基本信息
罗威伟  男  博导  中国科学院武汉病毒研究所
电子邮件: wwluo@wh.iov.cn
通信地址: 武汉市武昌区小洪山中区44号中国科学院武汉病毒研究所
邮政编码:

研究领域

(1)抗病毒天然免疫和炎症信号转导及其机制研究

(2)天然免疫和机体代谢的交互机制及其对病理进程的影响

招生信息

   
招生专业
071010-生物化学与分子生物学
100102-免疫学
招生方向
抗病毒免疫信号转导与调控
免疫代谢交互调控
病毒致病机理

教育背景

2011-09--2016-06   武汉大学   博士
2006-09--2010-06   武汉大学   学士

工作经历

   
工作简历
2021-01~现在, 中国科学院武汉病毒研究所, 研究员
2020-10~2020-12,中国科学院武汉病毒研究所, 青年研究员
2018-08~2020-10,武汉病毒研究所, 副研究员
2016-07~2018-07,武汉病毒研究所, 博士后(副研究员职称)

专利与奖励

   
奖励信息
(1) 国自然优秀青年基金, 国家级, 2020
(2) 中国科学院青年创新促进会, , 院级, 2019
(3) 湖北省细胞生物学会优秀青年学者, 省级, 2019
(4) 武汉市“黄鹤英才”, , 市地级, 2019
(5) 武汉病毒所年度青年人物, 研究所(学校), 2018
(6) 武汉大学学术创新奖, 一等奖, 研究所(学校), 2016
(7) 国家博士后创新人才支持计划, 国家级, 2016

出版信息

   
发表论文
[1] Luo, WeiWei, Tong, Zhen, Cao, Pan, Wang, FuBing, Liu, Ying, Zheng, ZhouQin, Wang, SuYun, Li, Shu, Wang, YanYi. Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-32401-1.
[2] Li, Chen, Feng, Lu, Luo, WeiWei, Lei, CaoQi, Li, Mi, Shu, HongBing. The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response. CELLDISCOVERY[J]. 2021, 7(1): 1-12, http://dx.doi.org/10.1038/s41421-021-00277-y.
[3] Li, WeiWei, Nie, Ying, Yang, Yan, Ran, Yong, Luo, WeiWei, Xiong, MeiGuang, Wang, SuYun, Xu, ZhiSheng, Wang, YanYi. Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(38): 23707-23716, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519224/.
[4] Zou, HongMei, Huang, ZheFu, Yang, Yan, Luo, WeiWei, Wang, SuYun, Luo, MinHua, Fu, YuZhi, Wang, YanYi. Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response. JOURNAL OF VIROLOGY[J]. 2020, 94(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307088/.
[5] HongYan Zhang, BoWei Liao, ZhiSheng Xu, Yong Ran, DongPeng Wang, Yan Yang, WeiWei Luo, YanYi Wang. USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.. PLOS PATHOGENS[J]. 2020, 16(1): https://doaj.org/article/ac1cfb79f25f49b1ac96310bc67d87ed.
[6] Ran, Yong, Xiong, Meiguang, Xu, Zhisheng, Luo, Weiwei, Wang, Suyun, Wang, YanYi. YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking. JOURNAL OF IMMUNOLOGY[J]. 2019, 203(6): 1560-1570, https://www.webofscience.com/wos/woscc/full-record/WOS:000484842100015.
[7] Pan Cao, WeiWei Luo, Chen Li, Zhen Tong, ZhouQin Zheng, Lu Zhou, Yong Xiong, Shu Li. The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors. PLOS PATHOGENS[J]. 2019, 15(8): http://dx.doi.org/10.1371/journal.ppat.1007983.
[8] WeiWei Luo, HongBing Shu. Delicate regulation of the cGAS–MITA-mediated innate immune response. CELLULAR AND MOLECULAR IMMUNOLOGY[J]. 2018, 15(7): 666-675, https://www.webofscience.com/wos/woscc/full-record/WOS:000448426600006.
[9] Lian, Huan, Zang, Ru, Wei, Jin, Ye, Wen, Hu, MingMing, Chen, YunDa, Zhang, XiaNan, Guo, Yi, Lei, CaoQi, Yang, Qing, Luo, WeiWei, Li, Shu, Shu, HongBing. The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors. IMMUNITY[J]. 2018, 49(3): 438-+, http://www.corc.org.cn/handle/1471x/2373240.
[10] Wei, Jin, Lian, Huan, Guo, Wei, Chen, YunDa, Zhang, XiaNan, Zang, Ru, Zhong, Li, Yang, Qing, Hu, MingMing, Luo, WeiWei, Shu, HongBing, Li, Shu. SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA. PLOSPATHOGENS[J]. 2018, 14(10): http://202.127.146.157/handle/2RYDP1HH/4011.
[11] Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, XiaNan Zhang, YunDa Chen, YuZhi Fu, MingMing Hu, CaoQi Lei, WeiWei Luo, Shu Li, HongBing Shu. ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response. NATURE COMMUNICATIONS[J]. 2018, 9(1): http://www.corc.org.cn/handle/1471x/2373248.
[12] Yang, Qing, Liu, TianTian, Lin, Heng, Zhang, Man, Wei, Jin, Luo, WeiWei, Hu, YunHong, Zhong, Bo, Hu, MingMing, Shu, HongBing. TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLOS PATHOGENS[J]. 2017, 13(9): http://dx.doi.org/10.1371/journal.ppat.1006600.
[13] Luo, WeiWei, Shu, HongBing. Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses. FEBS LETTERS[J]. 2017, 591(20): 3182-3189, http://www.corc.org.cn/handle/1471x/2373362.
[14] Luo, WeiWei, Li, Shu, Li, Chen, Zheng, ZhouQin, Cao, Pan, Tong, Zhen, Lian, Huan, Wang, SuYun, Shu, HongBing, Wang, YanYi. iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. PLOS PATHOGENS[J]. 2017, 13(11): http://202.127.146.157/handle/2RYDP1HH/4387.
[15] Luo, WeiWei, Li, Shu, Li, Chen, Lian, Huan, Yang, Qing, Zhong, Bo, Shu, HongBing. iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. NATURE IMMUNOLOGY[J]. 2016, 17(9): 1057-1066, http://dx.doi.org/10.1038/ni.3510.
[16] Luo, WeiWei, Lian, Huan, Zhong, Bo, Shu, HongBing, Li, Shu. Kruppel-like factor 4 negatively regulates cellular antiviral immune response. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2016, 13(1): 65-72, http://dx.doi.org/10.1038/cmi.2014.125.
[17] Yang, Yan, Wang, SuYun, Huang, ZheFu, Zou, HongMei, Yan, BingRu, Luo, WeiWei, Wang, YanYi. The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. CELL RESEARCH[J]. 2016, 26(3): 288-303, http://dx.doi.org/10.1038/cr.2016.16.

科研活动

   
科研项目
( 1 ) MITA的N-聚糖修饰在抗DNA病毒天然免疫中的作用和机制研究, 主持, 国家级, 2018-01--2020-12
( 2 ) IRF8抗DNA病毒免疫应答中的作用和机制研究, 主持, 国家级, 2019-01--2022-12
( 3 ) 青年创新促进会, 主持, 部委级, 2019-01--2022-12
( 4 ) 葡萄糖/能量代谢稳态与抗病毒天然免疫信号“交互”的分子机制研究, 主持, 部委级, 2019-09--2023-09
( 5 ) 菱形蛋白酶iRhom2在RNA病毒诱导的天然免疫反应和炎症形成中的作用机制研究, 主持, 国家级, 2016-07--2018-07
( 6 ) 抗病毒天然免疫反应与葡萄糖代谢, 主持, 国家级, 2021-01--2023-12
( 7 ) 病毒感染过程中的免疫与代谢交互调控机制, 主持, 国家级, 2021-12--2026-11