071009-细胞生物学
071011-生物物理学
071010-生物化学与分子生物学

细胞信号转导
生物体系物理化学

2012-08--2017-12   新加坡国立大学   博士
2009-08--2012-06   东南大学   硕士
2005-08--2009-06   东南大学   本科

   

2022-02~现在, 中国科学院上海有机化学研究所, 研究员
2019-09~2022-01,复旦大学, 青年研究员
2018-02~2019-09,加州大学伯克利分校, 博士后
2018-01~2018-02,新加坡国立大学, 访问学者

   

（ 1 ） 一种对肿瘤细胞同时进行磁感应加热、成像及测温的方法, 发明专利, 2009, 第 6 作者, 专利号: CN101601607

   

[1] Dongmyung Oh, Zhongwen Chen, Kabir H Biswas, Funing Bai, Hui Ting Ong, Michael P Sheetz, Jay T Groves. Competition for shared downstream signaling molecules establishes indirect negative feedback between EGFR and EphA2. BIOPHYSICAL JOURNAL[J]. 2022, 121(10): 1897-1908, [2] Zhongwen Chen, Kabir H Biswas, And Jay T Groves. Patterned Substrate of Mobile and Immobile Ligands to Probe EphA2 Receptor Clustering. BIO-PROTOCOL. 2022, 12(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243512/.
[3] Wong, Joyce J, Chen, Zhongwen, Chung, Jean K, Groves, Jay T, Jardetzky, Theodore S. EphrinB2 clustering by Nipah virus G is required to activate and trap F intermediates at supported lipid bilayer-cell interfaces. SCIENCE ADVANCES[J]. 2021, 7(5): http://dx.doi.org/10.1126/sciadv.abe1235.
[4] Chen, Zhongwen, Cao, Yuhong, Lin, ChunWei, Alvarez, Steven, Oh, Dongmyung, Yang, Peidong, Groves, Jay T. Nanopore-mediated protein delivery enabling three-color single-molecule tracking in living cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 118(5): [5] Zhongwen Chen, Dongmyung Oh, Kabir Hassan Biswas, Ronen ZaidelBar, Jay T Groves. Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility. ELIFE[J]. 2021, 10: http://dx.doi.org/10.7554/eLife.67379.
[6] Ravasio, Andrea, Myaing, Myint Z, Chia, Shumei, Arora, Aditya, Sathe, Aneesh, Cao, Elaine Yiqun, Bertocchi, Cristina, Sharma, Ankur, Arasi, Bakya, Chung, Vin Yee, Green, Adrianne C, Tan, Tuan Zea, Chen, Zhongwen, Ong, Hui Ting, Iyer, N Gopalakrishna, Huang, Ruby YunJu, DasGupta, Ramanuj, Groves, Jay T, Viasnoff, Virgile. Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1): http://dx.doi.org/10.1038/s42003-020-01136-4.
[7] N O Alieva, A K Efremov, S Hu, D Oh, Zhongwen Chen, M Natarajan, H T Ong, A Jgou, G RometLemonne, J T Groves, M P Sheetz, J Yan, A D Bershadsky. Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-14, http://dx.doi.org/10.1038/s41467-019-10964-w.
[8] Biswas, Kabir H, Chen Zhongwen, Dubey, Alok Kumar, Oh, Dongmyung, Groves, Jay T. Multicomponent Supported Membrane Microarray for Monitoring Spatially Resolved Cellular Signaling Reactions. ADVANCED BIOSYSTEMS[J]. 2018, 2(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000446969400007.
[9] Chen, Zhongwen, Oh, Dongmyung, Dubey, Alok Kumar, Yao, Mingxi, Yang, Beverly, Groves, Jay T, Sheetz, Michael. EGFR family and Src family kinase interactions: mechanics matters?. CURRENT OPINION IN CELL BIOLOGY[J]. 2018, 51: 97-102, http://dx.doi.org/10.1016/j.ceb.2017.12.003.
[10] Chen, Zhongwen, Oh, Dongmyung, Biswas, Kabir H, Yu, ChengHan, ZaidelBar, Ronen, Groves, Jay T. Spatially modulated ephrinA1: EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(25): E5696-E5705, https://www.webofscience.com/wos/woscc/full-record/WOS:000435585200011.
[11] Song, Lina, Huang, Chao, Zhang, Wei, Ma, Ming, Chen, Zhongwen, Gu, Ning, Zhang, Yu. Graphene oxide-based Fe2O3 hybrid enzyme mimetic with enhanced peroxidase and catalase-like activities. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2016, 506: 747-755, http://dx.doi.org/10.1016/j.colsurfa.2016.07.037.
[12] Yang, Fang, Li, Mingxi, Cui, Huating, Wang, Tuantuan, Chen, Zhongwen, Song, Lina, Gu, Zhuxiao, Zhang, Yu, Gu, Ning. Altering the response of intracellular reactive oxygen to magnetic nanoparticles using ultrasound and microbubbles. SCIENCE CHINA-MATERIALS[J]. 2015, 58(6): 467-480, https://www.webofscience.com/wos/woscc/full-record/WOS:000364479200006.
[13] Yu, Chenghan, Rafiq, Nisha Bte Mohd, Cao, Fakun, Zhou, Yuhuan, Krishnasamy, Anitha, Biswas, Kabir Hassan, Ravasio, Andrea, Chen, Zhongwen, Wang, YuHsiu, Kawauchi, Keiko, Jones, Gareth E, Sheetz, Michael P. Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force. NATURE COMMUNICATIONS[J]. 2015, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000364936800001.
[14] Liu, Peidang, Huang, Zhihai, Chen, Zhongwen, Xu, Ruizhi, Wu, Hao, Zang, Fengchao, Wang, Cailian, Gu, Ning. Silver nanoparticles: a novel radiation sensitizer for glioma?. NANOSCALE[J]. 2013, 5(23): 11829-11836, https://www.webofscience.com/wos/woscc/full-record/WOS:000326982000060.
[15] Li Yan, Chen ZhongWen, Gu Ning. In vitro biological effects of magnetic nanoparticles. CHINESE SCIENCE BULLETIN[J]. 2012, 57(31): 3972-3978, http://lib.cqvip.com/Qikan/Article/Detail?id=43499057.
[16] Chen, Zhongwen, Yin, JunJie, Zhou, YuTing, Zhang, Yu, Song, Lina, Song, Mengjie, Hu, Sunling, Gu, Ning. Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity. ACS NANO[J]. 2012, 6(5): 4001-4012, https://www.webofscience.com/wos/woscc/full-record/WOS:000304231700039.

   

（ 1 ） 基于纳米孔蛋白递送的神经干细胞单分子成像, 负责人, 国家任务, 2022-01--2024-12
（ 2 ） SARS-COV-2病毒与细胞融合过程的重建与单分子观测, 负责人, 地方任务, 2020-11--2022-10
（ 3 ） 信号转导的物理化学调控, 负责人, 研究所自选, 2022-02--2023-02

现指导学生

胡湘子  博士研究生  071009-细胞生物学  

麻敏  硕士研究生  071009-细胞生物学  

陈希夷  硕士研究生  071009-细胞生物学