利用系统生物学与合成生物学方法，研究肠道中病原真菌的耐药机制和致病机制，关注肠道微生物群落中真菌与细菌的互作关系及其对疾病发生、进展产生的影响。研究成果以第一作者或通讯作者发表在Nature Medicine, Nature Microbiology, mBio, Current Opinion in Microbiology等学术期刊。

   

071005-微生物学
071010-生物化学与分子生物学

肠道真菌与系统性真菌感染
真菌耐药机制
真菌细菌互作

2008-08--2014-08   德克萨斯农工大学   博士

   

2021-07~现在, 中国科学院深圳先进技术研究院, 研究员
2014-12~2021-06,纪念斯隆凯特琳癌症中心, 博士后/助理研究员

   

[1] Farnaz Daneshnia MSc, Joo N de Almeida Jnior MD, Prof Macit Ilkit MD, Lisa Lombardi PhD, Austin M Perry PhD, Marilyn Gao PhD, Clarissa J Nobile PhD, Matthias Egger MD, Prof David S Perlin MD, Bing Zhai PhD, Prof Tobias M Hohl MD PhD, Prof Toni Gabaldn, Prof Arnaldo Lopes Colombo, Prof Martin Hoenigl MD, Amir Arastehfar PhD. Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap. THE LANCET MICROBE. 2023, 4(6): e470-e480, http://dx.doi.org/10.1016/S2666-5247(23)00067-8.
[2] OBrien, Caoimhe E, Zhai, Bing, Ola, Mihaela, Bergin, Sean A, Cinneide, Eoin O, OConnor, Isla, Rolling, Thierry, Miranda, Edwin, Babady, N Esther, Hohl, Tobias M, Butler, Geraldine. Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events. G3-GENES GENOMES GENETICS[J]. 2022, 12(1): http://dx.doi.org/10.1093/g3journal/jkab367.
[3] Bergin, Sean A, Zhao, Fang, Ryan, Adam P, Muller, Carolin A, Nieduszynski, Conrad A, Zhai, Bing, Rolling, Thierry, Hohl, Tobias M, Morio, Florent, Scully, Jillian, Wolfe, Kenneth H, Butler, Geraldine. Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in RTA3 That is Associated with Drug Resistance. MBIO[J]. 2022, 13(5): http://dx.doi.org/10.1128/mbio.01777-22.
[4] Bing Zhai, Robert T Wheeler. The dominoes fall after long-term antibiotic exposure. CELL HOST & MICROBE[J]. 2022, 30(7): 903-905, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598949/.
[5] Rolling, Thierry, Zhai, Bing, Frame, John, Hohl, Tobias M, Taur, Ying. Customization of a DADA2-based pipeline for fungal internal transcribed spacer1 (ITS1) amplicon data sets. JCI INSIGHT[J]. 2022, 7(1): http://dx.doi.org/10.1172/jci.insight.151663.
[6] McDonough, Liam D, Mishra, Animesh A, Tosini, Nicholas, Kakade, Pallavi, Penumutchu, Swathi, Liang, ShenHuan, Maufrais, Corrine, Zhai, Bing, Taur, Ying, Belenky, Peter, Bennett, Richard J, Hohl, Tobias M, Koh, Andrew Y, Ene, Iuliana, V. Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract. MBIO[J]. 2021, 12(6): http://dx.doi.org/10.1128/mBio.02878-21.
[7] Rolling, Thierry, Zhai, Bing, Gjonbalaj, Mergim, Tosini, Nicholas, YasumaMitobe, Keiko, Fontana, Emily, Amoretti, Luigi A, Wright, Roberta J, Ponce, Doris M, Perales, Miguel A, Xavier, Joao B, van den Brink, Marcel R M, Markey, Kate A, Peled, Jonathan U, Taur, Ying, Hohl, Tobias M. Haematopoietic cell transplantation outcomes are linked to intestinal mycobiota dynamics and an expansion of Candida parapsilosis complex species. NATURE MICROBIOLOGY[J]. 2021, 6(12): 1505-+, http://dx.doi.org/10.1038/s41564-021-00989-7.
[8] Zhai, Bing, Rolling, Thierry, Hohl, Tobias M. Exploring Candida auris in its habitat. CELL HOST & MICROBE. 2021, 29(2): 150-151, http://dx.doi.org/10.1016/j.chom.2021.01.010.
[9] Guo, Yahui, Kasahara, Shinji, Jhingran, Anupam, Tosini, Nicholas L, Zhai, Bing, Aufiero, Mariano A, Mills, Kathleen A M, Gjonbalaj, Mergim, Espinosa, Vanessa, Rivera, Amariliz, Luster, Andrew D, Hohl, Tobias M. During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate ImmuneDefense throughCXCR3-Dependent Crosstalk. CELL HOST & MICROBE[J]. 2020, 28(1): 104-+, http://dx.doi.org/10.1016/j.chom.2020.05.002.
[10] Zhai, Bing, Ola, Mihaela, Rolling, Thierry, Tosini, Nicholas L, Joshowitz, Sari, Littmann, Eric R, Amoretti, Luigi A, Fontana, Emily, Wright, Roberta J, Miranda, Edwin, Veelken, Charlotte A, Morjaria, Sejal M, Peled, Jonathan U, van den Brink, Marcel R M, Babady, N Esther, Butler, Geraldine, Taur, Ying, Hohl, Tobias M. High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis. NATURE MEDICINE[J]. 2020, 26(1): 59-+, http://dx.doi.org/10.1038/s41591-019-0709-7.
[11] Rolling, Thierry, Hohl, Tobias M, Zhai, Bing. Minority report: the intestinal mycobiota in systemic infections. CURRENT OPINION IN MICROBIOLOGY[J]. 2020, 56: 1-6, http://dx.doi.org/10.1016/j.mib.2020.05.004.
[12] Damian J Krysan, Bing Zhai, Sarah R Beattie, Kara M Misel, Melanie Wellington, Xiaorong Lin. Host Carbon Dioxide Concentration Is an Independent Stress for Cryptococcus neoformans That Affects Virulence and Antifungal Susceptibility. MBIO[J]. 2019, 10(4): https://doaj.org/article/4b040329046441d3861d17cf72848fa2.
[13] Rebecca A Drummond, Muthulekha Swamydas, Vasileios Oikonomou, Bing Zhai, Ivy M Dambuza, Brian C Schaefer, Andrea C Bohrer, Katrin D MayerBarber, Sergio A Lira, Yoichiro Iwakura, Scott G Filler, Gordon D Brown, Bernhard Hube, Julian R Naglik, Tobias M Hohl, Michail S Lionakis. CARD9 + Microglia Promote Antifungal Immunity via IL-1β and CXCL1-mediated Neutrophil Recruitment. NATURE IMMUNOLOGY. 2019, 20(5): 559-570, [14] Bing Zhai, Karen L Wozniak, Jorge MassoSilva, Srijana Upadhyay, Camaron Hole, Amariliz Rivera, Floyd L Wormley, Xiaorong Lin. Development of Protective Inflammation and Cell-Mediated Immunity against Cryptococcus neoformans after Exposure to Hyphal Mutants. MBIO[J]. 2015, 6(5): https://doaj.org/article/5173ce4e16454e8f9a1c3ff0f48c11c0.
[15] Zhai, Bing, Lin, Xiaorong. Evaluation of the anticryptococcal activity of the antibiotic polymyxin B in vitro and in vivo. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS[J]. 2013, 41(3): 250-254, http://dx.doi.org/10.1016/j.ijantimicag.2012.11.006.
[16] Zhai, Bing, Zhu, Pinkuan, Foyle, Dylan, Upadhyay, Srijana, Idnurm, Alexander, Lin, Xiaorong. Congenic Strains of the Filamentous Form of Cryptococcus neoformans for Studies of Fungal Morphogenesis and Virulence. INFECTION AND IMMUNITY[J]. 2013, 81(7): 2626-2637, https://www.webofscience.com/wos/woscc/full-record/WOS:000320307300036.
[17] Wang, Linqi, Zhai, Bing, Lin, Xiaorong. The Link between Morphotype Transition and Virulence in Cryptococcus neoformans. PLOS PATHOGENS[J]. 2012, 8(6): http://dx.doi.org/10.1371/journal.ppat.1002765.
[18] Zhai, Bing, Wu, Cheng, Wang, Linqi, Sachs, Matthew S, Lin, Xiaorong. The Antidepressant Sertraline Provides a Promising Therapeutic Option for Neurotropic Cryptococcal Infections. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2012, 56(7): 3758-3766, https://www.webofscience.com/wos/woscc/full-record/WOS:000305673000040.

   

（ 1 ） 耐药真菌诊疗的基因回路设计与合成, 负责人, 国家任务, 2021-12--2026-11

（1）Intestinal mycobiome in allogeneic hematopoietic cell transplantation   2022-03-15
（2）The dynamics of the mycobiome during hematopoietic stem cell transplantation   2021-03-27
（3）Candida Intestinal Colonization and Bloodstream Infections   2019-10-04