie, Amanda B, Sedgwick, Adam C, Li, Jia, He, XiaoPeng, James, Tony D. Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications. CHEMICAL SCIENCE[J]. 2020, 11(32): 8567-8571, http://dx.doi.org/10.1039/d0sc02438d.
[15] Dong, Lei, Fu, Mengqi, Liu, Lifang, Han, HaiHao, Zang, Yi, Chen, GuoRong, Li, Jia, He, XiaoPeng, Vidal, Sebastien. Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2020, 26(63): 14445-14452, http://dx.doi.org/10.1002/chem.202002772.
[16] Chai, Xianzhi, Han, HaiHao, Sedgwick, Adam C, Li, Na, Zang, Yi, James, Tony D, Zhang, Junji, Hu, XiLe, Yu, Yang, Li, Yao, Wang, Yan, Li, Jia, He, XiaoPeng, Tian, He. Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(42): 18005-18013, http://dx.doi.org/10.1021/jacs.0c05379.
[17] Jia, Zhiyuan, Han, HaiHao, Sedgwick, Adam C, Williams, George T, Gwynne, Lauren, Brewster, James T, II, Bull, Steven D, Jenkins, A Toby A, He, XiaoPeng, Schoenherr, Holger, Sessler, Jonathan L, James, Tony D. Protein Encapsulation: A Nanocarrier Approach to the Fluorescence Imaging of an Enzyme-Based Biomarker. FRONTIERS IN CHEMISTRY[J]. 2020, 8: https://doaj.org/article/a1278cfa6415454d85fd337a0bb33517.
[18] Zhang, Chao, Wang, Guanzhen, Han, HaiHao, Hu, XiLe, Field, Robert A, Chen, GuoRong, Li, Jia, Ye, Bing, He, XiaoPeng, Zang, Yi. Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging. FRONTIERS IN CHEMISTRY[J]. 2019, 7: https://doaj.org/article/02970d9a6bfc4f83accb15e767b53c96.
[19] Wu, Luling, Liu, Liyuan, Han, HaiHao, Tian, Xue, Odyniec, Maria L, Feng, Lei, Sedgwick, Adam C, He, XiaoPeng, Bull, Steven D, James, Tony D. ESIPT-based fluorescence probe for the ratiometric detection of superoxide. NEW JOURNAL OF CHEMISTRY[J]. 2019, 43(7): 2875-2877, http://dx.doi.org/10.1039/c8nj05656k.
[20] Chai, Xianzhi, Han, HaiHao, Zang, Yi, Li, Jia, He, XiaoPeng, Zhang, Junji, Tian, He. Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 15(1): 2380-2389, https://doaj.org/article/3cb29750876940ccb256c05fb6b412db.
[21] Odyniec, Maria L, Han, HaiHao, Garidner, Jordan E, Sedgwick, Adam C, He, XiaoPeng, Bull, Steven D, James, Tony D. Peroxynitrite Activated Drug Conjugate Systems Based on a Coumarin Scaffold Toward the Application of Theranostics. FRONTIERS IN CHEMISTRY[J]. 2019, 7: https://doaj.org/article/a5d648c848b74e0b8ecb11b11e6647cc.
[22] Han, HaiHao, Qiu, YuJiao, Shi, YuanYuan, Wen, Wen, He, XiaoPeng, Dong, LiWei, Tan, YeXiong, Long, YiTao, Tian, He, Wang, HongYang. Glypican-3-targeted precision diagnosis of hepatocellular carcinoma on clinical sections with a supramolecular 2D imaging probe. THERANOSTICS[J]. 2018, 8(12): 3268-3274, https://www.webofscience.com/wos/woscc/full-record/WOS:000432355000008.
[23] Sedgwick, Adam C, Han, HaiHao, Gardiner, Jordan E, Bull, Steven D, He, XiaoPeng, James, Tony D. The development of a novel AND logic based fluorescence probe for the detection of peroxynitrite and GSH. CHEMICAL SCIENCE[J]. 2018, 9(15): 3672-3676, http://dx.doi.org/10.1039/c8sc00733k.
[24] Fu, Youxin, Han, HaiHao, Zhang, Junji, He, XiaoPeng, Feringa, Ben L, Tian, He. Photocontrolled Fluorescence "Double-Check" Bioimaging Enabled by a Glycoprobe-Protein Hybrid. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(28): 8671-8674, https://www.webofscience.com/wos/woscc/full-record/WOS:000439532000012.
[25] Junji Zhang, Youxin Fu, HaiHao Han, Yi Zang, Jia Li, XiaoPeng He, Ben L Feringa, He Tian. Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/38b9e4ddd134408fb171407a6ead5705.
[26] Wang, ChangZheng, Han, HaiHao, Tang, XinYing, Zhou, DongMing, Wu, Changfeng, Chen, GuoRong, He, XiaoPeng, Tian, He. Sialylglycan-Assembled Supra-Dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(30): 25164-25170, https://www.webofscience.com/wos/woscc/full-record/WOS:000407089300012.
[27] Sedgwick, Adam C, Han, HaiHao, Gardiner, Jordan E, Bull, Steven D, He, XiaoPeng, James, Tony D. Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite. CHEMICAL COMMUNICATIONS[J]. 2017, 53(95): 12822-12825, http://dx.doi.org/10.1039/c7cc07845e.
[28] Han, HaiHao, Wang, ChangZheng, Zang, Yi, Li, Jia, James, Tony D, He, XiaoPeng. Supramolecular core-glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy. CHEMICAL COMMUNICATIONS[J]. 2017, 53(70): 9793-9796, https://www.webofscience.com/wos/woscc/full-record/WOS:000409381800027.

   

（ 1 ） 肝星状细胞活化中脂质代谢过程的原位与动态荧光可视化研究, 负责人, 国家任务, 2022-01--2024-12