071005-微生物学

蜱传病毒资源发现、流行传播与演化
出血热病毒出血机制

2006-09--中国科学院武汉病毒研究所   博士
2001-09--武汉大学生命科学院   理学学士

   

2021-08~现在, 中国科学院武汉病毒研究所, 青年研究员
2018-09~现在, 中国科学院武汉病毒研究所, 副研究员
2012-07~现在, 中国科学院武汉病毒研究所, 助理研究员
2006-09~现在, 中国科学院武汉病毒研究所, 博士
2001-09~现在, 武汉大学生命科学院, 理学学士

   

（ 1 ） 一种抗SFTSV的中和性单克隆抗体及其应用, 2022, 第 2 作者, 专利号: CN113980125A

（ 2 ） 用于提高杆状病毒对哺乳动物细胞转导效率的方法, 2011, 第 4 作者, 专利号: CN102199629A

   

（1） Developing and characterizing monoclonal antibodies of Guertu bandavirus nucleoprotein for developing methods of Guertu bandavirus and severe fever with thrombocytopenia syndrome virus detection, Braz J Microbiol, 2023, 通讯作者
（2） Tamdy病毒糖蛋白基因的重组表达及抗体制备, Recombinant Expression of Glycoprotein Gene of Tamdy Virus and Antibody Preparation, 病毒学报, 2023, 第 2 作者
（3） Diverse viromes in polar regions: A retrospective study of metagenomic data from Antarctic animal feces and Arctic frozen soil in 2012–2014, VIROLOGICA SINICA, 2022, 通讯作者
（4） Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism, VIROLOGICA SINICA, 2022, 通讯作者
（5） 蜱源抗凝血因子研究进展, Research advances in anticoagulant factors from ticks, 昆虫学报, 2022, 第 2 作者
（6） Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases, BMC MEDICINE, 2022, 第 1 作者
（7） Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China, FRONTIERS IN MICROBIOLOGY, 2022, 通讯作者
（8） Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan,China, Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China, 创新(英文), 2022, 第 16 作者
（9） 四种FDA批准药物抑制发热伴血小板减少综合征病毒的作用研究, Four FDA-approved drugs exhibited inhibition effect on severe fever with thrombocytopenia syndrome virus in vitro, 海南医学院学报, 2022, 其他（合作组作者）
（10） Differential characteristics of mammalian and tick-derived promoters to trigger protein expression in transfected tick cell lines, TICKS AND TICK-BORNE DISEASES, 2022, 通讯作者
（11） A new luciferase immunoprecipitation system assay provided serological evidence for missed diagnosis of severe fever with thrombocytopenia syndrome, A new luciferase immunoprecipitation system assay provided serological evidence for missed diagnosis of severe fever with thrombocytopenia syndrome, VIROLOGICA SINICA, 2022, 通讯作者
（12） Identification of a Novel Astrovirus in Pinnipeds, Frontiers in Microbiology, 2022, 
（13） SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19, NATURE COMMUNICATIONS, 2021, 第 6 作者
（14） Occurrence of COVID-19 Symptoms During SARS-CoV-2 Infection Defines Waning of Humoral Immunity, FRONTIERS IN IMMUNOLOGY, 2021, 第 6 作者
（15） A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes, NATURE COMMUNICATIONS, 2021, 第 6 作者
（16） Tetrasubstituted imidazoles as incognito Toll-like receptor 8a(nta)gonists, NATURE COMMUNICATIONS, 2021, 第 14 作者
（17） Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 通讯作者
（18） Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom Onset, FRONTIERS IN IMMUNOLOGY,12,(2021-06-16), 2021, 第 4 作者
（19） Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse, Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse, VIROLOGICA SINICA, 2021, 通讯作者
（20） SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism, JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 第 1 作者
（21） Metagenomic Profiling of Viruses Associated with Rhipicephalus microplus Ticks in Yunnan Province,China, Metagenomic Profiling of Viruses Associated with Rhipicephalus microplus Ticks in Yunnan Province, China, VIROLOGICA SINICA, 2021, 第 2 作者
（22） Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System, FRONTIERS IN MICROBIOLOGY, 2021, 第 2 作者
（23） Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes, Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes, VIROLOGICA SINICA, 2021, 通讯作者
（24） Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2, JOURNAL OF INFECTION, 2021, 第 8 作者
（25） Viromes and surveys of RNA viruses in camel-derived ticks revealing transmission patterns of novel tick-borne viral pathogens in Kenya, EMERGING MICROBES & INFECTIONS, 2021, 通讯作者
（26） Recent Advances in Bunyavirus Reverse Genetics Research: Systems Development, Applications, and Future Perspectives, FRONTIERS IN MICROBIOLOGY, 2021, 第 2 作者
（27） Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes, PLOS BIOLOGY, 2021, 第 6 作者
（28） Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,11,(2021-03-24), 2021, 第 4 作者
（29） Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China, SCIENTIFIC REPORTS, 2021, 第11作者
（30） Fine mapping epitope on Glycoprotein-Gn from Severe Fever with Thrombocytopenia Syndrome Virus, PLOS ONE, 2021, 第 3 作者
（31） 古尔图病毒重组截短糖蛋白基因的表达及抗体的制备, Expression and antibody preparation of recombinant truncated glycoprotein of Guertu virus, 中华微生物学和免疫学杂志, 2020, 第 2 作者
（32） Crimean-Congo Hemorrhagic Fever Virus in Humans and Livestock, Pakistan, 2015–2017, EMERGING INFECTIOUS DISEASES, 2020, 第 20 作者
（33） Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation, NATURE MICROBIOLOGY, 2020, 第 6 作者
（34） Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2, JOURNAL OF INFECTION, 2020, 第 8 作者
（35） Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan, EMERGING INFECTIOUS DISEASES, 2020, 通讯作者
（36） Genomic and transcriptional analyses of novel parvoviruses identified from dead peafowl, VIROLOGY, 2020, 第 8 作者
（37） Transcriptome analysis of the innate immune system of Hyalomma asiaticum, JOURNAL OF INVERTEBRATE PATHOLOGY, 2020, 第 5 作者
（38） Serological Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses, Pakistan, Emerging Infectious Diseases, 2020, 通讯作者
（39） Detection and characterization of a novel hepacivirus in long-tailed ground squirrels (Spermophilus undulatus) in China, ARCHIVES OF VIROLOGY, 2019, 第 3 作者
（40） Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization, VIROLOGY, 2019, 第 5 作者
（41） Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection, JOURNAL OF VIROLOGY, 2019, 第 5 作者
（42） First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang, China, EMERGING MICROBES & INFECTIONS, 2019, 通讯作者
（43） Taxonomy of the order Bunyavirales : update 2019, ARCHIVES OF VIROLOGY, 2019, 第 77 作者
（44） Fine epitope mapping of glycoprotein Gn in Guertu virus, PLOS ONE, 2019, 第 4 作者
（45） The first laboratory-confirmed sfts case from the xinjiang uygur autonomous region importing to hainan international tourism island, ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, 2018, 第 13 作者
（46） Isolation,Characterization,and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province,China, Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China, VIROLOGICA SINICA, 2018, 第 2 作者
（47） The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly, JOURNAL OF VIROLOGY, 2018, 第 2 作者
（48） Tick-Borne Viruses, VIROLOGICA SINICA, 2018, 通讯作者
（49） Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang,China, Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang,China, 中国病毒学：英文版, 2018, 第 3 作者
（50） A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen, EMERGING MICROBES & INFECTIONS, 2018, 第 1 作者
（51） Isolation,Characterization,and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province,China, Isolation,Characterization,and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province,China, 中国病毒学：英文版, 2018, 第 2 作者
（52） 布尼亚病毒目新分类概述, A review and novel classification of Bunyavirales, 生物多样性, 2018, 第 2 作者
（53） Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang,China, Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang,China, VIROLOGICA SINICA, 2018, 第 3 作者
（54） Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea, PLOS ONE, 2018, 第 7 作者
（55） Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus., Infect Genet Evol., 2017, 
（56） A cluster of symptomatic and asymptomatic infections of severe fever with thrombocytopenia syndrome caused by person-to-person transmission, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2017, 通讯作者
（57） A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China, VIROLOGICA SINICA, 2017, 第 2 作者
（58） Deltabaculoviruses encode a functional type i budded virus envelope fusion protein, JOURNAL OF GENERAL VIROLOGY, 2017, 第 2 作者
（59） Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus, INFECTION GENETICS AND EVOLUTION, 2017, 通讯作者
（60） Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016, VIROLOGICA SINICA, 2017, 通讯作者
（61） Severe fever with thrombocytopenia syndrome complicated with polyuria: report of a case and review of literature, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 第 2 作者
（62） Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province, China, VIROLOGICA SINICA, 2017, 第 2 作者
（63） Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation, JOURNAL OF VIROLOGY, 2016, 第 8 作者
（64） Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus, VIROLOGICASINICA, 2016, 第 1 作者
（65） Pathologic Studies of Fatal Encephalomyelitis in Children Caused by Enterovirus 71, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2016, 第 3 作者
（66） Spatial Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in China Using a Geographically Weighted Logistic Regression Model, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2016, 第 5 作者
（67） Molecular basis for the formation of ribonucleoprotein complex of crimean-congo hemorrhagic fever virus, JOURNAL OF STRUCTURAL BIOLOGY, 2016, 第 4 作者
（68） Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus, JOURNAL OF GENERAL VIROLOGY, 2016, 第 1 作者
（69） 滇西横断山区家畜体表蜱类调查及鉴定, Tick species and genetic variants analysis of tick gene in Hengduan Mountains, west Yunnan Province, China, 中国人兽共患病学报, 2016, 第 2 作者
（70） The FP25K Acts as a Negative Factor for the Infectivity of AcMNPV Budded Virus, PLOS ONE, 2015, 第 3 作者
（71） The FP25K Acts as a Negative Factor for the Infectivity of AcMNPV Budded Virus, PLOS ONE, 2015, 第 3 作者
（72） Viral suppression of innate immunity via spatial isolation of TBK1/IKK epsilon from mitochondrial antiviral platform, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 第 4 作者
（73） Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antivirai platform, Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antivirai platform, 分子细胞生物学报：英文版, 2014, 第 4 作者
（74） Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 第 4 作者
（75） Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro, JOURNAL OF GENERAL VIROLOGY, 2012, 第 1 作者
（76） Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro, JOURNAL OF GENERAL VIROLOGY, 2012, 第 1 作者
（77） Partial Functional Rescue of Helicoverpa armigera Single Nucleocapsid Nucleopolyhedrovirus Infectivity by Replacement of F Protein with GP64 from Autographa californica Multicapsid Nucleopolyhedrovirus ▿, JOURNAL OF VIROLOGY, 2010, 第 3 作者
（78） Specificity of Baculovirus P6.9 Basic DNA-Binding Proteins and Critical Role of the C Terminus in Virion Formation ▿ †, JOURNAL OF VIROLOGY, 2010, 第 3 作者
（79） Diverse viromes in polar regions: A retrospective study of metagenomic data from Antarctic animal feces and Arctic frozen soil in 2012–2014, VIROLOGICA SINICA, 第 10 作者
（80） BMC MEDICINE, 第 1 作者
（81） A Cluster of Symptomatic and Asymptomatic Infections of Severe Fever with Thrombocytopenia Syndrome Caused by Person-to-Person Transmission, THEAMERICANJOURNALOFTROPICALMEDICINEANDHYGIENE, 第 13 作者

   

（ 1 ） 发热伴血小板减少综合征病毒SFTSV的遗传进化与感染, 负责人, 地方任务, 2019-01--2020-12
（ 2 ） 基于微流控技术从病人血液中高效分离中和性抗体, 参与, 国家任务, 2019-08--2023-07
（ 3 ） 定向项目, 参与, 国家任务, 2019-01--2022-12
（ 4 ） 潜在威胁人类病原体发现与挖掘, 参与, 国家任务, 2021-01--2023-12
（ 5 ） 虫媒病毒资源自主获取与保藏能力建设, 负责人, 中国科学院计划, 2021-07--2024-06
（ 6 ） CCHFV感染出血机制研究, 负责人, 研究所自主部署, 2021-01--2022-12
（ 7 ） 蜱细胞系建立及其在蜱传病毒病原学中的应用研究, 负责人, 中国科学院计划, 2023-01--2025-12

（1）Phylogeny and antiviral strategies of Severe fever with thrombocytopenia syndrome virus   第四届青年生命科学论坛   2022-12-05
（2）我国新疆地区蜱传病毒调查   2019年人兽共患国际研讨会暨中国狂犬病年会   2019-05-10