基本信息
夏建业  男  博导  中国科学院天津工业生物技术研究所
电子邮件: xiajy@tib.cas.cn
通信地址: 天津市西七道32号
邮政编码:

招生信息

   
招生专业
086000-生物与医药
招生方向
发酵工程,系统生物技术,生物过程工程,发酵优化与放大

教育背景

2003-09--2008-06   华东理工大学   工学博士

工作经历

   
工作简历
2016-01~2017-01,查尔姆斯理工大学, 访问学者
2008-07~2021-04,华东理工大学, 副研究员

专利与奖励

   
奖励信息
(1) 中国轻工业联合会科技进步二等奖, 二等奖, 部委级, 2019
(2) 上海市科技进步二等奖, 二等奖, 省级, 2018
专利成果
( 1 ) 一种多级连续发酵系统, 发明专利, 2021, 第 1 作者, 专利号: CN202110686197.9

出版信息

   
发表论文
[1] Min Chen, Huan Li, Yingping Zhuang, Jianye Xia, Jens Nielsen. Yeast increases glycolytic flux to support higher growth rates accompanied by decreased metabolite regulation and lower protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America[J]. 2023, 120(25): e2302779120-, [2] Ning Qin, Lingyun Li, Xu Ji, Rui Pereira, Yu Chen, Shile Yin, Chaokun Li, Xiaozhen Wan, Danye Qiu, Junfeng Jiang, Hao Luo, Yueping Zhang, Genlai Dong, Yiming Zhang, Shuobo Shi, Henning J Jessen, Jianye Xia, Yun Chen, Christer Larsson, Tianwei Tan, Zihe Liu, Jens Nielsen. Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast. CELL. 2023, 186(4): 748-763.e15, http://dx.doi.org/10.1016/j.cell.2023.01.014.
[3] Fan, Meng, Gu, Zhen, Chen, Wei, Wang, HuiFeng, Zhuang, YingPing, Xia, Jianye. Micro-electrochemical DO sensor with ultra-micropore matrix fabricated with femtosecond laser processing successfully applied in on-line DO monitoring for yeast culture. BIOTECHNOLOGY LETTERS. 2023, [4] 虞思倩, 夏建业, 庄英萍. 基于热力学原理约束的代谢网络模型研究进展及其应用. 中国生物工程杂志[J]. 2022, 42: 2-, [5] Wang, JiaQi, Zhao, Jie, Xia, JianYe. gamma-PGA Fermentation by Bacillus subtilis PG-001 with Glucose Feedback Control pH-stat Strategy. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2022, 194(5): 1871-1880, http://dx.doi.org/10.1007/s12010-021-03755-x.
[6] Tingting Xie, Min Chen, Jens Nielsen, Jianye Xia. Multi-omics analysis of the transition to the Crabtree effect in S. cerevisiae reveals a key role for the citric acid shuttle. FEMS Yeast Research[J]. 2022, 22(1): foac030-, [7] 夏建业, 刘晶, 庄英萍. 人工智能时代发酵优化与放大技术的机遇与挑战. 生物工程学报[J]. 2022, 38(11): 4180-4199, http://lib.cqvip.com/Qikan/Article/Detail?id=7108545591.
[8] Xia, Jianye, Sanchez, Benjamin J, Chen, Yu, Campbell, Kate, Kasvandik, Sergo, Nielsen, Jens. Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000799632400011.
[9] 冯涛, 夏建业, 储炬. 带档板摇瓶中流场数值模拟及克拉维酸发酵培养研究. 华东理工大学学报:自然科学版[J]. 2021, 47(5): 584-591, [10] Zhou, Jingru, Zhuang, Yingping, Xia, Jianye. Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions. MICROBIAL CELL FACTORIES[J]. 2021, 20(1): http://dx.doi.org/10.1186/s12934-021-01614-2.
[11] 周静茹, 刘鹏, 夏建业, 庄英萍. 基于约束的基因组规模代谢网络模型构建方法研究进展. 生物工程学报[J]. 2021, 37(5): 2-, [12] Xia, Jianye, Wang, Guan, Fan, Meng, Chen, Min, Wang, Zeyu, Zhuang, Yingping. Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains. CHINESE JOURNAL OF CHEMICAL ENGINEERINGnull. 2021, 30(2): 178-184, http://lib.cqvip.com/Qikan/Article/Detail?id=7104562240.
[13] Xinxin Wang, Jiachen Zhao, Jianye Xia, Guan Wang, Ju Chu, Yingping Zhuang. Impact of Altered Trehalose Metabolism on Physiological Response of Penicillium chrysogenum Chemostat Cultures during Industrially Relevant Rapid Feast/Famine Conditions. PROCESSES[J]. 2021, 9(118): https://doaj.org/article/42696c05d02040fbb3f0506cc5e9c83d.
[14] Liu, Peng, Hua, Ye, Zhang, Wei, Xie, Tingting, Zhuang, Yingping, Xia, Jianye, Noorman, Henk. A new strategy for dynamic metabolic flux estimation by integrating transient metabolome data into genome-scale metabolic models. BIOPROCESS AND BIOSYSTEMS ENGINEERING[J]. 2021, 44(12): 2553-2565, http://dx.doi.org/10.1007/s00449-021-02626-3.
[15] Liu, Peng, Wang, Shuai, Li, Chao, Zhuang, Yingping, Xia, Jianye, Noorman, Henk. Dynamic response of Aspergillus niger to periodical glucose pulse stimuli in chemostat cultures. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2021, 118(6): 2265-2282, http://dx.doi.org/10.1002/bit.27739.
[16] Li, Chao, Teng, Xiaonuo, Peng, Huadong, Yi, Xiaoping, Zhuang, Yingping, Zhang, Siliang, Xia, Jianye. Novel scale-up strategy based on three-dimensional shear space for animal cell culture. CHEMICAL ENGINEERING SCIENCE[J]. 2020, 212: http://dx.doi.org/10.1016/j.ces.2019.115329.
[17] 夏建业, 田锡炜, 刘娟, 庄英萍. 人工智能时代的智能生物制造. 生物加工过程[J]. 2020, 18(1): 13-20, http://lib.cqvip.com/Qikan/Article/Detail?id=7100987749.
[18] Li, Chao, Tian, Jiangtao, Wang, Weifei, Peng, Huadong, Zhang, Ming, Hang, Haifeng, Zhang, Siliang, Xia, JianYe. Numerical and experimental assessment of a miniature bioreactor equipped with a mechanical agitator and non-invasive biosensors. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY[J]. 2019, 94(8): 2671-2683, https://www.webofscience.com/wos/woscc/full-record/WOS:000475479300028.
[19] Wang, Shuai, Liu, Peng, Shu, Wei, Li, Chao, Li, Huan, Liu, Shanshan, Xia, Jianye, Noorman, Henk. Dynamic response of Aspergillus niger to single pulses of glucose with high and low concentrations. BIORESOURCES AND BIOPROCESSING[J]. 2019, 6(1): http://dx.doi.org/10.1186/s40643-019-0251-y.
[20] Li, Chao, Shu, Wei, Wang, Shuai, Liu, Peng, Zhuang, Yingpping, Zhang, Siliang, Xia, Jianye. Dynamic metabolic response of Aspergillus niger to glucose perturbation: evidence of regulatory mechanism for reduced glucoamylase production. JOURNAL OF BIOTECHNOLOGY[J]. 2018, 287: 28-40, http://dx.doi.org/10.1016/j.jbiotec.2018.08.005.

科研活动

   
科研项目
( 1 ) 新型工业微生物全基因组代谢网络模型的优化设计和构建研究, 参与, 国家级, 2020-01--2024-12
( 2 ) 多组学整合下酿酒酵母酶磷酸化修饰与异构调节对代谢流调控机制的基础研究, 主持, 国家级, 2018-01--2021-12
( 3 ) 高效理性发酵过程优化与放大技术研究, 主持, 市地级, 2021-02--2024-01