1. 阿尔茨海默病等神经精神疾病的遗传基础和发病机制

2. 转基因树鼩疾病模型建立

3. 线粒体与神经退行性疾病

2009-09--2014-12   中国科学院大学   博士
2005-09--2009-06   云南大学   学士

博士研究生

2014年于中国科学院大学获得理学博士学位

   

2018-01~现在, 中国科学院昆明动物研究所, 副研究员
2015-01~2017-12,中国科学院昆明动物研究所, 助理研究员

2015年   云南省科学技术奖励二等奖(自然科学奖); 项目名称: Leber遗传性视神经病遗传易感分析; 获奖人员: 姚永刚、张阿梅、余丹丹、毕蕊.

2015年  昆明市科学技术进步奖二等奖; 项目名称: 线粒体DNA突变对母系遗传性高血压影响的临床应用; 获奖人员: 郭皓，余丹丹，袁勇，郭立，毕蕊，田青，王玮，冯月梅，熊国昌

2013 年  三好学生标兵

2012年  中国科学院大学 国家奖学金

2012年  朱李月华优秀博士生奖

2011年  中国科学院院长奖，优秀奖

2010年  中国科学院地奥奖学金，二等奖

（1） Leber遗传性视神经病遗传易感分析, 二等奖, 省级, 2015

   

[1] Li, Yu, Xu, Min, Xiang, BoLin, Li, Xiao, Zhang, DengFeng, Zhao, Hui, Bi, Rui, Yao, YongGang. Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer's disease. NEUROPSYCHOPHARMACOLOGY. 2023, http://dx.doi.org/10.1038/s41386-023-01542-2.
[2] Xiao Li, Deng-Feng Zhang, Rui Bi, Li-Wen Tan, Xiaogang Chen, Min Xu, Yong-Gang Yao. Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease. ALZHEIMER'S RESEARCH & THERAPY[J]. 2023, 15(1): 1-14, http://dx.doi.org/10.1186/s13195-022-01159-5.
[3] Rui Bi, Yu Li, Min Xu, Quanzhen Zheng, DengFeng Zhang, Xiao Li, Guolan Ma, Bolin Xiang, Xiaojia Zhu, Hui Zhao, Xingxu Huang, Ping Zheng, YongGang Yao. Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing. The Innovation[J]. 2022, 3(6): 100329-, http://lib.cqvip.com/Qikan/Article/Detail?id=7108387636.
[4] Zheng, Quanzhen, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, LiWen, Lu, YaPing, Yao, YongGang. Exploring the Genetic Association of the ABAT Gene with Alzheimer's Disease. MOLECULAR NEUROBIOLOGY[J]. 2021, 58(5): 1894-1903, http://dx.doi.org/10.1007/s12035-020-02271-z.
[5] Yao, YuLin, Yu, Dandan, Xu, Ling, Gu, Tianle, Li, Yu, Zheng, Xiao, Bi, Rui, Yao, YongGang. Tupaia OASL1 Promotes Cellular Antiviral Immune Responses by Recruiting MDA5 to MAVS. JOURNAL OF IMMUNOLOGY[J]. 2020, 205(12): 3419-3428, https://www.webofscience.com/wos/woscc/full-record/WOS:000596840500017.
[6] Wu, Yong, Bi, Rui, Zeng, Chunhua, Ma, Changguo, Sun, Chunli, Li, Jingzheng, Xiao, Xiao, Li, Ming, Zhang, DengFeng, Zheng, Ping, Sheng, Nengyin, Luo, XiongJian, Yao, YongGang. Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci. EBIOMEDICINE[J]. 2019, 44: 530-541, http://dx.doi.org/10.1016/j.ebiom.2019.05.006.
[7] Wang, Guihong, Zhang, DengFeng, Jiang, HongYan, Fan, Yu, Ma, Lingyan, Shen, Zonglin, Bi, Rui, Xu, Min, Tan, Liwen, Shan, Baoci, Yao, YongGang, Feng, Tao. Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease. JOURNAL OF PSYCHIATRIC RESEARCH[J]. 2019, 113: 141-147, http://ir.kiz.ac.cn:8080/handle/152453/12407.
[8] Zhang, DengFeng, Fan, Yu, Xu, Min, Wang, Guihong, Wang, Dong, Li, Jin, Kong, LiLi, Zhou, Hejiang, Luo, Rongcan, Bi, Rui, Wu, Yong, Li, GuoDong, Li, Ming, Luo, XiongJian, Jiang, HongYan, Tan, Liwen, Zhong, Chunjiu, Fang, Yiru, Zhang, Chen, Sheng, Nengyin, Jiang, Tianzi, Yao, YongGang. Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese. NATIONAL SCIENCE REVIEW[J]. 2019, 6(2): 257-274, [9] Zhang, DengFeng, Xu, Min, Bi, Rui, Yao, YongGang. Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives. ACS CHEMICAL NEUROSCIENCEnull. 2019, 10(2): 890-901, http://dx.doi.org/10.1021/acschemneuro.8b00435.
[10] Xu, Min, Zhang, DengFeng, Luo, Rongcan, Wu, Yong, Zhou, Hejiang, Kong, LiLi, Bi, Rui, Yao, YongGang. A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease. ALZHEIMERS & DEMENTIA[J]. 2018, 14(2): 215-229, http://dx.doi.org/10.1016/j.jalz.2017.08.012.
[11] Bi, Rui, Zhang, Wen, Zhang, DengFeng, Xu, Min, Fan, Yu, Hu, QiuXiang, Jiang, HongYan, Tan, Liwen, Li, Tao, Fang, Yiru, Zhang, Chen, Yao, YongGang. Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese. NEUROPSYCHOPHARMACOLOGY[J]. 2018, 43(11): 2264-2276, https://www.webofscience.com/wos/woscc/full-record/WOS:000444406700014.
[12] DengFeng Zhang, Dong Wang, YongGang Yao, Mahadev Malhi, Rui Bi, Yong Wu, Min Xu, XiuFeng Yu, Heng Long, YuYe Li. Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese. THE AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2018, 102(102): 794–805-, http://159.226.149.26:8080/handle/152453/12340.
[13] Yu Fan, Rongcan Luo, LingYan Su, Qun Xiang, Dandan Yu, Ling Xu, JiaQi Chen, Rui Bi, DongDong Wu, Ping Zheng, YongGang Yao. Does the Genetic Feature of the Chinese Tree Shrew ( Tupaia belangeri chinensis ) Support Its Potential as a Viable Model for Alzheimer’s Disease Research?. JOURNAL OF ALZHEIMER'S DISEASE: JAD[J]. 2018, 61(3): http://doi: 10.3233/JAD-170594..
[14] Wang, D, Zhang, D F, Li, G D, Bi, R, Fan, Y, Wu, Y, Yu, X F, Long, H, Li, Y Y, Yao, Y G. A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China. BRITISH JOURNAL OF DERMATOLOGY[J]. 2018, 178(4): 931-939, http://159.226.149.26:8080/handle/152453/12341.
[15] Bi, Rui, Kong, LiLi, Xu, Min, Li, GuoDong, Zhang, DengFeng, Li, Tao, Fang, Yiru, Zhang, Chen, Zhang, Buchang, Yao, YongGang. The Arc Gene Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese. MOLECULAR NEUROBIOLOGY[J]. 2018, 55(2): 1217-1226, http://www.corc.org.cn/handle/1471x/2154716.
[16] Wang, Dong, Fan, Yu, Malhi, Mahadev, Bi, Rui, Wu, Yong, Xu, Min, Yu, XiuFeng, Long, Heng, Li, YuYe, Zhang, DengFeng, Yao, YongGang. Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese. AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2018, 102(5): 794-805, http://dx.doi.org/10.1016/j.ajhg.2018.03.006.
[17] Rakha, Allah, Fatima, Peng, MinSheng, Adan, Atif, Bi, Rui, Yasmin, Memona, Yao, YongGang. mtDNA sequence diversity of Hazara ethnic group from Pakistan. FORENSIC SCIENCE INTERNATIONAL-GENETICS[J]. 2017, 30(**): E1-E5, http://159.226.149.26:8080/handle/152453/11950.
[18] Bi R, Logan I, Yao YG. Leber Hereditary Optic Neuropathy: A Mitochondrial Disease Unique in Many Ways. HANDBOOK OF EXPERIMENTAL PHARMACOLOGY[J]. 2017, **(**): Published online-, http://www.irgrid.ac.cn/handle/1471x/1154520.
[19] Zhang, AMei, Bi, Rui, Hu, QiuXiang, Fan, Yu, Zhang, Qingjiong, Yao, YongGang. The OPA1 Gene Mutations Are Frequent in Han Chinese Patients with Suspected Optic Neuropathy. MOLECULARNEUROBIOLOGY[J]. 2017, 54(3): 1622-1630, https://www.webofscience.com/wos/woscc/full-record/WOS:000398506900003.
[20] Xiang Qun, Bi Rui, Xu Min, Zhang DengFeng, Tan Liwen, Zhang Chen, Fang Yiru, Yao YongGang. Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer’s Disease in Han Chinese. MOLECULARNEUROBIOLOGY[J]. 2017, [21] Li, ChaoHui, Yan, LanZhen, Ban, WenZan, Tu, Qiu, Wu, Yong, Wang, Lin, Bi, Rui, Ji, Shuang, Ma, YuHua, Nie, WenHui, Lv, LongBao, Yao, YongGang, Zhao, XuDong, Zheng, Ping. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. CELL RESEARCH[J]. 2017, 27(2): 241-252, https://www.webofscience.com/wos/woscc/full-record/WOS:000394187900007.
[22] Li, GuoDong, Bi, Rui, Zhang, DengFeng, Xu, Min, Luo, Rongcan, Wang, Dong, Fang, Yiru, Li, Tao, Zhang, Chen, Yao, YongGang. Female-specific effect of the BDNF gene on Alzheimer's disease. NEUROBIOLOGY OF AGING[J]. 2017, 53(X): 192.e11-192.e19, http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.023.
[23] Xiang, Qun, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, Liwen, Zhang, Chen, Fang, Yiru, Yao, YongGang. Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer's Disease in Han Chinese. MOLECULAR NEUROBIOLOGY[J]. 2017, 54(7): 5192-5200, http://dx.doi.org/10.1007/s12035-016-0065-2.
[24] Wang Dong, Li GuoDong, Fan Yu, Zhang DengFeng, Bi Rui, Yu XiuFeng, Long Heng, Li YuYe, Yao YongGang. The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China. JOURNAL OF DERMATOLOGICAL SCIENCE[J]. 2017, [25] Li, Hong, Bi, Rui, Fan, Yu, Wu, Yong, Tang, Yanqing, Li, Zongchang, He, Ying, Zhou, Jun, Tang, Jinsong, Chen, Xiaogang, Yao, YongGang. mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia. MOLECULAR NEUROBIOLOGY[J]. 2017, 54(6): 4343-4352, https://www.webofscience.com/wos/woscc/full-record/WOS:000405710900033.
[26] Wang, HuiZhen, Bi, Rui, Hu, QiuXiang, Xiang, Qun, Zhang, Chen, Zhang, DengFeng, Zhang, Wen, Ma, Xiaohong, Guo, Wanjun, Deng, Wei, Zhao, Liansheng, Ni, Peiyan, Li, Mingli, Fang, Yiru, Li, Tao, Yao, YongGang. Validating GWAS-Identified Risk Loci for Alzheimer's Disease in Han Chinese Populations. MOLECULAR NEUROBIOLOGY[J]. 2016, 53(1): 379-390, http://dx.doi.org/10.1007/s12035-014-9015-z.
[27] Zhang, DengFeng, Li, Jin, Wu, Huan, Cui, Yue, Bi, Rui, Zhou, HeJiang, Wang, HuiZhen, Zhang, Chen, Wang, Dong, Kong, QingPeng, Li, Tao, Fang, Yiru, Jiang, Tianzi, Yao, YongGang, ADNI. CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease. NEUROPSYCHOPHARMACOLOGY[J]. 2016, 41(4): 1034-1045, http://dx.doi.org/10.1038/npp.2015.232.
[28] Zhang, DengFeng, Fan, Yu, Wang, Dong, Bi, Rui, Zhang, Chen, Fang, Yiru, Yao, YongGang. PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses. MOLECULAR NEUROBIOLOGY[J]. 2016, 53(6): 4034-4045, http://www.corc.org.cn/handle/1471x/2374523.
[29] Wang, HuiZhen, Bi, Rui, Zhang, DengFeng, Li, GuoDong, Ma, XiaoHong, Fang, Yiru, Li, Tao, Zhang, Chen, Yao, YongGang. Neprilysin Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese. MOLECULAR NEUROBIOLOGY[J]. 2016, 53(7): 4883-4892, http://www.corc.org.cn/handle/1471x/2374429.
[30] Bi, Rui, Tang, Jinsong, Zhang, Wen, Li, Xiao, Chen, ShiYi, Yu, Dandan, Chen, Xiaogang, Yao, YongGang. Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. SCHIZOPHRENIA RESEARCH[J]. 2016, 171(1-3): 200-206, http://dx.doi.org/10.1016/j.schres.2016.01.011.
[31] Guo, Li, Yuan, Yong, Bi, Rui. Mitochondrial DNA mutation m.5512A > G in the acceptor-stem of mitochondrial tRNA(Trp) causing maternally inherited essential hypertension. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2016, 479(4): 800-807, http://dx.doi.org/10.1016/j.bbrc.2016.09.129.
[32] Bi, Rui, Zhang, Wen, Yu, Dandan, Li, Xiao, Wang, HuiZhen, Hu, QiuXiang, Zhang, Chen, Lu, Weihong, Ni, Jianliang, Fang, Yiru, Li, Tao, Yao, YongGang. Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese. NEUROBIOLOGY OF AGING[J]. 2015, 36(3): 1604.e7-1604.e16, http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.009.
[33] Bi, Rui, Zhao, Liansheng, Zhang, Chen, Lu, Weihong, Feng, JiaQi, Wang, Yingcheng, Ni, Jianliang, Zhang, Jiangtao, Li, GuoDong, Hu, QiuXiang, Wang, Dong, Yao, YongGang, Li, Tao. No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals. NEUROBIOLOGY OF AGING[J]. 2014, 35(2): 444.e5-444.e9, http://dx.doi.org/10.1016/j.neurobiolaging.2013.08.013.
[34] Zheng, Min, Bi, Rui, Li, Wei, Landeck, Lilla, Chen, JiaQi, Lao, LiMin, Cai, SuiQing, Yao, YongGang, Man, XiaoYong. Generalized Pure Cutaneous Rosai-Dorfman Disease: a Link Between Inflammation and Cancer Not Associated with Mitochondrial DNA and SLC29A3 Gene Mutation?. DISCOVERY MEDICINE[J]. 2013, 16(89): 193-200, http://www.irgrid.ac.cn/handle/1471x/1154468.
[35] Bi, Rui, Zhang, AMei, Jia, Xiaoyun, Zhang, Qingjiong, Yao, YongGang. Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G > A and Leber hereditary optic neuropathy. MOLECULAR VISION[J]. 2012, 18(316): 3087-3094, [36] Bi, Rui, Zhang, AMei, Yao, YongGang. Leber's Hereditary Optic Neuropathy. OPHTHALMOLOGYnull. 2011, 118(7): 1489-1489, http://dx.doi.org/10.1016/j.ophtha.2011.04.007.
[37] Bi, Rui, Li, WenLiang, Chen, MingQing, Zhu, Zhu, Yao, YongGang. Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS[J]. 2011, 709-10(X): 15-20, http://dx.doi.org/10.1016/j.mrfmmm.2011.02.016.
[38] Bi, Rui, Zhang, AMei, Zhang, Wen, Kong, QingPeng, Wu, BeiLing, Yang, XiaoHong, Wang, Dong, Zou, Yang, Zhang, YaPing, Yao, YongGang. The Acquisition of an Inheritable 50-bp Deletion in the Human mtDNA Control Region Does Not Affect the mtDNA Copy Number in Peripheral Blood Cells. HUMAN MUTATION[J]. 2010, 31(5): 538-543, http://www.irgrid.ac.cn/handle/1471x/1150636.
[39] Bi, Rui, Zhang, AMei, Yu, Dandan, Chen, Diana, Yao, YongGang. Screening the three LHON primary mutations in the general Chinese population by using an optimized multiplex allele-specific PCR. CLINICA CHIMICA ACTA[J]. 2010, 411(21-22): 1671-1674, http://dx.doi.org/10.1016/j.cca.2010.06.026.
[40] Rui Bi, Yu Li, Min Xu, Quanzhen Zheng, DengFeng Zhang, Xiao Li, Guolan Ma, Bolin Xiang, Xiaojia Zhu, Hui Zhao, Xingxu Huang, Ping Zheng, YongGang Yao. Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing. THE INNOVATION. http://dx.doi.org/10.1016/j.xinn.2022.100329.

   

（ 1 ） 线粒体基因变异和功能异常参与阿尔茨海默病发生的遗传机制, 主持, 国家级, 2020-01--2023-12
（ 2 ） 中国科学院青年创新促进会, 主持, 部委级, 2020-01--2023-12
（ 3 ） 基于外显子捕获技术研究线粒体基因影响阿尔茨海默病风险的遗传机制, 主持, 省级, 2019-10--2022-09
（ 4 ） 云南省万人计划青年拔尖人才, 主持, 省级, 2019-01--2023-12