071007-遗传学

病毒感染动物模型建立与抗病毒天然免疫研究

2002-09--2005-06   南京农业大学   硕士
1998-09--2002-06   南京农业大学   本科

   

2007-12~现在, 中国科学院昆明动物研究所, 副研究员
2005-07~2007-11,中国农业科学院上海兽医研究所, 研究实习员
2002-09~2005-06,南京农业大学, 硕士
1998-09~2002-06,南京农业大学, 本科

   

（1） Leber遗传性视神经病遗传易感研究, 二等奖, 省级, 2015

   

（1） SARS-CoV-2 Spike protein S2 subunit modulates gama-secretase and enhances amyloid-beta production in COVID-19 neuropathy, Cell Discovery, 2022, 
（2） Characterizing the role of Tupaia DNA damage inducible transcript 3 (DDIT3) gene in viral infections, Developmental & Comparative Immunology, 2022, 通讯作者
（3） Characteristics of replication and pathogenicity of SARS-CoV-2 Alpha and Delta isolates, VIROLOGICA SINICA, 2022, 第 2 作者
（4） Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection, Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection, 动物学研究(英文), 2022, 其他（合作组作者）
（5） A combination vaccine against SARS-CoV-2 and H1N1 influenza based on receptor binding domain trimerized by six-helix bundle fusion core, EBIOMEDICINE, 2022, 第 8 作者
（6） Optimization of Milk Substitutes for the Artificial Rearing of Chinese Tree Shrews (Tupaia belangeri chinensis), ANIMALS, 2022, 第 3 作者
（7） Infectivity of SARS-CoV-2 and protection against reinfection in rats, Infectivity of SARS-CoV-2 and protection against reinfection in rats, 动物学研究(英文), 2022, 第 1 作者
（8） SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, CELL RESEARCH, 2021, 第 24 作者
（9） Tupaia guanylate-binding protein 1 interacts with vesicular stomatitis virus phosphoprotein and represses primary transcription of the viral genome, CYTOKINE, 2021, 第 2 作者
（10） Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, ZOOLOGICAL RESEARCH, 2021, 第 9 作者
（11） Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2, Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2, CELL RESEARCH, 2021, 第 16 作者
（12） Tupaia OASL1 Promotes Cellular Antiviral Immune Responses by Recruiting MDA5 to MAVS, JOURNAL OF IMMUNOLOGY, 2020, 第 2 作者
（13） An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3, JOURNAL OF IMMUNOLOGY, 2020, 第 2 作者
（14） Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B, JOURNAL OF IMMUNOLOGY, 2020, 第 2 作者
（15） COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2（共同第一）, Zoological Research, 2020, 第 1 作者
（16） Establishment and transcriptomic features of an immortalized hepatic cell line of the Chinese tree shrew, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 通讯作者
（17） Tupaia MAVS is a dual target during hepatitis C virus infection for innate immune evasion and viral replication via NF-κB （共同第一）, The Journal of Immunology, 2020, 第 1 作者
（18） Molecular characterization of the 2′,5′-oligoadenylate synthetase family in the Chinese tree shrew (Tupaia belangeri chinensis), CYTOKINE, 2019, 第 2 作者
（19） Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew （Tupaia belangeri chinesis） （共同通讯）, Applied Microbiology and Biotechnology, 2019, 通讯作者
（20） Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis), APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 第 2 作者
（21） Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I, Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I, JOURNAL OF GENETICS AND GENOMICS, 2019, 第 2 作者
（22） Molecular identification and antiviral function of the guanylate-binding protein (GBP) genes in the Chinese tree shrew (Tupaia belangeri chinesis), DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 第 2 作者
（23） The 3 ' UTR of human MAVS mRNA contains multiple regulatory elements for the control of protein expression and subcellular localization, BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2019, 第 4 作者
（24） Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew ( Tupaia belangeri chinensis ), DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2016, 第 1 作者
（25） Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew（共同第一）, Proceedings of the National Academy of Sciences of the United States of America, 2016, 第 1 作者
（26） Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia, SCHIZOPHRENIA RESEARCH, 2016, 第 6 作者
（27） Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis), DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2015, 第 2 作者
（28） Molecular characterization, tissue distribution and expression analysis of TRIM25 in Gallus gallus domesticus, GENE, 2015, 第 5 作者
（29） Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens, GENE, 2014, 第 1 作者
（30） IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma, MEDICAL SCIENCE MONITOR, 2014, 通讯作者
（31） Diverse Interleukin-7 mRNA Transcripts in Chinese Tree Shrew (Tupaia belangeri chinensis), PLOS ONE, 2014, 第 1 作者
（32） Is mitochondrial tRNA(phe) variant m.593T>C a synergistically pathogenic mutation in Chinese LHON families with m.11778G>A?, PLOS ONE, 2011, 第 6 作者
（33） Mitochondrial DNA Sequence Variation and Haplogroup Distribution in Chinese Patients with LHON and m.14484T > C, PLOS ONE, 2010, 通讯作者
（34） Molecular characterization of six Chinese families with m.3460G > A and Leber hereditary optic neuropathy, NEUROGENETICS, 2010, 第 1 作者
（35） Reverse genetic manipulation of the overlapping coding regions for structural proteins of the type II porcine reproductive and respiratory syndrome virus, VIROLOGY, 2009, 第 1 作者

   

（ 1 ） lncRNA调控树鼩天然免疫反应及影响HCV复制的机制研究, 负责人, 地方任务, 2018-06--2021-05
（ 2 ） 线粒体MAVS基因3'UTR在家鸡抗病毒感染过程中的作用机制研究, 负责人, 国家任务, 2011-01--2013-12
（ 3 ） 树鼩基因组数据库与生物信息平台搭建, 负责人, 地方任务, 2013-10--2016-09
（ 4 ） 树鼩HCV进入因子EphA2影响HCV复制及持续性感染的研究, 负责人, 地方任务, 2020-06--2023-05
（ 5 ） 干扰素刺激基因影响树鼩抗病毒免疫反应的遗传机制, 负责人, 中国科学院计划, 2021-01--2023-12