071009-细胞生物学

订制干细胞及疾病的动物模型
胚胎来源干细胞及基因编辑
原始内胚层干细胞及新冠病毒的动物模型

2012-09--2018-04   Max Planck Research Unit for Neurogenetics   博士学位
2007-08--2009-06   上海生物化学与细胞生物学研究所   联合培养硕士研究生
2006-09--2009-06   扬州大学   硕士学位
2001-09--2005-06   湖南师范大学   学士学位

   

2019-09~现在, 中国科学院昆明动物研究所, 研究员
2018-04~2019-09,亥姆霍兹慕尼黑研究中心-表观遗传学与干细胞研究所, 博士后
2009-07~2012-07,上海生物化学与细胞生物学研究所, 研究实习员，助理研究员

2021-04-03-今,云南省干细胞学会, 理事

   

（1） 上海市科学技术奖, 一等奖, 省级, 2017

   

[1] Junzhu Yi, Xinlin Lei, Fangteng Guo, Qiubing Chen, Xueyong Chen, Kaitao Zhao, Chengliang Zhu, Xiaoming Cheng, Jiangwei Lin, Hao Yin, Yuchen Xia. Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models. ANTIVIRAL RESEARCH. 2023, 215: http://dx.doi.org/10.1016/j.antiviral.2023.105618.
[2] Nakatani, Tsunetoshi, Lin, Jiangwei, Ji, Fei, Ettinger, Andreas, Pontabry, Julien, Tokoro, Mikiko, AltamiranoPacheco, Luis, Fiorentino, Jonathan, Mahammadov, Elmir, Hatano, Yu, Van Rechem, Capucine, Chakraborty, Damayanti, RuizMorales, Elias R, Pascualli, Paola Y Arguello, Scialdone, Antonio, Yamagata, Kazuo, Whetstine, Johnathan R, Sadreyev, Ruslan, I, TorresPadilla, MariaElena. DNA replication fork speed underlies cell fate changes and promotes reprogramming. NATURE GENETICS[J]. 2022, 54(3): 318-+, http://dx.doi.org/10.1038/s41588-022-01023-0.
[3] Yu DD, Long Y, Xu L, Han JB, Xi J, Xu J, Yang LX, Zou QC, Qu W, Lin J, Li MH, 姚永刚. Infectivity of SARS-CoV-2 and protection against reinfection in rats. ZOOLOGICAL RESEARCH[J]. 2022, 43(6): 945-948, [4] Katidou, Markella, Grosmaitre, Xavier, Lin, Jiangwei, Mombaerts, Peter. G-protein coupled receptors Mc4r and Drd1a can serve as surrogate odorant receptors in mouse olfactory sensory neurons. MOLECULAR AND CELLULAR NEUROSCIENCE[J]. 2018, 88: 138-147, http://dx.doi.org/10.1016/j.mcn.2018.01.010.
[5] Lin, Jiangwei, Khan, Mona, Zapiec, Bolek, Mombaerts, Peter. PDGFRA Is Not Essential for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines. STEM CELL REPORTS[J]. 2017, 9(4): 1062-1070, http://dx.doi.org/10.1016/j.stemcr.2017.08.005.
[6] Koentgen, Frank, Lin, Jiangwei, Katidou, Markella, Chang, Isabelle, Khan, Mona, Watts, Jacqui, Mombaerts, Peter. Exclusive transmission of the embryonic stem cell-derived genome through the mouse germline. GENESIS[J]. 2016, 54(6): 326-333, https://www.webofscience.com/wos/woscc/full-record/WOS:000379165300002.
[7] Lin, Jiangwei, Khan, Mona, Zapiec, Bolek, Mombaerts, Peter. Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000389890100001.
[8] Qin, Yiren, Lin, Jiangwei, Zhou, Chikai, Yin, Qi, Xie, Zhenfei, Zhang, Xuan, Liu, XinYuan, Gao, Weiqiang, Li, Jinsong. Mice cloned from white adipose tissue-derived cells. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2013, 5(5): 348-350, https://www.webofscience.com/wos/woscc/full-record/WOS:000325491200008.
[9] Lin, Jiangwei, Shi, Linyu, Zhang, Man, Yang, Hui, Qin, Yiren, Zhang, Jun, Gong, Daoqing, Zhang, Xuan, Li, Dangsheng, Li, Jinsong. Defects in Trophoblast Cell Lineage Account for the Impaired In Vivo Development of Cloned Embryos Generated by Somatic Nuclear Transfer. CELL STEM CELL[J]. 2011, 8(4): 371-375, http://dx.doi.org/10.1016/j.stem.2011.02.007.
[10] Jiang, Jing, Ding, Guohui, Lin, Jiangwei, Zhang, Man, Shi, Linyu, Lv, Wenjian, Yang, Hui, Xiao, Huasheng, Pei, Gang, Li, Yixue, Wu, Jiarui, Li, Jinsong. Different developmental potential of pluripotent stem cells generated by different reprogramming strategies. JOURNAL OF MOLECULAR CELL BIOLOGY. 2011, 3(3): 197-199, https://www.webofscience.com/wos/woscc/full-record/WOS:000293624900010.
[11] Li, Xiang, Zhu, Lili, Yang, Acong, Lin, Jiangwei, Tang, Fan, Jin, Shibo, Wei, Zhe, Li, Jinsong, Jin, Ying. Calcineurin-NFAT Signaling Critically Regulates Early Lineage Specification in Mouse Embryonic Stem Cells and Embryos. CELL STEM CELL[J]. 2011, 8(1): 46-58, http://dx.doi.org/10.1016/j.stem.2010.11.027.
[12] Yang, Hui, Shi, Linyu, Zhang, Shenghua, Lin, Jiangwei, Jiang, Jing, Li, Jinsong. High-efficiency somatic reprogramming induced by intact MII oocytes. CELL RESEARCH[J]. 2010, 20(9): 1034-1042, http://dx.doi.org/10.1038/cr.2010.97.

   

（ 1 ） 启动经费, 主持, 市地级, 2019-10--2022-09
（ 2 ） 核移植囊胚的细胞谱系重编程机制, 主持, 国家级, 2020-01--2023-12

现指导学生

陈雪永  硕士研究生  085238-生物工程  

席佳玮  硕士研究生  085238-生物工程  

郭强  博士研究生  071007-遗传学  

于婷婷  博士研究生  071009-细胞生物学  

李国蒙  博士研究生  071009-细胞生物学