基本信息
沈爱军 男 上海科技大学
电子邮件: shenaj@simm.ac.cn
通信地址: 上海市浦东新区祖冲之路555号
邮政编码:
电子邮件: shenaj@simm.ac.cn
通信地址: 上海市浦东新区祖冲之路555号
邮政编码:
招生信息
招生专业
100706-药理学
招生方向
肿瘤个体化靶向治疗肿瘤免疫治疗
教育背景
2005-09--2011-06 中国科学院上海药物研究所 博士1998-09--2002-06 第二军医大学 学士
工作经历
工作简历
2018-08~现在, 中国科学院上海药物研究所, 副研究员2016-10~2018-07,University of Texas, Southwestern Medical Center, Assistant Instructor2011-07~2015-06,中国科学院上海药物研究所, 助理研究员2005-09~2011-06,中国科学院上海药物研究所, 博士2002-10~2004-09,药明康德新药开发有限公司, 分析员1998-09~2002-06,第二军医大学, 学士
专利与奖励
奖励信息
(1) 分子靶向抗肿瘤药物生物标志物关键技术研发与应用, 一等奖, 省级, 2017(2) c-Met抑制剂疗效监控标志物的发现与确证, , 其他, 2016(3) c-Myc作为c-Met抑制剂疗效监控标志物的应用研究, 一等奖, 省级, 2015
出版信息
发表论文
(1) Identification and therapeutic intervention of coactivated anaplastic lymphoma kinase, fibroblast growth factor receptor 2, and ephrin type-A receptor 5 kinases in hepatocellular carcinoma, Hepatology, 2019, 通讯作者(2) Design, synthesis, and bioactivity evaluation of novel Bcl-2/HDAC dual-target inhibitors for the treatment of multiple myeloma, Bioorg Med Chem Lett, 2019, 通讯作者(3) A tight controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma, Theranostics, 2018, 通讯作者(4) Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs, Eur J Med Chem, 2018, 通讯作者(5) c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors, Clin Cancer Res, 2017, 第 2 作者(6) Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives, ACS Med Chem Lett, 2017, 通讯作者(7) Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors, Eur J Med Chem, 2017, 通讯作者(8) Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions, J Med Chem, 2016, 第 1 作者(9) Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer, Acta Pharm Sin B, 2016, 第 1 作者(10) Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors, Eur J Med Chem, 2016, 第 1 作者(11) c-Myc Alterations Confer Therapeutic Response and Acquired Resistance to c-Met Inhibitors in MET-Addicted Cancers, Cancer Res, 2015, 第 1 作者(12) Molecularly targeted cancer therapy: some lessons from the past decade, Trends Pharmacol Sci, 2014, 第 2 作者
科研活动
科研项目
( 1 ) 针对c-Myc作为激酶抑制剂疗效监控分子标志物的无创性检测体系的开发研究, 负责人, 国家任务, 2017-01--2020-12( 2 ) c-Met抑制剂SCC244疗效监控标志物研究, 负责人, 中国科学院计划, 2019-01--2020-12