基本信息
汪敏先  男  博导  中国科学院北京基因组研究所（国家生物信息中心）
电子邮件： wangmx@big.ac.cn
通信地址： 北京市朝阳区北辰西路1号院104号楼
邮政编码：

研究概述

围绕实验室 60 万例冠心病相关基因组测序、电子病历与影像学数据等，开发人群疾病与健康大队列和生物样本库等生物大数据解析所必需的关键算法、服务设施及开放计算平台，围绕基因组医学的临床实际应用需求，致力于解析心脑血管疾病的遗传基础机制、发掘致病新基 因、药物新靶标及发展疾病风险预测人工智能新模型，建立基于基因组学与表型组学的疾病精确防诊治新模型与应用新方案。已发表 SCI 论文 36 篇，在 N. Engl. J. Med、J. Am. Coll. Cardiol.、Mol Biol Evol.、Nat Commun.、PNAS 和 J Am Soc Nephrol. 等国际知名期刊以第一或通讯作者 (含 共同) 发表论文 14 篇。系列成果实现了从遗传机制研究到临床服务的应用转化，部署于医院 临床。部分研究工作被美国国家人类基因组研究所评为遗传信息用于临床实践领域的十大重 要突破之一，并被 Science 等杂志及 The Times 等媒体亮点报道。现为国际 CARDIoGRAMplusC4D (Coronary ARtery DIsease Genome wide Replication and Meta- analysis (CARDIoGRAM) plus The Coronary Artery Disease (C4D) Genetics) 联盟及 NIH PRIMED (Polygenic Risk Methods in Diverse Populations) 项目成员。

研究方向

  1. 课题组现有56万人（5万患者和51万对照）冠心病队列数据，所有个体包括全基因组/全外显子组测序数据和电子病历数据，利用基因组功能性罕见变异解析冠心病的遗传基础机制；
  2. 整合分析大规模人群队列数据、多维组学数据、疾病临床影像学数据等解析心脑血管疾病的遗传基础机制，发掘疾病风险新基因、新生物标志物及治疗新靶标； 
  3. 立足于中国人群生命健康大数据，开发针对中国人群优化适用的疾病风险预测新模型；
  4. 利用现代云设施，开发安全、高效、可分享的生物医学大数据解析关键云设施与平台；
  5. 开发遗传统计、机器学习及人工智能新算法解析生物医学大数据。


招生专业
0710Z1-基因组学
0710J3-生物信息学
招生方向
基因组学
精准医学

教育背景

2009-09--2015-01   中国科学院大学   博士
2005-09--2009-06   吉林大学   学士

工作经历

   
工作简历
2018-01~2021-08,The Broad Institute of MIT and Harvard, Computational Biologist
2015-03~2018-01,Harvard Medical School, Postdoc

教授课程

Bioinformatics and system biology
⽣物信息⼤数据挖掘分析和实践

出版信息

   
发表论文
[1] Dron, Jacqueline S, Patel, Aniruddh P, Zhang, Yiyi, Jurgens, Sean J, Maamari, Dimitri J, Wang, Minxian, Boerwinkle, Eric, Morrison, Alanna C, de Vries, Paul S, Fornage, Myriam, Hou, Lifang, LloydJones, Donald M, Psaty, Bruce M, Tracy, Russell P, Bis, Joshua C, Vasan, Ramachandran S, Levy, Daniel, HeardCosta, Nancy, Rich, Stephen S, Guo, Xiuqing, Taylor, Kent D, Gibbs, Richard A, Rotter, Jerome I, Willer, Cristen J, Oelsner, Elizabeth C, Moran, Andrew E, Peloso, Gina M, Natarajan, Pradeep, Khera, Amit V. Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease. JAMA CARDIOLOGY. 2023, http://dx.doi.org/10.1001/jamacardio.2022.5271.
[2] Chun, Justin, Riella, Cristian, V, Chung, Hyunjae, Shah, Shrijal S, Wang, Minxian, Magraner, Jose M, Ribas, Guilherme T, Ribas, Hennrique T, Zhang, JiaYue, Alper, Seth L, Friedman, David J, Pollak, Martin R. DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY[J]. 2022, 33(5): 889-907, [3] Fahed, Akl C, Wang, Minxian, Patel, Aniruddh P, Ajufo, Ezimamaka, Maamari, Dimitri J, Aragam, Krishna G, Brockman, Deanna G, Vosburg, Trish, Ellinor, Patrick T, Ng, Kenney, Khera, Amit, V. Association of the Interaction Between Familial Hypercholesterolemia Variants and Adherence to a Healthy Lifestyle With Risk of Coronary Artery Disease. JAMA NETWORK OPEN[J]. 2022, 5(3): http://dx.doi.org/10.1001/jamanetworkopen.2022.2687.
[4] Biddinger, Kiran J, Emdin, Connor A, Haas, Mary E, Wang, Minxian, Hindy, George, Ellinor, Patrick T, Kathiresan, Sekar, Khera, Amit, V, Aragam, Krishna G. Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease. JAMA NETWORK OPEN[J]. 2022, 5(3): http://dx.doi.org/10.1001/jamanetworkopen.2022.3849.
[5] Khera, Amit, V, Wang, Minxian, Chaffin, Mark, Emdin, Connor A, Samani, Nilesh J, Schunkert, Heribert, Watkins, Hugh, McPherson, Ruth, Erdmann, Jeanette, Elosua, Roberto, Boerwinkle, Eric, Ardissino, Diego, Butterworth, Adam S, Di Angelantonio, Emanuele, Naheed, Aliya, Danesh, John, Chowdhury, Rajiv, Krumholz, Harlan M, Sheu, Wayne HH, Rich, Stephen S, Rotter, Jerome, I, Chen, Yiider Ida, Gabriel, Stacey, Lander, Eric S, Saleheen, Danish, Kathiresan, Sekar. Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. CIRCULATION-GENOMIC AND PRECISION MEDICINE[J]. 2022, 15(6): 551-559, [6] Patel, Aniruddh P, Dron, Jacqueline S, Wang, Minxian, Pirruccello, James P, Ng, Kenney, Natarajan, Pradeep, Lebo, Matthew, Ellinor, Patrick T, Aragam, Krishna G, Khera, Amit, V. Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality. JAMA CARDIOLOGY[J]. 2022, 7(7): 723-732, http://dx.doi.org/10.1001/jamacardio.2022.0901.
[7] Milosavljevic, Julian, Lempicki, Camille, Lang, Konrad, Heinkele, Helena, Kampf, Lina L, Leroy, Claire, Chen, Mengmeng, Gerstner, Lea, Spitz, Dominik, Wang, Minxian, Knob, Andrea U, Kayser, Severine, Helmstadter, Martin, Walz, Gerd, Pollak, Martin R, Hermle, Tobias. Nephrotic Syndrome Gene TBC1D8B Is Required for Endosomal Maturation and Nephrin Endocytosis in Drosophila. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY[J]. 2022, 33(12): 2174-2193, http://dx.doi.org/10.1681/ASN.2022030275.
[8] Saaket Agrawal, Minxian Wang, Marcus D R Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J Jurgens, Patrick T Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S Udler, Puneet Batra, Amit V Khera. Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots. NATURE COMMUNICATIONS[J]. 2022, 13(1): 1-17, https://doaj.org/article/708f44bb6b094581a53300838b54ced3.
[9] Lihong Peng, Jialiang Yang, Minxian Wang, Liqian Zhou. Editorial: Machine Learning-Based Methods for RNA Data Analysis. FRONTIERS IN GENETICS[J]. 2022, 13: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175173/.
[10] Dron, Jacqueline S, Wang, Minxian, Patel, Aniruddh P, Kartoun, Uri, Ng, Kenney, Hegele, Robert A, Khera, Amit V. Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations. CIRCULATION-GENOMIC AND PRECISION MEDICINEnull. 2021, 14(1): http://dx.doi.org/10.1161/CIRCGEN.120.003182.
[11] Wang, Minxian, LeeKim, Vivian S, Atri, Deepak S, Elowe, Nadine H, Yu, John, Garvie, Colin W, Won, HongHee, Hadaya, Joseph E, MacDonald, Bryan T, Trindade, Kevin, Melander, Olle, Rader, Daniel J, Natarajan, Pradeep, Kathiresan, Sekar, Kaushik, Virendar K, Khera, Amit V, Gupta, Rajat M. Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease Insights From Functional Genomics and Large-Scale Sequencing Analyses. CIRCULATION-GENOMIC AND PRECISION MEDICINE[J]. 2021, 14(5): http://dx.doi.org/10.1161/CIRCGEN.121.003399.
[12] Weng, Patricia L, Majmundar, Amar J, Khan, Kamal, Lim, Tze Y, Shril, Shirlee, Jin, Gina, Musgrove, John, Wang, Minxian, Ahram, Dina F, Aggarwal, Vimla S, Bier, Louise E, Heinzen, Erin L, OnuchicWhitford, Ana C, Mann, Nina, Buerger, Florian, Schneider, Ronen, Deutsch, Konstantin, Kitzler, Thomas M, Klambt, Verena, Kolb, Amy, Mao, Youying, El Achkar, Christelle Moufawad, Mitrotti, Adele, Martino, Jeremiah, Beck, Bodo B, Altmuller, Janine, Benz, Marcus R, Yano, Shoji, Mikati, Mohamad A, Gunduz, Talha, Cope, Heidi, Shashi, Vandana, Trachtman, Howard, Bodria, Monica, Caridi, Gianluca, Pisani, Isabella, Fiaccadori, Enrico, AbuMaziad, Asmaa S, MartinezAgosto, Julian A, Yadin, Ora, Zuckerman, Jonathan, Kim, Arang, JohnKroegel, Ulrike, Tyndall, Amanda, V, Parboosingh, Jillian S, Innes, A Micheil, Bierzynska, Agnieszka, Koziell, Ania B, Muorah, Mordi, Saleem, Moin A, Hoefele, Julia, Riedhammer, Korbinian M, Gharavi, Ali G, Jobanputra, Vaidehi, PierceHoffman, Emma, Seaby, Eleanor G, ODonnellLuria, Anne, Rehm, Heidi L, Mane, Shrikant, DAgati, Vivette D, Pollak, Martin R, Ghiggeri, Gian Marco, Lifton, Richard P, Goldstein, David B, Davis, Erica E, Hildebrandt, Friedhelm, SannaCherchi, Simone, Undiagnosed Dis Network, UCLA Clinical Genomics Ctr. De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis. AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2021, 108(2): 357-367, http://dx.doi.org/10.1016/j.ajhg.2021.01.008.
[13] Cai, Yudong, Yang, Jialiang, Huang, Tao, Wang, Minxian Wallace. Editorial: Computational Methods in Predicting Complex Disease Associated Genes and Environmental Factors. FRONTIERS IN GENETICS[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097088/.
[14] Fahed, Akl C, Wang, Minxian, Homburger, Julian R, Patel, Aniruddh P, Bick, Alexander G, Neben, Cynthia L, Lai, Carmen, Brockman, Deanna, Philippakis, Anthony, Ellinor, Patrick T, Cassa, Christopher A, Lebo, Matthew, Ng, Kenney, Lander, Eric S, Zhou, Alicia Y, Kathiresan, Sekar, Khera, Amit V. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-17374-3.
[15] Chun, Justin, Wang, Minxian, Wilkins, Maris S, Knob, Andrea U, Benjamin, Ave, Bu, Lihong, Pollak, Martin R. Autosomal Dominant Tubulointerstitial Kidney Disease-Uromodulin Misclassified as Focal Segmental Glomerulosclerosis or Hereditary Glomerular Disease. KIDNEY INTERNATIONAL REPORTS[J]. 2020, 5(4): 519-529, http://dx.doi.org/10.1016/j.ekir.2019.12.016.
[16] Emdin, Connor A, Bhatnagar, Pallav, Wang, Minxian, Pillai, Sreekumar G, Li, Lin, Qian, HuiRong, Riesmeyer, Jeffrey S, Lincoff, A Michael, Nicholls, Stephen J, Nissen, Steven E, Ruotolo, Giacomo, Kathiresan, Sekar, Khera, Amit V. Genome-Wide Polygenic Score and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease A Nested Case-Control Study. CIRCULATION-GENOMIC AND PRECISION MEDICINEnull. 2020, 13(1): e002767-e002767, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031044/.
[17] Patel, Aniruddh P, Wang, Minxian, Fahed, Akl C, MasonSuares, Heather, Brockman, Deanna, Pelletier, Renee, Amr, Sami, Machini, Kalotina, Hawley, Megan, Witkowski, Leora, Koch, Christopher, Philippakis, Anthony, Cassa, Christopher A, Ellinor, Patrick T, Kathiresan, Sekar, Ng, Kenney, Lebo, Matthew, Khera, Amit, V. Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syndrome, and Lynch Syndrome With Disease Risk in Adults According to Family History. JAMA NETWORK OPEN[J]. 2020, 3(4): e203959-e203959, http://dx.doi.org/10.1001/jamanetworkopen.2020.3959.
[18] Wang Minxian. Lp(a) (Lipoprotein [a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease. Arteri osclerosis, Thrombosis, and Vascular Biology. 2020, [19] Pirruccello, James P, Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D, Post, Wendy S, Rich, Stephen, Lima, Joao A C, Rotter, Jerome I, Philippakis, Anthony, Lubitz, Steven A, Ellinor, Patrick T, Khera, Amit V, Kathiresan, Sekar, Aragam, Krishna G. Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://gooa.las.ac.cn/external/index?type=-1&pid=1590503.
[20] Wang, Minxian, Menon, Ramesh, Mishra, Sanghamitra, Patel, Aniruddh P, Chaffin, Mark, Tanneeru, Deepak, Deshmukh, Manjari, Mathew, Oshin, Apte, Sanika, Devanboo, Christina S, Sundaram, Sumathi, Lakshmipathy, Praveena, Murugan, Sakthivel, Sharma, Krishna Kumar, Rajendran, Karthikeyan, Santhosh, Sam, Thachathodiyl, Rajesh, Ahamed, Hisham, Balegadde, Aniketh Vijay, Alexander, Thomas, Swaminathan, Krishnan, Gupta, Rajeev, Mullasari, Ajit S, Sigamani, Alben, Kanchi, Muralidhar, Peterson, Andrew S, Butterworth, Adam S, Danesh, John, Di Angelantonio, Emanuele, Naheed, Aliya, Inouye, Michael, Chowdhury, Rajiv, Vedam, Ramprasad L, Kathiresan, Sekar, Gupta, Ravi, Khera, Amit V. Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY[J]. 2020, 76(6): 703-714, http://dx.doi.org/10.1016/j.jacc.2020.06.024.
[21] Feng, Di, Kumar, Mukesh, Muntel, Jan, Gurley, Susan B, Birrane, Gabriel, Stillman, Isaac E, Ding, Lai, Wang, Minxian, Ahmed, Saima, Schlondorff, Johannes, Alper, Seth L, Ferrante, Tom, Marquez, Susan L, Ng, Carlos F, Novak, Richard, Ingber, Donald E, Steen, Hanno, Pollak, Martin R. Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY[J]. 2020, 31(7): 1479-1495, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351002/.
[22] Wang, Minxian, Chun, Justin, Genovese, Giulio, Knob, Andrea U, Benjamin, Ava, Wilkins, Maris S, Friedman, David J, Appel, Gerald B, Lifton, Richard P, Mane, Shrikant, Pollak, Martin R. Contributions of Rare Gene Variants to Familial and Sporadic FSGS. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY[J]. 2019, 30(9): 1625-1640, [23] Riella, Cristian, Siemens, Tobias A, Wang, Minxian, Campos, Rodrigo P, Moraes, Thyago P, Riella, Leonardo, V, Friedman, David J, Riella, Miguel C, Pollak, Martin R. APOL1-Associated Kidney Disease in Brazil. KIDNEY INTERNATIONAL REPORTS[J]. 2019, 4(7): 923-929, http://dx.doi.org/10.1016/j.ekir.2019.03.006.
[24] Khetarpal, Sumeet A, Wang, Minxian, Khera, Amit V. Volanesorsen, Familial Chylomicronemia Syndrome, and Thrombocytopenia. NEW ENGLAND JOURNAL OF MEDICINEnull. 2019, 381(26): 2582-2584, http://dx.doi.org/10.1056/NEJMc1912350.
[25] Khera, Amit V, MasonSuares, Heather, Brockman, Deanna, Wang, Minxian, VanDenburgh, Martin J, SenolCosar, Ozlem, Patterson, Candace, NewtonCheh, Christopher, Zekavat, Seyedeh M, Pester, Julie, Chasman, Daniel I, Kabrhel, Christopher, Jensen, Majken K, Manson, JoAnn E, Gaziano, J Michael, Taylor, Kent D, Sotoodehnia, Nona, Post, Wendy S, Rich, Stephen S, Rotter, Jerome I, Lander, Eric S, Rehm, Heidi L, Ng, Kenney, Philippakis, Anthony, Lebo, Matthew, Albert, Christine M, Kathiresan, Sekar. Rare Genetic Variants Associated With Sudden Cardiac Death in Adults. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY[J]. 2019, 74(21): 2623-2634, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067308/.
[26] Feng, Di, Notbohm, Jacob, Benjamin, Ava, He, Shijie, Wang, Minxian, Ang, LayHong, Bantawa, Minaspi, Bouzid, Mehdi, Del Gado, Emanuela, Krishnan, Ramaswamy, Pollak, Martin R. Disease-causing mutation in alpha-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(7): 1517-1522, https://www.webofscience.com/wos/woscc/full-record/WOS:000424876000069.
[27] Zhang, JiaYue, Wang, Minxian, Tian, Lei, Genovese, Giulio, Yan, Paul, Wilson, James G, Thadhani, Ravi, Mottl, Amy K, Appel, Gerald B, Bick, Alexander G, Sampson, Matthew G, Alper, Seth L, Friedman, David J, Pollak, Martin R. UBD modifies APOL1-induced kidney disease risk. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(13): 3446-3451, https://www.webofscience.com/wos/woscc/full-record/WOS:000428382400069.
[28] Zhou, Bin, Dong, Hui, He, Yungang, Sun, Jian, Jin, Weirong, Xie, Qing, Fan, Rong, Wang, Minxian, Li, Ran, Chen, Yangyi, Xie, Shaoqing, Shen, Yan, Huang, Xin, Wang, Shengyue, Lu, Fengming, Jia, Jidong, Zhuang, Hui, Locarnini, Stephen, Zhao, GuoPing, Jin, Li, Hou, Jinlin. Composition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response During Telbivudine Therapy. SCIENTIFIC REPORTS[J]. 2015, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000365198100002.
[29] He, Yungang, Wang, Minxian, Huang, Xin, Li, Ran, Xu, Hongyang, Xu, Shuhua, Jin, Li. A probabilistic method for testing and estimating selection differences between populations. GENOME RESEARCH[J]. 2015, 25(12): 1903-1909, https://www.webofscience.com/wos/woscc/full-record/WOS:000365830400012.
[30] Wang, Minxian, Huang, Xin, Li, Ran, Xu, Hongyang, Jin, Li, He, Yungang. Detecting Recent Positive Selection with High Accuracy and Reliability by Conditional Coalescent Tree. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2014, 31(11): 3068-3080, https://www.webofscience.com/wos/woscc/full-record/WOS:000344622800020.
[31] Jiang, Yueming, Wang, Minxian, Zheng, Hongxiang, Wang, Wei R, Jin, Li, He, Yungang. Resolving ambiguity in the phylogenetic relationship of genotypes A, B, and C of hepatitis B virus. BMC EVOLUTIONARY BIOLOGY[J]. 2013, 13(1): 120-120, http://dx.doi.org/10.1186/1471-2148-13-120.
[32] Li, Ran, Wang, Minxian, Jin, Li, He, Yungang. A Monte Carlo Permutation Test for Random Mating Using Genome Sequences. PLOS ONE[J]. 2013, 8(8): https://doaj.org/article/fa8cc36f7d3e49d598712f50bd9dafa9.

科研活动

   
科研项目
（ 1 ） 科研启动经费, 负责人, 研究所自选, 2021-10--2025-10
参与会议
（1）Dissect the genetic basis of fat depots quantified from the whole-body MRI data of 38,965 individuals   第八届全国计算生物与生物信息学大会   2022-07-22

指导学生

现指导学生

李佳  硕士研究生  0710Z1-基因组学  

陈秋丽  硕士研究生  0710Z1-基因组学  

阿云嘎  博士研究生  0710J3-生物信息学  

陈星宇  博士研究生  0710J3-生物信息学  

胡圣禹  硕士研究生  0710J3-生物信息学  

王劭祺  硕士研究生  0710J3-生物信息学  

于康  硕士研究生  0710J3-生物信息学  

于宇  硕士研究生  0710J3-生物信息学  

周欣雨  博士研究生  0710J3-生物信息学