基本信息
黄河  男  硕导  中国科学院上海药物研究所
电子邮件: hhuang@simm.ac.cn
通信地址: 上海市浦东张江祖冲之路555号
邮政编码:

招生信息

   
招生专业
100706-药理学
招生方向
化学生物学,蛋白质组学,表观遗传学,药物化学

教育背景

2004-09--2010-06   中国科学院上海药物研究所   药物设计学博士
2000-09--2004-06   同济大学   理学学士

工作经历

   
工作简历
2019-01~现在, 中国科学院上海药物研究所, 研究员
2015-09~2019-01,美国芝加哥大学, 研究助理
2012-11~2015-08,美国芝加哥大学, 博士后
2010-08~2012-10,美国西北大学, 博士后
2004-09~2010-06,中国科学院上海药物研究所, 药物设计学博士
2000-09~2004-06,同济大学, 理学学士

专利与奖励

   
奖励信息
(1) 中国科学院院长优秀奖, 院级, 2010
(2) 上海市高等学校优秀毕业生, 省级, 2010
(3) Eli Lilly亚洲优秀学位论文, 一等奖, 其他, 2010
(4) 首届中华医药澳门论坛最佳论文奖, 其他, 2009
(5) 第六届世界华人药物化学会议优秀墙报奖, 其他, 2008
专利成果
( 1 ) Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors, 2017, 第 2 作者, 专利号: US9682950B2
( 2 ) Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors, 2016, 第 2 作者, 专利号: US9242957B2
( 3 ) Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition., 2015, 第 3 作者, 专利号: US8932842B2
( 4 ) Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors., 2014, 第 2 作者, 专利号: US8735606B2
( 5 ) Selective neuronal nitric oxide synthase inhibitors., 2013, 第 3 作者, 专利号: US8557552B2

出版信息

   
发表论文
(1) p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis., Mol Cell, 2018, 第 1 作者
(2) Lysine benzoylation is a histone mark regulated by SIRT2., Nat Commun, 2018, 第 1 作者
(3) Landscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway., Cell Res, 2018, 第 1 作者
(4) Quantitative crotonylome analysis expands the roles of p300 in the regulation of lysine crotonylation pathway., Proteomics, 2018, 第 11 作者
(5) Structure of p300 in complex with acyl-CoA variants., Nat Chem Biol, 2017, 第 4 作者
(6) 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae., Proc Natl Acad Sci USA, 2017, 第 5 作者
(7) Metabolic Regulation of Gene Expression by Histone Lysine-X modification, Mol Cell, 2016, 第 5 作者
(8) Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain., Mol Cell, 2016, 第 8 作者
(9) Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters., Mol Cell, 2016, 第 3 作者
(10) TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions., Mol Cell, 2016, 第 5 作者
(11) Quantitative Proteomic Analysis of Histone Modifications, Chem Rev, 2015, 第 1 作者
(12) Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation,, Mol Cell, 2015, 第 3 作者
(13) Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors, J Med Chem, 2015, 第 7 作者
(14) SnapShot: Histone Modifications., Cell, 2014, 第 1 作者
(15) Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5., Cell Metab, 2014, 第 9 作者
(16) Silverman RB. Potent and Selective Double-headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma., J Med Chem, 2014, 第 1 作者
(17) Arylazanyl pyrazolone derivatives as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis., J Med Chem, 2013, 第 3 作者
(18) Structure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase., J Med Chem, 2013, 第 1 作者
(19) Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations., J Am Chem Soc, 2012, 第 1 作者
(20) Iron deprivation caused by a novel iron chelator thiosemicarbazone-24 suppresses hepatocellular carcinoma in vitro and in vivo., Clin Cancer Res, 2011, 第 1 作者
(21) A class of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity,, J Med Chem, 2010, 第 1 作者
(22) PH006, a novel and highly potent Src kinase inhibitor, suppresses tumor growth and metastasis in vitro and in vivo., Breast Cancer Res Tr, 2010, 第 1 作者
(23) Ligand-free Iron/Copper Cocatalyzed N-Arylations of Aryl Halides with Amines under Microwave Irradiation,, Green Chem, 2010, 第 2 作者
(24) Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors, Eur J Med Chem, 2009, 第 1 作者
(25) A Simple and Efficient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature,, J Org Chem, 2009, 第 1 作者
(26) Microwave-assisted Synthesis of Quinazolinone Derivatives by Efficient and Rapid Iron-Catalyzed Cyclization in Water,, Green Chem, 2009, 第 6 作者
(27) Efficient Iron/Copper Cocatalyzed Alkynylation of Aryl Iodides with Terminal Alkynes, J Org Chem, 2008, 第 1 作者
(28) Rapid and Efficient Pd-Catalyzed Sonogashira Coupling of Aryl Chlorides, J Org Chem, 2008, 第 1 作者
(29) Efficient Copper-Promoted N-Arylations of Aryl Halides with Amines, J Comb Chem, 2008, 第 1 作者
(30) Efficient Iron-Catalyzed N-Arylation of Aryl Halides with Amines, Org Lett, 2008, 第 2 作者

科研活动

   
参与会议
(1)Lysine benzoylation is a new type of histone mark regulated by SIRT2   2018-06-03
(2)Quantitative Proteomic Approach Reveals Landscape of the Regulatory Elements for Lysine β-hydroxybutyrylation   2017-06-04
(3)Landscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway   2017-04-25
(4)Lysine β-hydroxybutyrylation is a new type of protein post-translational modification associated with diverse pathophysiology   2016-06-05