071010-生物化学与分子生物学
071009-细胞生物学
100102-免疫学

肿瘤免疫学
免疫治疗
肿瘤微环境

2007-09--2013-06   浙江大学   博士
2003-09--2007-06   浙江工业大学   学士

   

2021-01~现在, 中科院分子细胞科学卓越创新中心, 研究员
2016-05~2021-01,耶鲁大学医学院, 博士后&副研究员
2013-09~2016-05,浙江大学, 讲师
2007-09~2013-06,浙江大学, 博士
2003-09~2007-06,浙江工业大学, 学士

   

（1） CRI-Irvington Postdoctoral Fellowship, 研究所（学校）, 2017

（ 1 ） Compositions and Methods Comprising Viral Vector Systems for Multiplexed Activation of Endogenous Genes as Immunotherapy and Viral-based Immune-Gene Therapy, 2020, 第 2 作者, 专利号: PCT/US2020/057113

（ 2 ） COMPOSITIONS AND METHODS FOR MULTIPLEXED TUMOR VACCINATION WITH ENDOGENOUS GENE ACTIVATION, 2019, 第 3 作者, 专利号: PCT/US20 19/027956

（ 3 ） 一种基因工程热稳定疫苗及其制备方法, 2017, 第 1 作者, 专利号: ZL 2013 1 0278495.X

（ 4 ） 一种制备热稳定疫苗的方法, 2014, 第 1 作者, 专利号: ZL 2012 1 0282409.8

   

（1） CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade, CANCER DISCOVERY, 2020, 第 1 作者
（2） Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity InVivo, CELL SYSTEMS, 2019, 第 3 作者
（3） In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens, NATURE METHODS, 2019, 第 2 作者
（4） Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells., Cell, 2019, 第 1 作者
（5） Multiplexed activation of endogenous genes by CRISPRa elicits potent anti-tumor immunity, NATURE IMMUNOLOGY, 2019, 第 1 作者
（6） Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening, SCIENCE ADVANCES, 2018, 第 1 作者
（7） AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma (vol 20, pg 1329, 2017), NATURE NEUROSCIENCE, 2017, 第 3 作者
（8） Robust vaccine formulation produced by assembling a hybrid coating of polyethyleneimine-silica, CHEMICAL SCIENCE, 2016, 第 1 作者
（9） Hydrated Silica Exterior Produced by Biomimetic Silicification Confers Viral Vaccine Heat-Resistance, ACS NANO, 2015, 第 1 作者
（10） Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 1 作者
（11） Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 第 1 作者
（12） Extracellular Silica Nanocoat Confers Thermotolerance on Individual Cells: A Case Study of Material-Based Functionalization of Living Cells, CHEMBIOCHEM, 2010, 第 1 作者

   

（ 1 ） CRISPR高通量筛选解析CD8+T细胞中介导MDSCs免疫抑制功能的关键基因, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） CRISPR技术解析肿瘤微环境中决定T细胞疗效的关键基因, 负责人, 地方任务, 2021-10--2023-09
（ 3 ） 肝癌肝移植免疫稳态维持的精准策略及选择性区域免疫耐受新靶点研究, 负责人, 国家任务, 2023-01--2025-12

（1）CRISPR SCREENING TO IDENTIFY THE KEY MODULATORS DURING THE CANCER-IMMUNE INTERACTIONS FOR EFFECTIVE IMMUNOTHERAPY   Guangchuan Wang, Ryan Chow, Zhigang Bai, Lupeng Ye, and Sidi Chen   2021-04-20
（2）Mapping the genetic features of immune checkpoint responsiveness using AAV-CRISPR mediated in vivo screen   Guangchuan Wang, Ryan Chow, Zhigang Bai, Lupeng Ye, and Sidi Chen   2018-09-30