071006-神经生物学
071010-生物化学与分子生物学
071009-细胞生物学

神经退行性疾病
神经病理
阿兹海默症

2005-09--2012-01   中国科学院神经科学研究所   研究生，理学博士
2001-09--2005-07   武汉大学   本科，理学学士

研究生

理学博士

   

2018-03~2019-08,美国宾夕法尼亚大学, 副研究员
2013-03~2018-02,美国宾夕法尼亚大学, 博士后
2012-01~2012-11,中国科学院神经科学研究所, 助理研究员

   

（1） AAIC2019, 其他, 2019
（2） Cold Spring Harbor Asia, 一等奖, 其他, 2012

   

[1] Yuliang Han, Zhuohao He. Concomitant protein pathogenesis in Parkinson’s disease and perspective mechanisms. FRONTIERS IN AGING NEUROSCIENCE[J]. 2023, 15: https://doaj.org/article/5118533edb5944bdae0a7f87215ec9f6.
[2] Zhang, Shengnan, Zhu, Yi, Lu, Jinxia, Liu, Zhenying, Lobato, Amanda G, Zeng, Wen, Liu, Jiaqi, Qiang, Jiali, Zeng, Shuyi, Zhang, Yaoyang, Liu, Cong, Liu, Jun, He, Zhuohao, Zhai, R Grace, Li, Dan. Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation- induced pathology. ELIFE[J]. 2022, 11: http://dx.doi.org/10.7554/eLife.79898.
[3] Xu, Gang, Li, Ying, Zhang, Shengyuan, Peng, Haoran, Wang, Yunyun, Li, Dekang, Jin, Taijie, He, Zhuohao, Tong, Yilun, Qi, Chunting, Wu, Guowei, Dong, Kangyun, Gou, Jizhou, Liu, Yang, Xiao, Tongyang, Qu, Jing, Li, Liang, Liu, Liang, Zhao, Ping, Zhang, Zheng, Yuan, Junying. SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. CELL RESEARCH[J]. 2021, 31(12): 1230-1243, http://dx.doi.org/10.1038/s41422-021-00578-7.
[4] Darwich, Nabil F, Phan, Jessica M, Kim, Boram, Suh, EunRan, Papatriantafyllou, John D, Changolkar, Lakshmi, Nguyen, Aivi T, ORourke, Caroline M, He, Zhuohao, Porta, Silvia, Gibbons, Garrett S, Luk, Kelvin C, Papageorgiou, Sokratis G, Grossman, Murray, Massimo, Lauren, Irwin, David J, McMillan, Corey T, Nasrallah, Ilya M, Toro, Camilo, Aguirre, Geoffrey K, Van Deerlin, Vivianna M, Lee, Edward B. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. SCIENCE[J]. 2020, 370(6519): 932-+, http://dx.doi.org/10.1126/science.aay8826.
[5] Zhuohao He, Jennifer D McBride, Hong Xu, Lakshmi Changolkar, Soojung Kim, Bin Zhang, Sneha Narasimhan, Garrett S Gibbons, Jing L Guo, Michael Kozak, Gerard D Schellenberg, John Q Trojanowski, Virginia M Y Lee. Transmission of tauopathy strains is independent of their isoform composition. NATURE COMMUNICATIONS[J]. 2020, 11(1): 1-18, http://dx.doi.org/10.1038/s41467-019-13787-x.
[6] Weitzman, Sarah A, Narasimhan, Sneha, He, Zhuohao, Changolkar, Lakshmi, McBride, Jennifer D, Zhang, Bin, Schellenberg, Gerard D, Trojanowski, John Q, Lee, Virginia M Y. Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY[J]. 2020, 79(9): 941-949, http://dx.doi.org/10.1093/jnen/nlaa086.
[7] Xu, Daichao, Zhao, Heng, Jin, Minzhi, Zhu, Hong, Shan, Bing, Geng, Jiefei, Dziedzic, Slawomir A, Amin, Palak, Mifflin, Lauren, Naito, Masanori Gomi, Najafov, Ayaz, Xing, Jing, Yan, Lingjie, Liu, Jianping, Qin, Ying, Hu, Xinqian, Wang, Huibing, Zhang, Mengmeng, Manuel, Vica Jean, Tan, Li, He, Zhuohao, Sun, Zhenyu J, Lee, Virginia M Y, Wagner, Gerhard, Yuan, Junying. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. NATURE[J]. 2020, 587(7832): 133-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000572352700003.
[8] He Zhuohao. Abeta Plaques Enhance Alzheimer Brain Tau Seeded Pathologies Via Facilitating Neuritic Plaque Tau Aggregation.. Nature Medicine. 2018, [9] He, Zhuohao, Wang, Y. TRPC Channel Downstream Signaling Cascades. TRANSIENT RECEPTOR POTENTIAL CANONICAL CHANNELS AND BRAIN DISEASES[J]. 2017, 976: 25-33, https://www.webofscience.com/wos/woscc/full-record/WOS:000429061700003.
[10] Guo, Jing L, Narasimhan, Sneha, Changolkar, Lakshmi, He, Zhuohao, Stieber, Anna, Zhang, Bin, Gathagan, Ronald J, Iba, Michiyo, McBride, Jennifer D, Trojanowski, John Q, Lee, Virginia M Y. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2016, 213(12): 2635-2654, https://www.webofscience.com/wos/woscc/full-record/WOS:000391122400009.
[11] Feng, Shengjie, He, Zhuohao, Li, Hongyu, Wang, Yizheng. Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development. NEUROSCIENCE BULLETIN[J]. 2015, 31(3): 351-356, http://ir.sibs.ac.cn/handle/331001/3946.
[12] Junfeng Wang, Rui Lu, Jian Yang, Hongyu Li, Zhuohao He, Naihe Jing,, Xiaoming Wang, Yizheng Wang. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.. NATURE COMMUNICATIONS. 2015, 6: http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201804160009449LZ.
[13] Zhuohao He, Caixia Jia, Shengjie Feng, Kechun Zhou, Yilin Tai, Xue Bai, Yizheng Wang. TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKIIα in Rat Hippocampal Neurons. THE JOURNAL OF NEUROSCIENCE. 2012, 32(27): 9383-9395, [14] Ding, Xia, He, Zhuohao, Zhou, Kechun, Cheng, Ju, Yao, Hailan, Lu, Dongliang, Cai, Rong, Jin, Yening, Dong, Bin, Xu, Yinghui, Wang, Yizheng. Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE[J]. 2010, 102(14): 1052-1068, http://www.irgrid.ac.cn/handle/1471x/502214.
[15] He Zhuohao. Targeting TRPC6 channels in oesophageal carcinoma growth. Expert opinion on therapeutic targets. Expert opinion on therapeutic targets. 2010, [16] Shi, Y, Ding, X, He, ZH, Zhou, KC, Wang, Q, Wang, YZ. Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. GUT[J]. 2009, 58(11): 1443-1450, http://www.irgrid.ac.cn/handle/1471x/502351.
[17] Tai, Yilin, Feng, Shengjie, Ge, Ruiliang, Du, Wanlu, Zhang, Xiaoxing, He, Zhuohao, Wang, Yizheng. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. JOURNAL OF CELL SCIENCE[J]. 2008, 121(14): 2301-2307, http://www.irgrid.ac.cn/handle/1471x/502221.
[18] Narasimhan Sneha, Guo Jing L., Changolkar Lakshmi, Stieber Anna, McBride Jennifer D., Silva Luisa V., He Zhuohao, Zhang Bin, Gathagan Ronald J., Trojanowski John Q., Lee Virginia M.Y.. Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain. THE JOURNAL OF NEUROSCIENCE. 37(47): 11406-11423, https://www.webofscience.com/wos/woscc/full-record/WOS:000416595200011.

   

（ 1 ） Studying an Alzheimer's disease specific tau strain, 主持, 研究所（学校）, 2018-07--2021-06

（1）Understanding tau pathology transmission in AD and FTLD using new mouse models.   2019-07-14
（2）Understanding tau pathology transmission in AD and FTLD using new mouse models.   2019-06-18