1. Natural product total synthesis

2. New chemical entity small molecule library construction

3. Target identification and verification of natural product

2009-09~2014-06   Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Ph.D.

2004-09~2009-06   Nanjing University, China, B.S.

2019-01~2019-10   Postdoctoral Associate, Scripps Research(Calibr devision, with Mike H. Petrassi)
2015-05~2018-12   Postdoctoral Associate, Scripps Research(Department of Chemistry, with Professor Phil S. Baran)
2014-07~2015-04   Research Assistant, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (with Professor Guo-Qiang Lin)

1.       Wang, J.; Sun, B.-F.*; Cui, K.; Lin, G.-Q.* An Efficient Total Synthesis of (–)-Epothilone B. Org. Lett. 2012, 14, 6354–6357.

2.       Wang, J.; Chen, S.-G.; Sun, B.-F.*; Lin, G.-Q.*; Shang Y.-J. Collective Total Synthesis of Englerin A and B, Orientalol E and F, and Oxyphyllol: Application of the Organocatalytic [4+3] Cycloaddition Reaction. Chem. Eur. J. 2013, 19, 2539–2547.

3.       Wang, X.-L.; Lu, Y.-Y.; Wang, J.; Wang, X.; Lin, G.-Q.*; Yao, H.-Q.; Sun, B.-F.* A Novel Synthetic Approach to the Bicyclo[5, 3, 1]undecan-11-one Framework of Vinigrol. Org. Biomol. Chem. 2014, 12, 3562–3566.

4.       Li, Y.-Z.; Wang, J.; Sun, W.-B.; Shan, Y.-F.; Sun, B.-F.*; Lin, G.-Q.*; Zou, J.-P. Enantioselective Synthesis of Bicyclo[2.2.2]octane-1-carboxylates under Metal Free Conditions. Org. Chem. Front. 2015, 2, 274–278.

5.       Wang, J.; Sun, W.-B.; Li, Y.-Z.; Wang, X.; Sun, B.-F.*; Lin G.-Q.*; Zou J.-P. A Concise Formal Synthesis of Platencin. Org. Chem. Front. 2015, 2, 674–676.

6.       Gianatassio, R.; Lopchuk, J. M.; Wang, J.; Pan, C.-M.; Malins, L. R.; Prieto, L.; Brandt, T. A.; Collins, M. R.; Gallego, G. M.; Sach, N. W.; Spangler, J. E.; Zhu, H.; Zhu, J.; Baran, P. S.* Strain-Release Amination. Science 2016, 351, 241–246.

7.       Cornella, J.; Edwards, J. T.; Qin, T,; Kawamura, S.; Wang, J.; Pan, C.-M.; Gianatassio, R.; Schmidt, M.; Eastgate, M. D.; Baran, P. S.* Practical Ni-Catalyzed Aryl−Alkyl Cross-Coupling of Secondary Redox-Active Esters.J. Am. Chem. Soc. 2016, 138, 2174–2177.

8.       Wang, J.; Qin, T.; Chen, T.-G.; Wimmer, L.; Edwards, J. T.; Cornella, J.; Vokits, B.; Shaw, S. A.; Baran, P. S.* Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids. Angew. Chem. Int. Ed. 2016, 55, 9676–9679.

9.       Lopchuk, J. M.; Fjelbye K.; Kawamata, Y.; Malins, L. R.; Pan C.-M.; Gianatassio, R.; Wang, J.; Prieto, L.; Bradow, J.; Brandt, T. A.; Collins, M. R.; Elleraas, J.; Ewanicki, J.; Farrell, W.; Fadeyi, O. O.; Gallego, G. M.; Mousseau, J. J.; Oliver, R.; Sach, N. W.; Smith, J. K.; Spangler, J. E.; Zhu, H.; Zhu, J.; Baran P. S.* Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity.J. Am. Chem. Soc. 2017, 139, 3209–3226.

10.    Li, C.;^† Wang, J.;^† Barton L. M.; Yu, S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu, A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S.* Decarboxylative Borylation. Science 2017, 356, eaam7355. (^†Contributed equally)

11.    Wang, J.;^† Lundberg, H.;^† Asaia, S.; Martin-Acosta, P.; Chen, J. S.; Brown, S.; Farrell, W.; Dushin, R.; O’Donnell, C. J.; Ratnayake, A. S.; Richardson, P.; Liu, Z.; Qin, T.; Blackmond, D. G.*; Baran, P. S.* Kinetically Guided Radical-Based Synthesis of C(sp³)-C(sp³) Linkages on DNA. Proc. Natl. Acad. Sci. U. S. A. 2018, 115, E6404–E6410. (^†Contributed equally)

12.    Wang, J.;^† Shang, M.;^† Lundberg, H.; Feu, K. S.; Hecker, S. J.; Qin, T.; Blackmond, D. G.*; Baran, P. S.* Cu-Catalyzed Decarboxylative Borylation. ACS Catal. 2018, 8, 9537–9542. (^†Contributed equally)

13.    Flood, D. T.; Asai, S.; Zhang, X.; Wang, J.; Yoon, L.; Adams, Z. C.; Dillingham, B. C.; Sanchez, B. B.; Vantourout, J. C; Flanagan, M. E.; Piotrowski, D. W.; Richardson, P.; Green, S. A; Shenvi, R. A.; Chen, J. S.; Baran, P. S.*; Dawson, P. E.* Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support. J. Am. Chem. Soc. 2019, 141, 9998–10006.

（ 1 ） CN102268031B, Synthetic intermediate of carbon segment 1-6 of epothilone, synthetic method and usage, 2014
（ 2 ） CN102675357B, Synthetic intermediate of carbon segment 7-19 of epothilone, synthetic method and usage, 2015
（ 3 ） WO2018/175173A1, Cu- and Ni-catalyzed decarboxylative borylation reactions, 2017
（ 4 ） WO/2021/035257A1, Monocyclic agonists of stimulator of interferon genes sting, 2019
（ 5 ） WO2021035258A1, Bicyclic agonists of stimulator of interferon genes sting, 2019

1. Natural product total synthesis

2. New chemical entity small molecule library construction

3. Target identification and verification of natural product

1.      Enantioselective synthesis of bicyclo[2.2.2]octane-1-carboxylates: application to formal synthesis of platencin (poster). Wang, J.;* Li Y.-Z.; Sun B.-F.; Lin G.-Q. Second International Symposium on Natural Product. Nanjing, China, 2014.

2.      Forging C(sp³)-C(sp³) and C(sp³)-C(sp²) bonds in DEL format (invited talk). Wang, J.* 8th International Symposium on DNA-Encoded Chemical Libraries. Chengdu, China, 2018.

现指导学生

周进锌  硕士研究生  078001-药物化学