基本信息

杨慧  女  博导  中国科学院深圳先进技术研究院
电子邮件: hui.yang@siat.ac.cn
通信地址: 广东省深圳市南山区学苑大道1068号
邮政编码:

研究领域

生物微机电系统

微纳流控技术

生物传感技术


招生信息

   
招生专业
083100-生物医学工程
招生方向
生物化学传感
纳米技术
生物微机电系统BioMEMS

教育背景

2009-08--2014-05   瑞士洛桑联邦理工大学(EPFL)   科学博士
2006-09--2009-06   厦门大学   工学硕士
2002-09--2006-07   厦门大学   工学学士
学历

博士

瑞士洛桑联邦理工大学EPFL

工作经历

杨慧,博士,副研究员。2009年至2015年于瑞士联邦理工大学攻读博士学位与博士后工作期间,从事微流控与生物医学微系统的相关前沿研究,参与多项瑞士国家自然科学基金、欧盟研究委员会高级研究项目、欧盟第七框架研究基金项目等,获得出色成果。在科技成果转化方面具有丰富的经验,2015年至2017年作为研究科学家任职于比利时欧洲微电子研究中心(IMEC),主要开展片上集成微流控芯片与微纳米光学技术的前沿研究,在IMEC重大科技攻关课题全集成人体全血检测芯片MiLab项目(6000万欧元投资)中从事技术研发与项目管理,负责四项子课题中的两项——片上免疫荧光检测片上全血流式细胞检测的相关工作。作为广东省珠江人才计划引进创新创业团队核心成员于201710月回国,在中科院深圳先进技术研究院继续开展生物医学微系统前沿科学研究。迄今已经在Chemical Society Reviews (IF: 40.443), Nano Letters (IF: 12.712), Small (IF: 10.856), Analytical Chemistry (IF: 6.32)等国际著名SCI刊物和国际会议上发表论文30余篇。科研成果被多个国际著名科技媒体进行专题报道,多次应邀做国际会议邀请报告,担任多个国际期刊审稿人,申请国际与国家发明专利10余项。目前主持国家自然科学基金、广东省重大科技专项与深圳市科创委基础研究重点项目等。

杨慧博士在先进院生物医学与健康工程研究所组建了“生物医学微系统与纳米器件”研究课题组(Laboratory of Biomedical Microsystems and Nanodevices, BioMiND Lab),致力于微流控技术在生物医学上的应用研究,包括三个方向:一是低成本疾病诊断技术;二是生物单分子检测与成像技术;三是基于细胞外泌体的精准治疗方案

工作简历
2015-08~2017-09,比利时欧洲微电子研究中心(IMEC), 研究科学家(Research Scientist)
2014-05~2015-06,瑞士洛桑联邦理工大学(EPFL), 博士后研究员

教授课程

纳米生物传感器的设计

专利与奖励

   
奖励信息
(1) 国家优秀自费留学生奖学金, 一等奖, 部委级, 2013
(2) 厦门大学优秀硕士毕业生, 特等奖, 研究所(学校), 2009
专利成果
( 1 ) System for optical detection and imaging of sub-diffraction-limited nano-objects, 发明, 2016, 第 1 作者, 专利号: WO2016020831
( 2 ) 一种微米级手术刀, 发明, 2010, 第 3 作者, 专利号: CN101411638B
( 3 ) 微透镜阵列、光学检测装置及微透镜阵列制备方法, 发明, 2018, 第 1 作者, 专利号: CN108051876A
( 4 ) 一种外囊泡的表征方法, 发明, 2019, 第 1 作者, 专利号: 201910368813.9
( 5 ) 微孔金属膜及制备方法, 发明, 2018, 第 1 作者, 专利号: 201811643287.4

出版信息

   
发表论文
[1] Qing Liu, Liangtao Yang, Zhilin Zhang, Hui Yang, Yi Zhang, Jinglong Wu. The Feature, Performance, and Prospect of Advanced Electrodes for Electroencephalogram. BIOSENSORS[J]. 2023, 13(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855417/.
[2] Zitong Yu, Rui Hao, Xi Chen, Lu Ma, Yi Zhang, Hui Yang. Protocol to develop a microfluidic human corneal barrier-on-a-chip to evaluate the corneal epithelial wound repair process. STAR PROTOCOLS[J]. 2023, 4(1): 102122-, http://dx.doi.org/10.1016/j.xpro.2023.102122.
[3] Yingkai Lyu, Lixiang An, Huaiyang Zeng, Feng Zheng, Jiajia Guo, Pengcheng Zhang, Hui Yang, Hao Li. First-passage time analysis of diffusion-controlled reactions in single-molecule detection. TALANTA. 2023, 260: http://dx.doi.org/10.1016/j.talanta.2023.124569.
[4] Hao, Rui, Hu, Shi, Zhang, Huitao, Chen, Xi, Yu, Zitong, Ren, Jingyi, Guo, Hang, Yang, Hui. Mechanical stimulation on a microfluidic device to highly enhance small extracellular vesicle secretion of mesenchymal stem cells. MATERIALS TODAY BIO[J]. 2023, 18: http://dx.doi.org/10.1016/j.mtbio.2022.100527.
[5] Zeng, Lin, Chen, Xi, Zhang, Rongrong, Hu, Shi, Zhang, Hongpeng, Zhang, Yi, Yang, Hui. High-Resolution Separation of Nanoparticles Using a Negative Magnetophoretic Microfluidic System. MICROMACHINES[J]. 2022, 13(3): http://dx.doi.org/10.3390/mi13030377.
[6] Du, Jing, Zeng, Lin, Yu, Zitong, Chen, Sihui, Chen, Xi, Zhang, Yi, Yang, Hui. A magnetically enabled simulation of microgravity represses the auxin response during early seed germination on a microfluidic platform. MICROSYSTEMS & NANOENGINEERING[J]. 2022, 8(1): http://dx.doi.org/10.1038/s41378-021-00331-5.
[7] Zeng, Lin, Hu, Shi, Chen, Xi, Zhang, Pengcheng, Gu, Guoqiang, Wang, Yuye, Zhang, Hongpeng, Zhang, Yi, Yang, Hui. Extraction of small extracellular vesicles by label-free and biocompatible on-chip magnetic separation. LAB ON A CHIP[J]. 2022, 22(13): 2476-2488, http://dx.doi.org/10.1039/d2lc00217e.
[8] Zitong Yu, Rui Hao, Jing Du, Xiaoliang Wu, Xi Chen, Yi Zhang, Wei Li, Zhongze Gu, Hui Yang. A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles. ISCIENCE[J]. 2022, 25(5): 104200-, [9] Liangtao Yang, Lu Gan, Zhenggan Zhang, Zhilin Zhang, Hui Yang, Yi Zhang, Jinglong Wu. Insight into the Contact Impedance between the Electrode and the Skin Surface for Electrophysical Recordings. ACS Omega[J]. 2022, [10] Zhang, Pengcheng, Yan, Bing, Gu, Guoqiang, Yu, Zitong, Chen, Xi, Wang, Zengbo, Yang, Hui. Localized photonic nanojet based sensing platform for highly efficient signal amplification and quantitative biosensing. SENSORS AND ACTUATORS B-CHEMICAL[J]. 2022, 357: http://dx.doi.org/10.1016/j.snb.2022.131401.
[11] Yu, Zitong, Zhao, Chao, Hu, Shi, Zhang, Huitao, Li, Wenbo, Zhang, Renjie, Luo, Qian, Yang, Hui. MALDI-MS-based biomarker analysis of extracellular vesicles from human lung carcinoma cells. RSC ADVANCES[J]. 2021, 11(41): 25375-25380, http://dx.doi.org/10.1039/d1ra04305f.
[12] Hao, Rui, Yu, Zitong, Du, Jing, Hu, Shi, Yuan, Chao, Guo, Hang, Zhang, Yi, Yang, Hui. A High-Throughput Nanofluidic Device for Exosome Nanoporation to Develop Cargo Delivery Vehicles. SMALL[J]. 2021, 17(35): http://dx.doi.org/10.1002/smll.202102150.
[13] Zeng, Lin, Chen, Xi, Du, Jing, Yu, Zitong, Zhang, Rongrong, Zhang, Yi, Yang, Hui. Label-free separation of nanoscale particles by an ultrahigh gradient magnetic field in a microfluidic device. NANOSCALE[J]. 2021, 13(7): 4029-4037, https://www.webofscience.com/wos/woscc/full-record/WOS:000621767000040.
[14] Guoqiang Gu, Pengcheng Zhang, Sihui Chen, Yi Zhang, Hui Yang. Inflection point: a perspective on photonic nanojets. PHOTONICS RESEARCH[J]. 2021, 9(7): 1157-1171, http://dx.doi.org/10.1364/PRJ.419106.
[15] Chen, Xi, Chen, Sihui, Zhang, Yi, Yang, Hui. Study on Functionality and Surface Modification of a Stair-Step Liquid-Triggered Valve for On-Chip Flow Control. MICROMACHINES[J]. 2020, 11(7): https://doaj.org/article/f04eb8bfbbfd40f7a30172c48e859a2b.
[16] Zhang, Pengcheng, Chen, Xi, Yang, Hui. Large-Scale Fabrication of Photonic Nanojet Array via Template-Assisted Self-Assembly. MICROMACHINES[J]. 2020, 11(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000540761400023.
[17] Sihui Chen, Rui Hao, Yi Zhang, Hui Yang. Optofluidics in bio-imaging applications. 光子学研究:英文版[J]. 2019, 7(5): 532-542, http://lib.cqvip.com/Qikan/Article/Detail?id=7002260996.
[18] Yang, Hui, Zhang, Yi, Chen, Sihui, Hao, Rui. Micro-optical Components for Bioimaging on Tissues, Cells and Subcellular Structures. MICROMACHINES[J]. 2019, 10(6): https://doaj.org/article/2d4626e40ad2460cab0793e3c863b7b3.
[19] Chen, Sihui, Hao, Rui, Zhang, Yi, Yang, Hui. Optofluidics in bio-imaging applications. PHOTONICS RESEARCH[J]. 2019, 7(5): 532-542, http://lib.cqvip.com/Qikan/Article/Detail?id=7002260996.
[20] Yang, Hui, Gijs, Martin A M. Micro-optics for microfluidic analytical applications. CHEMICAL SOCIETY REVIEWSnull. 2018, 47(4): 1391-1458, http://ir.siat.ac.cn:8080/handle/172644/14438.
[21] Huszka, Gergely, Yang, Hui, Gijs, Martin A M. Microsphere-based super-resolution scanning optical microscope. OPTICS EXPRESS[J]. 2017, 25(13): 15079-15092, https://www.webofscience.com/wos/woscc/full-record/WOS:000404189800106.
[22] Yang, Hui, Trouillon, Raphael, Huszka, Gergely, Gijs, Martin A M. Super-Resolution Imaging of a Dielectric Microsphere Is Governed by the Waist of Its Photonic Nanojet. NANO LETTERS[J]. 2016, 16(8): 4862-4870, http://dx.doi.org/10.1021/acs.nanolett.6b01255.
[23] Yang, Hui, Gijs, Martin A M. Optical microscopy using a glass microsphere for metrology of sub-wavelength nanostructures. MICROELECTRONIC ENGINEERING[J]. 2015, 143: 86-90, http://dx.doi.org/10.1016/j.mee.2015.03.072.
[24] Yang, Hui, Cornaglia, Matteo, Gijs, Martin A M. Photonic Nanojet Array for Fast Detection of Single Nanoparticles in a Flow. NANO LETTERS[J]. 2015, 15(3): 1730-1735, http://dx.doi.org/10.1021/nl5044067.
[25] Yang, Hui, Moullan, Norman, Auwerx, Johan, Gijs, Martin A M. Super-Resolution Biological Microscopy Using Virtual Imaging by a Microsphere Nanoscope. SMALL[J]. 2014, 10(9): 1712-1718, http://dx.doi.org/10.1002/smll.201302942.
[26] Yang, Hui, Gijs, Martin A M. Microtextured Substrates and Microparticles Used as in Situ Lenses for On-Chip Immunofluorescence Amplification. ANALYTICAL CHEMISTRY[J]. 2013, 85(4): 2064-2071, http://dx.doi.org/10.1021/ac303471x.
[27] Shen, M, Yang, H, Sivagnanam, V, Gijs, M A M. Microfluidic Protein Preconcentrator Using a Microchannel-Integrated Nafion Strip: Experiment and Modeling. ANALYTICAL CHEMISTRY[J]. 2010, 82(24): 9989-9997, http://dx.doi.org/10.1021/ac102149f.

科研活动

   
科研项目
( 1 ) 基于MEMS/NEMS技术的植入式生理信息传感器关键技术研究, 主持, 省级, 2018-05--2021-03
( 2 ) 片上集成免疫荧光检测微机电系统关键技术研究, 参与, 省级, 2017-07--2020-06
( 3 ) 新型高灵敏度柔性仿生触觉传感技术研发及产业化, 参与, 省级, 2017-07--2022-06
( 4 ) 基于微纳光学结构阵列的超分辨扫描荧光生物成像, 主持, 国家级, 2019-01--2021-12
( 5 ) 深圳先进技术研究院-湃尔生物科技体外诊断先进技术与应用联合实验室, 主持, 院级, 2019-01--2021-12
( 6 ) 深圳先进技术研究院-利诺康医学检验实验室智能miRNA癌筛应用联合实验室, 主持, 院级, 2019-04--2022-03
参与会议
(1)Detection and quantification of single nanoparticles in a microfluidic device   2019-06-15
(2)Detection and quantification of single nanoparticles in a flow by a photonic nanojet array   2018-08-05
(3)Fast detection of single nanoparticles in a microfluidic channel   2017-12-11
(4)集成微透镜阵列的微流控系统在单个纳米颗粒检测中的应用   中国微米纳米技术学会首届微流控技术应用创新论坛   2017-12-09
(5)Fast detection of single nanoparticles in a microfluidic channel and super- resolution imaging of sub-wavelength nanostructures with dielectric microlenses   2017-07-25
(6)Fast detection of single nanoparticles in a microfluidic channel by a microlens array in combination with a conventional optical microscope   Yang H*, Cornaglia M, Gijs MAM.   2015-10-25
(7)Determination of sub-diffraction-limited organelles and biomolecules using microsphere lenses in combination with fluorescence microscopy   Yang H*, Moullan N, Auwerx J, Gijs MAM   2015-02-07
(8)Study of constrained Brownian motion of nanoparticles near an interface using optical tweezers   Yang H*, Cornaglia M, Trouillon R, Lehnert T, Gijs MAM   2015-02-07
(9)Lens array by electrostatic patterning of dielectric microspheres in a Parylene-C well template   Yang H*, Cornaglia M, Gijs MAM   2014-10-26
(10)Super-resolution optical microscopy using a glass microsphere nanoscope   Yang H*, Gijs MAM   2014-09-22
(11)Self-assembled melamine microlens arrays for immunofluorescence enhancement   Yang H*, Tekin HC, Sayah A, Gijs MAM   2013-10-27
(12)High-performance protein preconcentrator using microchannel-integrated Nafion strip   Yang H*, Shen M, Sivagnanam V, Gijs MAM   2011-06-09
(13)Study of spatio-temporal immunofluorescence on bead patterns in a microfluidic channel   2010-05-25