课题组主要以计算生物学、进化遗传学和高通量基因组测序技术为手段，研究体细胞和肿瘤细胞的基因组进化模式与机制，并探讨其在临床中的意义。课题组的主要研究方向有：1）基于高通量测序数据和单细胞数据，构建体细胞和肿瘤细胞的克隆进化历史；2）采用定量模型阐述组织更新、肿瘤发生和转移过程中的群体动力学；3）结合高通量测序技术、定量模型和实验，解析利用合成细菌治疗实体肿瘤中的细胞相互作用和适应性基因组进化。

招收博士生和硕士生。

071010-生物化学与分子生物学
071007-遗传学
0710J3-生物信息学

肿瘤克隆进化
肿瘤转移与耐药机制

2010-09--2015-06   中科院北京基因组研究所   博士
2006-09--2010-06   华中科技大学   本科

   

   

（1） 创新基因组研究所博士后奖, , 其他, 2016
（2） 人类前沿科学项目奖, , 其他, 2016
（3） 中国科学院院长优秀奖, 院级, 2013
（4） 中国青少年科技创新奖, 国家级, 2010

   

[1] Kaya, Neslihan A, Chen, Jianbin, Lai, Hannah, Yang, Hechuan, Ma, Liang, Liu, Xiaodong, Alvarez, Jacob Santiago, Liu, Jin, Hillmer, Axel M, Tai, David, Sheng, Joe Yeong Poh, Hu, Zheng, Chan, Yun Shen, Chow, Pierce K H, Mu, Yuguang, Wuestefeld, Torsten, Zhai, Weiwei. Genome instability is associated with ethnic differences between Asians and Europeans in hepatocellular carcinoma. THERANOSTICS[J]. 2022, 12(10): 4703-4717, http://dx.doi.org/10.7150/thno.71676.
[2] Li, Zhichao, Xu, Haibo, Gong, Yanqing, Chen, Wei, Zhan, Yonghao, Yu, Lei, Sun, Yangyang, Li, Aolin, He, Shiming, Guan, Bao, Wu, Yucai, Xiong, Gengyan, Fang, Dong, He, Yuhui, Tang, Qi, Yao, Lin, Hu, Zheng, Mei, Hongbing, He, Zhisong, Cai, Zhiming, Guo, Yinglu, Li, Xuesong, Zhou, Liqun, Huang, Weiren. Patient-Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening. ADVANCED SCIENCE[J]. 2022, 9(4): http://dx.doi.org/10.1002/advs.202103999.
[3] Tang, Zhongjie, Lu, Zhaolian, Chen, Baizhen, Zhang, Weixing, Chang, Howard Y, Hu, Zheng, Xu, Jin. A Genetic Bottleneck of Mitochondrial DNA During Human Lymphocyte Development. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2022, 39(5): http://dx.doi.org/10.1093/molbev/msac090.
[4] 白艳芬, 聂朋, 熊成鹤, 温骏林, 甘海云, 马晴, 胡政, 李雪飞, 于涛, 黄建东, 梅辉. 以非天然核酸为遗传物质的人工生命构建. 科学通报[J]. 2021, 66(3): 347-355, https://www.sciengine.com/doi/10.1360/TB-2020-0474.
[5] Hu, Zheng, Li, Zan, Ma, Zhicheng, Curtis, Christina. Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases. NATURE GENETICS[J]. 2020, 52(7): 701-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343625/.
[6] Hu, Zheng, Curtis, Christina. Looking backward in time to define the chronology of metastasis. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-16995-y.
[7] Hu, Zheng, Ding, Jie, Ma, Zhicheng, Sun, Ruping, Seoane, Jose A, Shaffer, J Scott, Suarez, Carlos J, Berghoff, Anna S, Cremolini, Chiara, Falcone, Alfredo, Loupakis, Fotios, Birner, Peter, Preusser, Matthias, Lenz, HeinzJosef, Curtis, Christina. Quantitative evidence for early metastatic seeding in colorectal cancer. NATURE GENETICS[J]. 2019, 51(7): 1113-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000473491900010.
[8] Sun, Ruping, Hu, Zheng, Sottoriva, Andrea, Graham, Trevor A, Harpak, Arbel, Ma, Zhicheng, Fischer, Jared M, Shibata, Darryl, Curtis, Christina. Between-region genetic divergence reflects the mode and tempo of tumor evolution. NATURE GENETICS[J]. 2017, 49(7): 1015-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000404253300010.

   

（1）Evolutionary dynamics of tumor growth and metastases   2019-12-02
（2）The timing and determinants of metastatic progression   2019-10-07
（3）Inferring the origin of metastasis throughspatial-temporal modeling   2017-11-04
（4）Quantitative evidence for early metastatic dissemination in colorectal cancer   2017-09-26