071010-生物化学与分子生物学
071005-微生物学

合成生物学，代谢工程

2013-09--2018-01   中国科学院天津工业生物技术研究所   博士

   

2020-07~现在, 中国科学院天津工业生物技术研究所, 副研究员
2018-03~2020-07,中国科学院天津工业生物技术研究所, 助理研究员

   

（1） 天津市科学技术进步一等奖, 一等奖, 省级, 2020
（2） 中国轻工业联合会科技进步奖, 二等奖, 部委级, 2020

（ 1 ） 合成钴(II)啉酸a，c-二酰胺的大肠杆菌重组菌及其构建方法与应用, 发明专利, 2020, 第 2 作者, 专利号: ZL201711296890.5
（ 2 ） 从头合成维生素B12的大肠杆菌重组菌及其构建方法与应用, 发明专利, 2020, 第 2 作者, 专利号: ZL201711296896.2
（ 3 ） 一种苜蓿中华根瘤菌 株及其组合物与应用, 发明专利, 2017, 第 5 作者, 专利号: ZL201410529336.7

   

[1] Li, Zhu, Wang, Huiying, Ding, Dongqin, Liu, Yongfei, Fang, Huan, Chang, Zhishuai, Chen, Tao, Zhang, Dawei. Metabolic engineering of Escherichia coli for production of chemicals derived from the shikimate pathway. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2020, 47(6-7): 525-535, https://www.webofscience.com/wos/woscc/full-record/WOS:000546526900001.
[2] Li, Dong, Fang, Huan, Gai, Yuanming, Zhao, Jing, Jiang, Pingtao, Wang, Lei, Wei, Qun, Yu, Dayu, Zhang, Dawei. Metabolic engineering and optimization of the fermentation medium for vitamin B-12 production in Escherichia coli. BIOPROCESS AND BIOSYSTEMS ENGINEERING[J]. 2020, 43(10): 1735-1745, https://www.webofscience.com/wos/woscc/full-record/WOS:000532114800001.
[3] Li, Zhu, Ding, Dongqin, Wang, Huiying, Liu, Linxia, Fang, Huan, Chen, Tao, Zhang, Dawei. Engineering Escherichia coli to improve tryptophan production via genetic manipulation of precursor and cofactor pathways. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2020, 5(3): 200-205, http://lib.cqvip.com/Qikan/Article/Detail?id=7103845004.
[4] Su, Yuan, Liu, Chuan, Fang, Huan, Zhang, Dawei. Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine. MICROBIAL CELL FACTORIES[J]. 2020, 19(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000568565000002.
[5] Ding, Dongqin, Li, Jinlong, Bai, Danyang, Fang, Huan, Lin, Jianping, Zhang, Dawei. Biosensor-based monitoring of the central metabolic pathway metabolites. BIOSENSORS & BIOELECTRONICS[J]. 2020, 167: http://dx.doi.org/10.1016/j.bios.2020.112456.
[6] Jiang, Pingtao, Fang, Huan, Zhao, Jing, Dong, Huina, Jin, Zhaoxia, Zhang, Dawei. Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies. MICROBIAL CELL FACTORIES[J]. 2020, 19(1): http://dx.doi.org/10.1186/s12934-020-01377-2.
[7] Zhao, Jing, Fang, Huan, Zhang, Dawei. Expanding application of CRISPR-Cas9 system in microorganisms. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2020, 5(4): 269-276, http://lib.cqvip.com/Qikan/Article/Detail?id=7103845394.
[8] Liu, Zhenquan, Dong, Huina. Identification of a xylose-inducible promoter and its application for improving vitamin B12 production in Sinorhizobium meliloti. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY[J]. 2020, [9] Helian, Yuankun, Gai, Yuanming, Fang, Huan, Sun, Yumei, Zhang, Dawei. A multistrategy approach for improving the expression ofE. coliphytase inPichia pastoris. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2020, 47(12): 1161-1172, https://www.webofscience.com/wos/woscc/full-record/WOS:000569548800001.
[10] Wang, Sijia, Fu, Gang, Li, Jinlong, Wei, Xunfan, Fang, Huan, Huang, Dawei, Lin, Jianping, Zhang, Dawei. High-Efficiency Secretion and Directed Evolution of Chitinase BcChiA1 in Bacillus subtilis for the Conversion of Chitinaceous Wastes Into Chitooligosaccharides. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2020, 8: https://doaj.org/article/2b75d730a2fa4526bb14c1946f148959.
[11] Fang, Huan, Li, Dong, Kang, Jie, Jiang, Pingtao, Sun, Jibin, Zhang, Dawei. Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B-12. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/41974b62655e445fba8edc4e6f45103f.

   

（ 1 ） 苜蓿中华根瘤菌腺苷咕啉醇酰胺磷酸的合成机理, 主持, 国家级, 2020-01--2022-12
（ 2 ） 新分子生化反应设计与核心生命途径重构, 参与, 国家级, 2019-07--2024-06
（ 3 ） 大肠杆菌从头合成维生素B12技术, 参与, 院级, 2019-06--2022-12
（ 4 ） 中科学院青年创新促进会项目, 主持, 研究所（学校）, 2020-01--2023-12
（ 5 ） 重要工业化学品生物制造菌种的新一代网络模型构建与应用, 参与, 国家级, 2021-07--2024-06