Immuno-genetics: Latency & reactivation of EBV；

Degree/ Date           University                                                 Major

(Title)

Senior Visiting                University of Nebraska Medical Center                 Cell Biology

Assoc. prof.                                          

Ph.D. 2000                      Kunming Institute of Zoology,                               Molecular Genetics

                                       Chinese Academy of Sciences. Co-cultivated with

                                       Northwest Agri.& Forestry Sci.-Tech University  

M.S. 1997                       Northwest Agri.& Forestry Sci.-Tech University     Animal Genetics 

B.S.  1984                       Gansu Agricultural University                                 Animal Production

​

Sep.2017∽Present  Deputy party secretary，Deputy Director in General, Professor, Guanzhou Institute of Biomedicine and Health, Chinese Academy of Sciences

May.2007∽present  Professor, Genetic Resources Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

May.2013∽Sep.2017  Deputy Director in General, Professor, Bureau of Science and Technology For Development, Chinese Academy of Sciences

Apr.2013∽Des. 2010  Deputy Director in General, Professor, Agricultural Programme office, Chinese Academy of Sciences

Nov.2010∽Dec.2007  Director and Professor, Division of Agri-biology and Biotec, The Bureau of Life Sciences & Biotechnology, Chinese Academy of Sciences

Nov.2007∽Dec.2006  Director and Associate Professor, Division of Agri- biology and Biotec, The Bureau of Life Sciences & Biotechnology, Chinese Academy of Sciences

Nov.2006∽Jul.2003  Vice Director and Associate Professor, Division of Agri-biology and Biotec, The Bureau of Life Sciences & Biotechnology, Chinese Academy of Sciences

Jun.2003∽May.2002 Officer and Associate Professor, Division of Agri- biology and Biotec, The Bureau of Life Sciences & Biotechnology, Chinese Academy of Sciences

Sep. 2002∽Aug.2000  Postdoctoral Research Associate, Laboratory Animal Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

Sep. 1998∽Aug. 2000  Associate professor (concurrent post ) , Department of Animal Science and Technology,Gansu Agricultural University

Sep. 1995∽Aug. 1998  Lecturer (concurrent post ) , Department of Animal Science and Technology,Gansu Agricultural University

Dec. 1992∽Aug. 1995   Lecturer, Department of Animal Science and Technology, Gansu Agricultural University

Sep. 1985∽Nov. 1992   Assistant Professor, Department of Animal Science and Technology,Gansu Agricultural University

Sep. 1984∽Aug. 1985  Internship Instructor, Department of Animal Science and Technology, Gansu Agricultural University

1.        Wang, X.; Zhang, Z.; Wang, X.; Bao, Q.; Wang, R.^⁎; Duan, Z^⁎. The Impact of Host Genotype, Intestinal Sites and Probiotics Supplementation on the Gut Microbiota Composition and Diversity in Sheep. Biology 2021, 10, 769.

2.        Ai S, Zhang Z, Wang X, Zhang Q, Yin W, Duan Z^⁎. The first survey and molecular identification of Entamoeba spp. in farm animals on Qinghai-Tibetan Plateau of China. Comp Immunol Microbiol Infect Dis. 2021,75:101607.

3.        Qingxun Zhang, Weiwen Yin, Xiaoqi Wang, Zhichao Zhang, Ruiying Zhang, Ziyuan Duan^⁎，Blastocystis infection and subtype distribution in domestic animals in the Qinghai-Tibetan Plateau Area (QTPA) in China: A preliminary study，Parasitology International,2020, 13: 1383-5769.

4.        Qingxun Zhang, Donghua Luo, Zhengde Xie^⁎, Hongxuan He^⁎, and Ziyuan Duan^⁎，The oncogenic role of miR-BART19-3p in Epstein-Barr virus associated diseases, BioMed Research International,2020, Jul.2,Article ID 5217039, 11 pages.

5.        Qingxun Zhang, Zhichao Zhang, Sitong Ai, Xiaoqi Wang, Ruiying Zhang, Ziyuan Duan^⁎, Cryptosporidium spp., Enterocytozoon bieneusi, and Giardia duodenalis from animal sources in the Qinghai-Tibetan Plateau Area (QTPA) in China，Comp Immunol Microbiol Infect Dis. 2019 Dec;67:101346. doi: 10.1016/j.cimid. 2019.101346. Epub 2019 Aug 29.

6.        Chongfeng Xu, Lei Sun, Wenjun Liu and Ziyuan Duan*，Latent membrane protein 1 of Epstein-Barr Virus promotes RIG-I degradation mediated by proteasome pathway, Frontiers in Immunology,2018, 9:1446. doi: 10.3389/fimmu. 2018.01446

7.        Xu C, Ai J, Zhang Q, Li T, Wu X, Xie Z, Duan Z.*，An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection，J Vis Exp. 2018 30(133),doi: 10.3791/56515.

8.        Bao Q, Li C, Xu C, Zhang R, Zhao K, Duan Z.*，Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation，Gene, 2017，29：pii: S0378-1119(17) 31035 -1. doi: 10.1016/j.gene.2017.11.070.

9.        Liu W, Li J, Zheng W, Shang Y, Zhao Z, Wang S, Bi Y, Zhang S, Xu C, Duan Z, Zhang L, Wang YL, Jiang Z, Liu W, Sun L, Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses, Elife,2017, 8;6. pii: e24425. doi: 10.7554/eLife.24425.

10.    Zhang R, Xu C, Duan Z. *，Novel antigenic shift in HA sequences of H1N1 viruses detected by big data analysis, Infect Genet Evol., 2017,51:138-142. doi: 10.1016/j.meegid.2017.03.028.

11.    Liu X, Xu C, Duan Z.*，A Simple Red Blood Cell Lysis Method for the Establishment of B Lymphoblastoid Cell Lines, J Vis Exp., 2017, 14(119). doi: 10.3791/55191.

12.    Xu C, Duan Z.*，The development of Chinese population genetics by Ruofu Du.，Protein Cell. 2017 Jan;8(1):1-3. doi: 10.1007/s13238-016-0265-6.

13.    Jinjin Wang, Guo Yang, Ruiyin Zhang, Xiaoqi Wang, Qinqin Ma, Cunfang Zhang,Wei Ding and Ziyuan Duan*, Effects of substituting maize silage with sweet sorghum silage on feed intake, digestibility, growth performance and carcass traits in lambs, Journal of Food, Agriculture & Environment, 2016,14 (2): 121-125

14.    Jing Li, Yuhan Rao, Qinglan Sun, Xiaoxu Wu, Jiao Jin, Yuhai Bi, Jin Chen, Fumin Lei, Qiyong Liu, Ziyuan Duan, Juncai Ma, George F. Gao, Di Liu & Wenjun Liu,  Identification of climate factors related to human infection with avian influenza A H7N9 and H5N1 viruses in China, Scientific Reports, 2015, 5

doi:10.1038/srep18094

15.    Yanhua Qu, Ruiying Zhang, Peng Cui, Gang Song, Ziyuan Duan*and Fumin Lei*， Evolutionary genomics of the pandemic 2009 H₁N₁ influenza viruses (pH1N 1v)，Virology Journal, 2011, 8:250-258

16.    Zhao K, Duan Z, Peng Z, Gan X, Zhang R, He S, Zhao X.，Phylogeography of the endemic Gymnocypris chilianensis (Cyprinidae): sequential westward colonization followed by allopatric evolution in response to cyclical Pleistocene glaciations on the Tibetan Plateau. Mol Phylogenet Evol. 2011 59(2):303-10.

17.    Xiangqun Li, Xue Han, Shengdian Wang and Ziyuan Duan*,Development and Characterization of Monoclonal Antibodies Against Mouse TSLP, Hybridoma, 2010, 29( 5) :425-430

18.    Xiao-Ling Liu, Feng-Lin Zhang, Zhi-Yong Zhou, Hua-Lu Zhao, Guo-Min Shen, Wu-Yun Baohan, Zi-Yuan Duan, Wei Li,Jun-Wu Zhang,  Analysis of two sequence variants in peroxisome proliferator activated receptor gamma gene in Tajik population at high altitudes and Han population at low altitudes in China, Molecular Biology Reports, 2010,37(1): 179-84

19.    Xiao-Ling Liu, Hua-Lu Zhao,Guo-Min Shen,Feng-Lin Zhang,Yan Li,Zhi-Yong Zhou, Jian-Hua Cui, Zi-Yuan Duan, Wei Li,Jun-Wu Zhang, Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in China,Med Sci Monit, 2010，16(10), 458-463

20.    Zhengbin Zhang,Ziyuan Duan,Zhaobo Chen,Ping Xu,Guoqiang, Food Security of China: The Past, Present and Future, Plant Omics Journal,2010,3(6):183-189

21.    Duan Ziyuan, Zhao Kai, Peng Zuogang, Li Junbing, Diogo Rui, Zhao Xinquan, He Shunping Comparative phylogeography of the Yellow River schizothoracine fishes (Cyprinidae): vicariance, expansion, and recent coalescence in response to the Quaternary environmental upheaval in the Tibetan Plateau. Molecular Phylogenetics and Evolution, 2009(53):1025–1031.

22.    Wenyong Ding , Lin Lin, Feng Ren, Hanfa Zou, Ziyuan Duan* , Jianwu Dai, Effects of splice sites on the intron retention in histamine H3 receptors from rats and mice，J. of Genetics and Genomics, 2009(36): 475-482

23.    Wenyong Ding, Lin Lin, Zhifeng Xiao, Hanfa Zou, Ziyuan Duan*, Jianwu Dai, Multiple sequence elements determine the intron retention in histamine H3 receptors in rats and mice, The International Journal of Biochemistry & Cell Biology, 2009 (41):2281-2286

24.    Zhao Kai, Duan Ziyuan (Co-first author), Peng Zuogang, Guo Songchang, Li Junbing, He Shunping, Zhao Xinquan， The youngest split in sympatric schizothoracine fish (Cyprinidae) is shaped by ecological adaptations in a Tibetan Plateau glacier lake, Molecular Ecology, 2009,18,3616–3628.

25.    Baojun Zhang, Ziyuan Duan, Yong Zhao, Mouse models with human immunity and their application in biomedical research, Journal of Cellular and Molecular Medicine, 2009(13):1043-1058.

26.    Wenyong Ding, Hanfa Zou, Jianwu Dai1 and Ziyuan Duan* , Combining Restriction Digestion and Touchdown PCR Permits Detection of Trace Isoforms of H3. BioTechniques, 2005,39(6): 841-845

27.    ZHAO Kai，DUAN Ziyuan(Co-first author),YANG Gongshe,PENG Zuogang, LI Junbing,HE Shunping,CHEN Yiyu，Origin of Gymnocypris przewalskii and population history of Gymnocypris eckloni(Teleostei:Cyprinidae). Progress in Natural Science, 2007,17(5):520-528

28.    Gui-Sheng Wu, Yong-Gang Yao, Kai-Xing Qu,Zhao-Li Ding,Hui Li, Malliya gounder Palanichamy, Zi-Yuan Duan, Nin Li, Yao-Sheng Chen,Ya-Ping Zhang, Population Phylogenomic Analysis of Mitochondrial DNA in Wild boars and Domestic Pigs Revealed Multiple Domestication Events in East Asia, Genome Biology, 2007,8(11): 245.1~12.

29.    Shan-Yuan Chen,Zi-Yuan Duan (Co-first author),Tao Sha, Jinggong Xiangyu, Shi-Fang Wu,Ya-Ping Zhang, Origin, genetic diversity, and population structure of Chinese domestic sheep,Gene,2006(376):216-223

30.    Li Ying , Duan Ziyuan (Co-first author),Jia Lu & Zhang Yaping, Episodic evolution of Prolactin gene in primates, Chinese Science Bulletin, 2005,50(13): 1348-1351.

31.    Zhao kai,Li Junbing,Yang Gongshe, Duan ziyuan, He Shunping & Chen Yiyu, Molecular phylogenetics of Gymnocypris (Teleostei:Cyprinidae) in Lake Qinghai and adjacent drainages, Chinese Science Bulletin, 2005 50(13)：1325-1333.

32.    Jingyu Zhang,Xia Wang,Bing Chen,Guangli Suo,Yanhong Zhao, Ziyuan Duan, Jianwu Dai, Expression of Nanog gene promotes NIH3T3 cell proliferation, Biochemical and Biophysical Research Communications, 2005(338):1098-1102

33.    Hui Peng,Yunlong Huang,Zhiyuan Duan, Nathan Erdmann,Dongsheng Xu, Shelley Herek and Jialin Zheng, Cellular IAP1 Regulates TRAIL-Induced Apoptosis in Human Fetal Cortical Neural Progenitor Cells, Journal of Neuroscience Research, 2005,82:295-305.

34.    Guangli Suo, Bing Chen,Jingyu Zhang, Ziyuan Duan, Zhengquan He,Wei Yao, Chaoyin Yue,Jianwu Dai, Effects of codon modification on human BMP2 gene expression in tobacco plants, Plant Cell Rep, 2006,25:689-697.

35.    Hongwen Huang, Ziyuan Duan, Consideration on scientific research about Chinese Botanic garden in 21 century, BG journal, 2006,3(2):2-3

36.    Yang De Jun，Wu Jin，Liu Yi，Duan Ziyuan, Shen Wen,Long Yan, A rapid method for total DNA extraction from microorganisms of intestinal tract,Chinese Journal of Microecology, 2006,18(2):91-93

37.    Gao Qi-yu，Wu Ji，Xu Guang-cu，Duan Zi-yuan, Efect of Oligosaccharide on the Intestinal Microbial Ecosystem of SPF Rats,Biotechnology, 2006,16(5):28-30

38.    Wu Jin,Duan Zi Yuan* ,Gao Qi Yu,Shen Wen,Ma Yan He, Hydrolytic Properties of β-Mannanase from Nocardioform actlnomycetes, Mirobiology, 2006,33(4):31-35

39.    Zhang Bao jun,Duan Zi Yuan, Zhao Yong, On Security Issue about Porcine endogenous retrovirus in xenotransplatation,Laboratory Animal Science And management, 2006,23(2):45-47

40.    Hu Wen-Ge, Duan Zi-Yuan, Wang Jin-Fu, Sheng Jin-Liang, Ma Run-Lin, Divergence and Systematical Evolution of Three Leuciscus Species in Xinjiang Based on Mitochondrial DNA Control Region Sequences, Acta Genetica Sinaca, 2004,31(9):970-975

41.    Hu Wen-Ge，Wang Jin-Fu，Sheng Jin-Liang，Duan Zi-Yuan，Ma Run-Lin, Polymorphism and Original Analysis of mtDNA D-loop of Three Leuciscus Species in Xinjiang, Hereditas(Beijing), 2003,25(4)：414-418

42.    Hu Wen-Ge,Duan Zi-Yuan, Wang Jin-Fu, Sheng Jin-Liang, Divergence and Systematical Evolution of Three Leuciscus Species in Xinjiang：Mitochondrial DNA Cytochrome b Sequences, Chinese Journal of Zoology, 2005,40(3):6-11

43.    Huang Zhaofeng，Zhong Naiqing，Tan Pingping，Duan Ziyuan*，Chen Weiping，Liu Yunzhong，Luo Tianyi, Analysis for Genetic Background of Laboratory Beagle Dog with Random Amplified Polymorphic DNA(RAPD), Acta Laboratorium Animals Scientia Sinica,2002,10(2): 65~68

44.    Cheng Hui,Huang Zhaofeng, Duan Ziyuan*, Advances in the Appfication of SPR Biosensors, China Biotechnology, 2003, 23(5):46-49

1.      DUAN Ziyuan, HOU Kaili, WANG Xiaoqi, ZHANG Ruiying，The high efficiency swine promoter and its application, CN105779455 B, 2016.

2.      DUAN Ziyuan, XU Chongfeng, XIE Zhengde, ZHANG Qingxu, A human NK / T cell line, CN108220237A, 2018.

Dr. Duan’s research interests include the mechanism of Epstein-Barr virus (EBV) latent infection, reactivation in vivo and related immunometabolism. Dr. Duan’s group has developed a new method to establish NK and T cell lines from patients with chronic active Epstein-Barr virus infection (CAEBV) and hemophagocytic lymphohistiocytosis (HLH) by culturing the peripheral blood mononuclear cells (PBMC) with the addition of recombinant human IL-2 (rhIL-2) and as little as 2 mL of whole blood. They discovered a new mechanism for latent membrane protein 1 (LMP1) of EBV to downregulate RIG-I signaling pathway and inhibit IFN-β production by promoting RIG-I degradation dependent on proteasome. They identified miRNAs regulation involved in EBV infection and associated diseases especially in its related tumors. He is leading Human Cell Lineage Atlas Facility (CLAF) project. He has won 1 second prize and 3 thrid prizes of provincial and ministeria level, and 10 national invention patents. He has published more than 50 research papers in international journals.

现指导学生

史林靖  硕士研究生  071009-细胞生物学  

涂幸  博士研究生  071009-细胞生物学  

李思奇  博士研究生  071009-细胞生物学  

余长发  硕士研究生  086000-生物与医药  

林紫涵  硕士研究生  071010-生物化学与分子生物学  

Third Class Award For Advancement in Science and Technology, the Government of Tibetan Autonomous Region, 2018 

First Class Award For Advancement in Science and Technology, Department of Sci.-Thch of Gansu province Government, 1998    

First Class Award For Advancement in Science and Technology, Department of Animal Science of Gansu province Government, 1997  

Third Class Award For Advancement in Science and Technology, Department of Animal Science of Gansu province Government, 1994

Third Class Award For Advancement in Science and Technology, Ministry of Education of China, 1992