基本信息
陈家文  男  硕导  中国科学院精密测量科学与技术创新研究院
电子邮件: jchen@wipm.ac.cn
通信地址: 湖北省武汉市武昌区小洪山西30号
邮政编码:

招生信息

   
招生专业
070304-物理化学
招生方向
生物物理,物理生物,分子建模,计算生物学

教育背景

2007-09--2013-07   武汉大学 物理科学与技术学院   博士
2003-09--2007-07   武汉大学 物理科学与技术学院   学士

工作经历

   
工作简历
2017-12~现在, 中国科学院武汉物理与数学研究所, 副研究员
2013-06~2017-11,美国 Albert Einstein College of Medicine, 博士后

出版信息

   
发表论文
[1] Wanqian Dong, Jiawen Chen, Rui Zhou, 舒正玉, 段谟杰. Phosphorylation Regulation on the Homo-Dimeric Binding of Transactive Response DNA-Binding Protein. JOURNALOFCHEMICALINFORMATIONANDMODELING[J]. 2022, [2] Haiyi Chen, Rui Zhou, Jinping Pang, Yue Guo, Jiawen Chen, Yu Kang, Duan, Mojie, tingjun hou. Molecular View on the Dissociation Pathways and Transactivation Regulation Mechanism of Nonsteroidal GR Ligands. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2021, [3] Chen, Jiawen, Qi, Yanping, Duan, Yong, Duan, Mojie, Yang, Minghui. C1188Dmutation abolishes specific recognition betweenMLL1-CXXCdomain andCpGsite by inducing conformational switch of flexible N-terminal. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS[J]. 2020, 88(11): 1401-1412, https://www.webofscience.com/wos/woscc/full-record/WOS:000545414800001.
[4] Wang, Bo, Xie, ZhongRu, Chen, Jiawen, Wu, Yinghao. Integrating Structural Information to Study the Dynamics of Protein-Protein Interactions in Cells. STRUCTURE[J]. 2018, 26(10): 1414-+, http://dx.doi.org/10.1016/j.str.2018.07.010.
[5] Chen, Jiawen, Wang, Bo, Wu, Yinghao. Structural Characterization and Function Prediction of Immunoglobulin-like Fold in Cell Adhesion and Cell Signaling. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2018, 58(2): 532-542, https://www.webofscience.com/wos/woscc/full-record/WOS:000426613800032.
[6] Jiawen Chen, Yinghao Wu. A multi-scale computational model for simulating the kinetics of protein complex assembly. METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.). 2018, 1764: 401-411, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003773/.
[7] Chen Jiawen, Xie ZhongRu, Wu Yinghao. Understand protein functions by comparing the similarity of local structural environments. BBA - PROTEINS AND PROTEOMICS[J]. 2017, 1865(2): 142-152, http://dx.doi.org/10.1016/j.bbapap.2016.11.008.
[8] Xie, ZhongRu, Chen, Jiawen, Wu, Yinghao. Predicting Protein-protein Association Rates using Coarse-grained Simulation and Machine Learning. SCIENTIFIC REPORTS[J]. 2017, 7: https://www.webofscience.com/wos/woscc/full-record/WOS:000399367200001.
[9] Chen, Jiawen, Almo, Steven C, Wu, Yinghao. General principles of binding between cell surface receptors and multi-specific ligands: A computational study. PLOS COMPUTATIONAL BIOLOGY[J]. 2017, 13(10): http://dx.doi.org/10.1371/journal.pcbi.1005805.
[10] Chen, Jiawen, Wu, Yinghao. Understanding the Functional Roles of Multiple Extracellular Domains in Cell Adhesion Molecules with a Coarse-Grained Model. JOURNAL OF MOLECULAR BIOLOGY[J]. 2017, 429(7): 1081-1095, http://dx.doi.org/10.1016/j.jmb.2017.02.013.
[11] Chen, Jiawen, Xie, ZhongRu, Wu, Yinghao. Elucidating the general principles of cell adhesion with a coarse-grained simulation model. MOLECULAR BIOSYSTEMS[J]. 2016, 12(1): 205-218, https://www.webofscience.com/wos/woscc/full-record/WOS:000367200100020.
[12] Chen, Jiawen, Newhall, Jillian, Xie, ZhongRu, Leckband, Deborah, Wu, Yinghao. A Computational Model for Kinetic Studies of Cadherin Binding and Clustering. BIOPHYSICAL JOURNAL[J]. 2016, 111(7): 1507-1518, http://dx.doi.org/10.1016/j.bpj.2016.08.038.
[13] Jiawen Chen, ZhongRu Xie, Yinghao Wu. Computational Modeling of the Interplay between Cadherin-Mediated Cell Adhesion and Wnt Signaling Pathway. PLOS ONE[J]. 2014, 9(6): https://doaj.org/article/dad2cfcc6ded413e97f935477dd1ea76.
[14] Chen, Jiawen, Xie, ZhongRu, Wu, Yinghao. A multiscale model for simulating binding kinetics of proteins with flexible linkers. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS[J]. 2014, 82(10): 2512-2522, https://www.webofscience.com/wos/woscc/full-record/WOS:000342849400019.

科研活动

   
科研项目
( 1 ) 产学研用协同的高通量材料计算融合服务平台, 参与, 国家级, 2018-07--2021-12