基本信息
王玉田  男  博导  中国科学院深圳先进技术研究院
电子邮件: wangyt@siat.ac.cn
通信地址: 中国科学院深圳先进技术研究院
邮政编码:

招生信息

   
招生专业
071006-神经生物学
071010-生物化学与分子生物学
071009-细胞生物学
招生方向
学习与记忆,突触可塑性,长时程易化,长时程抑制,突触传递,神经中枢,神经网络,神经介质,神经介质受体,GABA-A受体,NMDA受体,AMPA受体,焦虑症,抑郁症,神经保护,自闭症
神经生物学、生物化学与分子生物学、细胞生物学、微生物学均可

教育背景

1988-09--1992-07   加拿大纽芬兰纪念大学医学院   博士
1982-09--1985-07   山东大学医学院生理系   硕士
1977-09--1982-07   山东大学医学院   学士

工作经历

   
工作简历
2019-12~现在, 中国科学院深圳先进技术研究院, 研究员
2001-07~现在, 加拿大不列颠哥伦比亚大学医学系, 终生教授及 BC & Y 中 风研究讲席教授
2000-07~2001-07,加拿大多伦多大学医学院实验医学和 病理学系, 副教授
1994-07~2000-07,加拿大多伦多大学医学院实验医学和 病理学系, 助理教授
1992-09~1994-06,加拿大多伦多大学医学院, 博士后
1985-09~1988-07,山东大学医学院生理系, 助教、讲师
1981-01~1982-07,山东大学医学院齐鲁医院, 实习医师

专利与奖励

   
奖励信息
(1) Innovation Award of the Canadian College of Neuropscyhopharmacology, , 其他, 2017
(2) Fellow of the Royal Society of Canada (the Academy of Sciences of Canada), 其他, 2006
(3) Killam Professor, UBC, 其他, 2005
(4) The J.A.F. Stevenson Lecturer of the Canadian Physiological Society, 其他, 2004
(5) UBC Distinguished University Scholar, 其他, 2002
(6) Michael Smith Foundation for Health Research Senior Scholar, 其他, 2002
(7) Howard Hughes Medical Institute International Scholar, 其他, 2001
(8) Canadian Institutes of Health Research Investigator, 其他, 2001
专利成果
( 1 ) INHIBITORS OF PHOSPHATASE AND TENSIN HONOLOG(PTEN) COMPOSITIONS,USES AND METHODS, 发明, 2016, 第 1 作者, 专利号: CA2777628
( 2 ) PEPTIDE DIRECTED PROTEIN KNOCKDOWN, 发明, 2019, 第 1 作者, 专利号: US2019/0315819A1
( 3 ) INHIBITORS OF PHOSPHATASE AND TENSIN HONOLOG(PTEN) COMPOSITIONS,USES AND METHODS, 发明, 2016, 第 1 作者, 专利号: US10258666B2
( 4 ) N-methyl-D-aspartate receptor (NMDAR) allosteric modulators and methods for their use., 发明, 2017, 第 1 作者, 专利号: PCT/CN2017/103398

出版信息

   
发表论文
[1] Aleksandrova, Lily R, Chen, Wenlin, Wang, Yu Tian. An Erbin Story: Amygdala Excitation-Inhibition Balance in Anxiety. BIOLOGICAL PSYCHIATRYnull. 2020, 87(10): 872-874, http://dx.doi.org/10.1016/j.biopsych.2020.03.005.
[2] Wang Yutian. NMDARs in Cell Survival and Death: Implications in Stroke Pathogenesis and Treatments.. Trends in Molecular Medicine. 2020, [3] Shuo Yu, Yumeng Li, Jinqin Chen, Yue Zhang, Xinling Tao, Qiuyun Dai, Yutian Wang, Shupeng Li, Mingxin Dong. TAT-Modified ω-Conotoxin MVIIA for Crossing the Blood-Brain Barrier. MARINE DRUGS[J]. 2019, 17(5): https://doaj.org/article/80e3f1a8ca76481fa9b16cbc9207dbac.
[4] Bai, YunFei, Chiu, Michelle, Chan, Elizabeth S, AxerioCilies, Peter, Lu, Jie, Huh, Linda, Connolly, Mary B, Guella, Ilaria, Farrer, Matthew J, Xu, ZhiQing David, Liu, Lidong, Demos, Michelle, Wang, Yu Tian. Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy. MOLECULAR BRAIN[J]. 2019, 12(1): http://dx.doi.org/10.1186/s13041-019-0513-9.
[5] Awasthi, Ankit, Ramachandran, Binu, Ahmed, Saheeb, Benito, Eva, Shinoda, Yo, Nitzan, Noam, Heukamp, Alina, Rannio, Sabine, Martens, Henrik, Barth, Jonas, Burk, Katja, Wang, Yu Tian, Fischer, Andre, Dean, Camin. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. SCIENCE[J]. 2019, 363(6422): 44-+, http://dx.doi.org/10.1126/science.aav1483.
[6] Aleksandrova, Lily R, Wang, Yu Tian, Phillips, Anthony G. Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant response. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWSnull. 2019, 105: 1-23, http://dx.doi.org/10.1016/j.neubiorev.2019.07.007.
[7] Zhou, Liqing, Chen, Long, Li, Xiaohuan, Li, Tingyu, Dong, Zhifang, Wang, Yu Tian. Food allergy induces alteration in brain inflammatory status and cognitive impairments. BEHAVIOURAL BRAIN RESEARCH[J]. 2019, 364: 374-382, http://dx.doi.org/10.1016/j.bbr.2018.01.011.
[8] Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jrgen Kast, Jie Lu, Yu Tian Wang. p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-16, http://dx.doi.org/10.1038/s41467-019-12096-7.
[9] Tan, Tao, Wang, Wei, Xu, Haitao, Huang, Zhilin, Wang, Yu Tian, Dong, Zhifang. Low-Frequency rTMS Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation Through Regulating the Synaptic GABA Transmission. FRONTIERS IN CELLULAR NEUROSCIENCE[J]. 2018, 12: https://doaj.org/article/d1bc49d5badb4c649cf0910730940127.
[10] Wang, Xiong, Liu, Dan, Huang, HeZhou, Wang, ZhiHao, Hou, TongYao, Yang, Xin, Pang, Pei, Wei, Na, Zhou, YaFan, Dupras, MarieJosee, Calon, Frederic, Wang, YuTian, Man, HengYe, Chen, JianGuo, Wang, JianZhi, Hebert, Sebastien S, Lu, Youming, Zhu, LingQiang. A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease. BIOLOGICAL PSYCHIATRY[J]. 2018, 83(5): 395-405, http://dx.doi.org/10.1016/j.biopsych.2017.07.023.
[11] Yu, Yanzhi, Huang, Zhilin, Dai, Chunfang, Du, Yehong, Han, Huili, Wang, Yu Tian, Dong, Zhifang. Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats. NEUROPHARMACOLOGY[J]. 2018, 133: 155-162, http://dx.doi.org/10.1016/j.neuropharm.2018.01.030.
[12] Connor, Steven A, Wang, Yu Tian. Getting "Ras''-ults: Solving Molecular Promiscuity through Microdomain-Selective Targeting. NEURONnull. 2018, 98(4): 675-678, http://dx.doi.org/10.1016/j.neuron.2018.05.001.
[13] Jin, Wuyang, Lin, Donghai, Nguyen, Anh H, Abdelrasoul, Gaser N, Chen, Jian, Ma, Arthur, Qian, Feng, Fang, Qiang, Kovalchuk, Igor, Wang, Yutian, Chen, Jie. Transfection of Difficult-to-Transfect Rat Primary Cortical Neurons with Magnetic Nanoparticles. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY[J]. 2018, 14(9): 1654-1664, https://www.webofscience.com/wos/woscc/full-record/WOS:000437426600012.
[14] Girling, Kimberly D, Demers, MarieJosee, Laine, Jean, Zhang, Shu, Wang, Yu Tian, Graham, Rona K. Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity. JOURNAL OF NEUROSCIENCE RESEARCH[J]. 2018, 96(3): 391-406, [15] Wang Yutian. Neuroprotective Effects of Ginsenoside Rf on Amyloid-β-Induced Neurotoxicity in vitro and in vivo.. Journal of Alzheimer's Disease.. 2018, [16] Connor, Steven A, AmmendrupJohnsen, Ina, Kishimoto, Yasushi, Tari, Parisa Karimi, Cvetkovska, Vedrana, Harada, Takashi, Ojima, Daiki, Yamamoto, Tohru, Wang, Yu Tian, Craig, Ann Marie. Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function. CELL REPORTS[J]. 2017, 21(13): 3637-3645, http://dx.doi.org/10.1016/j.celrep.2017.11.109.
[17] Aleksandrova Lily R., Phillips Anthony G., Wang Yu Tian. Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism. JOURNAL OF PSYCHIATRY & NEUROSCIENCE : JPN. 42(4): 222-229, https://www.webofscience.com/wos/woscc/full-record/WOS:000404331200003.

指导学生

现指导学生

周仕达  博士研究生  071006-神经生物学  

朱孝苍  博士研究生  071006-神经生物学