071010-生物化学与分子生物学

蛋白质生物合成的分子基础与相关疾病

2004-09--2009-05   中国科学院上海生命科学研究院   获得博士学位
2000-09--2004-06   安徽师范大学   获得学士学位

   

2019-05~2024-04,中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 任职研究组长
2017-11~2024-04,中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 任职研究员
2009-06~2017-10,中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 任职助理研究员、副研究员
2004-09~2009-05,中国科学院上海生命科学研究院, 获得博士学位
2000-09~2004-06,安徽师范大学, 获得学士学位

2019-05-01-2024-04-30,中国生物化学与分子生物学学会核酸专业委员会青年委员会, 副主任

   

（1） 上海市青年科技启明星, 一等奖, 省级, 2016
（2） 赛诺菲-中科院上海生命科学研究院优秀青年人才奖, 一等奖, 研究所（学校）, 2012
（3） 中科院卢嘉锡青年人才奖, 一等奖, 院级, 2011

   

（1） Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023, 通讯作者
（2） Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023, 第 9 作者
（3） Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022, 通讯作者
（4） Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022, 通讯作者
（5） Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022, 通讯作者
（6） RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022, 通讯作者
（7） Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022, 通讯作者
（8） Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021, 通讯作者
（9） 多氨基酰-tRNA合成酶复合物的发生发展, The development of multiple synthetase complex(MSC), 生命科学, 2021, 第 2 作者
（10） Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 通讯作者
（11） The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021, 通讯作者
（12） Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021, 通讯作者
（13） Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA-LIFE SCIENCES, 2021, 通讯作者
（14） Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020, 通讯作者
（15） Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020, 通讯作者
（16） Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA^(Lys), Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA(Lys), SCIENCE CHINA-LIFE SCIENCES, 2020, 通讯作者
（17） 氨基酰-tRNA合成酶与神经系统疾病, Aminoacyl-tRNA synthetase in neuropathy, 生命科学, 2020, 第 2 作者
（18） The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019, 通讯作者
（19） Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019, 通讯作者
（20） Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, NUCLEIC ACIDS RESEARCH, 2018, 第 2 作者
（21） A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, NUCLEIC ACIDS RESEARCH, 2018, 通讯作者
（22） A natural non-Watson-Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations, NUCLEIC ACIDS RESEARCH, 2018, 通讯作者
（23） Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism, HUMAN MUTATION, 2017, 第 1 作者
（24） Translational Quality Control by Bacterial Threonyl-tRNA Synthetases, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 1 作者
（25） A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 通讯作者
（26） C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 通讯作者
（27） Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 通讯作者
（28） Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 6 作者
（29） A minimalist mitochondrial threonyl-tRNA synthetase exhibits tRNA-isoacceptor specificity during proofreading, NUCLEIC ACIDS RESEARCH, 2014, 第 1 作者
（30） Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode, NUCLEIC ACIDS RESEARCH, 2014, 通讯作者

   

（ 1 ） 蛋白质生物合成, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） 人线粒体tRNA修饰及其缺陷导致线粒体相关疾病的机理研究, 负责人, 国家任务, 2019-01--2022-12
（ 3 ） 线粒体tRNAThr及苏氨酰-tRNA合成酶基因突变导致线粒体脑肌病的机理研究, 负责人, 国家任务, 2017-01--2020-12

（1）氨基酰-tRNA合成酶与线粒体疾病   第10届全国核糖核酸会议   2018-06-15
（2）Nitric Oxide (NO)-induced S-nitrosation inhibits aminoacylation and editing activities of human mitochondrial threonyl-tRNA synthetase   2017-10-28
（3）KARS突变导致耳聋与智障的分子机理研究   第十三届全国酶学学术讨论会   2017-08-18
（4）Human threonyl-tRNA synthetase and disease   全国生化大会   2016-10-20
（5）Mitochondrial threonyl-tRNA synthetase and human disease   2015-10-17