Cell Fate Regulation and Systems Biology

2003-2007 Hubei University,  Biological Science，Bachelor

2007-2012 Guangzhou Institutes of Biomedical and Health, Chinese Academy of Sciences，Biochemical and Molecular Biology，Ph.D

Since July 2012, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, PI

Lin, R., Z. Zhai, J. Kuang, C. Wu, Y. Yao, R. Shi, J. He, S. Xu, P. Li, Y. Fan, W. Li, Z. Wu, X. Li, J. Ming, J. Guo, B. Wang, D. Li, S. Cao, X. Zhang, Y. Li, D. Pei and J. Liu (2022). "H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition." Cell Biosci 12(1): 89.

 Wu, H., C. Li, M. Masood, Z. Zhang, E. Gonzalez-Almela, A. Castells-Garcia, G. Zou, X. Xu, L. Wang, G. Zhao, S. Yu, P. Zhu, B. Wang, D. Qin and J. Liu (2022). "Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation." Cells 11(15).

Yu, S., C. Zhou, J. He, Z. Yao, X. Huang, B. Rong, H. Zhu, S. Wang, S. Chen, X. Wang, B. Cai, G. Zhao, Y. Chen, L. Xiao, H. Liu, Y. Qin, J. Guo, H. Wu, Z. Zhang, M. Zhang, X. Zhao, F. Lan, Y. Wang, J. Chen, S. Cao, D. Pei and J. Liu (2022). "BMP4 drives primed to naive transition through PGC-like state." Nat Commun 13(1): 2756.

Kuang J^#, Zhai Z^#, Li P, Shi R, Guo W, Yao Y, Guo J, Zhao G, He J, Xu S, Wu C, Yu S, Zhou C, Wu L, Qin Y, Cai B, Li W, Wu Z, Li X, Chu S, Yang T, Wang B, Cao S, Li D, Zhang X, Chen J, Liu J*, Pei D* (2021). SS18 regulates pluripotent-somatic transition through phase separation. Nat Commun. 2021 Jul 2;12(1):4090.  

Liu Y, He J, Chen R, Liu H, Chen J, Liu Y, Wang B, Guo L, Pei D, Wang J, Liu J*, Chen J* (2021). AP-1 activity is a major barrier of human somatic cell reprogramming. Cell Mol Life Sci. 2021 Aug;78(15):5847-5863.

Fu M^#, Chen H^#, Cai Z, Yang Y, Feng Z, Zeng M, Chen L, Qin Y, Cai B, Zhu P, Zhou C, Yu S, Guo J, Liu J*, Cao S*, Pei D* (2021). Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency. Cell Regen . 2021 Jul 2;10(1):17.

Wu, L., Zhao, G., Xu, S., Kuang, J., Min, J., Wu, G., Wang, T., Wang, B., Zhu, P., Pei, D. *, Liu J* (2021). The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure. J Biol Chem. 2021 Jan-Jun;296:100022.

Yu, S. ^#, C. Zhou^#, S. Cao^#, J. He^#, B. Cai, K. Wu, Y. Qin, X. Huang, L. Xiao, J. Ye, S. Xu, W. Xie, J. Kuang, S. Chu, J. Guo, H. Liu, W. Pang, L. Guo, M. Zeng, X. Wang, R. Luo, C. Li, G. Zhao, B. Wang, L. Wu, J. Chen, J. Liu* and D. Pei* (2020). "BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling." Nat Cell Biol 22(6): 651-662.

Wang, B., L. Wu, D. Li, Y. Liu, J. Guo, C. Li, Y. Yao, Y. Wang, G. Zhao, X. Wang, M. Fu, H. Liu, S. Cao, C. Wu, S. Yu, C. Zhou, Y. Qin, J. Kuang, J. Ming, S. Chu, X. Yang, P. Zhu, G. Pan, J. Chen, J. Liu* and D. Pei (2019). "Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4." Cell Rep 27(12): 3473-3485 e3475.

Cao, S^#., S. Yu^#, D. Li^#, J. Ye, X. Yang, C. Li, X. Wang, Y. Mai, Y. Qin, J. Wu, J. He, C. Zhou, H. Liu, B. Zhao, X. Shu, C. Wu, R. Chen, W. Chan, G. Pan, J. Chen*, J. Liu* and D. Pei* (2018). "Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency." Cell Stem Cell 22(4): 529-542 e525.

Wang, B., D. Li, J. Chen, J. Liu* and D. Pei* (2018). "Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension." Cell Regen 7(1): 16-21.

Li, D^#., J. Liu^#, X. Yang^#, C. Zhou, J. Guo, C. Wu, Y. Qin, L. Guo, J. He, S. Yu, H. Liu, X. Wang, F. Wu, J. Kuang, A. P. Hutchins*, J. Chen* and D. Pei* (2017). "Chromatin Accessibility Dynamics during iPSC Reprogramming." Cell Stem Cell 21(6): 819-833 e816.

Cao, S., S. Yu, Y. Chen, X. Wang, C. Zhou, Y. Liu, J. Kuang, H. Liu, D. Li, J. Ye, Y. Qin, S. Chu, L. Wu, L. Guo, Y. Li, X. Shu, J. Chen, J. Liu* and D. Pei* (2017). "Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage." J Biol Chem 292(46): 19122-19132.

Liu, J., Q. Han, T. Peng, M. Peng, B. Wei, D. Li, X. Wang, S. Yu, J. Yang, S. Cao, K. Huang, A. P. Hutchins, H. Liu, J. Kuang, Z. Zhou, J. Chen, H. Wu, L. Guo, Y. Chen, Y. Chen, X. Li, H. Wu, B. Liao, W. He, H. Song, H. Yao, G. Pan, J. Chen* and D. Pei* (2015). "The oncogene c-Jun impedes somatic cell reprogramming." Nat Cell Biol 17(7): 856-867.

Ouyang, J^#., W. Yu^#, J. Liu^#, N. Zhang, L. Florens, J. Chen, H. Liu, M. Washburn, D. Pei* and T. Xie* (2015). "Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state." J Biol Chem 290(37): 22782-22794.

Chen, J^#., J. Liu^#, J. Yang, Y. Chen, J. Chen, S. Ni, H. Song, L. Zeng, K. Ding and D. Pei* (2011). "BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone." Cell Res 21(1): 205-212.

Chen, J. ^#, J. Liu^#, Y. Chen, J. Yang, J. Chen, H. Liu, X. Zhao, K. Mo, H. Song, L. Guo, S. Chu, D. Wang, K. Ding and D. Pei * (2011). "Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics." Cell Res 21(6): 884-894.

Chen, J^#., J. Liu^#, Q. Han, D. Qin, J. Xu, Y. Chen, J. Yang, H. Song, D. Yang, M. Peng, W. He, R. Li, H. Wang, Y. Gan, K. Ding, L. Zeng, L. Lai, M. A. Esteban and D. Pei* (2010). "Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells." J Biol Chem 285(40): 31066-31072.

Cell fate regulation mechanism based on iPSC and PNT system;

Establishment of multispecies pluripotent stem cell lines and disease animal models;

Multidimensional data analysis and mathematical modeling of cell fate transformation process.