071007-遗传学

认知及其它社会行为表型的生物学机制

2011-08--2016-08   约翰霍普金斯大学   博士
2010-08--2011-05   约翰霍普金斯大学   公共卫生硕士
2005-09--2009-06   武汉大学   理学学士

   

2022-10~现在, 中国科学院昆明动物研究所, 研究员
2020-04~2022-10,中国科学院昆明动物研究所, 副研究员
2016-10~2020-04,中国科学院昆明动物研究所, 助理研究员
2011-08~2016-08,约翰霍普金斯大学, 博士
2010-08~2011-05,约翰霍普金斯大学, 公共卫生硕士
2005-09~2009-06,武汉大学, 理学学士

   

（1） An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data, MOLECULAR PSYCHIATRY, 2022, 第 2 作者
（2） A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MT(d2d3) and Mushroom Dendritic Spine Density, SCHIZOPHRENIA BULLETIN, 2021, 第 4 作者
（3） Translational genomics and beyond in bipolar disorder, Molecular Psychiatry, 2021, 
（4） Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene, SCHIZOPHRENIA BULLETIN, 2021, 第 7 作者
（5） Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs, SCIENCE BULLETIN, 2021, 第 8 作者
（6） Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus, BIOLOGICAL PSYCHIATRY, 2021, 通讯作者
（7） Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals A Genome-Wide Association Study and Meta-analysis, JAMA PSYCHIATRY, 2021, 第 47 作者
（8） Regulation of TRANK1 by GSK-3 in the brain: unexpected interactions, MOLECULAR PSYCHIATRY, 2021, 第 4 作者
（9） Further confirmation of netrin 1 receptor ( DCC ) as a depression risk gene via integrations of multi-omics data, TRANSLATIONALPSYCHIATRY, 2020, 通讯作者
（10） Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32, Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32, ZOOLOGICAL RESEARCH, 2020, 第 13 作者
（11） Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci, NEUROPSYCHOPHARMACOLOGY, 2020, 通讯作者
（12） Genome-wide Association Study of Creativity Reveals Genetic Overlap With Psychiatric Disorders, Risk Tolerance, and Risky Behaviors, SCHIZOPHRENIA BULLETIN, 2020, 第 8 作者
（13） The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine, MOLECULAR PSYCHIATRY, 2020, 通讯作者
（14） The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population, TRANSLATIONAL PSYCHIATRY, 2019, 通讯作者
（15） Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder, NEUROPSYCHOPHARMACOLOGY, 2019, 通讯作者
（16） Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 2019, 第 18 作者
（17） Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders, MOLECULAR PSYCHIATRY, 2019, 第 2 作者
（18） Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study., LANCETPSYCHIATRY, 2018, 第 16 作者
（19） The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders, MOLECULAR PSYCHIATRY, 2018, 
（20） The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders, MOLECULAR PSYCHIATRY, 2018, 
（21） Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population, TRANSLATIONAL PSYCHIATRY, 2018, 通讯作者
（22） The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder, NEUROPSYCHOPHARMACOLOGY, 2018, 第 1 作者
（23） Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations, TRANSLATIONAL PSYCHIATRY, 2018, 第 7 作者
（24） The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions, MOLECULAR PSYCHIATRY, 2017, 
（25） Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1, MOLECULAR NEUROBIOLOGY, 2017, 通讯作者
（26） Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders, TRANSLATIONAL PSYCHIATRY, 2017, 第 1 作者
（27） Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2013, 第 3 作者
（28） Genetic association and identification of a functional SNP at GSK3 beta for schizophrenia susceptibility, SCHIZOPHRENIA RESEARCH, 2011, 第 4 作者

   

（ 1 ） 抑郁症风险基因PCDH9在发病过程中的生物学机制研究, 负责人, 国家任务, 2021-01--2024-12
（ 2 ） 基于多组学分析探索精神疾病的遗传基础与生物学机制, 负责人, 地方任务, 2021-06--2024-05
（ 3 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2018-01--2021-12
（ 4 ） LncRNA HNF1A-AS1在结直肠癌中表达上调分子机制及其参与姜黄素化学预防作用机理的研究, 参与, 国家任务, 2020-01--2023-12
（ 5 ） 精神疾病的遗传基础与生物学机制, 负责人, 中国科学院计划, 2022-03--2025-02
（ 6 ） Synaptotagmin 14（SYT14）通过影响小脑浦肯野神经元功能参与情感障碍的机制研究, 负责人, 地方任务, 2022-06--2025-05
（ 7 ） 精神疾病跨诊断表型的遗传机理, 负责人, 国家任务, 2023-01--2025-12