纳米酶设计开发及其生物医学应用

   

071010-生物化学与分子生物学
0703J1-纳米科学与技术
083100-生物医学工程

纳米生物医学工程
纳米酶的开发与应用
抗菌抗病毒

2013-12--2015-07   美国宾夕法尼亚大学   博士后
2010-01--2013-11   美国康奈尔大学   博士后
2006-09--2010-01   美国匹兹堡大学   博士后
2003-09--2006-07   中国科学院生物物理研究所   博士
2000-09--2003-06   吉林大学   硕士
1996-09--2000-06   吉林大学   本科

   

2015-08~2019-08,扬州大学, 教授

   

（1） 国际牙医协会口腔护理创新奖, 其他, 2015
（2） 北京市科学技术奖, 一等奖, 省级, 2010

[1] 阎锡蕴, 高利增, 范克龙, 孟祥芹. 硫铁矿纳米酶、抗肿瘤药物及应用. CN: CN112791099A, 2021-05-14.
[2] 高利增, 蒋静, 马若楠. 一种抗菌硫化铁水剂、其制备方法及应用. CN: CN112089730A, 2020-12-18.
[3] 阎锡蕴, 范克龙, 高利增, 段德民. 优化纳米酶颗粒活性的方法. CN: CN108067309A, 2018-05-25.
[4] 阎锡蕴, 范克龙, 高利增, 段德民, 张德玺, 桑建彬. 一种具有止血、杀菌功能的纳米酶止血剂及其应用. CN: CN107496449A, 2017-12-22.
[5] 阎锡蕴, 张锦彬, 高利增, 杨东玲, 冯 静. 用于有机污染物处理的磁性纳米材料. CN: CN101549294A, 2009-10-07.
[6] 阎锡蕴, 庄洁, 高利增, 杨东玲, 冯静. 检测过氧化氢含量的新试剂和新方法. CN: CN101530798A, 2009-09-16.
[7] 阎锡蕴, 高利增, 聂棱, 王太宏. 磁性纳米材料的新功能及新用途. CN: CN101037676A, 2007-09-19.
[8] 阎锡蕴, 高利增, 王太宏, 聂棱. 碳纳米管的生物学应用. CN: CN1796567A, 2006-07-05.

   

[1] 范克龙, 高利增, 魏辉, 江冰, 王大吉, 张若飞, 贺久洋, 孟祥芹, 王卓然, 樊慧真, 温涛, 段德民, 陈雷, 姜伟, 芦宇, 蒋冰, 魏咏华, 李唯, 袁野, 董海姣, 张鹭, 洪超仪, 张紫霞, 程苗苗, 耿欣, 侯桐阳, 侯亚欣, 李建茹, 汤国恒, 赵越, 赵菡卿, 张帅, 谢佳颖, 周子君, 任劲松, 黄兴禄, 高兴发, 梁敏敏, 张宇, 许海燕, 曲晓刚, 阎锡蕴. 纳米酶. 化学进展[J]. 2023, 35(1): 1-87, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7419143&detailType=1.
[2] Pang, Jing, Feng, Xu, Liang, Qian, Zheng, Xiaoyan, Duan, Yiman, Zhang, Xin, Zhang, Jubiao, Chen, Yang, Fan, Kelong, Gao, Lizeng, Li, Juxue. Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model. ACS NANO[J]. 2022, 16(3): 4175-4185, http://dx.doi.org/10.1021/acsnano.1c10029.
[3] Zhou, Caiyu, Wang, Qian, Jiang, Jing, Gao, Lizeng. Nanozybiotics: Nanozyme-Based Antibacterials against Bacterial Resistance. ANTIBIOTICS-BASEL[J]. 2022, 11(3): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000775450700001.
[4] Meng, Xiangqin, Zou, Sijia, Li, Dandan, He, Jiuyang, Fang, Ling, Wang, Haojue, Yan, Xiyun, Duan, Demin, Gao, Lizeng. Nanozyme-strip for rapid and ultrasensitive nucleic acid detection of SARS-CoV-2. BIOSENSORS & BIOELECTRONICS[J]. 2022, 217: http://dx.doi.org/10.1016/j.bios.2022.114739.
[5] Meng, Xiangqin, Li, Dandan, Chen, Lei, He, Helen, Wang, Qian, Hong, Chaoyi, He, Jiuyang, Gao, Xingfa, Yang, Yili, Jiang, Bing, Nie, Guohui, Yan, Xiyun, Gao, Lizeng, Fan, Kelong. High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis-Ferroptosis Synergistic Tumor Therapy. ACS NANO[J]. 2021, 15(3): 5735-5751, http://dx.doi.org/10.1021/acsnano.1c01248.
[6] Wang, Qian, Jiang, Jing, Gao, Lizeng. Nanozyme-based medicine for enzymatic therapy: progress and challenges. BIOMEDICAL MATERIALSnull. 2021, 16(4): http://dx.doi.org/10.1088/1748-605X/abe7b4.
[7] Xi, Juqun, An, Lanfang, Huang, Yaling, Jiang, Jian, Wang, Yanqiu, Wei, Gen, Xu, Zhilong, Fan, Lei, Gao, Lizeng. Ultrasmall FeS2 Nanoparticles-Decorated Carbon Spheres with Laser-Mediated Ferrous Ion Release for Antibacterial Therapy. SMALL[J]. 2021, 17(13): http://dx.doi.org/10.1002/smll.202005473.
[8] Yan, Bing Chun, Cao, Jianwen, Liu, Jiajia, Gu, Yunhao, Xu, Zhuobin, Li, Dandan, Gao, Lizeng. Dietary Fe3O4 Nanozymes Prevent the Injury of Neurons and Blood-Brain Barrier Integrity from Cerebral Ischemic Stroke. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2021, 7(1): 299-310, https://www.webofscience.com/wos/woscc/full-record/WOS:000610825900025.
[9] Chen, Xiaohang, Xing, Helin, Zhou, Zilan, Hao, Yujia, Zhang, Xiaoxuan, Qi, Feng, Zhao, Jing, Gao, Lizeng, Wang, Xing. Nanozymes go oral: nanocatalytic medicine facilitates dental health (vol 9, pg 1491, 2021). JOURNAL OF MATERIALS CHEMISTRY B. 2021, https://www.webofscience.com/wos/woscc/full-record/WOS:000642581400001.
[10] Chen, Xiaohang, Xing, Helin, Zhou, Zilan, Hao, Yujia, Zhang, Xiaoxuan, Qi, Feng, Zhao, Jing, Gao, Lizeng, Wang, Xing. Nanozymes go oral: nanocatalytic medicine facilitates dental health. JOURNAL OF MATERIALS CHEMISTRY Bnull. 2021, 9(6): 1491-1502, http://dx.doi.org/10.1039/d0tb02763d.
[11] Yuan, Ye, Wang, Liping, Gao, Lizeng. Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications. FRONTIERSINCHEMISTRY[J]. 2020, 8: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512625/.
[12] Liang, Qian, Xi, Juqun, Gao, Xuejiao J, Zhang, Ruofei, Yang, Yili, Gao, Xingfa, Yan, Xiyun, Gao, Lizeng, Fan, Kelong. A metal-free nanozyme-activated prodrug strategy for targeted tumor catalytic therapy. NANO TODAY[J]. 2020, 35: http://dx.doi.org/10.1016/j.nantod.2020.100935.
[13] Wang, Huihui, Cheng, Lu, Ma, Shang, Ding, Liming, Zhang, Wei, Xu, Zhuobin, Li, Dandan, Gao, Lizeng. Self-Assembled Multiple-Enzyme Composites for Enhanced Synergistic Cancer Starving-Catalytic Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(18): 20191-20201, https://www.webofscience.com/wos/woscc/full-record/WOS:000535170300006.
[14] Qin, Tao, Ma, Shang, Miao, Xinyu, Tang, Yan, Huangfu, Dandan, Wang, Jinyuan, Jiang, Jing, Xu, Nuo, Yin, Yuncong, Chen, Sujuan, Liu, Xiufan, Yin, Yinyan, Peng, Daxin, Gao, Lizeng. Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant. ADVANCED SCIENCE[J]. 2020, 7(18): https://doaj.org/article/46f24d61e93a45eea5e3c61229aa7d2d.
[15] Wang, Yanqiu, Shen, Xinyu, Ma, Shang, Guo, Qianqian, Zhang, Wei, Cheng, Lu, Ding, Liming, Xu, Zhuobin, Jiang, Jing, Gao, Lizeng. Oral biofilm elimination by combining iron-based nanozymes and hydrogen peroxide-producing bacteria. BIOMATERIALS SCIENCE[J]. 2020, 8(9): 2447-2458, https://www.webofscience.com/wos/woscc/full-record/WOS:000532529400006.
[16] 高利增, 魏辉, 曲晓刚. 纳米生物催化的研究现状和发展态势. 中国科学:生命科学[J]. 2020, 50(7): 682-697, https://www.sciengine.com/doi/10.1360/SSV-2020-0070.
[17] Li, Feng, Li, Shuai, Guo, Xiaocui, Dong, Yuhang, Yao, Chi, Liu, Yangping, Song, Yuguang, Tan, Xiaoli, Gao, Lizeng, Yang, Dayong. Chiral Carbon Dots Mimicking Topoisomerase I To Mediate the Topological Rearrangement of Supercoiled DNA Enantioselectively. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(27): 11087-11092, https://www.webofscience.com/wos/woscc/full-record/WOS:000528891500001.
[18] 马尚, 殷立晗, 秦涛, 蒋静, 阴银燕, 高利增. β-胡萝卜素对小鼠骨髓源树突状细胞成熟的影响. 扬州大学学报:农业与生命科学版[J]. 2020, 41(2): 74-78, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=JSNX202002013&v=MDMyMjZxZVp1ZHRGeUhnVzc3Qkx6N0Zkckc0SE5ITXJZOUVaNFI4ZVgxTHV4WVM3RGgxVDNxVHJXTTFGckNVUjc=.
[19] 苏欣, 余凡, 高利增, 朱晓芳. 纳米硫化铁对小鼠感染性湿疹模型的影响及机制研究. 扬州大学学报:农业与生命科学版[J]. 2020, 41(4): 64-70, http://lib.cqvip.com/Qikan/Article/Detail?id=7103004316.
[20] Zhang, Shan, Wu, Shu, Shen, Yiru, Xiao, Yunqi, Gao, Lizeng, Shi, Shourong. Cytotoxicity studies of Fe3O4 nanoparticles in chicken macrophage cells. ROYAL SOCIETY OPEN SCIENCE[J]. 2020, 7(4): https://doaj.org/article/00a16a30219b4a57bd56bfd1b611421e.
[21] Shen, Xinyu, Ma, Ruonan, Huang, Yixin, Chen, Lei, Xu, Zhuobin, Li, Dandan, Meng, Xiangqin, Fan, Kelong, Xi, Juqun, Yan, Xiyun, Koo, Hyun, Yang, Yili, Jiang, Jing, Gao, Lizeng. Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy. NANO TODAY[J]. 2020, 35: http://dx.doi.org/10.1016/j.nantod.2020.100981.
[22] Li, Dandan, Guo, Qianqian, Ding, Liming, Zhang, Wei, Cheng, Lu, Wang, Yanqiu, Xu, Zhuobin, Wang, Huihui, Gao, Lizeng. Bimetallic CuCo2S4 Nanozymes with Enhanced Peroxidase Activity at Neutral pH for Combating Burn Infections. CHEMBIOCHEM[J]. 2020, 21(18): 2620-2627, https://www.webofscience.com/wos/woscc/full-record/WOS:000544193800001.
[23] Qin, Tao, Ma, Ruonan, Yin, Yinyan, Miao, Xinyu, Chen, Sujuan, Fan, Kelong, Xi, Juqun, Liu, Qi, Gu, Yunhao, Yin, Yuncong, Hu, Jiao, Liu, Xiufan, Peng, Daxin, Gao, Lizeng. Catalytic inactivation of influenza virus by iron oxide nanozyme. THERANOSTICS[J]. 2019, 9(23): 6920-6935, https://www.webofscience.com/wos/woscc/full-record/WOS:000487830500013.
[24] Gao, Lizeng, Fan, Kelong, Yan, Xiyun. Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications. THERANOSTICSnull. 2017, 7(13): 3207-3227, http://dx.doi.org/10.7150/thno.19738.
[25] Fan, Kelong, Wang, Hui, Xi, Juqun, Liu, Qi, Meng, Xiangqin, Duan, Demin, Gao, Lizeng, Yan, Xiyun. Optimization of Fe3O4 nanozyme activity via single amino acid modification mimicking an enzyme active site. CHEMICAL COMMUNICATIONS[J]. 2017, 53(2): 424-427, https://www.webofscience.com/wos/woscc/full-record/WOS:000391736100031.
[26] Gao, Lizeng, Yan, Xiyun. Nanozymes: an emerging field bridging nanotechnology and biology. SCIENCE CHINA-LIFE SCIENCES[J]. 2016, 59(4): 400-402, https://www.webofscience.com/wos/woscc/full-record/WOS:000374101500010.
[27] Gao LiZeng, Yan XiYun. Discovery and Current Application of Nanozyme. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2013, 40(10): 892-902, https://www.webofscience.com/wos/woscc/full-record/WOS:000326312500002.
[28] Gao LiZeng, Yan XiYun. Discovery and Current Application of Nanozyme. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2013, 40(10): 892-902, https://www.webofscience.com/wos/woscc/full-record/WOS:000326312500002.
[29] Fan, Kelong, Gao, Lizeng, Yan, Xiyun. Human ferritin for tumor detection and therapy. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY[J]. 2013, 5(4): 287-298, http://www.irgrid.ac.cn/handle/1471x/756682.
[30] Zhuang, Jie, Fan, Kelong, Gao, Lizeng, Lu, Di, Feng, Jing, Yang, Dongling, Gu, Ning, Zhang, Yu, Liang, Minmin, Yan, Xiyun. Ex Vivo Detection of Iron Oxide Magnetic Nanoparticles in Mice Using Their Intrinsic Peroxidase-Mimicking Activity. MOLECULAR PHARMACEUTICS[J]. 2012, 9(7): 1983-1989, http://www.irgrid.ac.cn/handle/1471x/756791.
[31] Zhuang, Jie, Cheng, Tao, Gao, Lizeng, Luo, Yongting, Ren, Quan, Lu, Di, Tang, Fangqiong, Ren, Xiangling, Yang, Dongling, Feng, Jing, Zhu, Jingdong, Yan, Xiyun. Silica coating magnetic nanoparticle-based silver enhancement immunoassay for rapid electrical detection of ricin toxin. TOXICON[J]. 2010, 55(1): 145-152, http://dx.doi.org/10.1016/j.toxicon.2009.07.015.
[32] Zhang, Jinbin, Zhuang, Jie, Gao, Lizeng, Zhang, Yu, Gu, Ning, Feng, Jing, Yang, Dongling, Zhu, Jingdong, Yan, Xiyun. Decomposing phenol by the hidden talent of ferromagnetic nanoparticles. CHEMOSPHERE[J]. 2008, 73(9): 1524-1528, http://dx.doi.org/10.1016/j.chemosphere.2008.05.050.
[33] Gao, Lizeng, Zhuang, Jie, Nie, Leng, Zhang, Jinbin, Zhang, Yu, Gu, Ning, Wang, Taihong, Feng, Jing, Yang, Dongling, Perrett, Sarah, Yan, Xiyun. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. NATURE NANOTECHNOLOGY[J]. 2007, 2(9): 577-583, http://ir.iphy.ac.cn/handle/311004/40215.
[34] Bu, Pengcheng, Gao, Lizeng, Zhuang, Jie, Feng, Jing, Yang, Dongling, Yan, Xiyun. Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kappa B activation. MOLECULAR CANCER THERAPEUTICS[J]. 2006, 5(11): 2872-2878, http://www.corc.org.cn/handle/1471x/2379472.

现指导学生

金宇茜  硕士研究生  071010-生物化学与分子生物学  

王前  硕士研究生  071009-细胞生物学  

周彩玉  硕士研究生  071009-细胞生物学  

曹浩林  硕士研究生  071010-生物化学与分子生物学  

王晓楠  博士研究生  071010-生物化学与分子生物学