071005-微生物学

病原细菌耐药机制以及基于噬菌体改造的耐药性阻断

2008-09--2011-06   中国农业大学   博士
2005-09--2008-06   石河子大学   硕士
2001-09--2005-06   石河子大学   学士

   

2018-10~现在, 中国科学院微生物研究所, 副研究员
2011-07~2018-10,中国科学院微生物研究所, 助理研究员
2008-09~2011-06,中国农业大学, 博士
2005-09~2008-06,石河子大学, 硕士
2001-09~2005-06,石河子大学, 学士

   

（ 1 ） β-内酰胺酶及其编码基因以及它们的应用, 2021, 第 4 作者, 专利号: CN110157699B

   

（1） In vivo evolution of carbapenem resistance in hypervirulent Klebsiella pneumoniae in a patient undergoing long-term treatment, Journal of Antimicrobial Chemotherapy, 2022, 第 6 作者
（2） An urban soil environmental E. coli ST354 isolate co-harbouring mcr-1 and bla NDM-9, Journal of Global Antimicrobial Resistance, 2022, 第 4 作者
（3） IS 26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics, mBio, 2022, 第 4 作者
（4） Streptococcus sputorum , a Novel Member of Streptococcus with Multidrug Resistance, Exhibits Cytotoxicity, Antibiotics, 2021, 第 6 作者
（5） The Shared Resistome of Human and Pig Microbiota Is Mobilized by Distinct Genetic Elements, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2021, 第 4 作者
（6） Systematic analysis of supervised machine learning as an effective approach to predicate beta-lactam resistance phenotype in Streptococcus pneumoniae, BRIEFINGS IN BIOINFORMATICS, 2020, 第 5 作者
（7） A new intrinsic aminoglycoside 6 '-N-acetyltransferase subclass, AAC(6 ')-III, in Burkholderia pseudomallei, Burkholderia mallei and Burkholderia oklahomensis, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2020, 第 1 作者
（8） Co-existence of the carbapenem resistance genes blaKPC-2 and blaNDM-1 in a Raoultella planticola isolate in China, JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2020, 第 7 作者
（9） A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus: naturally occurring variants reveal diverse resistance levels against chloramphenicol, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2019, 第 1 作者
（10） Real time monitoring of Aeromonas salmonicida evolution in response to successive antibiotic therapies in a commercial fish farm, ENVIRONMENTAL MICROBIOLOGY, 2019, 第 6 作者
（11） 细菌中基因组岛的转移与调控机制研究进展, Regulation, excision and horizontal transfer of genomic islands in bacteria, 微生物学通报, 2018, 第 2 作者
（12） Five novel carbapenem-hydrolysing OXA-type beta-lactamase groups are intrinsic in Acinetobacter spp., JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 第 2 作者
（13） A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination, PLOS GENETICS, 2017, 第 1 作者
（14） Iscr2 is associated with the dissemination of multiple resistance genes among vibrio spp. and pseudoalteromonas spp. isolated from farmed fish, ARCHIVES OF MICROBIOLOGY, 2017, 
（15） 细菌固有耐药的研究进展, The intrinsic resistance of bacteria, 遗传, 2016, 第 1 作者
（16） Identification of Novel Cryptic Aminoglycoside Phosphotransferases in Pseudomonas aeruginosa, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 第 1 作者
（17） Insights into the evolutionary trajectories of fluoroquinolone resistance in Streptococcus pneumoniae, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015, 第 1 作者
（18） Functional characterization and phylogenetic analysis of acquired and intrinsic macrolide phosphotransferases in the Bacillus cereus group, ENVIRONMENTAL MICROBIOLOGY, 2015, 第 4 作者
（19） Mechanism for transfer of transposon Tn2010 carrying macrolide resistance genes in Streptococcus pneumoniae and its effects on genome evolution, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 第 3 作者
（20） Characterization of a Multiresistant Mosaic Plasmid from a Fish Farm Sediment Exiguobacterium sp. Isolate Reveals Aggregation of Functional Clinic-Associated Antibiotic Resistance Genes, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2014, 第 5 作者
（21） 肺炎链球菌对氟喹诺酮类抗生素耐药研究进展, 中国实用内科杂志, 2014, 第 1 作者
（22） Identification of a novel resistance mutation in parE that confers high-level resistance to moxifloxacin in Streptococcus pneumoniae, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 第 1 作者

   

（ 1 ） 重组酶Iscr2和ResG协同介导耐药元件iscr2-sul2的移动机制研究, 负责人, 国家任务, 2021-01--2024-12
（ 2 ） 病原细菌中转移酶固有耐药组的发现及其进化研究, 负责人, 国家任务, 2016-01--2018-12