071006-神经生物学
071008-发育生物学
071009-细胞生物学

神经退行性疾病发病机制研究及药物开发
神经突触发育的分子机制研究

2009-09--2014-12   浙江大学   博士
2005-09--2009-06   上海交通大学   学士

   

2017-07~2021-08,加州大学圣地亚哥分校, 博士后
2015-01~2017-02,浙江大学, 博士后
2009-09~2014-12,浙江大学, 博士
2005-09~2009-06,上海交通大学, 学士

   

（ 1 ） 苯酰胺衍生物在制备Caspase-1抑制剂中的应用, 2016, 第 3 作者, 专利号: CN105853408A

   

（1） Planar cell polarity signaling components are a direct target of beta-amyloid-associated degeneration of glutamatergic synapses, SCIENCE ADVANCES, 2021, 第 1 作者
（2） Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex, SCIENCE ADVANCES, 2021, 第 3 作者
（3） Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures, CELL REPORTS, 2020, 第 2 作者
（4） LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone–growth cone communication, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 3 作者
（5） Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility, BRITISH JOURNAL OF PHARMACOLOGY, 2020, 第 2 作者
（6） Microglial displacement of GABAergic synapses has endogenous protective function in generation of complex febrile seizures, Microglial displacement of GABAergic synapses has endogenous protective function in generation of complex febrile seizures, 中国药理学与毒理学杂志, 2018, 第 3 作者
（7） Correction to: Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures, Correction to: Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures, 神经科学通报：英文版, 2018, 第 3 作者
（8） Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures (vol 30, pg 913, 2014), NEUROSCIENCE BULLETIN, 2018, 第 3 作者
（9） Transient increase of interleukin-1 beta after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling, SCIENTIFIC REPORTS, 2016, 第 1 作者
（10） Generation of Febrile Seizures and Subsequent Epileptogenesis, NEUROSCIENCE BULLETIN, 2016, 第 1 作者
（11） Early hypoactivity of hippocampal rhythms during epileptogenesis after prolonged febrile seizures in freely-moving rats, NEUROSCIENCE BULLETIN, 2015, 第 1 作者
（12） Protective effect of carnosine on febrile seizures in immature mice, NEUROSCIENCE LETTERS, 2015, 第 3 作者
（13） Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures, NEUROSCIENCE BULLETIN, 2014, 第 3 作者
（14） Prolonged febrile seizures increase seizure susceptibility in adulthood via a cascade increase of IL-1 beta and CB1R signaling, JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 第 2 作者
（15） Dysfunction of thermoregulation contributes to the generation of hyperthermia-induced seizures, NEUROSCIENCE LETTERS, 2014, 第 1 作者
（16） Transient augment of IL-1 beta promotes seizure susceptibility via upregulating CB1 receptor in prolonged febrile seizures, ACTA PHARMACOLOGICA SINICA, 2013, 第 2 作者
（17） Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine, EPILEPSY & BEHAVIOR, 2012, 第 3 作者
（18） Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice, Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice, 中国药理学报：英文版, 2010, 第 3 作者
（19） Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice, ACTA PHARMACOLOGICA SINICA, 2010, 第 3 作者

   

（ 1 ） Wnt/PCP通路介导小胶质细胞特异性修剪Celsr3阳性突触的分子机制研究, 负责人, 其他, 2022-10--2025-10
（ 2 ） 阿尔兹海默症早期小胶质细胞靶向吞噬Celsr3阳性突触的分子机制研究, 负责人, 其他, 2023-01--2025-12