基本信息
苏浩 男 博导 中国科学院天津工业生物技术研究所
电子邮件: suhao@tib.cas.cn
通信地址: 天津市空港经济区西七道32号
邮政编码: 300308
电子邮件: suhao@tib.cas.cn
通信地址: 天津市空港经济区西七道32号
邮政编码: 300308
招生信息
招生专业
071010-生物化学与分子生物学070304-物理化学
招生方向
密度泛函理论计算,QM/MM,酶催化反应,量子化学酶理性设计
教育背景
2012-09--2017-06 山东大学 理学博士学位2008-09--2012-07 山西大同大学 理学学士学位
工作经历
工作简历
2021-10~现在, 中国科学院天津工业生物技术研究所, 副研究员2019-04~2021-06,瑞典皇家理工学院, 博士后2017-07~2019-04,耶路撒冷希伯莱大学, 博士后2012-09~2017-06,山东大学, 理学博士学位2008-09~2012-07,山西大同大学, 理学学士学位
出版信息
发表论文
(1) Combined Theoretical and Experimental Studies Unravel Multiple Pathways to Convergent Asymmetric Hydrogenation of Enamides, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 第 5 作者(2) Microscopic Insights into Cation-Coupled Electron Hopping Transport in a Metal–Organic Framework, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 第 2 作者(3) Molecular Basis of the Unusual Seven-Membered Methylenedioxy Bridge Formation Catalyzed by Fe (II)/α-KG-Dependent Oxygenase CTB9, ACS Catalysis, 2022, 第 3 作者(4) Site- and Enantioselective Iridium-Catalyzed Desymmetric Mono-Hydrogenation of 1,4-Dienes, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 第 2 作者(5) Nonbonded Zr4+ and Hf4+ Models for Simulations of Condensed Phase Metal-Organic Frameworks, JOURNAL OF PHYSICAL CHEMISTRY C, 2021, 第 1 作者(6) Quantum-Mechanical/Molecular-Mechanical Studies of CYP11A1-Catalyzed Biosynthesis of Pregnenolone from Cholesterol Reveal a C-C Bond Cleavage Reaction That Occurs by a Compound I-Mediated Electron Transfer, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 1 作者(7) Protonation state and fine structure of the active site determine the reactivity of dehydratase: hydration and isomerization of -myrcene catalyzed by linalool dehydratase/isomerase from Castellaniella defragrans, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2018, 第 3 作者(8) Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes, INORGANIC CHEMISTRY, 2018, 第 1 作者(9) Mechanism of Sulfoxidation and C-S Bond Formation Involved in the Biosynthesis of Ergothioneine Catalyzed by Ergothioneine Synthase (EgtB), ACS CATALYSIS, 2018, 第 2 作者(10) Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes, INORGANIC CHEMISTRY, 2018, 第 1 作者(11) Heteronuclear assembly of Ni-Cu dithiolato complexes: synthesis, structures, and reactivity studies, INORGANIC CHEMISTRY FRONTIERS, 2017, 第 3 作者(12) Fluorescence detection of endogenous bisulfite in liver cancer cells using an effective ESIPT enhanced FRET platform, CHEMICAL COMMUNICATIONS, 2017, 第 3 作者(13) Insights into the unprecedented epoxidation mechanism of fumitremorgin B endoperoxidase (FtmOx1) from Aspergillus fumigatus by QM/MM calculations, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2017, 第 2 作者(14) Catalytic mechanism of acetolactate decarboxylase from Brevibacillus brevis towards both enantiomers of alpha-acetolactate, RSC ADVANCES, 2016, 第 2 作者(15) Theoretical study of the hydrolysis mechanism of dihydrocoumarin catalyzed by serum paraoxonase 1 (PON1): different roles of Glu53 and His115 for catalysis, RSC ADVANCES, 2016, 第 2 作者(16) Exploring the substrate specificity and catalytic mechanism of imidazolonepropionase (HutI) from Bacillus subtilis, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2016, 第 1 作者(17) Insights into the catalytic mechanism of N-acetylglucosaminidase glycoside hydrolase from Bacillus subtilis: a QM/MM study, ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 第 1 作者(18) Quantum mechanics and molecular mechanics study of the reaction mechanism of quorum quenching enzyme: N-acyl homoserine lactonase with C6-HSL, RSC ADVANCES, 2016, 第 2 作者(19) A QM/MM study of the catalytic mechanism of alpha-1,4-glucan lyase from the red seaweed Gracilariopsis lemaneiformis (vol 4, pg 54398, 2014), RSC ADVANCES, 2015, 第 1 作者(20) Uncoupled Epimerization and Desaturation by Carbapenem Synthase: Mechanistic Insights from QM/MM Studies, ACS CATALYSIS, 2015, 第 3 作者(21) Exploring the substrate-assisted acetylation mechanism by UDP-linked sugar N-acetyltransferase from QM/MM calculations: the role of residue Asn84 and the effects of starting geometries, RSC ADVANCES, 2015, 第 3 作者(22) A QM/MM study of the catalytic mechanism of alpha-1,4-glucan lyase from the red seaweed Gracilariopsis lemaneiformis, RSC ADVANCES, 2014, 第 1 作者
科研活动
科研项目
( 1 ) P450酶催化机理的理论研究与理性设计, 负责人, 地方任务, 2022-02--2025-01( 2 ) P450酶催化芳香化合物碳-碳偶联反应机制的理论研究, 负责人, 国家任务, 2023-01--2025-12
参与会议
(1)酶催化机理的理论研究 2022年天津工业生物所-天津科大 中青年学者学术论坛 2023-06-28