基本信息
赵岩  男  博导  中国科学院生物物理研究所
电子邮件: zhaoy@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
膜蛋白的结构与功能研究

教育背景

2010-09--2015-07   中国科学技术大学 & 中科院生物物理所   获博士学位
2006-09--2010-07   德州学院物理系   获学士学位

工作经历

   
工作简历
2020-01~现在, 中国科学院生物物理研究所, 研究员、课题组长
2015-07~2019-12,美国俄勒冈健康与科学大学/霍华德·休斯医学研究所, 博士后
2010-09~2015-07,中国科学技术大学 & 中科院生物物理所, 获博士学位
2006-09~2010-07,德州学院物理系, 获学士学位

出版信息

   
发表论文
(1) Structural basis of ligand binding modes of human EAAT2., Nature Communications, 2022, 通讯作者
(2) Structural basis for modulations of human NaV by clinical drug and selective antagonist., Nature Communications, 2022, 通讯作者
(3) Structure, gating and pharmacology of human CaV3.3 channel., Nature Communications, 2022, 通讯作者
(4) Structural basis of autoinhibition of the human NHE3-CHP1 complex, Science advances, 2022, 通讯作者
(5) TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells, eLife, 2021, 第 6 作者
(6) Closed-state inactivation and pore-blocker modulation mechanisms of human Ca(V)2.2, CELL REPORTS, 2021, 通讯作者
(7) Kainate receptor modulation by NETO2, NATURE, 2021, 通讯作者
(8) Structure and mechanism of the human NHE1-CHP1 complex, NATURE COMMUNICATIONS, 2021, 通讯作者
(9) Structure of human glycosylphosphatidylinositol transamidase, Nature Structural and Molecular Biology, 2021, 通讯作者
(10) Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM, SCIENCE, 2019, 第 1 作者
(11) Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion, FASEB JOURNAL, 2018, 第 2 作者
(12) Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion, The FASEB Journal, 2018, 第 1 作者
(13) Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM, CELL, 2017, 第 2 作者
(14) Thermodynamics of ABC transporters, Thermodynamics of ABC transporters, PROTEIN & CELL, 2016, 第 3 作者
(15) Crystal structure of E. coli lipoprotein diacylglyceryl transferase, NATURE COMMUNICATIONS, 2016, 第 2 作者
(16) Architecture of fully occupied GluA2 AMPA receptor – TARP complex elucidated by cryo-EM, NATURE, 2016, 第 1 作者
(17) Proton transfer-mediated GPCR activation, Protein, 2015, 第 4 作者
(18) Substrate-bound structure of the E. coli multidrug resistance transporter MdfA., CELL RESEARCH, 2015, 第 2 作者
(19) Energy coupling mechanisms of MFS transporters, PROTEIN SCIENCE, 2015, 第 2 作者
(20) How does transmembrane electrochemical potential drive the rotation of Fo motor in an ATP synthase?, How does transmembrane electrochemical potential drive the rotation of Fo motor in an ATP synthase?, PROTEIN & CELL, 2015, 第 3 作者
(21) Proton transfer-mediated GPCR activation, Proton transfer-mediated GPCR activation, PROTEIN & CELL, 2015, 第 4 作者
(22) Crystal structure and biochemical studies of Brucella melitensis 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 第 2 作者
(23) Structural basis for lipopolysaccharide insertion in the bacterial outer membrane, NATURE, 2014, 第 3 作者
(24) Crystal Structure of the E.coli Peptide Transporter YbgH, STRUCTURE, 2014, 第 1 作者
(25) Structure of the nonameric bacterial amyloid secretion channel, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 2 作者
(26) Crystal structure of lipid phosphatase Escherichia coli phosphatidylglycerophosphate phosphatase B., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 3 作者
(27) Atomic resolution structure of the E. coli YajR transporter YAM domain, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 第 2 作者
(28) Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 2 作者
(29) Crystal structure of 1,3Gal43A, an exo-beta-1,3-galactanase from Clostridium thermocellum, JOURNAL OF STRUCTURAL BIOLOGY, 2012, 第 4 作者
(30) Crystal structure of 1,3Gal43A, an exo-β-1,3-galactanase from Clostridium thermocellum, Journal of Structural Biology, 2012, 第 4 作者

科研活动

   
科研项目
( 1 ) 糖基磷脂酰肌醇生物合成相关蛋白复合物的结构与功能 研究, 负责人, 国家任务, 2022-01--2024-12
( 2 ) 高分辨率原位结构解析技术, 参与, 国家任务, 2021-12--2026-12
( 3 ) 精子特异的关键膜蛋白复合物结构与功能研究, 负责人, 中国科学院计划, 2020-01--2024-12
( 4 ) 离子型谷氨酸受体在突触中的转运、富集和功能调控机制, 负责人, 国家任务, 2022-08--2027-07