071005-微生物学
071010-生物化学与分子生物学

疫苗开发，病原诊断，致病机理研究

2010-09--2014-07   中国科学院武汉病毒研究所   学生/研究生博士
2007-09--2010-07   福建农林大学   学生/研究生硕士
2003-09--2007-07   青岛农业大学   学生/本科学士

研究生

博士

   

2015-10~2019-12,University of Texas Medical Branch, 博士后
2014-07~2015-08,Novartis Institute for Tropical Diseases (Singapore), 科研助理

   

（ 1 ） Reverse Genetics System of Zika Virus, 实用新型, 2019, 第 3 作者, 专利号: 16/098,401

   

[1] Wenlin Ren, Yu Zhang, Juhong Rao, Ziyi Wang, Jun Lan, Kunpeng Liu, Xuekai Zhang, Xue Hu, Chen Yang, Guocai Zhong, Rong Zhang, Xinquan Wang, Chao Shan, Qiang Ding, XiangJin Meng. Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant. MBIO[J]. 2023, 14(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127688/.
[2] Wang, Ran, Zhang, Meng, Zhang, Linlin, Liu, Mengjia, Shan, Chao, An, Jing, Xie, Zhengde. Japanese Encephalitis Vaccine Generates Cross-Reactive Memory T Cell Responses to Zika Virus in Humans. JOURNAL OF TROPICAL MEDICINE[J]. 2022, 2022: http://dx.doi.org/10.1155/2022/8379286.
[3] Mingqing Lu, Kunpeng Liu, Yun Peng, Zhe Ding, Yingwen Li, Alexander Tendu, Xue Hu, Ge Gao, Weiwei Guo, Hang Liu, Juhong Rao, Jiaxuan Zhao, Miaoyu Chen, Zhiming Yuan, Gary Wong, Chao Shan, Yanfeng Yao, Jiaming Lan. Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice. VIROLOGICA SINICA. 2022, 37(4): 581-590, http://dx.doi.org/10.1016/j.virs.2022.05.006.
[4] Zhang, Jing, Wang, Bin, Gao, Xiaoxiao, Peng, Cheng, Shan, Chao, Johnson, Silas F, Schwartz, Richard C, Zheng, YongHui. RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-33805-9.
[5] Wang, Ziyan, An, Jiao, Liu, Kunpeng, Yu, Pin, Fang, Xin, Li, Jiadai, Zhu, Hua, Zhu, Qianjun, Huang, Chuanqi, Zhang, Chao, Zhao, Binbin, Bao, Linlin, Song, Yujiao, Cao, Xiayao, Hu, Dongdong, Jiang, Yuanxiang, Shi, Likang, Zhou, Lingyun, Fan, Jiang, Guan, Wuxiang, Zhou, Chenliang, Hu, Zhongyu, Yuan, Zhiming, Liu, Jiangning, Shan, Chao, Liu, Ge. A potent, broadly protective vaccine against SARS-CoV-2 variants of concern. NPJ VACCINES[J]. 2022, 7(1): http://dx.doi.org/10.1038/s41541-022-00571-0.
[6] Maria I Giraldo, Hongjie Xia, Leopoldo AguileraAguirre, Adam Hage, Sarah van Tol, Chao Shan, Xuping Xie, Gail L Sturdevant, Shelly J Robertson, Kristin L McNally, Kimberly MeadeWhite, Sasha R Azar, Shannan L Rossi, Wendy Maury, Michael Woodson, Holly Ramage, Jeffrey R Johnson, Nevan J Krogan, Marc C Morais, Sonja M Best, PeiYong Shi, Ricardo Rajsbaum. Envelope Protein Ubiquitination Drives Zika Virus Entry and Pathogenesis. NATURE. 2020, 585(7825): 414-419, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501154/.
[7] Shan, Chao, Yao, YanFeng, Yang, XingLou, Zhou, YiWu, Gao, Ge, Peng, Yun, Yang, Lian, Hu, Xue, Xiong, Jin, Jiang, RenDi, Zhang, HuaJun, Gao, XiaoXiao, Peng, Cheng, Min, Juan, Chen, Ying, Si, HaoRui, Wu, Jia, Zhou, Peng, Wang, YanYi, Wei, HongPing, Pang, Wei, Hu, ZhengFei, Lv, LongBao, Zheng, YongTang, Shi, ZhengLi, Yuan, ZhiMing. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. CELL RESEARCH[J]. 2020, 30(8): 670-677, http://lib.cqvip.com/Qikan/Article/Detail?id=7102918057.
[8] Xu, Pei, Shan, Chao, Dunn, Tiffany J, Xie, Xuping, Xia, Hongjie, Gao, Junling, Allende Labastida, Javier, Zou, Jing, Villarreal, Paula P, Schlagal, Caitlin R, Yu, Yongjia, Vargas, Gracie, Rossi, Shannan L, Vasilakis, Nikolaos, Shi, PeiYong, Weaver, Scott C, Wu, Ping. Role of microglia in the dissemination of Zika virus from mother to fetal brain. PLOS NEGLECTED TROPICAL DISEASES[J]. 2020, 14(7): https://doaj.org/article/27c67549d70f43b58c2f73aac794300f.
[9] Jiang, RenDi, Liu, MeiQin, Chen, Ying, Shan, Chao, Zhou, YiWu, Shen, XuRui, Li, Qian, Zhang, Lei, Zhu, Yan, Si, HaoRui, Wang, Qi, Min, Juan, Wang, Xi, Zhang, Wei, Li, Bei, Zhang, HuaJun, Baric, Ralph S, Zhou, Peng, Yang, XingLou, Shi, ZhengLi. Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. CELL[J]. 2020, 182(1): 50-+, http://dx.doi.org/10.1016/j.cell.2020.05.027.
[10] Nunes, Bruno T D, FontesGarfias, Camila R, Shan, Chao, Muruato, Antonio E, Nunes, Jannyce G C, Burbano, Rommel M R, Vasconcelos, Pedro F C, Shi, PeiYong, Medeiros, Daniele B A. Zika structural genes determine the virulence of African and Asian lineages. EMERGING MICROBES & INFECTIONS[J]. 2020, 9(1): 1023-1033, http://dx.doi.org/10.1080/22221751.2020.1753583.
[11] Feng, Liqiang, Wang, Qian, Shan, Chao, Yang, Chenchen, Feng, Ying, Wu, Jia, Liu, Xiaolin, Zhou, Yiwu, Jiang, Rendi, Hu, Peiyu, Liu, Xinglong, Zhang, Fan, Li, Pingchao, Niu, Xuefeng, Liu, Yichu, Zheng, Xuehua, Luo, Jia, Sun, Jing, Gu, Yingying, Liu, Bo, Xu, Yongcun, Li, Chufang, Pan, Weiqi, Zhao, Jincun, Ke, Changwen, Chen, Xinwen, Xu, Tao, Zhong, Nanshan, Guan, Suhua, Yuan, Zhiming, Chen, Ling. An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. NATURE COMMUNICATIONS[J]. 2020, 11(1): https://doaj.org/article/30d2b47ccb1d4b11a9dcc003e80a75d7.
[12] Wang, Shuang, Peng, Yun, Wang, Rongjuan, Jiao, Shasha, Wang, Min, Huang, Weijin, Shan, Chao, Jiang, Wen, Li, Zepeng, Gu, Chunying, Chen, Ben, Hu, Xue, Yao, Yanfeng, Min, Juan, Zhang, Huajun, Chen, Ying, Gao, Ge, Tang, Peipei, Li, Gang, Wang, An, Wang, Lan, Zhang, Jinchao, Chen, Shuo, Gui, Xun, Yuan, Zhiming, Liu, Datao. Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys. NATURE COMMUNICATIONS[J]. 2020, 11(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666115/.
[13] Li, Anzhong, Lu, Mijia, Yu, Jingyou, Harder, Olivia, Attia, Zayed, Shan, Chao, Liang, Xueya, Xue, Miaoge, Shi, PeiYong, Peeples, Mark E, Liu, ShanLu, Boyaka, Prosper N, Niewiesk, Stefan, Li, Jianrong. Novel non-segmented negative-sense RNA virus-based vaccine platforms for Zika virus. JOURNAL OF IMMUNOLOGYnull. 2020, 204(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000589972402041.
[14] Shi, Rui, Shan, Chao, Duan, Xiaomin, Chen, Zhihai, Liu, Peipei, Song, Jinwen, Song, Tao, Bi, Xiaoshan, Han, Chao, Wu, Lianao, Gao, Ge, Hu, Xue, Zhang, Yanan, Tong, Zhou, Huang, Weijin, Liu, William Jun, Wu, Guizhen, Zhang, Bo, Wang, Lan, Qi, Jianxun, Feng, Hui, Wang, FuSheng, Wang, Qihui, Gao, George Fu, Yuan, Zhiming, Yan, Jinghua. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. NATURE[J]. 2020, 584(7819): 120-+, http://dx.doi.org/10.1038/s41586-020-2381-y.
[15] Shan, Chao, Xia, Hongjie, Haller, Sherry L, Azar, Sasha R, Liu, Yang, Liu, Jianying, Muruato, Antonio E, Chen, Rubing, Rossi, Shannan L, Wakamiya, Maki, Vasilakis, Nikos, Pei, Rongjuan, FontesGarfias, Camila R, Singh, Sanjay Kumar, Xie, Xuping, Weaver, Scott C, Shi, PeiYong. A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(33): 20190-20197, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443865/.
[16] Huanle Luo, Guangyu Li, Binbin Wang, Bing Tian, Junling Gao, Jing Zou, Shuizhen Shi, Shuang Zhu, BiHung Peng, Awadalkareem Adam, Ariza Martinez, Kimberly Hein, Evandro R Winkelmann, Yoseph Mahmoud, Xiaofei Zhou, Chao Shan, Shannan Rossi, Scott Weaver, Alan D T Barrett, ShaoCong Sun, Wenbo Zhang, PeiYong Shi, Ping Wu, Tian Wang. Peli1 signaling blockade attenuates congenital zika syndrome. PLOS PATHOGENS[J]. 2020, 16(6): https://doaj.org/article/e6aaf087f9c54d1ebedc84ee5fae74d3.
[17] Chao Shan, Xuping Xie, Huanle Luo, Antonio E Muruato, Yang Liu, Maki Wakamiya, JunHo La, Jin Mo Chung, Scott C Weaver, Tian Wang, PeiYong Shi. Maternal vaccination and protective immunity against Zika virus vertical transmission. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-12, http://dx.doi.org/10.1038/s41467-019-13589-1.
[18] Muruato, Antonio E, Shan, Chao, FontesGarfias, Camila R, Liu, Yang, Cao, Zengguo, Gao, Qiang, Weaver, Scott C, Shi, PeiYong. Genetic stability of live-attenuated Zika vaccine candidates. ANTIVIRAL RESEARCH[J]. 2019, 171: http://dx.doi.org/10.1016/j.antiviral.2019.104596.
[19] Xia, Hongjie, Xie, Xuping, Shan, Chao, Shi, PeiYong. Potential Mechanisms for Enhanced Zika Epidemic and Disease. ACS INFECTIOUS DISEASESnull. 2018, 4(5): 656-659, http://dx.doi.org/10.1021/acsinfecdis.8b00004.
[20] Shan, Chao, Xie, Xuping, Zou, Jing, Zust, Roland, Zhang, Bo, Ambrose, Rebecca, Mackenzie, Jason, Fink, Katja, Shi, PeiYong. Using a Virion Assembly-Defective Dengue Virus as a Vaccine Approach. JOURNAL OF VIROLOGY[J]. 2018, 92(21): http://202.127.146.157/handle/2RYDP1HH/5987.
[21] Shan, Chao, Xie, Xuping, Shi, PeiYong. Zika Virus Vaccine: Progress and Challenges. CELL HOST & MICROBEnull. 2018, 24(1): 12-17, http://dx.doi.org/10.1016/j.chom.2018.05.021.
[22] Chao Shan, Antonio E Muruato, Brett W Jagger, Justin Richner, Bruno T D Nunes, Daniele B A Medeiros, Xuping Xie, Jannyce G C Nunes, Kaitlyn M Morabito, WingPui Kong, Theodore C Pierson, Alan D Barrett, Scott C Weaver, Shannan L Rossi, Pedro F C Vasconcelos, Barney S Graham, Michael S Diamond, PeiYong Shi. A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/0a510d6c03284bc5b71d32aceb231ae8.
[23] FontesGarfias, Camila R, Shan, Chao, Luo, Huanle, Muruato, Antonio E, Medeiros, Daniele B A, Mays, Elizabeth, Xie, Xuping, Zou, Jing, Roundy, Christopher M, Wakamiya, Maki, Rossi, Shannan L, Wang, Tian, Weaver, Scott C, Shi, PeiYong. Functional Analysis of Glycosylation of Zika Virus Envelope Protein. CELL REPORTS[J]. 2017, 21(5): 1180-1190, http://dx.doi.org/10.1016/j.celrep.2017.10.016.
[24] Chao Shan. Evolutionary enhancement of Zika virus infectivity in mosquitos. Nature. 2017, [25] Shan, Chao, Muruato, Antonio E, Nunes, Bruno T D, Luo, Huanle, Xie, Xuping, Medeiros, Daniele B A, Wakamiya, Maki, Tesh, Robert B, Barrett, Alan D, Wang, Tian, Weaver, Scott C, Vasconcelos, Pedro F C, Rossi, Shannan L, Shi, PeiYong. A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models. NATURE MEDICINE[J]. 2017, 23(6): 763-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000402768000019.
[26] Richner, Justin M, Jagger, Brett W, Shan, Chao, Fontes, Camila R, Dowd, Kimberly A, Cao, Bin, Himansu, Sunny, Caine, Elizabeth A, Nunes, Bruno T D, Medeiros, Daniele B A, Muruato, Antonio E, Foreman, Bryant M, Luo, Huanle, Wang, Tian, Barrett, Alan D, Weaver, Scott C, Vasconcelos, Pedro F C, Rossi, Shannan L, Ciaramella, Giuseppe, Mysorekar, Indira U, Pierson, Theodore C, Shi, PeiYong, Diamond, Michael S. Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease. CELL[J]. 2017, 170(2): 273-+, http://dx.doi.org/10.1016/j.cell.2017.06.040.
[27] Yang, Yujiao, Shan, Chao, Zou, Jing, Muruato, Antonio E, Bruno, Diniz Nunes, Daniele, Barbosa de Almeida Medeiros, Vasconcelos, Pedro F C, Rossi, Shannan L, Weaver, Scott C, Xie, Xuping, Shi, PeiYong. A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine. EBIOMEDICINE[J]. 2017, 17(C): 145-156, https://doaj.org/article/bf1a6628023f45e08132dc377e34d103.
[28] Shan, Chao, Ortiz, Daniel A, Yang, Yujiao, Wong, Susan J, Kramer, Laura D, Shi, PeiYong, Loeffelholz, Michael J, Ren, Ping. Evaluation of a Novel Reporter Virus Neutralization Test for Serological Diagnosis of Zika and Dengue Virus Infection. JOURNALOFCLINICALMICROBIOLOGY[J]. 2017, 55(10): 3028-3036, https://www.webofscience.com/wos/woscc/full-record/WOS:000411617400019.
[29] Shan, Chao, Xie, Xuping, Ren, Ping, Loeffelholz, Michael J, Yang, Yujiao, Furuya, Andrea, Dupuis, Alan P, II, Kramer, Laura D, Wong, Susan J, Shi, PeiYong. A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients. EBIOMEDICINE[J]. 2017, 17(C): 157-162, http://dx.doi.org/10.1016/j.ebiom.2017.03.006.
[30] Shan, Chao, Xie, Xuping, Muruato, Antonio E, Rossi, Shannan L, Roundy, Christopher M, Azar, Sasha R, Yang, Yujiao, Tesh, Robert B, Boume, Nigel, Barrett, Alan D, Vasilakis, Nikos, Weaver, Scott C, Shi, PeiYong. An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors. CELL HOST & MICROBE[J]. 2016, 19(6): 891-900, http://dx.doi.org/10.1016/j.chom.2016.05.004.
[31] Mengying Liang, Wanbo Tai, Yunyun Wang, Yulong Dai, Yanfeng Yao, Juan Min, Yiwu Zhou, Liang Liu, Chao Shan, Han Xia, Zhiming Yuan. SARS-CoV-2 infection induces testicular injury in Rhesus macaque. VIROLOGICA SINICA. http://dx.doi.org/10.1016/j.virs.2022.10.008.

（1） Reverse Genetics of RNA Viruses: Methods and Protocols, Springer, 2017-05, 第 5 作者

   

（ 1 ） 2019nCoV灭活疫苗, 主持, 国家级, 2020-01--2020-12
（ 2 ） 人才引进院匹配支持经费, 主持, 部委级, 2020-01--2022-09
（ 3 ） 人才引进匹配支持经费, 主持, 市地级, 2019-10--2022-09

（1）A single-dose live-attenuated Zika vaccine   2017-11-15
（2）A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models   2017-08-23
（3）A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models   2017-06-24
（4）An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors   2016-06-18

现指导学生

李纯洁  硕士研究生  085238-生物工程