100706-药理学

分子系统药理学，生理学，生物化学
肿瘤学
肠道炎症性疾病

2001-09--中科院研究生院／中科院昆明动物研究所   硕博连读／理学博士
1997-09--陕西师范大学   本科学习／理学学士

   

2018-04~现在, 中科院昆明植物研究所, 研究员
2010-10~现在, Brigham & Women's hospital, Harvard Medical School, Research Fellow
2008-09~现在, university of illinois -urbana Champaign, Postdoctoral research fellow
2007-07~现在, 中科院昆明动物研究所, 助理研究员

2011-07-13-今,the Innovation Advisory Board member, AB SCIEX, Inc
2011-06-15-今,scientific editor, American Journal of Cardiovascular Disease Research,
2011-05-10-今,scientific editor, International Journal of Genetics and Molecular Biology

   

（ 1 ） 大蹼铃蟾非晶状体晶状体蛋白与三叶因子蛋白复合物何基因及制法及用途, 发明, 2010, 第 2 作者, 专利号: CN101230339B
（ 2 ） 眼镜王蛇毒蛋白酶抑制剂及其衍生物的应用, 发明, 2010, 第 3 作者, 专利号: CN101186646B

   

（1） The human milk oligosaccharide 2’-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation., Gut, 2016, 第 1 作者
（2） Molecular changes in endometriosis-associated ovarian clear cell carcinoma., European Journal of Cancer., 2015, 第 2 作者
（3） Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine., Mucosal Immunology, 2014, 第 1 作者
（4） Tolerance induction to human stem celltransplants with extension to their differentiated progeny., Nat Commun, 2014, 第 4 作者
（5） A Long Lasting b1 Adrenergic Receptor Stimulation of cAMP/Protein Kinase A (PKA) Signal in Cardiac Myocytes., J Bio. Chemistry., 2014, 第 6 作者
（6） Inference on differences between classes using cluster-specific contrasts of mixed effects., Biostatistics, 2014, 第 6 作者
（7） Putative Events in the development of clear cell ovarian carcinoma from endometriosis: An evaluation using immunohistochemistry and Gene expression profiling., Gynecologic Oncology, 2014, 第 2 作者
（8） The role of C-Terminal Binding Proteins in BRCA1 silencing and genetic instability of ovarian cancer cells., Clinical Cancer Research, 2013, 第 1 作者
（9） The Application of a Novel Nanovolume Capillary Electrophoresis- Based Protein Analysis System in Personalized & Translational Medicine Research., Journal of Bioanalysis and Biomedicine,, 2013, 第 1 作者
（10） BRCA1 Expression Is Epigenetically Repressed in Sporadic Ovarian Cancer Cells by Overexpression of C-Terminal Binding Protein 2, Neoplasia., 2013, 第 4 作者
（11） Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts., Proc Natl Acad Sci U S A., 2012, 第 1 作者
（12） Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells., EMBO Mol Med, 2012, 第 4 作者
（13） Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures, BMC Cancer, 2012, 第 4 作者
（14） FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes., Biochem Biophys Res Commun, 2011, 第 1 作者
（15） Galphas-biased beta2 adrenergic receptor signaling from restoring synchronous contraction in the failing heart., Sci Transl Med., 2011, 第 9 作者
（16） The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge., J Cell Sci., 2011, 第 4 作者
（17） Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes., Mol Pharmacol, 2010, 第 2 作者
（18） A Novel Non-Lens -Crystallin and Trefoil Factor Complex from Amphibian Skin and Its Functional Implications., PLoS ONE, 2008, 通讯作者
（19） Acute toxicity of bg-CAT, a naturally existing non-lens -crystallin and trefoil factor complex from frog Bombina maxima skin secretions., Toxicon., 2008, 第 1 作者
（20） bg-CAT, a non-lens bg-crystallin and trefoil factor complex from amphibian skin secretions, caused endothelium-dependent myocardial depression in isolated rabbit hearts,, Toxicon., 2008, 第 1 作者
（21） Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra., Peptides., 2008, 第 1 作者
（22） Melanoma cell growth inhibition by -CAT, a non-lens bg-crystallin and trefoil factor complex from frog Bombina maxima skin., Toxicon, 2008, 第 1 作者
（23） Cloning of bradykinin precursor cDNAs from skin of Bombina maxima reveals novel bombinakinin M antagonists and a bradykinin potential peptide., Regulatory Peptides, 2005, 第 2 作者
（24） Identification and molecular cloning of a novel neuromedin U analog from the skin secretions of toad Bombina maxima., Regulatory Peptides, 2005, 第 2 作者
（25） Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima., Regulatory Peptides, 2005, 第 2 作者

   

（ 1 ） GPCR动态信号转导解析炎症性疾病机制及天然活性产物筛选(Y8677211K1), 主持, 市地级, 2018-04--2021-04
（ 2 ） 动态解析炎症性心衰中GPCR信号转导机制及天然产物活性筛选(Y8690211Z1), 主持, 市地级, 2018-05--2020-05
（ 3 ） 时空动态筛选炎症性疾病的GPCR靶向药物, 主持, 部委级, 2019-05--2022-04

现指导学生

林健  硕士研究生  078006-药理学  

陈成  博士研究生  100706-药理学