071007-遗传学

基因调控
表观遗传调控
三维基因组学

1997-09--2004-06   中国科学院上海生物化学与细胞生物学研究所   理学博士
1993-09--1997-06   复旦大学   理学学士

   

2022-09~现在, 中国科学院昆明动物研究所, 研究员
2013-08~2022-08,南方科技大学, 副教授
2009-12~2013-08,美国埃默里大学, 博士后
2004-11~2009-11,美国国立卫生研究院, 访问学者博士后
2004-07~2004-11,中国科学院上海生物化学与细胞生物学研究所, 研究助理
1997-09~2004-06,中国科学院上海生物化学与细胞生物学研究所, 理学博士
1993-09~1997-06,复旦大学, 理学学士

表观遗传学
免疫学

   

（1） High-throughput Pore-C reveals the single-allele topology and cell type-specificity of 3D genome folding, NATURE COMMUNICATIONS, 2023, 第 7 作者
（2） Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis, CELL REPORTS, 2023, 其他（合作组作者）
（3） Genome-wide identification of functional enhancers and their potential roles in pig breeding, Genome-wide identification of functional enhancers and their potential roles in pig breeding, JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2022, 第 9 作者
（4） Integration of Count Difference and Curve Similarity in Negative Regulatory Element Detection, FRONTIERS IN GENETICS, 2022, 通讯作者
（5） Extensive Chromatin Structure-Function Associations Revealed by Accurate 3D Compartmentalization Characterization, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 第 5 作者
（6） The dynamic proteome in Arabidopsis thaliana early embryogenesis, DEVELOPMENT, 2022, 第 3 作者
（7） Interrogating global chromatin interaction network by high-throughput chromosome conformation capture (Hi-C) in plants, Methods Mol Biol., 2022, 通讯作者
（8） Original PKC inhibitors regulate stem cell self-renewal by regulating H3K27me3 and H3K9me3, AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2022, 通讯作者
（9） Nucleosome remodeling and deacetylation complex and MBD3 influence mouse embryonic stem cell naïve pluripotency under inhibition of protein kinase C, CELL DEATH DISCOVERY, 2022, 第 5 作者
（10） Three-dimensional folding dynamics of the Xenopus tropicalis genome, NATURE GENETICS, 2021, 通讯作者
（11） De novo genome assembly and Hi-C analysis reveal an association between chromatin architecture alterations and sex differentiation in the woody plant Jatropha curcas, GIGASCIENCE, 2020, 通讯作者
（12） An extracellular matrix protein promotes anillin-dependent processes in the Caenorhabditis elegans germline, LIFE SCIENCE ALLIANCE, 2019, 第 9 作者
（13） Global Quantitative Mapping of Enhancers in Rice by STARR-seq, GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 通讯作者
（14） Amplification-free library preparation with SAFE Hi-C uses ligation products for deep sequencing to improve traditional Hi-C analysis, COMMUNICATIONS BIOLOGY, 2019, 通讯作者
（15） Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system, FASEB JOURNAL, 2019, 其他（合作组作者）
（16） RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions, CELLSTEMCELL, 2017, 第 15 作者
（17） Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, CELL RESEARCH, 2017, 第 10 作者
（18） Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macroor bridged-rings, NATURE COMMUNICATIONS, 2016, 第 10 作者
（19） Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing, MOLECULAR CELL, 2015, 第 3 作者
（20） Throwing transcription for a loop: expression of the genome in the 3D nucleus, CHROMOSOMA, 2012, 第 1 作者
（21） Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains, MOLECULAR CELL, 2012, 第 1 作者
（22） CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the beta-globin locus, NUCLEIC ACIDS RESEARCH, 2012, 第 3 作者
（23） Distinct Ldb1/NLI complexes orchestrate gamma-globin repression and reactivation through ETO2 in human adult erythroid cells, BLOOD, 2011, 第 3 作者
（24） Insulators and imprinting from flies to mammals, BMC BIOLOGY, 2010, 第 1 作者
（25） Cell type specificity of chromatin organization mediated by CTCF and cohesin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 第 1 作者
（26） Nups Take Leave of the Nuclear Envelope to Regulate Transcription, CELL, 2010, 第 1 作者
（27） Involvement of Sp1/Sp3 in the activation of the GATA-1 erythroid promoter in K562 cells, CELL RESEARCH, 2008, 第 1 作者
（28） Epigenetics of beta-globin gene regulation, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2008, 第 2 作者
（29） CTCF-dependent enhancer-blocking by alternative chromatin loop formation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 第 1 作者
（30） A positive role for NLI/Ldb1 in long-range beta-globin locus control region function, MOLECULAR CELL, 2007, 第 2 作者
（31） Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells, EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 第 2 作者
（32） Functional analysis of multiple transcription factor sites in a regulatory element of human epsilon-globin gene, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2004, 
（33） Effects of Huangqi (Hex) on inducing cell differentiation and cell death in K562 and HEL cells, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2004, 
（34） The in vitro reconstitution of nucleosome and its binding patterns with HMG1/2 and HMG14/17 proteins, CELL RESEARCH, 2003, 
（35） Screening of genes related to the expression of human epsilon-globin gene by using yeast one-hybrid system, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2001, 
（36） CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus, 第 3 作者

   

（ 1 ） 植物基因组功能性增强子鉴定及调控机制分析, 负责人, 地方任务, 2021-06--2022-12
（ 2 ） 获得性性状的跨代遗传的机制研究, 参与, 国家任务, 2019-01--2021-12
（ 3 ） 真核基因组DNA调控元件相互作用网络与细胞分化特异性基因表达调控研究, 负责人, 国家任务, 2016-01--2019-12
（ 4 ） 新学科组启动经费-侯春晖, 负责人, 研究所自主部署, 2022-05--2027-12